LOCUS       NM_009972               1129 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus casein beta (Csn2), transcript variant 1, mRNA.
ACCESSION   NM_009972
VERSION     NM_009972.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1129)
  AUTHORS   Lin,H., Yan,Y., Luo,Y., So,W.Y., Wei,X., Zhang,X., Yang,X.,
            Zhang,J., Su,Y., Yang,X., Zhang,B., Zhang,K., Jiang,N.,
            Chow,B.K.C., Han,W., Wang,F. and Rao,F.
  TITLE     IP6-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic
            checkpoint to safeguard glucose-induced insulin secretion
  JOURNAL   Nat Commun 12 (1), 2461 (2021)
   PUBMED   33911083
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1129)
  AUTHORS   Kobayashi,K., Oyama,S., Kuki,C., Tsugami,Y., Matsunaga,K.,
            Suzuki,T. and Nishimura,T.
  TITLE     Distinct roles of prolactin, epidermal growth factor, and
            glucocorticoids in beta-casein secretion pathway in lactating
            mammary epithelial cells
  JOURNAL   Mol Cell Endocrinol 440, 16-24 (2017)
   PUBMED   27836773
  REMARK    GeneRIF: These results indicate that PRL, EGF and glucocorticoids
            have distinct roles in the establishment of beta-casein secretion
            pathway.
REFERENCE   3  (bases 1 to 1129)
  AUTHORS   Kobayashi,K., Tsugami,Y., Matsunaga,K., Oyama,S., Kuki,C. and
            Kumura,H.
  TITLE     Prolactin and glucocorticoid signaling induces lactation-specific
            tight junctions concurrent with beta-casein expression in mammary
            epithelial cells
  JOURNAL   Biochim Biophys Acta 1863 (8), 2006-2016 (2016)
   PUBMED   27130254
  REMARK    GeneRIF: Dexamethasone signaling upregulates Claudin-3 and -4
            without beta-casein expression. Prolactin and dexamethasone
            signaling synergistically upregulate beta-casein expression.
REFERENCE   4  (bases 1 to 1129)
  AUTHORS   Elias,S., Thion,M.S., Yu,H., Sousa,C.M., Lasgi,C., Morin,X. and
            Humbert,S.
  TITLE     Huntingtin regulates mammary stem cell division and differentiation
  JOURNAL   Stem Cell Reports 2 (4), 491-506 (2014)
   PUBMED   24749073
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1129)
  AUTHORS   Qian,X. and Zhao,F.Q.
  TITLE     Interactions of the ubiquitous octamer-binding transcription
            factor-1 with both the signal transducer and activator of
            transcription 5 and the glucocorticoid receptor mediate prolactin
            and glucocorticoid-induced beta-casein gene expression in mammary
            epithelial cells
  JOURNAL   Int J Biochem Cell Biol 45 (3), 724-735 (2013)
   PUBMED   23313770
  REMARK    GeneRIF: octamer-binding transcription factor-1 may serve as a
            master regulator that facilitates the DNA binding of both signal
            transducer and activator of transcription 5 and glucocorticoid
            receptor in hormone-induced beta-casein expression
REFERENCE   6  (bases 1 to 1129)
  AUTHORS   Schmitt-Ney,M., Happ,B., Ball,R.K. and Groner,B.
  TITLE     Developmental and environmental regulation of a mammary
            gland-specific nuclear factor essential for transcription of the
            gene encoding beta-casein
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 3130-3134 (1992)
   PUBMED   1557422
REFERENCE   7  (bases 1 to 1129)
  AUTHORS   Lee,C.S. and Oka,T.
  TITLE     A pregnancy-specific mammary nuclear factor involved in the
            repression of the mouse beta-casein gene transcription by
            progesterone
  JOURNAL   J Biol Chem 267 (9), 5797-5801 (1992)
   PUBMED   1556095
REFERENCE   8  (bases 1 to 1129)
  AUTHORS   Schmitt-Ney,M., Doppler,W., Ball,R.K. and Groner,B.
  TITLE     Beta-casein gene promoter activity is regulated by the
            hormone-mediated relief of transcriptional repression and a
            mammary-gland-specific nuclear factor
  JOURNAL   Mol Cell Biol 11 (7), 3745-3755 (1991)
   PUBMED   2046676
REFERENCE   9  (bases 1 to 1129)
  AUTHORS   Yoshimura,M. and Oka,T.
  TITLE     Transfection of beta-casein chimeric gene and hormonal induction of
            its expression in primary murine mammary epithelial cells
  JOURNAL   Proc Natl Acad Sci U S A 87 (10), 3670-3674 (1990)
   PUBMED   2187188
REFERENCE   10 (bases 1 to 1129)
  AUTHORS   Yoshimura,M. and Oka,T.
  TITLE     Isolation and structural analysis of the mouse beta-casein gene
  JOURNAL   Gene 78 (2), 267-275 (1989)
   PUBMED   2673924
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC074046.9 and AK052805.1.
