LOCUS       NM_007782               3907 bp    mRNA    linear   ROD 02-MAY-2023
DEFINITION  Mus musculus colony stimulating factor 3 receptor (granulocyte)
            (Csf3r), transcript variant 1, mRNA.
ACCESSION   NM_007782
VERSION     NM_007782.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3907)
  AUTHORS   Gungabeesoon J, Gort-Freitas NA, Kiss M, Bolli E, Messemaker M,
            Siwicki M, Hicham M, Bill R, Koch P, Cianciaruso C, Duval F,
            Pfirschke C, Mazzola M, Peters S, Homicsko K, Garris C, Weissleder
            R, Klein AM and Pittet MJ.
  TITLE     A neutrophil response linked to tumor control in immunotherapy
  JOURNAL   Cell 186 (7), 1448-1464 (2023)
   PUBMED   37001504
REFERENCE   2  (bases 1 to 3907)
  AUTHORS   Wang BA, Mehta HM, Penumutchu SR, Tolbert BS, Cheng C, Kimmel M,
            Haferlach T, Maciejewski JP and Corey SJ.
  TITLE     Alternatively spliced CSF3R isoforms in SRSF2 P95H mutated myeloid
            neoplasms
  JOURNAL   Leukemia 36 (10), 2499-2508 (2022)
   PUBMED   35941213
  REMARK    GeneRIF: Alternatively spliced CSF3R isoforms in SRSF2 P95H mutated
            myeloid neoplasms.
REFERENCE   3  (bases 1 to 3907)
  AUTHORS   Isojima T, Walker EC, Poulton IJ, McGregor NE, Wicks IP, Gooi JH,
            Martin TJ and Sims NA.
  TITLE     G-CSF Receptor Deletion Amplifies Cortical Bone Dysfunction in Mice
            With STAT3 Hyperactivation in Osteocytes
  JOURNAL   J Bone Miner Res 37 (10), 1876-1890 (2022)
   PUBMED   35856245
  REMARK    GeneRIF: G-CSF Receptor Deletion Amplifies Cortical Bone
            Dysfunction in Mice With STAT3 Hyperactivation in Osteocytes.
REFERENCE   4  (bases 1 to 3907)
  AUTHORS   Sapra A, Jaksik R, Mehta H, Biesiadny S, Kimmel M and Corey SJ.
  TITLE     Effect of the unfolded protein response and oxidative stress on
            mutagenesis in CSF3R: a model for evolution of severe congenital
            neutropenia to myelodysplastic syndrome/acute myeloid leukemia
  JOURNAL   Mutagenesis 35 (5), 381-389 (2020)
   PUBMED   33511998
  REMARK    GeneRIF: Effect of the unfolded protein response and oxidative
            stress on mutagenesis in CSF3R: a model for evolution of severe
            congenital neutropenia to myelodysplastic syndrome/acute myeloid
            leukemia.
REFERENCE   5  (bases 1 to 3907)
  AUTHORS   Karagiannidis I, Jerman SJ, Jacenik D, Phinney BB, Yao R, Prossnitz
            ER and Beswick EJ.
  TITLE     G-CSF and G-CSFR Modulate CD4 and CD8 T Cell Responses to Promote
            Colon Tumor Growth and Are Potential Therapeutic Targets
  JOURNAL   Front Immunol 11, 1885 (2020)
   PUBMED   33042110
  REMARK    GeneRIF: G-CSF and G-CSFR Modulate CD4 and CD8 T Cell Responses to
            Promote Colon Tumor Growth and Are Potential Therapeutic Targets.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3907)
  AUTHORS   Sciaky D, Jenkins NA, Gilbert DJ, Copeland NG, Sonoda G, Testa JR
            and Cohen MB.
  TITLE     Mapping of guanylin to murine chromosome 4 and human chromosome
            1p34-p35
  JOURNAL   Genomics 26 (2), 427-429 (1995)
   PUBMED   7601480
REFERENCE   7  (bases 1 to 3907)
  AUTHORS   Avraham KB, Levanon D, Negreanu V, Bernstein Y, Groner Y, Copeland
            NG and Jenkins NA.
  TITLE     Mapping of the mouse homolog of the human runt domain gene, AML2,
            to the distal region of mouse chromosome 4
  JOURNAL   Genomics 25 (2), 603-605 (1995)
   PUBMED   7790005
REFERENCE   8  (bases 1 to 3907)
  AUTHORS   Ito Y, Seto Y, Brannan CI, Copeland NG, Jenkins NA, Fukunaga R and
            Nagata S.
