LOCUS       NM_001411643            2808 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Mus musculus c-src tyrosine kinase (Csk), transcript variant 5,
            mRNA.
ACCESSION   NM_001411643 XM_030244037
VERSION     NM_001411643.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2808)
  AUTHORS   Inoue,T., Matsumoto,Y., Kawai,C., Ito,M., Nada,S., Okada,M. and
            Kurosaki,T.
  TITLE     Csk restrains BCR-mediated ROS production and contributes to
            germinal center selection and affinity maturation
  JOURNAL   J Exp Med 221 (7) (2024)
   PUBMED   38753246
  REMARK    GeneRIF: Csk restrains BCR-mediated ROS production and contributes
            to germinal center selection and affinity maturation.
REFERENCE   2  (bases 1 to 2808)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2808)
  AUTHORS   Kashiwakura,J.I., Kawahara,S., Inagaki,I., Inui,K., Saitoh,K.,
            Kagohashi,K., Sasaki,Y., Kobayashi,F., Kitai,Y., Muromoto,R.,
            Oritani,K. and Matsuda,T.
  TITLE     STAP-2 negatively regulates BCR-mediated B cell activation by
            recruiting tyrosine-protein kinase CSK to LYN
  JOURNAL   FEBS Lett 597 (19), 2433-2445 (2023)
   PUBMED   37669828
  REMARK    GeneRIF: STAP-2 negatively regulates BCR-mediated B cell activation
            by recruiting tyrosine-protein kinase CSK to LYN.
REFERENCE   4  (bases 1 to 2808)
  AUTHORS   Zhong,X., Song,Z., Ning,Z., Wu,J. and Song,X.
  TITLE     Inhibition of Src improves cardiac fibrosis in AngII-induced
            hypertrophy by regulating the expression of galectin-3
  JOURNAL   Microvasc Res 142, 104347 (2022)
   PUBMED   35231451
REFERENCE   5  (bases 1 to 2808)
  AUTHORS   Brian,B.F. 4th, Sauer,M.L., Greene,J.T., Senevirathne,S.E.,
            Lindstedt,A.J., Funk,O.L., Ruis,B.L., Ramirez,L.A., Auger,J.L.,
            Swanson,W.L., Nunez,M.G., Moriarity,B.S., Lowell,C.A.,
            Binstadt,B.A. and Freedman,T.S.
  TITLE     A dominant function of LynB kinase in preventing autoimmunity
  JOURNAL   Sci Adv 8 (16), eabj5227 (2022)
   PUBMED   35452291
REFERENCE   6  (bases 1 to 2808)
  AUTHORS   Thomas,S.M., Soriano,P. and Imamoto,A.
  TITLE     Specific and redundant roles of Src and Fyn in organizing the
            cytoskeleton
  JOURNAL   Nature 376 (6537), 267-271 (1995)
   PUBMED   7617039
REFERENCE   7  (bases 1 to 2808)
  AUTHORS   Nada,S., Okada,M., Aizawa,S. and Nakagawa,H.
  TITLE     Identification of major tyrosine-phosphorylated proteins in
            Csk-deficient cells
  JOURNAL   Oncogene 9 (12), 3571-3578 (1994)
   PUBMED   7526315
REFERENCE   8  (bases 1 to 2808)
  AUTHORS   Klages,S., Adam,D., Class,K., Fargnoli,J., Bolen,J.B. and
            Penhallow,R.C.
  TITLE     Ctk: a protein-tyrosine kinase related to Csk that defines an
            enzyme family
  JOURNAL   Proc Natl Acad Sci U S A 91 (7), 2597-2601 (1994)
   PUBMED   7511815
REFERENCE   9  (bases 1 to 2808)
  AUTHORS   Gilardi-Hebenstreit,P., Nieto,M.A., Frain,M., Mattei,M.G.,
            Chestier,A., Wilkinson,D.G. and Charnay,P.
  TITLE     An Eph-related receptor protein tyrosine kinase gene segmentally
            expressed in the developing mouse hindbrain
  JOURNAL   Oncogene 7 (12), 2499-2506 (1992)
   PUBMED   1281307
  REMARK    Erratum:[Oncogene. 1993 Apr;8(4):1103.. PMID: 8455939]
REFERENCE   10 (bases 1 to 2808)
  AUTHORS   Armstrong,E., Cannizzaro,L., Bergman,M., Huebner,K. and Alitalo,K.
  TITLE     The c-src tyrosine kinase (CSK) gene, a potential antioncogene,
            localizes to human chromosome region 15q23----q25
  JOURNAL   Cytogenet Cell Genet 60 (2), 119-120 (1992)
   PUBMED   1377109
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122528.3.
