LOCUS       NM_007784               1466 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus casein alpha s1 (Csn1s1), transcript variant 1, mRNA.
ACCESSION   NM_007784 XM_904101
VERSION     NM_007784.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1466)
  AUTHORS   Smirnov,A.V., Kontsevaya,G.V., Shnaider,T.A., Yunusova,A.M.,
            Feofanova,N.A., Gerlinskaya,L.A., Serova,I.A., Serov,O.L. and
            Battulin,N.R.
  TITLE     Evaluation of the alpha-casein (CSN1S1) locus as a potential target
            for a site-specific transgene integration
  JOURNAL   Sci Rep 12 (1), 7983 (2022)
   PUBMED   35568783
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1466)
  AUTHORS   Chen,J.Q., Mori,H., Cardiff,R.D., Trott,J.F., Hovey,R.C.,
            Hubbard,N.E., Engelberg,J.A., Tepper,C.G., Willis,B.J., Khan,I.H.,
            Ravindran,R.K., Chan,S.R., Schreiber,R.D. and Borowsky,A.D.
  TITLE     Abnormal Mammary Development in 129:STAT1-Null Mice is
            Stroma-Dependent
  JOURNAL   PLoS One 10 (6), e0129895 (2015)
   PUBMED   26075897
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1466)
  AUTHORS   Kolb,A.F., Huber,R.C., Lillico,S.G., Carlisle,A., Robinson,C.J.,
            Neil,C., Petrie,L., Sorensen,D.B., Olsson,I.A. and Whitelaw,C.B.
  TITLE     Milk lacking alpha-casein leads to permanent reduction in body size
            in mice
  JOURNAL   PLoS One 6 (7), e21775 (2011)
   PUBMED   21789179
  REMARK    GeneRIF: The role of the milk protein alpha-casein by inactivating
            the corresponding gene in mice, was analysed.
REFERENCE   4  (bases 1 to 1466)
  AUTHORS   Rogers,R.L., Van Seuningen,I., Gould,J., Hertzog,P.J., Naylor,M.J.
            and Pritchard,M.A.
  TITLE     Transcript profiling of Elf5+/- mammary glands during pregnancy
            identifies novel targets of Elf5
  JOURNAL   PLoS One 5 (10), e13150 (2010)
   PUBMED   20949099
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1466)
  AUTHORS   Triplett,A.A., Sakamoto,K., Matulka,L.A., Shen,L., Smith,G.H. and
            Wagner,K.U.
  TITLE     Expression of the whey acidic protein (Wap) is necessary for
            adequate nourishment of the offspring but not functional
            differentiation of mammary epithelial cells
  JOURNAL   Genesis 43 (1), 1-11 (2005)
   PUBMED   16106354
REFERENCE   6  (bases 1 to 1466)
  AUTHORS   Altherr,M.R., Wasmuth,J.J., Seldin,M.F., Nadeau,J.H., Baehr,W. and
            Pittler,S.J.
  TITLE     Chromosome mapping of the rod photoreceptor cGMP phosphodiesterase
            beta-subunit gene in mouse and human: tight linkage to the
            Huntington disease region (4p16.3)
  JOURNAL   Genomics 12 (4), 750-754 (1992)
   PUBMED   1315306
REFERENCE   7  (bases 1 to 1466)
  AUTHORS   Pittler,S.J., Lee,A.K., Altherr,M.R., Howard,T.A., Seldin,M.F.,
            Hurwitz,R.L., Wasmuth,J.J. and Baehr,W.
  TITLE     Primary structure and chromosomal localization of human and mouse
            rod photoreceptor cGMP-gated cation channel
  JOURNAL   J Biol Chem 267 (9), 6257-6262 (1992)
   PUBMED   1372902
REFERENCE   8  (bases 1 to 1466)
  AUTHORS   Smith,E.A., Seldin,M.F., Martinez,L., Watson,M.L., Choudhury,G.G.,
            Lalley,P.A., Pierce,J., Aaronson,S., Barker,J., Naylor,S.L. et al.
  TITLE     Mouse platelet-derived growth factor receptor alpha gene is deleted
            in W19H and patch mutations on chromosome 5
  JOURNAL   Proc Natl Acad Sci U S A 88 (11), 4811-4815 (1991)
   PUBMED   1647018
REFERENCE   9  (bases 1 to 1466)
  AUTHORS   Grusby,M.J., Mitchell,S.C., Nabavi,N. and Glimcher,L.H.
  TITLE     Casein expression in cytotoxic T lymphocytes
  JOURNAL   Proc Natl Acad Sci U S A 87 (17), 6897-6901 (1990)
   PUBMED   2395885
REFERENCE   10 (bases 1 to 1466)
  AUTHORS   Seldin,M.F., Martinez,L., Howard,T.A., Naylor,S.L. and
            Sakaguchi,A.Y.
