LOCUS       NM_009971               1363 bp    mRNA    linear   ROD 11-OCT-2024
DEFINITION  Mus musculus colony stimulating factor 3 (granulocyte) (Csf3),
            mRNA.
ACCESSION   NM_009971
VERSION     NM_009971.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1363)
  AUTHORS   Kurihara,Y., Tashiro,H., Konomi,Y., Sadamatsu,H., Ihara,S.,
            Takamori,A., Kimura,S., Sueoka-Aragane,N. and Takahashi,K.
  TITLE     Thymic stromal lymphopoietin contributes to ozone-induced
            exacerbations of eosinophilic airway inflammation via granulocyte
            colony-stimulating factor in mice
  JOURNAL   Allergol Int 73 (2), 313-322 (2024)
   PUBMED   38145912
  REMARK    GeneRIF: Thymic stromal lymphopoietin contributes to ozone-induced
            exacerbations of eosinophilic airway inflammation via granulocyte
            colony-stimulating factor in mice.
REFERENCE   2  (bases 1 to 1363)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1363)
  AUTHORS   Wickramasinghe,L.C., Tsantikos,E., Kindt,A., Raftery,A.L.,
            Gottschalk,T.A., Borger,J.G., Malhotra,A., Anderson,G.P., van
            Wijngaarden,P., Hilgendorff,A. and Hibbs,M.L.
  TITLE     Granulocyte Colony-Stimulating Factor is a Determinant of Severe
            Bronchopulmonary Dysplasia and Coincident Retinopathy
  JOURNAL   Am J Pathol 193 (12), 2001-2016 (2023)
   PUBMED   37673326
REFERENCE   4  (bases 1 to 1363)
  AUTHORS   Kemuriyama,K., An,J., Motoyama,S., Nagaki,Y., Yamaguchi,T.,
            Sato,Y., Wakita,A., Minamiya,Y. and Kuba,K.
  TITLE     Squamous cell carcinoma-derived G-CSF promotes tumor growth and
            metastasis in mice through neutrophil recruitment and tumor cell
            proliferation, associated with poor prognosis of the patients
  JOURNAL   Genes Cells 28 (8), 573-584 (2023)
   PUBMED   37248626
  REMARK    GeneRIF: Squamous cell carcinoma-derived G-CSF promotes tumor
            growth and metastasis in mice through neutrophil recruitment and
            tumor cell proliferation, associated with poor prognosis of the
            patients.
REFERENCE   5  (bases 1 to 1363)
  AUTHORS   Mulazzani,E., Kong,K., Arostegui,J.I., Ng,A.P., Ranathunga,N.,
            Abeysekera,W., Garnham,A.L., Ng,S.L., Baker,P.J., Jackson,J.T.,
            Lich,J.D., Hibbs,M.L., Wicks,I.P., Louis,C. and Masters,S.L.
  TITLE     G-CSF drives autoinflammation in APLAID
  JOURNAL   Nat Immunol 24 (5), 814-826 (2023)
   PUBMED   36997670
REFERENCE   6  (bases 1 to 1363)
  AUTHORS   Asano,M. and Nagata,S.
  TITLE     Constitutive and inducible factors bind to regulatory element 3 in
            the promoter of the gene encoding mouse granulocyte
            colony-stimulating factor
  JOURNAL   Gene 121 (2), 371-375 (1992)
   PUBMED   1280241
REFERENCE   7  (bases 1 to 1363)
  AUTHORS   Nishizawa,M. and Nagata,S.
  TITLE     cDNA clones encoding leucine-zipper proteins which interact with
            G-CSF gene promoter element 1-binding protein
  JOURNAL   FEBS Lett 299 (1), 36-38 (1992)
   PUBMED   1371974
REFERENCE   8  (bases 1 to 1363)
  AUTHORS   Demetri,G.D. and Griffin,J.D.
  TITLE     Granulocyte colony-stimulating factor and its receptor
  JOURNAL   Blood 78 (11), 2791-2808 (1991)
   PUBMED   1720034
  REMARK    Review article
REFERENCE   9  (bases 1 to 1363)
  AUTHORS   Roelink,H., Wagenaar,E., Lopes da Silva,S. and Nusse,R.
  TITLE     Wnt-3, a gene activated by proviral insertion in mouse mammary
            tumors, is homologous to int-1/Wnt-1 and is normally expressed in
            mouse embryos and adult brain
  JOURNAL   Proc Natl Acad Sci U S A 87 (12), 4519-4523 (1990)
   PUBMED   2162045
REFERENCE   10 (bases 1 to 1363)
  AUTHORS   Fukunaga,R., Ishizaka-Ikeda,E., Seto,Y. and Nagata,S.
