LOCUS       NM_007781               4740 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus colony stimulating factor 2 receptor, beta 2,
            low-affinity (granulocyte-macrophage) (Csf2rb2), transcript variant
            1, mRNA.
ACCESSION   NM_007781
VERSION     NM_007781.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4740)
  AUTHORS   Boieri,M., Malishkevich,A., Guennoun,R., Marchese,E., Kroon,S.,
            Trerice,K.E., Awad,M., Park,J.H., Iyer,S., Kreuzer,J., Haas,W.,
            Rivera,M.N. and Demehri,S.
  TITLE     CD4+ T helper 2 cells suppress breast cancer by inducing terminal
            differentiation
  JOURNAL   J Exp Med 219 (7) (2022)
   PUBMED   35657353
REFERENCE   2  (bases 1 to 4740)
  AUTHORS   Charlet,A., Kappenstein,M., Keye,P., Klasener,K., Endres,C.,
            Poggio,T., Gorantla,S.P., Kreutmair,S., Sanger,J., Illert,A.L.,
            Miething,C., Reth,M., Duyster,J., Rummelt,C. and von Bubnoff,N.
  TITLE     The IL-3, IL-5, and GM-CSF common receptor beta chain mediates
            oncogenic activity of FLT3-ITD-positive AML
  JOURNAL   Leukemia 36 (3), 701-711 (2022)
   PUBMED   34750506
REFERENCE   3  (bases 1 to 4740)
  AUTHORS   Baasch,S., Giansanti,P., Kolter,J., Riedl,A., Forde,A.J., Runge,S.,
            Zenke,S., Elling,R., Halenius,A., Brabletz,S., Hengel,H.,
            Kuster,B., Brabletz,T., Cicin-Sain,L., Arens,R., Vlachos,A.,
            Rohr,J.C., Stemmler,M.P., Kopf,M., Ruzsics,Z. and Henneke,P.
  TITLE     Cytomegalovirus subverts macrophage identity
  JOURNAL   Cell 184 (14), 3774-3793 (2021)
   PUBMED   34115982
REFERENCE   4  (bases 1 to 4740)
  AUTHORS   Rauschmeier,R., Gustafsson,C., Reinhardt,A., A-Gonzalez,N.,
            Tortola,L., Cansever,D., Subramanian,S., Taneja,R., Rossner,M.J.,
            Sieweke,M.H., Greter,M., Mansson,R., Busslinger,M. and
            Kreslavsky,T.
  TITLE     Bhlhe40 and Bhlhe41 transcription factors regulate alveolar
            macrophage self-renewal and identity
  JOURNAL   EMBO J 38 (19), e101233 (2019)
   PUBMED   31414712
REFERENCE   5  (bases 1 to 4740)
  AUTHORS   Oh,S.A., Liu,M., Nixon,B.G., Kang,D., Toure,A., Bivona,M. and
            Li,M.O.
  TITLE     Foxp3-independent mechanism by which TGF-beta controls peripheral T
            cell tolerance
  JOURNAL   Proc Natl Acad Sci U S A 114 (36), E7536-E7544 (2017)
   PUBMED   28827353
REFERENCE   6  (bases 1 to 4740)
  AUTHORS   Liboi,E., Jubinsky,P., Andrews,N.C., Nathan,D.G. and
            Mathey-Prevot,B.
  TITLE     Enhanced expression of interleukin-3 and granulocyte-macrophage
            colony-stimulating factor receptor subunits in murine hematopoietic
            cells stimulated with hematopoietic growth factors
  JOURNAL   Blood 80 (5), 1183-1189 (1992)
   PUBMED   1387562
REFERENCE   7  (bases 1 to 4740)
  AUTHORS   Gorman,D.M., Itoh,N., Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and
            Miyajima,A.
  TITLE     Chromosomal localization and organization of the murine genes
            encoding the beta subunits (AIC2A and AIC2B) of the interleukin 3,
            granulocyte/macrophage colony-stimulating factor, and interleukin 5
            receptors
  JOURNAL   J Biol Chem 267 (22), 15842-15848 (1992)
   PUBMED   1386365
REFERENCE   8  (bases 1 to 4740)
  AUTHORS   Park,L.S., Martin,U., Sorensen,R., Luhr,S., Morrissey,P.J.,
            Cosman,D. and Larsen,A.