  TITLE     Structural analysis of the functional gene and pseudogene encoding
            the murine granulocyte colony-stimulating-factor receptor
  JOURNAL   Eur J Biochem 220 (3), 881-891 (1994)
   PUBMED   8143742
REFERENCE   9  (bases 1 to 3907)
  AUTHORS   McClanahan T, Dalrymple S, Barkett M and Lee F.
  TITLE     Hematopoietic growth factor receptor genes as markers of lineage
            commitment during in vitro development of hematopoietic cells
  JOURNAL   Blood 81 (11), 2903-2915 (1993)
   PUBMED   8499630
REFERENCE   10 (bases 1 to 3907)
  AUTHORS   Fukunaga R, Ishizaka-Ikeda E, Seto Y and Nagata S.
  TITLE     Expression cloning of a receptor for murine granulocyte
            colony-stimulating factor
  JOURNAL   Cell 61 (2), 341-350 (1990)
   PUBMED   2158861
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK144318.1, AK089305.1 and AL627101.25.
            
            [WARNING] On May 9, 2023 this sequence was replaced by NM_007782.4.
            
            On Nov 24, 2011 this sequence version replaced NM_007782.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M58288.1, BC116635.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AK144318.1         1-112
            113-2595            AK089305.1         58-2540
            2596-3273           AK144318.1         2637-3314
            3274-3907           AL627101.25        76672-77305
FEATURES             Location/Qualifiers
     source          1..3907
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 59.77 cM"
     gene            1..3907
                     /gene="Csf3r"
                     /gene_synonym="Cd114; Csfgr; G-CSF-R; G-CSFR"
                     /note="colony stimulating factor 3 receptor (granulocyte)"
                     /db_xref="GeneID:12986"
                     /db_xref="MGI:MGI:1339755"
     exon            1..137
                     /gene="Csf3r"
                     /gene_synonym="Cd114; Csfgr; G-CSF-R; G-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            138..236
                     /gene="Csf3r"
                     /gene_synonym="Cd114; Csfgr; G-CSF-R; G-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            237..320
                     /gene="Csf3r"
                     /gene_synonym="Cd114; Csfgr; G-CSF-R; G-CSFR"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..2770
                     /gene="Csf3r"
                     /gene_synonym="Cd114; Csfgr; G-CSF-R; G-CSFR"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; granulocyte colony-stimulating factor receptor;
                     G-CSF receptor"
                     /codon_start=1
                     /product="granulocyte colony-stimulating factor receptor
                     isoform 1 precursor"
                     /protein_id="NP_031808.2"
                     /db_xref="CCDS:CCDS18640.1"
                     /db_xref="GeneID:12986"
                     /db_xref="MGI:MGI:1339755"
                     /translation="MVGLGACTLTGVTLIFLLLPRSLESCGHIEISPPVVRLGDPVLA
                     SCTISPNCSKLDQQAKILWRLQDEPIQPGDRQHHLPDGTQESLITLPHLNYTQAFLFC
                     LVPWEDSVQLLDQAELHAGYPPASPSNLSCLMHLTTNSLVCQWEPGPETHLPTSFILK
                     SFRSRADCQYQGDTIPDCVAKKRQNNCSIPRKNLLLYQYMAIWVQAENMLGSSESPKL
                     CLDPMDVVKLEPPMLQALDIGPDVVSHQPGCLWLSWKPWKPSEYMEQECELRYQPQLK
                     GANWTLVFHLPSSKDQFELCGLHQAPVYTLQMRCIRSSLPGFWSPWSPGLQLRPTMKA
                     PTIRLDTWCQKKQLDPGTVSVQLFWKPTPLQEDSGQIQGYLLSWSSPDHQGQDIHLCN
                     TTQLSCIFLLPSEAQNVTLVAYNKAGTSSPTTVVFLENEGPAVTGLHAMAQDLNTIWV
                     DWEAPSLLPQGYLIEWEMSSPSYNNSYKSWMIEPNGNITGILLKDNINPFQLYRITVA
                     PLYPGIVGPPVNVYTFAGERAPPHAPALHLKHVGTTWAQLEWVPEAPRLGMIPLTHYT
