LOCUS       NM_001286015            1442 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus casein alpha s1 (Csn1s1), transcript variant 2, mRNA.
ACCESSION   NM_001286015
VERSION     NM_001286015.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1442)
  AUTHORS   Smirnov,A.V., Kontsevaya,G.V., Shnaider,T.A., Yunusova,A.M.,
            Feofanova,N.A., Gerlinskaya,L.A., Serova,I.A., Serov,O.L. and
            Battulin,N.R.
  TITLE     Evaluation of the alpha-casein (CSN1S1) locus as a potential target
            for a site-specific transgene integration
  JOURNAL   Sci Rep 12 (1), 7983 (2022)
   PUBMED   35568783
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1442)
  AUTHORS   Chen,J.Q., Mori,H., Cardiff,R.D., Trott,J.F., Hovey,R.C.,
            Hubbard,N.E., Engelberg,J.A., Tepper,C.G., Willis,B.J., Khan,I.H.,
            Ravindran,R.K., Chan,S.R., Schreiber,R.D. and Borowsky,A.D.
  TITLE     Abnormal Mammary Development in 129:STAT1-Null Mice is
            Stroma-Dependent
  JOURNAL   PLoS One 10 (6), e0129895 (2015)
   PUBMED   26075897
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1442)
  AUTHORS   Kolb,A.F., Huber,R.C., Lillico,S.G., Carlisle,A., Robinson,C.J.,
            Neil,C., Petrie,L., Sorensen,D.B., Olsson,I.A. and Whitelaw,C.B.
  TITLE     Milk lacking alpha-casein leads to permanent reduction in body size
            in mice
  JOURNAL   PLoS One 6 (7), e21775 (2011)
   PUBMED   21789179
  REMARK    GeneRIF: The role of the milk protein alpha-casein by inactivating
            the corresponding gene in mice, was analysed.
REFERENCE   4  (bases 1 to 1442)
  AUTHORS   Rogers,R.L., Van Seuningen,I., Gould,J., Hertzog,P.J., Naylor,M.J.
            and Pritchard,M.A.
  TITLE     Transcript profiling of Elf5+/- mammary glands during pregnancy
            identifies novel targets of Elf5
  JOURNAL   PLoS One 5 (10), e13150 (2010)
   PUBMED   20949099
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1442)
  AUTHORS   Triplett,A.A., Sakamoto,K., Matulka,L.A., Shen,L., Smith,G.H. and
            Wagner,K.U.
  TITLE     Expression of the whey acidic protein (Wap) is necessary for
            adequate nourishment of the offspring but not functional
            differentiation of mammary epithelial cells
  JOURNAL   Genesis 43 (1), 1-11 (2005)
   PUBMED   16106354
REFERENCE   6  (bases 1 to 1442)
  AUTHORS   Altherr,M.R., Wasmuth,J.J., Seldin,M.F., Nadeau,J.H., Baehr,W. and
            Pittler,S.J.
  TITLE     Chromosome mapping of the rod photoreceptor cGMP phosphodiesterase
            beta-subunit gene in mouse and human: tight linkage to the
            Huntington disease region (4p16.3)
  JOURNAL   Genomics 12 (4), 750-754 (1992)
   PUBMED   1315306
REFERENCE   7  (bases 1 to 1442)
  AUTHORS   Pittler,S.J., Lee,A.K., Altherr,M.R., Howard,T.A., Seldin,M.F.,
            Hurwitz,R.L., Wasmuth,J.J. and Baehr,W.
  TITLE     Primary structure and chromosomal localization of human and mouse
            rod photoreceptor cGMP-gated cation channel
  JOURNAL   J Biol Chem 267 (9), 6257-6262 (1992)
   PUBMED   1372902
REFERENCE   8  (bases 1 to 1442)
  AUTHORS   Smith,E.A., Seldin,M.F., Martinez,L., Watson,M.L., Choudhury,G.G.,
            Lalley,P.A., Pierce,J., Aaronson,S., Barker,J., Naylor,S.L. et al.
  TITLE     Mouse platelet-derived growth factor receptor alpha gene is deleted
            in W19H and patch mutations on chromosome 5
  JOURNAL   Proc Natl Acad Sci U S A 88 (11), 4811-4815 (1991)
   PUBMED   1647018
REFERENCE   9  (bases 1 to 1442)
  AUTHORS   Grusby,M.J., Mitchell,S.C., Nabavi,N. and Glimcher,L.H.
  TITLE     Casein expression in cytotoxic T lymphocytes
  JOURNAL   Proc Natl Acad Sci U S A 87 (17), 6897-6901 (1990)
   PUBMED   2395885
REFERENCE   10 (bases 1 to 1442)
  AUTHORS   Seldin,M.F., Martinez,L., Howard,T.A., Naylor,S.L. and
            Sakaguchi,A.Y.