  TITLE     Cloning of the low-affinity murine granulocyte-macrophage
            colony-stimulating factor receptor and reconstitution of a
            high-affinity receptor complex
  JOURNAL   Proc Natl Acad Sci U S A 89 (10), 4295-4299 (1992)
   PUBMED   1533931
REFERENCE   9  (bases 1 to 4740)
  AUTHORS   Hara,T. and Miyajima,A.
  TITLE     Two distinct functional high affinity receptors for mouse
            interleukin-3 (IL-3)
  JOURNAL   EMBO J 11 (5), 1875-1884 (1992)
   PUBMED   1582416
REFERENCE   10 (bases 1 to 4740)
  AUTHORS   Fung,M.C., Mak,N.K., Leung,K.N. and Hapel,A.J.
  TITLE     Distinguishing between mouse IL-3 and IL-3 receptor-like
            (IL-5/GM-CSF receptor converter) mRNAs using the polymerase chain
            reaction method
  JOURNAL   J Immunol Methods 149 (1), 97-103 (1992)
   PUBMED   1583316
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL589692.10.
            
            On Dec 13, 2013 this sequence version replaced NM_007781.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M29855.1, AK155675.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               AL589692.10        10142-10285
            145-381             AL589692.10        17485-17721
            382-508             AL589692.10        18761-18887
            509-696             AL589692.10        21334-21521
            697-854             AL589692.10        22998-23155
            855-1023            AL589692.10        23234-23402
            1024-1159           AL589692.10        23892-24027
            1160-1317           AL589692.10        24150-24307
            1318-1454           AL589692.10        26902-27038
            1455-1614           AL589692.10        27816-27975
            1615-1705           AL589692.10        28800-28890
            1706-1763           AL589692.10        29094-29151
            1764-1867           AL589692.10        29780-29883
            1868-4740           AL589692.10        30484-33356
FEATURES             Location/Qualifiers
     source          1..4740
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.22 cM"
     gene            1..4740
                     /gene="Csf2rb2"
                     /gene_synonym="AIC2A; BetaIl3; Bil3; Csfgmrb; Il3r; Il3rb;
                     Il3rb2"
                     /note="colony stimulating factor 2 receptor, beta 2,
                     low-affinity (granulocyte-macrophage)"
                     /db_xref="GeneID:12984"
                     /db_xref="MGI:MGI:1339760"
     exon            1..144
                     /gene="Csf2rb2"
                     /gene_synonym="AIC2A; BetaIl3; Bil3; Csfgmrb; Il3r; Il3rb;
                     Il3rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            145..381
                     /gene="Csf2rb2"
                     /gene_synonym="AIC2A; BetaIl3; Bil3; Csfgmrb; Il3r; Il3rb;
                     Il3rb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..2930
                     /gene="Csf2rb2"
                     /gene_synonym="AIC2A; BetaIl3; Bil3; Csfgmrb; Il3r; Il3rb;
                     Il3rb2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; interleukin-3 receptor class 2 subunit beta;
                     IL-3R class 2 subunit beta; IL-3 receptor class 2 subunit
                     beta; interleukin-3 receptor class II beta chain;
                     colony-stimulating factor 2 receptor subunit beta-2"
                     /codon_start=1
