LOCUS       NM_009970               1850 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus colony stimulating factor 2 receptor, alpha,
            low-affinity (granulocyte-macrophage) (Csf2ra), mRNA.
ACCESSION   NM_009970 XM_977426
VERSION     NM_009970.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1850)
  AUTHORS   Shima,K., Arumugam,P., Sallese,A., Horio,Y., Ma,Y., Trapnell,C.,
            Wessendarp,M., Chalk,C., McCarthy,C., Carey,B.C., Trapnell,B.C. and
            Suzuki,T.
  TITLE     A murine model of hereditary pulmonary alveolar proteinosis caused
            by homozygous Csf2ra gene disruption
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 322 (3), L438-L448 (2022)
   PUBMED   35043685
  REMARK    GeneRIF: A murine model of hereditary pulmonary alveolar
            proteinosis caused by homozygous Csf2ra gene disruption.
REFERENCE   2  (bases 1 to 1850)
  AUTHORS   Zhan,Y., Zhang,Y., Zhang,S., Coughlan,H., Baldoni,P.L.,
            Jacquelot,N., Cao,W.H.J., Preston,S., Louis,C., Rautela,J.,
            Pellegrini,M., Wicks,I.P., Alexander,W.S., Harrison,L.C., Lew,A.M.,
            Smyth,G.K., Nutt,S.L. and Chopin,M.
  TITLE     Differential requirement for the Polycomb repressor complex 2 in
            dendritic cell and tissue-resident myeloid cell homeostasis
  JOURNAL   Sci Immunol 6 (63), eabf7268 (2021)
   PUBMED   34533976
REFERENCE   3  (bases 1 to 1850)
  AUTHORS   De Alessandris,S., Ferguson,G.J., Dodd,A.J., Juss,J.K.,
            Devaprasad,A., Piper,S., Wyatt,O., Killick,H., Corkill,D.J.,
            Cohen,E.S., Pandit,A., Radstake,T.R.D.J., Simmonds,R.,
            Condliffe,A.M., Sleeman,M.A., Cowburn,A.S., Finch,D.K. and
            Chilvers,E.R.
  TITLE     Neutrophil GM-CSF receptor dynamics in acute lung injury
  JOURNAL   J Leukoc Biol 105 (6), 1183-1194 (2019)
   PUBMED   30942918
  REMARK    GeneRIF: These data show that loss of membrane GM-CSFRalpha
            following GM-CSF exposure does not preclude sustained
            GM-CSF/GM-CSFRalpha signaling and that this receptor plays a key
            role in ligand clearance. Hence neutrophilic activation via GM-CSFR
            may play an important role in neutrophilic lung inflammation even
            in the absence of high GM-CSF levels or GM-CSFRalpha expression.
REFERENCE   4  (bases 1 to 1850)
  AUTHORS   Hui,Z., Zhou,L., Xue,Z., Zhou,L., Luo,Y., Lin,F., Liu,X., Hong,S.,
            Li,W., Wang,D., Lu,L., Wang,J. and Wang,L.
  TITLE     Cxxc Finger Protein 1 Positively Regulates GM-CSF-Derived
            Macrophage Phagocytosis Through Csf2ralpha-Mediated Signaling
  JOURNAL   Front Immunol 9, 1885 (2018)
   PUBMED   30154795
  REMARK    GeneRIF: we have demonstrated that CFP1 plays a crucial role in
            GM-CSF-derived macrophages, in which it positively regulates
            phagocytic and bactericidal activity mainly through promoting
            Csf2ralpha expression and the subsequent activation of downstream
            pathways.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1850)
  AUTHORS   Ifergan,I., Davidson,T.S., Kebir,H., Xu,D., Palacios-Macapagal,D.,
            Cann,J., Rodgers,J.M., Hunter,Z.N., Pittet,C.L., Beddow,S.,
            Jones,C.A., Prat,A., Sleeman,M.A. and Miller,S.D.
  TITLE     Targeting the GM-CSF receptor for the treatment of CNS autoimmunity
  JOURNAL   J Autoimmun 84, 1-11 (2017)
   PUBMED   28641926
  REMARK    GeneRIF: GM-CSF Ralpha blockade in relapsing-remitting experimental
            autoimmune encephalomyelitis prevented disease relapses and
            inhibited T cell responses specific for both the inducing and
            spread myelin peptides
REFERENCE   6  (bases 1 to 1850)
  AUTHORS   Nishijima,I., Nakahata,T., Hirabayashi,Y., Inoue,T., Kurata,H.,
            Miyajima,A., Hayashi,N., Iwakura,Y., Arai,K. and Yokota,T.
