LOCUS       NM_007785               1049 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus casein alpha s2-like A (Csn1s2a), transcript variant
            1, mRNA.
ACCESSION   NM_007785
VERSION     NM_007785.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1049)
  AUTHORS   Triplett,A.A., Sakamoto,K., Matulka,L.A., Shen,L., Smith,G.H. and
            Wagner,K.U.
  TITLE     Expression of the whey acidic protein (Wap) is necessary for
            adequate nourishment of the offspring but not functional
            differentiation of mammary epithelial cells
  JOURNAL   Genesis 43 (1), 1-11 (2005)
   PUBMED   16106354
REFERENCE   2  (bases 1 to 1049)
  AUTHORS   Hadsell,D.L., Bonnette,S., George,J., Torres,D., Klimentidis,Y.,
            Gao,S., Haney,P.M., Summy-Long,J., Soloff,M.S., Parlow,A.F.,
            Sirito,M. and Sawadogo,M.
  TITLE     Diminished milk synthesis in upstream stimulatory factor 2 null
            mice is associated with decreased circulating oxytocin and
            decreased mammary gland expression of eukaryotic initiation factors
            4E and 4G
  JOURNAL   Mol Endocrinol 17 (11), 2251-2267 (2003)
   PUBMED   12907752
  REMARK    Erratum:[Mol Endocrinol. 2006 Nov;20(11):2975. Klementidis, Yann
            [corrected to Klimentidis, Yann]]
REFERENCE   3  (bases 1 to 1049)
  AUTHORS   Rijnkels,M., Elnitski,L., Miller,W. and Rosen,J.M.
  TITLE     Multispecies comparative analysis of a mammalian-specific genomic
            domain encoding secretory proteins
  JOURNAL   Genomics 82 (4), 417-432 (2003)
   PUBMED   13679022
REFERENCE   4  (bases 1 to 1049)
  AUTHORS   Kolb,A.F.
  TITLE     Structure and regulation of the murine gamma-casein gene
  JOURNAL   Biochim Biophys Acta 1579 (2-3), 101-116 (2002)
   PUBMED   12427545
  REMARK    GeneRIF: promoter is active in lactating mammary tissue; can be
            induced synergistically by glucocorticoids and prolactin;
            regulation of the promoter was analysed in cell culture models and
            compared to the regulaton of the beta casein promoter
REFERENCE   5  (bases 1 to 1049)
  AUTHORS   George,S., Clark,A.J. and Archibald,A.L.
  TITLE     Physical mapping of the murine casein locus reveals the gene order
            as alpha-beta-gamma-epsilon-kappa
  JOURNAL   DNA Cell Biol 16 (4), 477-484 (1997)
   PUBMED   9150435
REFERENCE   6  (bases 1 to 1049)
  AUTHORS   Tomlinson,A.M., Cox,R.D., Lehrach,H.R. and Dalrymple,M.A.
  TITLE     Restriction map of two yeast artificial chromosomes spanning the
            murine casein locus
  JOURNAL   Mamm Genome 7 (7), 542-544 (1996)
   PUBMED   8672136
REFERENCE   7  (bases 1 to 1049)
  AUTHORS   Sasaki,M., Sasaki,T. and Enami,J.
  TITLE     Prolactin-dependent growth and gamma-casein gene expression in
            Ba/F3 cells transfected with a long form of mouse mammary prolactin
            receptor
  JOURNAL   Endocr J 43 (1), 45-52 (1996)
   PUBMED   8732451
REFERENCE   8  (bases 1 to 1049)
  AUTHORS   Sasaki,T., Sasaki,M. and Enami,J.
  TITLE     Mouse gamma-casein cDNA: PCR cloning and sequence analysis
  JOURNAL   Zoolog Sci 10 (1), 65-72 (1993)
   PUBMED   7763793
REFERENCE   9  (bases 1 to 1049)
  AUTHORS   Hennighausen,L.G. and Sippel,A.E.
  TITLE     Characterization and cloning of the mRNAs specific for the
            lactating mouse mammary gland
  JOURNAL   Eur J Biochem 125 (1), 131-141 (1982)
   PUBMED   6896688
REFERENCE   10 (bases 1 to 1049)
  AUTHORS   Gupta,P., Rosen,J.M., D'Eustachio,P. and Ruddle,F.H.
  TITLE     Localization of the casein gene family to a single mouse chromosome
  JOURNAL   J Cell Biol 93 (1), 199-204 (1982)
   PUBMED   6896059
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC074046.9, AK142688.1 and BB661763.1.