                     /product="interleukin-3 receptor class 2 subunit beta
                     isoform 1 precursor"
                     /protein_id="NP_031807.1"
                     /db_xref="CCDS:CCDS27611.1"
                     /db_xref="GeneID:12984"
                     /db_xref="MGI:MGI:1339760"
                     /translation="MDQQMALTWGLCYMALVALCWGHEVTEEEETVPLKTLECYNDYT
                     NRIICSWADTEDAQGLINMTLLYHQLDKIQSVSCELSEKLMWSECPSSHRCVPRRCVI
                     PYTRFSNGDNDYYSFQPDRDLGIQLMVPLAQHVQPPPPKDIHISPSGDHFLLEWSVSL
                     GDSQVSWLSSKDIEFEVAYKRLQDSWEDASSLHTSNFQVNLEPKLFLPNSIYAARVRT
                     RLSAGSSLSGRPSRWSPEVHWDSQPGDKAQPQNLQCFFDGIQSLHCSWEVWTQTTGSV
                     SFGLFYRPSPAAPEEKCSPVVKEPQASVYTRYRCSLPVPEPSAHSQYTVSVKHLEQGK
                     FIMSYYHIQMEPPILNQTKNRDSYSLHWETQKIPKYIDHTFQVQYKKKSESWKDSKTE
                     NLGRVNSMDLPQLEPDTSYCARVRVKPISDYDGIWSEWSNEYTWTTDWVMPTLWIVLI
                     LVFLIFTLLLALHFGRVYGYRTYRKWKEKIPNPSKSLLFQDGGKGLWPPGSMAAFATK
                     NPALQGPQSRLLAEQQGVSYEHLEDNNVSPLTIEDPNIIRDPPSRPDTTPAASSESTE
                     QLPNVQVEGPIPSSRPRKQLPSFDFNGPYLGPPQSHSLPDLPGQLGSPQVGGSLKPAL
                     PGSLEYMCLPPGGQVQLVPLSQVMGQGQAMDVQCGSSLETTGSPSVEPKENPPVELSV
                     EKQEARDNPMTLPISSGGPEGSMMASDYVTPGDPVLTLPTGPLSTSLGPSLGLPSAQS
                     PSLCLKLPRVPSGSPALGPPGFEDYVELPPSVSQAATSPPGHPAPPVASSPTVIPGEP
                     REEVGPASPHPEGLLVLQQVGDYCFLPGLGPGSLSPHSKPPSPSLCSETEDLDQDLSV
                     KKFPYQPLPQAPAIQFFKSLKY"
     exon            382..508
                     /gene="Csf2rb2"
                     /gene_synonym="AIC2A; BetaIl3; Bil3; Csfgmrb; Il3r; Il3rb;
                     Il3rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            509..696
                     /gene="Csf2rb2"
                     /gene_synonym="AIC2A; BetaIl3; Bil3; Csfgmrb; Il3r; Il3rb;
                     Il3rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            697..854
                     /gene="Csf2rb2"
                     /gene_synonym="AIC2A; BetaIl3; Bil3; Csfgmrb; Il3r; Il3rb;
                     Il3rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1023
                     /gene="Csf2rb2"
                     /gene_synonym="AIC2A; BetaIl3; Bil3; Csfgmrb; Il3r; Il3rb;
                     Il3rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1159
                     /gene="Csf2rb2"
                     /gene_synonym="AIC2A; BetaIl3; Bil3; Csfgmrb; Il3r; Il3rb;
                     Il3rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1317
                     /gene="Csf2rb2"
                     /gene_synonym="AIC2A; BetaIl3; Bil3; Csfgmrb; Il3r; Il3rb;
                     Il3rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1454
                     /gene="Csf2rb2"
                     /gene_synonym="AIC2A; BetaIl3; Bil3; Csfgmrb; Il3r; Il3rb;
                     Il3rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1614
                     /gene="Csf2rb2"
                     /gene_synonym="AIC2A; BetaIl3; Bil3; Csfgmrb; Il3r; Il3rb;
                     Il3rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1705
                     /gene="Csf2rb2"
                     /gene_synonym="AIC2A; BetaIl3; Bil3; Csfgmrb; Il3r; Il3rb;
                     Il3rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1763
                     /gene="Csf2rb2"
                     /gene_synonym="AIC2A; BetaIl3; Bil3; Csfgmrb; Il3r; Il3rb;