  TITLE     Localization of mouse melanoma growth stimulatory activity gene
            (Mgsa) between Afp and Gus on chromosome 5 using interspecific
            backcross mice
  JOURNAL   Cytogenet Cell Genet 54 (1-2), 68-70 (1990)
   PUBMED   1979024
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK052808.1, M36780.1 and BE335666.1.
            
            On Oct 26, 2013 this sequence version replaced NM_007784.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085690.1, BC007192.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849375,
                                           SAMN00849381 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AK052808.1         2-62
            62-1432             M36780.1           1-1371
            1433-1466           BE335666.1         417-450
FEATURES             Location/Qualifiers
     source          1..1466
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 43.56 cM"
     gene            1..1466
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /note="casein alpha s1"
                     /db_xref="GeneID:12990"
                     /db_xref="MGI:MGI:88540"
     exon            1..49
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            50..112
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1003
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; alpha-S1-casein; alpha-casein"
                     /codon_start=1
                     /product="alpha-S1-casein isoform a precursor"
                     /protein_id="NP_031810.1"
                     /db_xref="CCDS:CCDS51534.1"
                     /db_xref="GeneID:12990"
                     /db_xref="MGI:MGI:88540"
                     /translation="MKLLILTCLVAAAFAMPRLHSRNAVSSQTQQQHSSSEEIFKQPK
                     YLNLNQEFVNNMNRQRALLTEQNDEIKVTMDAASEEQAMASAQEDSSISSSSEESEEA
                     IPNITEQKNIANEDMLNQCTLEQLQRQFKYNQLLQKASLAKQASLFQQPSLVQQASLF
                     QQPSLLQQASLFQQPSMAQQASLLQQLLLAQQPSLALQVSPAQQSSLVQQAFLAQQAS
                     LAQKHHPRLSQSYYPHMEQPYRMNAYSQVQMRHPMSVVDQALAQFSVQPFPQIFQYDA
                     FPLWAYFPQDMQYLTPKAVLNTFKPIVSKDTEKTNVW"
     exon            113..145
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            146..172
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            173..211
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            212..235
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            236..274
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            275..298
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            299..322
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            323..352
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            353..385
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            386..430
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            431..472
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            473..490
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            491..508
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            509..526
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            527..544
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            545..562
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            563..580
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            581..598
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            599..616
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            617..634
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            635..652
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            653..670
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            671..688
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            689..706
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            707..724
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            725..766
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            767..808
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            809..835
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            836..859
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1002
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1046
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1436
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcttcttga tcatctccca gattccctct ccctactctt gggttcaaga tcttggcaac
       61 catgaaactc ctcatcctca cctgcctcgt ggctgctgct tttgctatgc ccagacttca
      121 tagtagaaat gcagttagca gtcaaactca gcaacagcat agcagcagtg aggaaatttt
      181 taaacaacca aagtatctca acctaaatca ggaattcgtc aacaacatga acagacagag
      241 agcacttctg acagaacaga acgatgaaat caaggtaact atggatgcag catctgagga
      301 acaagcaatg gcaagtgctc aggaagactc ttcaatcagc tcatcaagtg aggaatctga
      361 ggaagctatt cccaatatca ctgagcagaa aaacattgca aatgaagaca tgctcaacca
      421 gtgcaccctg gaacagcttc agagacagtt taagtacaac caacttctcc agaaagcttc
      481 cctggctaag caagcttccc tgtttcagca accttccctg gtacagcaag cttccctgtt
      541 tcagcaacct tccctgcttc agcaagcttc cctgtttcag caaccttcca tggctcagca
      601 agcttccctg ctacagcaac ttctcctggc ccagcaacct tccctggcac tgcaagtttc
      661 cccagcacag caatcttccc tggtacagca agctttcctg gcacagcaag cttccctggc
      721 acagaaacat catccaagac tgagccagtc ctactatcca catatggaac agccttacag
      781 aatgaatgca tacagccaag ttcaaatgag acatcctatg agtgtagtgg atcaggcact
      841 ggcccagttc tctgttcagc ccttcccaca aatcttccag tatgatgcct ttcccctttg
      901 ggcttacttt ccacaggata tgcagtacct tactcccaaa gctgtcctta acaccttcaa
      961 gcccattgtc tccaaggata ctgaaaaaac caatgtgtgg tgagatatta agacatctct
     1021 caggaactcc acagttataa catttgatgt gactggaccc tccattctcc atccacctca
     1081 tgtctctcta ttcattctat ggagcctctg ttttacctaa aggcttgact gctattttag
     1141 agtagataaa acaccatata gaggccaatg attcatcttg agttgtctac tgcatattag
     1201 atagcatagc atccttcctt aagctaacct ttcctagaca gattcttttt tctaaattcc
     1261 agttgcatca tctgagcgga gagaatcaag gcctttaaca agtttctatt atggaaaatt
     1321 tgttttaaaa gtctttaaat ggattcttct gaaaatgtta tcattttggg taattgtgtg
     1381 tagtaactga gattgtcttt ttcctctttt caataaatta cattttaagg cacaaaaaaa
     1441 aaaaaaaaaa aaaaaaaaaa aaaaaa
//