            
            On Feb 11, 2015 this sequence version replaced NM_007785.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI455982.1, BI249282.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AC074046.9         71378-71500         c
            124-1037            AK142688.1         2-915
            1038-1049           BB661763.1         114-125
FEATURES             Location/Qualifiers
     source          1..1049
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 43.56 cM"
     gene            1..1049
                     /gene="Csn1s2a"
                     /gene_synonym="Csng; PP22"
                     /note="casein alpha s2-like A"
                     /db_xref="GeneID:12993"
                     /db_xref="MGI:MGI:88542"
     exon            1..161
                     /gene="Csn1s2a"
                     /gene_synonym="Csng; PP22"
                     /inference="alignment:Splign:2.1.0"
     exon            162..224
                     /gene="Csn1s2a"
                     /gene_synonym="Csng; PP22"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..728
                     /gene="Csn1s2a"
                     /gene_synonym="Csng; PP22"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; alpha-S2-casein-like A; gamma casein; milk
                     protein"
                     /codon_start=1
                     /product="alpha-S2-casein-like A isoform 1 precursor"
                     /protein_id="NP_031811.1"
                     /db_xref="CCDS:CCDS39132.1"
                     /db_xref="GeneID:12993"
                     /db_xref="MGI:MGI:88542"
                     /translation="MKFFIFACLVVVALAKHEIKDKSSSEESSASIYPGKSKLDNSVF
                     FQTTKDSASSSSSEESSEEVSEKIVQSEEQKVNLNQQKKFKQFSQESSFSQCCTPLHQ
                     QQQSSVNQWPQPNAIHNTPTQESISTSVEEILKKIIDMIKYIQYQQVTIPQLPQALHP
                     QIPVSYWYPSKDYTFPNAHYTRFY"
     exon            225..251
                     /gene="Csn1s2a"
                     /gene_synonym="Csng; PP22"
                     /inference="alignment:Splign:2.1.0"
     exon            252..278
                     /gene="Csn1s2a"
                     /gene_synonym="Csng; PP22"
                     /inference="alignment:Splign:2.1.0"
     exon            279..320
                     /gene="Csn1s2a"
                     /gene_synonym="Csng; PP22"
                     /inference="alignment:Splign:2.1.0"
     exon            321..347
                     /gene="Csn1s2a"
                     /gene_synonym="Csng; PP22"
                     /inference="alignment:Splign:2.1.0"
     exon            348..371
                     /gene="Csn1s2a"
                     /gene_synonym="Csng; PP22"
                     /inference="alignment:Splign:2.1.0"
     exon            372..416
                     /gene="Csn1s2a"
                     /gene_synonym="Csng; PP22"
                     /inference="alignment:Splign:2.1.0"
     exon            417..542
                     /gene="Csn1s2a"
                     /gene_synonym="Csng; PP22"
                     /inference="alignment:Splign:2.1.0"
     exon            543..566
                     /gene="Csn1s2a"
                     /gene_synonym="Csng; PP22"
                     /inference="alignment:Splign:2.1.0"
     exon            567..593
                     /gene="Csn1s2a"
                     /gene_synonym="Csng; PP22"
                     /inference="alignment:Splign:2.1.0"
     exon            594..716
                     /gene="Csn1s2a"
                     /gene_synonym="Csng; PP22"
                     /inference="alignment:Splign:2.1.0"
     exon            717..762
                     /gene="Csn1s2a"
                     /gene_synonym="Csng; PP22"
                     /inference="alignment:Splign:2.1.0"
     exon            763..1038
                     /gene="Csn1s2a"
                     /gene_synonym="Csng; PP22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1021..1026
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csn1s2a"
                     /gene_synonym="Csng; PP22"
                     /note="hexamer: ATTAAA"
     polyA_site      1038
                     /gene="Csn1s2a"
                     /gene_synonym="Csng; PP22"
                     /note="major polyA site"
ORIGIN      
        1 caatttctaa ttatagtgct ttcttagaat tacaatgact tttaggtatt tgaaaccaca
       61 gaattagaat atgatgataa aacatggttt aaatagtatg gaaactatcc actgcagatc
      121 atcatctacc tattcctctc gtcttccatt tggggagcaa ggaacaagta accatgaagt
      181 tcttcatctt tgcctgcctg gtggttgttg ctctggcaaa gcacgaaata aaggataagt
      241 cctccagtga ggaatcatct gccagcatct acccaggaaa gtctaagctg gacaatagcg
      301 tgttcttcca aacaactaag gattctgcta gcagttcatc cagtgaggaa tcttccgagg
      361 aagtcagtga aaaaattgta caatctgaag aacaaaaggt caacctaaac cagcagaaaa
      421 aattcaagca attttcccag gagtcttcct tttcccaatg ttgcacacct cttcaccagc
      481 agcagcagag cagtgtgaac cagtggcccc agcctaatgc catccataac acgcccaccc
      541 aggaatccat cagcacctct gtggaggaaa tcctgaagaa gattattgat atgatcaagt
      601 acatccaata tcaacaggtc accatccccc aacttcccca agctcttcat ccccagatac
      661 ctgtgagcta ctggtacccc agtaaggatt acaccttccc aaatgctcac tatacgagat
      721 tctactaaga ttcctaaaat aactgctgct acctagctat aggcttgagt agaaaattgg
      781 tttcttcgtg gtttccccat cacctcctac tattaacatt ccctaagatg cttcttgaaa
      841 agacaacaat attgagccag aagaagagag agtgggatat tttctgtatt gtttgtaatc
      901 tttttggatt gagttgtgtg ttccaacttt ggactgtgga gccgtattaa ctgcattgtt
      961 taattgaagt cttttcagta ctacttctga gataagaacc aaaatatctc tcgccaagac
     1021 attaaagttt taaacgcaaa aaaaaaaaa
//
