LOCUS       NM_001356570             876 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus casein kappa (Csn3), transcript variant 2, mRNA.
ACCESSION   NM_001356570 XM_006534765
VERSION     NM_001356570.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 876)
  AUTHORS   Gruper,Y., Wolff,A.S.B., Glanz,L., Spoutil,F., Marthinussen,M.C.,
            Osickova,A., Herzig,Y., Goldfarb,Y., Aranaz-Novaliches,G.,
            Dobes,J., Kadouri,N., Ben-Nun,O., Binyamin,A., Lavi,B., Givony,T.,
            Khalaila,R., Gome,T., Wald,T., Mrazkova,B., Sochen,C., Besnard,M.,
            Ben-Dor,S., Feldmesser,E., Orlova,E.M., Hegedus,C., Lampe,I.,
            Papp,T., Felszeghy,S., Sedlacek,R., Davidovich,E., Tal,N.,
            Shouval,D.S., Shamir,R., Guillonneau,C., Szondy,Z., Lundin,K.E.A.,
            Osicka,R., Prochazka,J., Husebye,E.S. and Abramson,J.
  TITLE     Autoimmune amelogenesis imperfecta in patients with APS-1 and
            coeliac disease
  JOURNAL   Nature 624 (7992), 653-662 (2023)
   PUBMED   37993717
REFERENCE   2  (bases 1 to 876)
  AUTHORS   Boro,M., Govatati,S., Kumar,R., Singh,N.K., Pichavaram,P.,
            Traylor,J.G. Jr., Orr,A.W. and Rao,G.N.
  TITLE     Thrombin-Par1 signaling axis disrupts COP9 signalosome subunit
            3-mediated ABCA1 stabilization in inducing foam cell formation and
            atherogenesis
  JOURNAL   Cell Death Differ 28 (2), 780-798 (2021)
   PUBMED   32968199
  REMARK    GeneRIF: Thrombin-Par1 signaling axis disrupts COP9 signalosome
            subunit 3-mediated ABCA1 stabilization in inducing foam cell
            formation and atherogenesis.
            Erratum:[Cell Death Differ. 2021 Jul;28(7):2303. doi:
            10.1038/s41418-020-00718-3.. PMID: 33437040]
REFERENCE   3  (bases 1 to 876)
  AUTHORS   Komori,R., Kobayashi,T., Matsuo,H., Kino,K. and Miyazawa,H.
  TITLE     Csn3 gene is regulated by all-trans retinoic acid during neural
            differentiation in mouse P19 cells
  JOURNAL   PLoS One 8 (4), e61938 (2013)
   PUBMED   23613978
  REMARK    GeneRIF: the Csn3 expression is upregulated via all-trans retinoic
            acid-bound RARalpha.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 876)
  AUTHORS   Kim,E., Yoon,S.J., Kim,E.Y., Kim,Y., Lee,H.S., Kim,K.H. and
            Lee,K.A.
  TITLE     Function of COP9 signalosome in regulation of mouse oocytes meiosis
            by regulating MPF activity and securing degradation
  JOURNAL   PLoS One 6 (10), e25870 (2011)
   PUBMED   21991377
  REMARK    GeneRIF: CSN3 and CSN5 are involved in oocyte meiosis by regulating
            degradation of Cyclin B1 and Securin via APC/C.
REFERENCE   5  (bases 1 to 876)
  AUTHORS   Lin,Q., Donahue,S.L., Moore-Jarrett,T., Cao,S., Osipovich,A.B. and
            Ruley,H.E.
  TITLE     Mutagenesis of diploid mammalian genes by gene entrapment
  JOURNAL   Nucleic Acids Res 34 (20), e139 (2006)
   PUBMED   17062627
REFERENCE   6  (bases 1 to 876)
  AUTHORS   Rijnkels,M., Wheeler,D.A., de Boer,H.A. and Pieper,F.R.
  TITLE     Structure and expression of the mouse casein gene locus
  JOURNAL   Mamm Genome 8 (1), 9-15 (1997)
   PUBMED   9021141
REFERENCE   7  (bases 1 to 876)
  AUTHORS   Gatesy,J., Hayashi,C., Cronin,M.A. and Arctander,P.
  TITLE     Evidence from milk casein genes that cetaceans are close relatives
            of hippopotamid artiodactyls
  JOURNAL   Mol Biol Evol 13 (7), 954-963 (1996)
   PUBMED   8752004
REFERENCE   8  (bases 1 to 876)
  AUTHORS   Tomlinson,A.M., Cox,R.D., Lehrach,H.R. and Dalrymple,M.A.
  TITLE     Restriction map of two yeast artificial chromosomes spanning the
            murine casein locus
  JOURNAL   Mamm Genome 7 (7), 542-544 (1996)
   PUBMED   8672136
REFERENCE   9  (bases 1 to 876)
  AUTHORS   Rijnkels,M., Kooiman,P.M., Krimpenfort,P.J., de Boer,H.A. and
            Pieper,F.R.