                     IFWADAGDHSFSVTLNISLHDFVLKHLEPASLYHVYLMATSRAGSTNSTGLTLRTLDP
                     SDLNIFLGILCLVLLSTTCVVTWLCCKRRGKTSFWSDVPDPAHSSLSSWLPTIMTEET
                     FQLPSFWDSSVPSITKITELEEDKKPTHWDSESSGNGSLPALVQAYVLQGDPREISNQ
                     SQPPSRTGDQVLYGQVLESPTSPGVMQYIRSDSTQPLLGGPTPSPKSYENIWFHSRPQ
                     ETFVPQPPNQEDDCVFGPPFDFPLFQGLQVHGVEEQGGF"
     exon            321..620
                     /gene="Csf3r"
                     /gene_synonym="Cd114; Csfgr; G-CSF-R; G-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            621..744
                     /gene="Csf3r"
                     /gene_synonym="Cd114; Csfgr; G-CSF-R; G-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            745..932
                     /gene="Csf3r"
                     /gene_synonym="Cd114; Csfgr; G-CSF-R; G-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1102
                     /gene="Csf3r"
                     /gene_synonym="Cd114; Csfgr; G-CSF-R; G-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1256
                     /gene="Csf3r"
                     /gene_synonym="Cd114; Csfgr; G-CSF-R; G-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1336
                     /gene="Csf3r"
                     /gene_synonym="Cd114; Csfgr; G-CSF-R; G-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1550
                     /gene="Csf3r"
                     /gene_synonym="Cd114; Csfgr; G-CSF-R; G-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1739
                     /gene="Csf3r"
                     /gene_synonym="Cd114; Csfgr; G-CSF-R; G-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1841
                     /gene="Csf3r"
                     /gene_synonym="Cd114; Csfgr; G-CSF-R; G-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1988
                     /gene="Csf3r"
                     /gene_synonym="Cd114; Csfgr; G-CSF-R; G-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2123
                     /gene="Csf3r"
                     /gene_synonym="Cd114; Csfgr; G-CSF-R; G-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2214
                     /gene="Csf3r"
                     /gene_synonym="Cd114; Csfgr; G-CSF-R; G-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2296
                     /gene="Csf3r"
                     /gene_synonym="Cd114; Csfgr; G-CSF-R; G-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..3907
                     /gene="Csf3r"
                     /gene_synonym="Cd114; Csfgr; G-CSF-R; G-CSFR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtccccccc accccccgcc tgtcattaac gacggggcta gaaagagaag tttcgggaac
       61 ttgccccaag aggagaggag acgagagaga agagagagca caagcgtggg ggctgggcac
      121 agcgccctag ccccagtcat tgctgagaca tgagtggtat tgttaagccc ctttttccta
      181 aatggagaaa ctgagactca gaatggtgaa gtaactcatc caagttcacc aggcaggtaa
      241 gcttcaagct ggcaaaatgg tagggctggg agcctgcacc ctgactggag ttaccctgat
      301 cttcttgcta ctccccagaa gtctggagag ctgtggacac atcgagattt caccccctgt
      361 tgtccgcctg ggggaccctg tcctggcctc ttgcaccatc agcccaaact gcagcaaact
      421 ggaccaacag gcaaagatct tatggagact gcaagatgag cccatccaac ctggggacag
      481 acagcatcat ctgcctgatg ggacccaaga gtccctcatc actctgcctc acttgaacta
      541 cacccaggcc ttcctcttct gcttagtgcc atgggaagac agcgtccaac tcctggatca
      601 agctgagctt cacgcaggct atccccctgc cagcccctca aacctatcct gcctcatgca
      661 cctcaccacc aacagcctgg tctgccagtg ggagccaggt cctgagaccc acctgcccac
      721 cagcttcatc ctaaagagct tcaggagccg cgccgactgt cagtaccaag gggacaccat
      781 cccggattgt gtggcaaaga agaggcagaa caactgctcc atcccccgaa aaaacttgct
      841 cctgtaccag tatatggcca tctgggtgca agcagagaat atgctagggt ccagcgagtc
      901 cccaaagctg tgcctcgacc ccatggatgt tgtgaaattg gagcctccca tgctgcaggc