  TITLE     Localization of mouse melanoma growth stimulatory activity gene
            (Mgsa) between Afp and Gus on chromosome 5 using interspecific
            backcross mice
  JOURNAL   Cytogenet Cell Genet 54 (1-2), 68-70 (1990)
   PUBMED   1979024
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK052808.1, M36780.1 and BE335666.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1, resulting in
            an isoform (b) that is shorter than isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006024.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849383,
                                           SAMN01164141 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AK052808.1         2-62
            62-274              M36780.1           1-213
            275-1408            M36780.1           238-1371
            1409-1442           BE335666.1         417-450
FEATURES             Location/Qualifiers
     source          1..1442
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 43.56 cM"
     gene            1..1442
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /note="casein alpha s1"
                     /db_xref="GeneID:12990"
                     /db_xref="MGI:MGI:88540"
     exon            1..49
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            50..112
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..979
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; alpha-S1-casein; alpha-casein"
                     /codon_start=1
                     /product="alpha-S1-casein isoform b precursor"
                     /protein_id="NP_001272944.1"
                     /db_xref="GeneID:12990"
                     /db_xref="MGI:MGI:88540"
                     /translation="MKLLILTCLVAAAFAMPRLHSRNAVSSQTQQQHSSSEEIFKQPK
                     YLNLNQEFVNNMNRQRALLTEQNDEIKEQAMASAQEDSSISSSSEESEEAIPNITEQK
                     NIANEDMLNQCTLEQLQRQFKYNQLLQKASLAKQASLFQQPSLVQQASLFQQPSLLQQ
                     ASLFQQPSMAQQASLLQQLLLAQQPSLALQVSPAQQSSLVQQAFLAQQASLAQKHHPR
                     LSQSYYPHMEQPYRMNAYSQVQMRHPMSVVDQALAQFSVQPFPQIFQYDAFPLWAYFP
                     QDMQYLTPKAVLNTFKPIVSKDTEKTNVW"
     exon            113..145
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            146..172
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            173..211
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            212..235
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            236..274
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            275..298
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            299..328
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            329..361
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            362..406
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            407..448
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            449..466
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            467..484
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            485..502
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            503..520
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            521..538
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            539..556
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            557..574
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            575..592
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            593..610
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            611..628
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            629..646
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            647..664
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            665..682
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            683..700
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            701..742
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            743..784
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            785..811
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            812..835
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            836..978
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1022
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1412
                     /gene="Csn1s1"
                     /gene_synonym="Csna"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcttcttga tcatctccca gattccctct ccctactctt gggttcaaga tcttggcaac
       61 catgaaactc ctcatcctca cctgcctcgt ggctgctgct tttgctatgc ccagacttca
      121 tagtagaaat gcagttagca gtcaaactca gcaacagcat agcagcagtg aggaaatttt
      181 taaacaacca aagtatctca acctaaatca ggaattcgtc aacaacatga acagacagag
      241 agcacttctg acagaacaga acgatgaaat caaggaacaa gcaatggcaa gtgctcagga
      301 agactcttca atcagctcat caagtgagga atctgaggaa gctattccca atatcactga
      361 gcagaaaaac attgcaaatg aagacatgct caaccagtgc accctggaac agcttcagag
      421 acagtttaag tacaaccaac ttctccagaa agcttccctg gctaagcaag cttccctgtt
      481 tcagcaacct tccctggtac agcaagcttc cctgtttcag caaccttccc tgcttcagca
      541 agcttccctg tttcagcaac cttccatggc tcagcaagct tccctgctac agcaacttct
      601 cctggcccag caaccttccc tggcactgca agtttcccca gcacagcaat cttccctggt
      661 acagcaagct ttcctggcac agcaagcttc cctggcacag aaacatcatc caagactgag
      721 ccagtcctac tatccacata tggaacagcc ttacagaatg aatgcataca gccaagttca
      781 aatgagacat cctatgagtg tagtggatca ggcactggcc cagttctctg ttcagccctt
      841 cccacaaatc ttccagtatg atgcctttcc cctttgggct tactttccac aggatatgca
      901 gtaccttact cccaaagctg tccttaacac cttcaagccc attgtctcca aggatactga
      961 aaaaaccaat gtgtggtgag atattaagac atctctcagg aactccacag ttataacatt
     1021 tgatgtgact ggaccctcca ttctccatcc acctcatgtc tctctattca ttctatggag
     1081 cctctgtttt acctaaaggc ttgactgcta ttttagagta gataaaacac catatagagg
     1141 ccaatgattc atcttgagtt gtctactgca tattagatag catagcatcc ttccttaagc
     1201 taacctttcc tagacagatt cttttttcta aattccagtt gcatcatctg agcggagaga
     1261 atcaaggcct ttaacaagtt tctattatgg aaaatttgtt ttaaaagtct ttaaatggat
     1321 tcttctgaaa atgttatcat tttgggtaat tgtgtgtagt aactgagatt gtctttttcc
     1381 tcttttcaat aaattacatt ttaaggcaca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1441 aa
//