  TITLE     Expression analysis of the individual bovine beta-, alpha s2- and
            kappa-casein genes in transgenic mice
  JOURNAL   Biochem J 311 (Pt 3) (Pt 3), 929-937 (1995)
   PUBMED   7487953
REFERENCE   10 (bases 1 to 876)
  AUTHORS   Thompson,M.D., Dave,J.R. and Nakhasi,H.L.
  TITLE     Molecular cloning of mouse mammary gland kappa-casein: comparison
            with rat kappa-casein and rat and human gamma-fibrinogen
  JOURNAL   DNA 4 (4), 263-271 (1985)
   PUBMED   4042811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022298.31 and AK164788.1.
            
            On Oct 11, 2017 this sequence version replaced XM_006534765.2.
            
            Transcript Variant: This variant (2) differs in the 3' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI653621.1, BI250529.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC022298.31        79845-79872
            29-858              AK164788.1         2-831
            859-876             AC022298.31        86799-86816
FEATURES             Location/Qualifiers
     source          1..876
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 43.56 cM"
     gene            1..876
                     /gene="Csn3"
                     /gene_synonym="CSN10; Csnk"
                     /note="casein kappa"
                     /db_xref="GeneID:12994"
                     /db_xref="MGI:MGI:107461"
     exon            1..100
                     /gene="Csn3"
                     /gene_synonym="CSN10; Csnk"
                     /inference="alignment:Splign:2.1.0"
     exon            101..162
                     /gene="Csn3"
                     /gene_synonym="CSN10; Csnk"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..651
                     /gene="Csn3"
                     /gene_synonym="CSN10; Csnk"
                     /note="isoform a precursor is encoded by transcript
                     variant 2; kappa-casein"
                     /codon_start=1
                     /product="kappa-casein isoform a precursor"
                     /protein_id="NP_001343499.1"
                     /db_xref="CCDS:CCDS19396.1"
                     /db_xref="GeneID:12994"
                     /db_xref="MGI:MGI:107461"
                     /translation="MMRNFIVVVNILALTLPFLAAEIQNPDSNCRGEKNDIVYDEQRV
                     LYTPVRSVLNFNQYEPNYYHYRPSLPATASPYMYYPLVVRLLLLRSPAPISKWQSMPN
                     FPQSAGVPYAIPNPSFLAMPTNENQDNTAIPTIDPITPIVSTPVPTMESIVNTVANPE
                     ASTVSINTPETTTVPVSSTAA"
     exon            163..192
                     /gene="Csn3"
                     /gene_synonym="CSN10; Csnk"
                     /inference="alignment:Splign:2.1.0"
     exon            193..684
                     /gene="Csn3"
                     /gene_synonym="CSN10; Csnk"
                     /inference="alignment:Splign:2.1.0"
     exon            685..876
                     /gene="Csn3"
                     /gene_synonym="CSN10; Csnk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      836..841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csn3"
                     /gene_synonym="CSN10; Csnk"
                     /note="hexamer: AATAAA"
     polyA_site      856
                     /gene="Csn3"
                     /gene_synonym="CSN10; Csnk"
                     /note="major polyA site"
     regulatory      859..864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csn3"
                     /gene_synonym="CSN10; Csnk"
                     /note="hexamer: AATACA"
     polyA_site      871
                     /gene="Csn3"
                     /gene_synonym="CSN10; Csnk"
ORIGIN      
        1 aataccctgt aattagtctc cgttatttat cttgggtctt ctctgcagct aagaggccgg
       61 gcaaacccta ctgccaagca agaattgact ccaaataaag gtgcaatgat gaggaatttt
      121 atcgtagttg tgaatattct ggcattaact ctgccctttt tggctgcaga gatacaaaac
      181 ccagattcaa actgccgtgg tgagaagaat gacatagtgt acgatgagca aagagtcctg
      241 tacacaccag tccgctccgt cctgaacttc aatcaatatg aacctaatta ctaccactac
      301 aggccatctt tgcctgctac tgctagccca tacatgtact acccacttgt tgttagacta
      361 cttctgctta ggtctccagc cccaatctcc aaatggcaat caatgccaaa tttcccccag
      421 tctgctggag taccttatgc cattccaaac ccatcctttc ttgccatgcc tacaaatgaa
      481 aatcaggata acaccgccat tccaaccatc gaccccatta ctcccattgt gtccacacca
      541 gttcctacca tggagtcaat agtaaatact gtggccaatc ctgaagcttc cacagtgtct
      601 atcaataccc ctgagactac tacagtccca gtgtcctcaa ctgcagcata aaacactaag
      661 gaaacattga aaaagacaat aaaggtctgg aaccaaattt caacttgaaa ctccttcagg
      721 ggaaactctg ccatcattca agagaaaatg caattttcac agattcagat ctttctcgtc
      781 ttcccttacc ttttacatta acatcacagt taattttgtg ttttgattct taaagaataa
      841 agttaatgaa atgcaattaa tacatcttaa acctta
//