            
            On Aug 30, 2022 this sequence version replaced XM_030244037.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422598.1342823.1,
                                           SRR7345562.3019785.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-615               AC122528.3         24510-25124
            616-667             AC122528.3         35200-35251
            668-718             AC122528.3         36074-36124
            719-795             AC122528.3         38676-38752
            796-909             AC122528.3         39111-39224
            910-1022            AC122528.3         39327-39439
            1023-1242           AC122528.3         39732-39951
            1243-1336           AC122528.3         40766-40859
            1337-1402           AC122528.3         41053-41118
            1403-1502           AC122528.3         41199-41298
            1503-1593           AC122528.3         41376-41466
            1594-1667           AC122528.3         41869-41942
            1668-1863           AC122528.3         42046-42241
            1864-1950           AC122528.3         42316-42402
            1951-2808           AC122528.3         42616-43473
FEATURES             Location/Qualifiers
     source          1..2808
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 31.18 cM"
     gene            1..2808
                     /gene="Csk"
                     /gene_synonym="p50CSK"
                     /note="c-src tyrosine kinase"
                     /db_xref="GeneID:12988"
                     /db_xref="MGI:MGI:88537"
     exon            1..615
                     /gene="Csk"
                     /gene_synonym="p50CSK"
                     /inference="alignment:Splign:2.1.0"
     exon            616..667
                     /gene="Csk"
                     /gene_synonym="p50CSK"
                     /inference="alignment:Splign:2.1.0"
     exon            668..718
                     /gene="Csk"
                     /gene_synonym="p50CSK"
                     /inference="alignment:Splign:2.1.0"
     exon            719..795
                     /gene="Csk"
                     /gene_synonym="p50CSK"
                     /inference="alignment:Splign:2.1.0"
     CDS             781..2133
                     /gene="Csk"
                     /gene_synonym="p50CSK"
                     /EC_number="2.7.10.2"
                     /note="C-Src kinase; protein-tyrosine kinase MPK-2"
                     /codon_start=1
                     /product="tyrosine-protein kinase CSK"
                     /protein_id="NP_001398572.1"
                     /db_xref="GeneID:12988"
                     /db_xref="MGI:MGI:88537"
                     /translation="MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKD
                     PNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETG
                     LFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDA
                     DGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNK
                     VAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVD
                     YLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFG
                     LTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPL
                     KDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAATRPTFLQLREQLEHIKTHELHL
                     "
     exon            796..909
                     /gene="Csk"
                     /gene_synonym="p50CSK"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1022
                     /gene="Csk"
                     /gene_synonym="p50CSK"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1242
                     /gene="Csk"
                     /gene_synonym="p50CSK"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1336
                     /gene="Csk"
                     /gene_synonym="p50CSK"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1402
                     /gene="Csk"
                     /gene_synonym="p50CSK"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1502
                     /gene="Csk"
                     /gene_synonym="p50CSK"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1593
                     /gene="Csk"
                     /gene_synonym="p50CSK"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1667
                     /gene="Csk"