  TITLE     Expression cloning of a receptor for murine granulocyte
            colony-stimulating factor
  JOURNAL   Cell 61 (2), 341-350 (1990)
   PUBMED   2158861
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M13926.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M13926.1, AK145177.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1363
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 62.45 cM"
     gene            1..1363
                     /gene="Csf3"
                     /gene_synonym="Csfg; G-CSF; MGI-IG"
                     /note="colony stimulating factor 3 (granulocyte)"
                     /db_xref="GeneID:12985"
                     /db_xref="MGI:MGI:1339751"
     exon            1..107
                     /gene="Csf3"
                     /gene_synonym="Csfg; G-CSF; MGI-IG"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..694
                     /gene="Csf3"
                     /gene_synonym="Csfg; G-CSF; MGI-IG"
                     /note="granulocyte colony-stimulating factor"
                     /codon_start=1
                     /product="granulocyte colony-stimulating factor precursor"
                     /protein_id="NP_034101.1"
                     /db_xref="CCDS:CCDS25360.1"
                     /db_xref="GeneID:12985"
                     /db_xref="MGI:MGI:1339751"
                     /translation="MAQLSAQRRMKLMALQLLLWQSALWSGREAVPLVTVSALPPSLP
                     LPRSFLLKSLEQVRKIQASGSVLLEQLCATYKLCHPEELVLLGHSLGIPKASLSGCSS
                     QALQQTQCLSQLHSGLCLYQGLLQALSGISPALAPTLDLLQLDVANFATTIWQQMENL
                     GVAPTVQPTQSAMPAFTSAFQRRAGGVLAISYLQGFLETARLALHHLA"
     exon            108..280
                     /gene="Csf3"
                     /gene_synonym="Csfg; G-CSF; MGI-IG"
                     /inference="alignment:Splign:2.1.0"
     exon            281..388
                     /gene="Csf3"
                     /gene_synonym="Csfg; G-CSF; MGI-IG"
                     /inference="alignment:Splign:2.1.0"
     exon            389..535
                     /gene="Csf3"
                     /gene_synonym="Csfg; G-CSF; MGI-IG"
                     /inference="alignment:Splign:2.1.0"
     exon            536..1363
                     /gene="Csf3"
                     /gene_synonym="Csfg; G-CSF; MGI-IG"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtataaaggc cccctggagc tgggccctgg cagagcccag agctgcagcc cagatcaccc
       61 agaatccatg gctcaacttt ctgcccagag gcgcatgaag ctaatggccc tgcagctgct
      121 gctgtggcaa agtgcactat ggtcaggacg agaggccgtt cccctggtca ctgtcagcgc
      181 tctgccacca tccctgcctc tgccccgaag cttcctgctt aagtccctgg agcaagtgag
      241 gaagatccag gccagcggct cggtgctgct ggagcagttg tgtgccacct acaagctgtg
      301 tcaccccgag gagctggtgt tgctgggcca ctctctgggg atcccgaagg cttccctgag
      361 tggctgctct agccaggccc tgcagcagac acagtgccta agccagctcc acagtgggct
      421 ctgcctctac caaggtctcc tgcaggctct atcgggtatt tcccctgccc tggcccccac
      481 cttggacttg cttcagctgg atgttgccaa ctttgccacc accatctggc agcagatgga
      541 aaacctaggg gtggccccta ctgtgcagcc cacacagagc gccatgccag ccttcacttc
      601 tgccttccag cgccgggcag gaggtgtcct ggccatttcg tacctgcagg gcttcctgga
      661 gacggctcgc cttgctctgc accacttggc ctagacctga gcagaaagcc ctttccagat
      721 agtttattta tctctattta atatttatgc atatttaagc ctactattta aagacaaaga
      781 cgagaaaatg gagctctaag cttctagatc attctctcca cttccgagtt ttgttctcct
      841 gcttagagca gagagagaag gctcttgtgt cctcctgtgg aggccaggga aggagatggg
      901 taaataccaa gtattgattc ctgctgctgc tccaggcacc cagttctgtg gcagtacccc
      961 caaaaaatca gtgagccctg ccgtgctgag gcaccatctc aggggggccc aggcagcatc
     1021 tggtctccct tccgggggac aagacatccc tgtttaatat ttaaacagca gtgttcccaa
     1081 actgggttct tatatccctt gctctggtca accaggttgc agggtttcct gtcctcacag
     1141 gaacgaagtc cctaaagaaa cagtggcagc caggtttagc cccggaattg actggattcc
     1201 ttttttaggg ccctgctggc ctggaagttg gagtgggggg cagaggaggc aggaggaagc
     1261 ctgggggggg ggttggcatg gagggaggcc ttcccatcca ccctcaccct ccaccccacc
     1321 tgtcactata gccaagcttg cggataataa agtgtggtgt tcc
//