                     Il3rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1867
                     /gene="Csf2rb2"
                     /gene_synonym="AIC2A; BetaIl3; Bil3; Csfgmrb; Il3r; Il3rb;
                     Il3rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..4740
                     /gene="Csf2rb2"
                     /gene_synonym="AIC2A; BetaIl3; Bil3; Csfgmrb; Il3r; Il3rb;
                     Il3rb2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4717..4722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csf2rb2"
                     /gene_synonym="AIC2A; BetaIl3; Bil3; Csfgmrb; Il3r; Il3rb;
                     Il3rb2"
                     /note="hexamer: AATAAA"
     polyA_site      4740
                     /gene="Csf2rb2"
                     /gene_synonym="AIC2A; BetaIl3; Bil3; Csfgmrb; Il3r; Il3rb;
                     Il3rb2"
                     /note="major polyA site"
ORIGIN      
        1 aaagctgctt gtgaaagggc actggcaact tcctcaatct gctctctgtt tcctccagat
       61 ggggcacaaa taaataggaa gagcctgcag ctcactggca cttggaggct cccgaaggag
      121 gctgcctgtc gcccaagcac agagccacaa aggatgcagt ctaggaggga agaatcacaa
      181 gccctgtaag atgagtggag ccaaaccccc agccaagcac caatacagaa ccccgggtca
      241 atgaggacac ccccctgccc atagcttcct gtgcagccac caaaagtgcc aaaatggacc
      301 agcaaatggc actcacatgg gggctgtgct acatggcact ggtggctctc tgctggggac
      361 acgaggtgac agaggaagaa gaaacggtcc ctctgaagac tctggagtgc tacaatgact
      421 acaccaaccg tatcatctgc agctgggcag acacagagga tgcccagggg ctaatcaaca
      481 tgaccctcct ctatcaccag ctagacaaga ttcaatcagt gtcctgtgag ctcagtgaga
      541 aactcatgtg gtcagagtgc ccgtcatccc accgctgtgt gcccagaaga tgtgtcatcc
      601 cctacacacg attttctaat ggagataacg actactactc cttccagcca gatcgtgacc
      661 tgggcatcca gctcatggtc ccactggccc agcatgtgca gccaccccct cccaaggaca
      721 tccacatcag cccctctggg gatcatttcc tgctggaatg gagtgtatct cttggggatt
      781 cccaggtctc ctggctttca tcaaaggaca tagagtttga ggtggcttat aagcggcttc
      841 aggactcctg ggaggatgcc tccagtctcc acactagcaa ctttcaggtg aatttagagc
      901 caaagctatt cctacccaac agcatctatg ctgcccgtgt gcgcactcgg ctgtccgcgg
      961 gttcaagctt gtctgggaga cccagcagat ggagcccaga ggttcactgg gactcccagc
     1021 caggggacaa ggcccagcca cagaaccttc aatgcttctt tgatgggatc cagtctctcc
     1081 actgctcctg ggaggtgtgg acccagacga ctggctctgt ttcctttggg ctcttctatc
     1141 gccccagccc tgcagctccg gaggagaaat gctctccggt ggtgaaggag ccgcaggcca
     1201 gcgtctacac ccgctaccgc tgcagtctac ctgtgcctga gcccagtgca cacagccagt
     1261 acacagtctc tgttaagcac ctggaacaag ggaagttcat catgagctat taccacatcc
     1321 agatggaacc tccaatcctc aaccagacca agaacagaga cagctacagc ctgcattggg
     1381 aaactcagaa aatacccaaa tacattgatc acactttcca ggtccagtac aagaagaagt
     1441 cagagagctg gaaggacagc aagacagaaa acctaggtcg agtcaatagc atggacctgc
     1501 cccagctgga gccggacacc tcatactgcg ccagggtgag ggtcaagccc atctctgact
     1561 acgacgggat ctggagcgag tggagcaatg agtacacttg gacgactgac tgggtgatgc
     1621 ccacgctgtg gatagtcctc atcctggtct ttctcatctt caccttgctc ctggctctcc
     1681 actttggccg tgtttatggg tacaggacat acaggaagtg gaaggaaaag atccccaacc
     1741 ccagcaagag cctcctgttc caggatggag gtaaaggtct ctggcctcct ggcagcatgg
     1801 cagccttcgc gactaagaac cccgctctcc aggggccaca gagcaggctt cttgctgagc
     1861 aacagggggt gtcatatgaa catttggaag acaacaacgt gtcacctctc actatagagg
     1921 accctaatat aattcgagat ccaccatcca ggcctgatac aaccccagct gcctcatctg