                     /gene_synonym="p50CSK"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1863
                     /gene="Csk"
                     /gene_synonym="p50CSK"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..1950
                     /gene="Csk"
                     /gene_synonym="p50CSK"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2808
                     /gene="Csk"
                     /gene_synonym="p50CSK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2781..2786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csk"
                     /gene_synonym="p50CSK"
                     /note="hexamer: AATAAA"
     polyA_site      2808
                     /gene="Csk"
                     /gene_synonym="p50CSK"
                     /note="major polyA site"
ORIGIN      
        1 accaggcctg cgagcttcct cccatcggag cccgggcgag ctgaggttgg ccgccgccgc
       61 tgagcctgct gccttccttg cgcttccgcg ccaccctgcg ccctgccccg gggaatccca
      121 ccggggtggg gtccgagcag ggccaacccg ggccgcgccg ccgtcggggc cgtccccggg
      181 ccagccgtcc ctcccgcctg gccagcctct ggccgcccag cctccggggt gtggggctta
      241 ggcaagccct gcgagcggcg atcgaacgcc cggggcggcc ccccggcggc ggcgcgacgt
      301 ccccaaaccg aacctccgtg gccgcgttcg gaagcggaac tctgccgggg ccgcgccggc
      361 tacattgttt cctccccccc ggactccctc ccgccccctt cccccgcctt tcttccctcc
      421 ccgcctgggg ctgcgcggca gtccccctgc ctgtctggct ccccttccct ctcttttcgc
      481 atccatacac ctctttgtac cgcaccccct ggggacccct gtgcccctcc cctccccctt
      541 ggccgcatgg actgtcctgc aggccactga tgccgccctc ggtgaggagg cctggaccgc
      601 agtgccccca gagaggaggc tgtaccctag gcagcataaa aatgccttgg atgaagggaa
      661 aggacagtca ttaggattgg acgagccatg aagtgccaag gataaggcct gacactgact
      721 ctcatggtac caagtcacag atcggccttc ctgtagcacg gggacgccag accgcagaag
      781 atgtcggcaa tacaggccgc ctggccatcc ggtacagaat gtattgccaa gtacaacttc
      841 catggcactg ctgagcaaga ccttcccttc tgcaaaggag atgtgctcac catcgtggct
      901 gtcaccaagg accccaactg gtacaaagcc aaaaacaaag tgggccgtga gggcatcatc
      961 ccagccaact atgtccagaa gcgtgagggt gtgaaggcag gcaccaaact cagccttatg
     1021 ccctggttcc acggcaagat cacacgggag caggccgagc ggcttcttta cccaccagag
     1081 acaggcctgt tcctcgtgcg ggaaagcacc aactaccctg gagactacac actgtgtgtg
     1141 agctgtgagg gcaaggtgga gcactaccgc atcatgtatc atgcgagcaa gctgagcatt
     1201 gatgaggagg tgtactttga gaacctcatg cagctggtgg agcactacac cacagatgcc
     1261 gatggactct gcactcgcct catcaaacca aaggtcatgg agggcaccgt ggcggcccag
     1321 gatgagttct accgcagtgg ctgggcactg aacatgaagg aactgaagct gctacagaca
     1381 atagggaagg gggagtttgg agatgtgatg ctgggggatt accggggcaa caaagttgca
     1441 gtcaagtgca tcaagaatga cgcaactgcc caggccttcc tggctgaagc ctccgtcatg
     1501 acgcaacttc ggcacagcaa cctcgtccag ctgctgggtg tgattgtgga ggagaagggt
     1561 gggctctaca tcgtcacaga gtacatggcc aaggggagtt tggtggacta tcttcgatca
     1621 cgtggtcgtt cggtgctagg tggagactgt ctcctcaaat tctcattaga cgtctgtgaa
     1681 gccatggagt acctggaggg taacaatttt gtgcaccggg acttggctgc ccggaatgtg
     1741 ctggtgtctg aagacaacgt ggccaaagtc agtgactttg gcctcactaa ggaagcctcc
     1801 agcactcagg acacaggcaa gctgccagtc aaatggacag cgcctgaagc cttgagagag
     1861 aagaaatttt ccaccaagtc tgatgtgtgg agtttcggaa tccttctctg ggaaatctat
     1921 tccttcgggc gagtgcctta cccaagaatt cccctgaagg acgtcgtccc tcgggtggaa
     1981 aagggctata agatggacgc tccggatggc tgcccgcccg cagtctacga ggtgatgaag
     2041 aactgctggc acctggatgc tgccacacgg cccacgtttt tgcagcttcg ggaacagctc
     2101 gagcacatca agacccatga gctgcacctg tgacctctgc ctccgccaag gccatgggcc
     2161 ggcagggaca gggcctcgga gattacagat ctggtgccct gctgcttgct gggcctgaac
     2221 ttgaactgag ccccagccgg ctggtaggcc tcttgcctct gacctgcctg tcccttctgg
     2281 cccccaggga ccccacctag gcctggcatc ttctctcatg gacccaccta tagggcttgg
     2341 ggtgcccact gaaggggctg aggagaggag gccaaggaac aggaggagtg ccgtgcagct
     2401 ggcctcctca aggccccacc attcgccttc ttagagtttt attcctttcc ttttttgaga
     2461 tttttttccg tgtgtttatt ttttattatt tttcaacata aggagaaaga aagtacccag
     2521 caaatgggca ttttacaaga agtacgaatc ttatttttcc tgtcctgccc ctgggggtgg
     2581 ggaggaatca gcctctctct agggacccat caccccagcc cgtcccccat cccgtgttcc
     2641 atgtccagtg ttgcctcggt cgcctgtgtt tgcgcttgac catgttgcgc tgtttgcatg
     2701 tgcccaaggc aggcgtctgt cgggggcttg gatttcatgt gctgtggccg ctcacccaca
     2761 ccgccttgtg agatggaatc aataaaccac tccatgagga caccgcca
//