      961 cctggacatt ggccctgatg tagtctctca ccagcctggc tgcctgtggc tgagctggaa
     1021 gccatggaag cccagtgagt acatggaaca ggagtgtgaa cttcgctacc agccacagct
     1081 caaaggagcc aactggactc tggtgttcca cctgccttcc agcaaggacc agtttgagct
     1141 ctgcgggctc catcaggccc cagtctacac cctacagatg cgatgcattc gctcatctct
     1201 gcctggattc tggagcccct ggagccccgg cctgcagctg aggcctacca tgaaggcccc
     1261 caccatcaga ctggacacgt ggtgtcagaa gaagcaacta gatccaggga cagtgagtgt
     1321 gcagctgttc tggaagccaa cgcccctgca ggaagacagt ggacagatcc agggctacct
     1381 gctgtcctgg agttccccag atcatcaagg gcaggacata cacctttgca acaccacgca
     1441 gctcagctgt atcttcctcc tgccctcaga ggcccagaac gtgacccttg tggcctacaa
     1501 caaagcaggg acctcttcac ctactacagt ggttttcctg gagaacgaag gtccagctgt
     1561 gaccggactc catgccatgg cccaagacct taacaccatc tgggtagact gggaagcccc
     1621 cagccttctg cctcagggct atctcattga gtgggaaatg agttctccca gctacaataa
     1681 cagctataag tcctggatga tagaacctaa cgggaacatc actggaattc tgttaaagga
     1741 caacataaat ccctttcagc tctacagaat tacagtggct cccctgtacc caggcatcgt
     1801 gggacctcct gtaaatgtct acaccttcgc tggagagaga gctcctcctc atgctccagc
     1861 gctgcatcta aagcatgttg gcacaacctg ggcacagctg gagtgggtac ctgaggcccc
     1921 taggctgggg atgatacccc tcacccacta caccatcttc tgggccgatg ctggggacca
     1981 ctccttctcc gtcaccctga acatctccct ccatgacttt gtcctgaagc acctggagcc
     2041 cgccagtttg tatcatgtct acctcatggc caccagtcgg gcagggtcca ccaacagtac
     2101 aggccttacc ctgaggaccc tagatccatc tgacttaaac attttcctgg gcatactttg
     2161 cttagtactc ttgtccacta cctgtgtagt gacctggctc tgctgcaaac gcagaggaaa
     2221 gacttccttc tggtcagatg tgccagaccc agcccacagt agcctgagct cctggttgcc
     2281 caccatcatg acagaggaaa ccttccagtt acccagcttc tgggactcca gcgtgccatc
     2341 aatcaccaag atcactgaac tggaggaaga caagaaaccg acccactggg attccgaaag
     2401 ctctgggaat ggtagccttc cagccctggt tcaggcctat gtgctccaag gagatccaag
     2461 agaaatttcc aaccagtccc agcctccctc tcgcactggt gaccaggtcc tctatggtca
     2521 ggtgcttgag agccccacca gcccaggagt aatgcagtac attcgctctg actccactca
     2581 gcccctcttg gggggcccca cccctagccc taaatcttat gaaaacatct ggttccattc
     2641 aagaccccag gagacctttg tgccccaacc tccaaaccag gaagatgact gtgtctttgg
     2701 gcctccattt gattttcccc tctttcaggg gctccaggtc catggagttg aagaacaagg
     2761 gggtttctag aactttgggg gtccttgtat cttgaagacc ctgccctatt cagaggagaa
     2821 gagccctccg ctgaaatcta ctggccctga gagaagcaga aaggcccagt gtgtctctgt
     2881 ctctggcccc tagcacctct cctctactct gagcttctca ggctataccc tgaggtcacc
     2941 cactctcaca ctctaaggtt cagatagata ctgcttacag cccaatggtc accattcgtc
     3001 tttcatataa tttcagtcca ttgaactgat tgtaggtttt gagttggggc tggtattttc
     3061 agaaattctg gctggacgtg gtggtacatg cctagcatcc caacatctgg gaggaagatg
     3121 caggaagatt gcaagttcca ggccagcctg ggctagccta catagtgaga tccaatctca
     3181 aaaattatgc tgggtgtggt ggtgcatgcc tttaatccca gcactcggga ggcagaggca
     3241 ggtagatttc tgagttcgag gccagcctgg tctacaaagt gagttccagg acagccaggg
     3301 ctatacagag aaaccctgtc ttgaaaaaaa aaattaagca aaagctgaat aaataaagtt
     3361 ttttttatga catgtacttg ttttgtgggg agtggggatt cagaggcaga ggtcagaaga
     3421 cacctacctt gtgggaatta actctggtct ccagcatgtg gatcttgaga agtggactca
     3481 aagcttagtg acaagcaccg cgttacccat ggaggcatct tattggtccc agaaaagaat
     3541 ctcttgagca tagcttaagt gtcttctacc cttgtttgtt ttttgtctct gcttgcttgt
     3601 ttttcttttt atgtattata aataagtaca atgttgctgt cttcagacac accagaagag
     3661 ggcatcagat ctcaatactg gtggttgtga accaccatgt ggttgctggg atttgaattt
     3721 aggacctttg gaagagcagt cagtgctcct acccgctgag ccatctcttc agtccagttt
     3781 atttgttttt caagacaggg tttctctgtg taacagccca acctatcctg gaacttactc
     3841 tatagatcag gctggcctca agatccacct gcctctgcct taaatgctgg gaataaaggt
     3901 gtgcacc
//