  TITLE     A human GM-CSF receptor expressed in transgenic mice stimulates
            proliferation and differentiation of hemopoietic progenitors to all
            lineages in response to human GM-CSF
  JOURNAL   Mol Biol Cell 6 (5), 497-508 (1995)
   PUBMED   7545029
REFERENCE   7  (bases 1 to 1850)
  AUTHORS   Tsuji,K., Copeland,N.G., Jenkins,N.A. and Obinata,M.
  TITLE     Mammalian antioxidant protein complements alkylhydroperoxide
            reductase (ahpC) mutation in Escherichia coli
  JOURNAL   Biochem J 307 (Pt 2) (Pt 2), 377-381 (1995)
   PUBMED   7733872
REFERENCE   8  (bases 1 to 1850)
  AUTHORS   Disteche,C.M., Brannan,C.I., Larsen,A., Adler,D.A.,
            Schorderet,D.F., Gearing,D., Copeland,N.G., Jenkins,N.A. and
            Park,L.S.
  TITLE     The human pseudoautosomal GM-CSF receptor alpha subunit gene is
            autosomal in mouse
  JOURNAL   Nat Genet 1 (5), 333-336 (1992)
   PUBMED   1363815
REFERENCE   9  (bases 1 to 1850)
  AUTHORS   Park,L.S., Martin,U., Sorensen,R., Luhr,S., Morrissey,P.J.,
            Cosman,D. and Larsen,A.
  TITLE     Cloning of the low-affinity murine granulocyte-macrophage
            colony-stimulating factor receptor and reconstitution of a
            high-affinity receptor complex
  JOURNAL   Proc Natl Acad Sci U S A 89 (10), 4295-4299 (1992)
   PUBMED   1533931
REFERENCE   10 (bases 1 to 1850)
  AUTHORS   Kitamura,T., Hayashida,K., Sakamaki,K., Yokota,T., Arai,K. and
            Miyajima,A.
  TITLE     Reconstitution of functional receptors for human
            granulocyte/macrophage colony-stimulating factor (GM-CSF): evidence
            that the protein encoded by the AIC2B cDNA is a subunit of the
            murine GM-CSF receptor
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5082-5086 (1991)
   PUBMED   1828890
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB664140.1, M85078.1, BU614102.1 and AW826169.1.
            
            On Nov 20, 2007 this sequence version replaced NM_009970.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.4536040.1, BC150696.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               BB664140.1         4-141
            139-449             M85078.1           80-390
            450-868             BU614102.1         277-695
            869-1840            M85078.1           810-1781
            1841-1850           AW826169.1         1-10                c
FEATURES             Location/Qualifiers
     source          1..1850
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 56.89 cM"
     gene            1..1850
                     /gene="Csf2ra"
                     /gene_synonym="CD116; Csfgmra; GM-CSF-Ra; GM-CSFR"
                     /note="colony stimulating factor 2 receptor, alpha,
                     low-affinity (granulocyte-macrophage)"
                     /db_xref="GeneID:12982"
                     /db_xref="MGI:MGI:1339754"
     exon            1..80
                     /gene="Csf2ra"
                     /gene_synonym="CD116; Csfgmra; GM-CSF-Ra; GM-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            81..174
                     /gene="Csf2ra"
                     /gene_synonym="CD116; Csfgmra; GM-CSF-Ra; GM-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            175..329
                     /gene="Csf2ra"
                     /gene_synonym="CD116; Csfgmra; GM-CSF-Ra; GM-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            330..450
                     /gene="Csf2ra"
                     /gene_synonym="CD116; Csfgmra; GM-CSF-Ra; GM-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            451..580
                     /gene="Csf2ra"
                     /gene_synonym="CD116; Csfgmra; GM-CSF-Ra; GM-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            581..750
                     /gene="Csf2ra"