     1981 aatccacaga gcaacttccc aatgttcaag tagagggacc aattccttct agccgaccca
     2041 ggaagcaatt acccagcttt gacttcaatg ggccctacct ggggcctccc caatcccact
     2101 ccctgcctga tctcccaggc cagctgggtt ctccccaggt gggtgggagc ctgaagccag
     2161 cactgccagg ctccttggag tacatgtgtc tgccccctgg aggtcaagtg caactggtcc
     2221 cattgtccca ggtgatggga cagggccagg ctatggatgt gcagtgtggg tccagcctgg
     2281 agaccacagg gagcccttcc gtggagccaa aggagaaccc tccagttgag ctgagcgtgg
     2341 agaaacagga ggcaagggac aacccaatga ctcttcccat aagctctggg ggccctgagg
     2401 gcagtatgat ggcctctgat tatgtcactc ctggagatcc ggtgctcact ctgcccacag
     2461 ggcccctgtc tacctctctg ggcccctctc tagggttgcc ctcagcccaa agccccagtc
     2521 tctgtcttaa gctgcccagg gtcccctctg gaagcccagc tctagggcca ccagggtttg
     2581 aggactatgt ggagctgcct ccaagtgtga gccaggcagc cacgtcccct ccaggccatc
     2641 ctgctcctcc tgtggcaagc agccccacag tgatcccagg agagcccagg gaggaagtgg
     2701 gcccagcatc cccacatccc gaaggcctcc ttgttcttca gcaggttggg gactactgct
     2761 tcctccctgg cctgggacct ggctccctct caccacacag taagccaccc tctccaagtc
     2821 tgtgttctga gactgaggac ctagaccagg acttgtctgt gaaaaagttt ccctatcaac
     2881 ccttgcccca ggccccagcc attcagtttt tcaagtccct aaagtattag gactacctgt
     2941 ccctgccccc ttgggacaat agccagtctg ggaaggtgtg ctgagtctgt cccctcccaa
     3001 tctcaccagc agcctggcac cgcagcctgt ggtcctcagc ctgagcatca ccacagaagc
     3061 ctctctgagt tcacactcct ccttgctccc tgctctgaca caacaatacc cccatatgtg
     3121 attttctctt ccccctctgt ccctcttccc ttccctccat ttccccctcc ccccacctct
     3181 ctttctctgt ctctctctgt ctctgtctct ctctctgtct ctgtctctct ctgtctctct
     3241 ctgtctctgt ctctctctct ctctctctct ctctctctct ctctctctct ctctgtctct
     3301 ctctctttcc agttttctgc cttctatggg atcttccttc ctgtccctcc gacctgttgg
     3361 agtggggagg cctgtgaggg tgagctctgc atggtctgtt tagggttgaa gaactcctga
     3421 ggtctgcttg tccaccatag gcattgatga taacacagca catttctgcc tctgtgtgaa
     3481 aagttggagt ctcaggtgaa ccccttggga ggacagactg taaaattggg caggctcttg
     3541 ttgctccaag aatagacatg gtcctctatg gttgtctgaa gctcctgggg agacctgggg
     3601 aaccttgtag aaggtacttg ggaccctgct tatgtacaga aatcactgat gtgcacaaag
     3661 ctggacacag ctatggccag gctggaggga tgagaagcaa tggggagggc tgggcgtcta
     3721 gatctcatgg tgtcaactgc agacaagctt agttgtggat cccggacagc acacccagag
     3781 actaagtcta gacagctgag ctgttcattc gttctccctc cagagcaaag cttggatacc
     3841 tgtgctccca ctggcctcag atgagggtct gctgtggtac tgtggccctt ggccatcacc
     3901 accctcttga caatccaggc acaatgccat tacctcattc tgttctcact ggacttgttt
     3961 gttcatggtc acgtttgcac atggcctttg tatgagtctt gagtattggc tttttggggg
     4021 gtggtgagga agtgaggttg ggagctgagc tcatgaacag ttttgtccct cagaatgtcc
     4081 ttttggatga gactgaatag ctctttccac atggcctttt gtgggacata catgtctccc
     4141 ttgaatgtgc taattttgtg caggaggcac aacagctccg tcagccattg gggccatatt
     4201 tgcagcagac tttgcaacaa atgtacatgt gccttatatt ctttcagtct ccttctgtgt
     4261 ctcgaacctt gaacaggatg tgataacttt tctagaccac atgcttgctc tgcagagttc
     4321 tgtccttata tgttctgtgg acctggagtc aatggacatt gcatcatttc tccacctatt
     4381 tgtgctctgt caggcactcc atgatccatc gttttacgac ctggatctgg tctgtcctat
     4441 ctcttggcct cactcactgg atggcagcca catgtcttca aatttgattt caaccctaag
     4501 caggcagatc aagtgttcct tggtctatgt tcactgcagc aaagaaaacc acaaacgtct
     4561 tgaaggtgtt gcagtggcaa tgttcaacaa aagcctgtca acactttcta aagtgactgc
     4621 tctagagaaa caaacaggaa cggcctccat gttaagatat gaacactgaa atgctttgct
     4681 ttaagaggaa acattgtaaa aacatttttt acatacaata aaacatagct aaaaaacaaa
//