            
            On Oct 26, 2013 this sequence version replaced NM_009972.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X04490.1, BC020356.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849377 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC074046.9         146525-146528
            5-1124              AK052805.1         2-1121
            1125-1129           AC074046.9         153327-153331
FEATURES             Location/Qualifiers
     source          1..1129
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 43.56 cM"
     gene            1..1129
                     /gene="Csn2"
                     /gene_synonym="Csnb"
                     /note="casein beta"
                     /db_xref="GeneID:12991"
                     /db_xref="MGI:MGI:88541"
     exon            1..47
                     /gene="Csn2"
                     /gene_synonym="Csnb"
                     /inference="alignment:Splign:2.1.0"
     exon            48..110
                     /gene="Csn2"
                     /gene_synonym="Csnb"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..755
                     /gene="Csn2"
                     /gene_synonym="Csnb"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; beta-casein"
                     /codon_start=1
                     /product="beta-casein isoform a precursor"
                     /protein_id="NP_034102.1"
                     /db_xref="CCDS:CCDS39131.1"
                     /db_xref="GeneID:12991"
                     /db_xref="MGI:MGI:88541"
                     /translation="MKVFILACLVALALARETTFTVSSETDSISSEESVEHINEQKLQ
                     KVNLMGQLQAEDVLQAKVHSSIQSQPQAFPYAQAQTISCNPVPQNIQPIAQPPVVPSL
                     GPVISPELESFLKAKATILPKHKQMPLLNSETVLRLINSQIPSLASLANLHLPQSLVQ
                     LLAQVVQAFPQTHLVSSQTQLSLPQSKVLYFLQQVAPFLPQDMSVQDLLQYLELLNPT
                     VQFPATPQHSVSV"
     exon            111..134
                     /gene="Csn2"
                     /gene_synonym="Csnb"
                     /inference="alignment:Splign:2.1.0"
     exon            135..155
                     /gene="Csn2"
                     /gene_synonym="Csnb"
                     /inference="alignment:Splign:2.1.0"
     exon            156..179
                     /gene="Csn2"
                     /gene_synonym="Csnb"
                     /inference="alignment:Splign:2.1.0"
     exon            180..224
                     /gene="Csn2"
                     /gene_synonym="Csnb"
                     /inference="alignment:Splign:2.1.0"
     exon            225..749
                     /gene="Csn2"
                     /gene_synonym="Csnb"
                     /inference="alignment:Splign:2.1.0"
     exon            750..794
                     /gene="Csn2"
                     /gene_synonym="Csnb"
                     /inference="alignment:Splign:2.1.0"
     exon            795..1129
                     /gene="Csn2"
                     /gene_synonym="Csnb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1101..1106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csn2"
                     /gene_synonym="Csnb"
                     /note="hexamer: AATAAA"
     polyA_site      1121
                     /gene="Csn2"
                     /gene_synonym="Csnb"
                     /note="major polyA site"
ORIGIN      
        1 ggacatcatc ctttcagctt cacctcctct cttgtcctcc actaaaggac ttgacagcca
       61 tgaaggtctt catcctcgcc tgccttgtgg cccttgctct tgcaagagag actacattta
      121 ctgtatcctc tgagactgat agtatttcca gtgaggaatc tgttgaacat atcaatgagc
      181 agaaacttca gaaggtgaat ctcatgggac agctgcaggc agaggatgtg ctccaggcta
      241 aagttcactc cagcatccag tcacagcccc aggcctttcc atatgctcag gctcaaacca
      301 tctcttgcaa tcccgtccca caaaacatcc agcctattgc tcaaccccct gtggtgccat
      361 ctcttgggcc tgtcatttct cctgaactgg aatccttcct taaagctaaa gccaccatcc
      421 ttcccaagca caaacagatg cccctcctta actctgaaac tgtgctccgc ctcataaact
      481 ctcaaatccc cagccttgcc agtcttgcta atctgcacct tcctcagtct ctggtccagc
      541 tcctggcaca ggttgttcag gcttttcctc agactcacct ggtttcttct cagacccagc
      601 tgtctcttcc tcagtccaaa gttctgtact ttctgcagca agtagcaccc ttccttccac
      661 aagatatgtc tgtccaagac cttctgcagt acctagaact tcttaacccc accgtccaat
      721 tccctgccac tccacaacat tccgtttctg tctaagagga tttccaggtt attttctcct
      781 ccttatgttt tttgaactga ctgaaactgg aaatgtacaa atcttttcac ctttggatca
      841 tgctacaaaa atgatatatt tctgaattaa tctacatgga agaaaagaaa atgtattctt
      901 ttatttattc tatgtattat atggcattca tttgaattcg acccatggac tctatatgct
      961 tctcagttat attacaggaa ttttataagt gttcaatatg gagttgaaaa tgcaagtcaa
     1021 taatgtatac aaaatagttt gtgaaaaatt ggattttcta ttttttttct ttgagaacct
     1081 atttcctttc cagtcatttc aataaaataa tcctttaggc atatttaag
//