                     /gene_synonym="CD116; Csfgmra; GM-CSF-Ra; GM-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            751..878
                     /gene="Csf2ra"
                     /gene_synonym="CD116; Csfgmra; GM-CSF-Ra; GM-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            879..908
                     /gene="Csf2ra"
                     /gene_synonym="CD116; Csfgmra; GM-CSF-Ra; GM-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1038
                     /gene="Csf2ra"
                     /gene_synonym="CD116; Csfgmra; GM-CSF-Ra; GM-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1135
                     /gene="Csf2ra"
                     /gene_synonym="CD116; Csfgmra; GM-CSF-Ra; GM-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1217
                     /gene="Csf2ra"
                     /gene_synonym="CD116; Csfgmra; GM-CSF-Ra; GM-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1849
                     /gene="Csf2ra"
                     /gene_synonym="CD116; Csfgmra; GM-CSF-Ra; GM-CSFR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1831..1836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csf2ra"
                     /gene_synonym="CD116; Csfgmra; GM-CSF-Ra; GM-CSFR"
                     /note="hexamer: AATAAA"
     polyA_site      1849
                     /gene="Csf2ra"
                     /gene_synonym="CD116; Csfgmra; GM-CSF-Ra; GM-CSFR"
                     /note="major polyA site"
ORIGIN      
        1 gggagacaga cggacagacg gacggacaca gacgctgcgc ccaggcctca ccatccatcg
       61 caggaagccc cctgtctcag atgacgtcat cacatgccat gaacatcacc cccctggctc
      121 agctcgccct gctcttctcc acgctactgc ttccgggaac tcaggccctt ctggctccga
      181 ccacaccgga cgccggctcc gccctcaacc tgaccttcga cccctggact cggacgctga
      241 cctgggcctg cgacaccgcc gcggggaacg tcacggtgac gtcatgcacc gtgacctcgc
      301 gggaggcggg gatacaccgg cgagtctcgc ccttcggttg ccgctgctgg ttcaggagga
      361 tgatggcgct gcaccacggt gtcacgctgg atgtcaatgg cacggtcggg ggcgcggccg
      421 cgcactggag gctgagcttc gtcaacgaag gcgcggcggg ctcgggggcg gagaacctga
      481 cctgcgagat ccgagccgcg cgcttccttt cctgcgcgtg gcgggagggg ccagcggcgc
      541 ccgcggacgt ccggtactcg ctgcgagtcc tcaactccac gggtcacgac gtggcgcgat
      601 gcatggccga ccccggggat gacgtcatca cacagtgcat tgcgaacgac ttgtcactgc
      661 tggggagtga ggcctacttg gtcgtgaccg gtcggagcgg tgcggggcca gtgcggttcc
      721 tggacgacgt ggtggctacg aaggcgctcg agcgactcgg tcccccacgt gacgtcaccg
      781 cgtcctgtaa ctcttcccac tgcaccgtct cgtgggcccc gccctcgacc tgggcatcct
      841 tgacggcccg ggacttccag tttgaggtcc agtggcagag cgcagagcca ggaagcacac
      901 cccggaaggt gctcgtcgtg gaggagaccc gcctcgcctt ccccagcccc gccccccacg
      961 gaggtcacaa ggtcaaggtg cgcgcgggcg acacgaggat gaagcactgg ggcgaatgga
     1021 gtcccgccca tcctctcgag gctgaggaca cgcgagtgcc cggtgcgctc ctgtatgcag
     1081 tgacagcctg cgcagtccta ctgtgcgcgc tggcgctcgg agtgacgtgc aggaggttcg
     1141 aggtgacgcg ccgactcttc ccgcccatcc cagggatcag ggacaaggtg tccgacgacg
     1201 tgcgagtgaa ccctgagacc ctcaggaagg acctcctgca gccctagacg tcccgccccc
     1261 aacgtgactg acaggaagga cttaaacttc atgacatcaa ctgatgtcat gaagcgatgc
     1321 tgatagacgt catcgtgacc gctccccacc cccacgtctg gtgtgactgg acccctgttg
     1381 ccctgttcat caatcaccaa agtgggcgtg tccagtctca tcctgtcaat caccctggaa
     1441 gggcatgttt aacgacattg atgtcaccgt gatatcacag tccaaccaaa tcctcctcta
     1501 tagccccgcc caccccgaca ggaagcacag gtgactggga agcctgccac tgtcaatcaa
     1561 ggccgcccat cccaaaaaaa tcagtactcg tggccatcct cctgcctcag ttccagggat
     1621 ggcagggaca gcgtgcatat ccccaccgta atagtttgct cagttcttaa caaaccctaa
     1681 cccttaatat tttaccttaa cagccagcac acacacacac acacacacac acacacacac
     1741 acacacagac acaaactgtc ataaaatcca acgtgccttc atgatcaaag ttcgatagtc
     1801 agtagtacta gaagaatcat atgtctgtaa aataaaagcc agaacattta
//
