LOCUS       NM_009969               1033 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Mus musculus colony stimulating factor 2 (granulocyte-macrophage)
            (Csf2), mRNA.
ACCESSION   NM_009969
VERSION     NM_009969.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1033)
  AUTHORS   Gan,Y., Zhou,H., Guo,Y., Huang,B., Liu,H., Wang,Z., Li,Z., Zhao,X.,
            Zhu,H., Han,Q., Ye,H., He,J., Wang,Q., Li,Z. and Sun,X.
  TITLE     A GITRL-mTORC1-GM-CSF Positive Loop Promotes Pathogenic Th17
            Response in Primary Sjogren Syndrome
  JOURNAL   Arthritis Rheumatol 76 (9), 1419-1430 (2024)
   PUBMED   38589318
  REMARK    GeneRIF: A GITRL-mTORC1-GM-CSF Positive Loop Promotes Pathogenic
            Th17 Response in Primary Sjogren Syndrome.
REFERENCE   2  (bases 1 to 1033)
  AUTHORS   Ngo,V.L., Lieber,C.M., Kang,H.J., Sakamoto,K., Kuczma,M.,
            Plemper,R.K. and Gewirtz,A.T.
  TITLE     Intestinal microbiota programming of alveolar macrophages
            influences severity of respiratory viral infection
  JOURNAL   Cell Host Microbe 32 (3), 335-348 (2024)
   PUBMED   38295788
REFERENCE   3  (bases 1 to 1033)
  AUTHORS   Wohner,M., Brechtelsbauer,S., Friedrich,N., Vorsatz,C., Bulang,J.,
            Liang,C., Schorr,L., Beschin,A., Guilliams,M., Ravetch,J.,
            Nimmerjahn,F. and Biburger,M.
  TITLE     Tissue niche occupancy determines the contribution of fetal- versus
            bone-marrow-derived macrophages to IgG effector functions
  JOURNAL   Cell Rep 43 (2), 113757 (2024)
   PUBMED   38354088
REFERENCE   4  (bases 1 to 1033)
  AUTHORS   Petrina,M., Alothaimeen,T., Bouzeineddine,N.Z., Trus,E., Banete,A.,
            Gee,K. and Basta,S.
  TITLE     Granulocyte macrophage colony stimulating factor exerts dominant
            effects over macrophage colony stimulating factor during macrophage
            differentiation in vitro to induce an inflammatory phenotype
  JOURNAL   Inflamm Res 73 (2), 253-262 (2024)
   PUBMED   38158446
  REMARK    GeneRIF: Granulocyte macrophage colony stimulating factor exerts
            dominant effects over macrophage colony stimulating factor during
            macrophage differentiation in vitro to induce an inflammatory
            phenotype.
REFERENCE   5  (bases 1 to 1033)
  AUTHORS   Evans,K.T., Blake,K., Longworth,A., Coburn,M.A.,
            Insua-Rodriguez,J., McMullen,T.P., Nguyen,Q.H., Ma,D., Lev,T.,
            Hernandez,G.A., Oganyan,A.K., Orujyan,D., Edwards,R.A., Pridans,C.,
            Green,K.N., Villalta,S.A., Blurton-Jones,M. and Lawson,D.A.
  TITLE     Microglia promote anti-tumour immunity and suppress breast cancer
            brain metastasis
  JOURNAL   Nat Cell Biol 25 (12), 1848-1859 (2023)
   PUBMED   37957324
REFERENCE   6  (bases 1 to 1033)
  AUTHORS   Okada,S., Nakauchi,H., Nagayoshi,K., Nakamura,M., Miura,Y. and
            Suda,T.
  TITLE     Synergistic effect of IL-3 and IL-6 on highly enriched murine
            hemopoietic progenitors
  JOURNAL   Exp Hematol 20 (5), 546-551 (1992)
   PUBMED   1350248
REFERENCE   7  (bases 1 to 1033)
  AUTHORS   Kaupmann,K., Simon-Chazottes,D., Guenet,J.L. and Jockusch,H.
  TITLE     Wobbler, a mutation affecting motoneuron survival and gonadal
            functions in the mouse, maps to proximal chromosome 11
  JOURNAL   Genomics 13 (1), 39-43 (1992)
   PUBMED   1349581
REFERENCE   8  (bases 1 to 1033)
  AUTHORS   Buckwalter,M.S., Lossie,A.C., Scarlett,L.M. and Camper,S.A.
  TITLE     Localization of the human chromosome 5q genes Gabra-1, Gabrg-2,
            Il-4, Il-5, and Irf-1 on mouse chromosome 11
  JOURNAL   Mamm Genome 3 (10), 604-607 (1992)
   PUBMED   1358285
REFERENCE   9  (bases 1 to 1033)
  AUTHORS   Karolyi,I.J., Guenet,J.L., Rey-Campos,J. and Camper,S.A.
  TITLE     The gene coding for variant hepatic nuclear factor 1 (Tcf-2), maps
            between the Edp-1 and Erba genes on mouse chromosome 11
  JOURNAL   Mamm Genome 3 (3), 184-185 (1992)
   PUBMED   1352161
REFERENCE   10 (bases 1 to 1033)
  AUTHORS   Baldacci,P.A., Richoux,V., Renard,J.P., Guenet,J.L. and Babinet,C.
  TITLE     The locus Om, responsible for the DDK syndrome, maps close to Sigje
            on mouse chromosome 11
  JOURNAL   Mamm Genome 2 (2), 100-105 (1992)
   PUBMED   1347470
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596103.22.
            
            On Apr 17, 2007 this sequence version replaced NM_009969.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK053196.1, BB533718.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-439               AL596103.22        153880-154318       c
            440-481             AL596103.22        153741-153782       c
            482-607             AL596103.22        152857-152982       c
            608-1033            AL596103.22        151689-152114       c
FEATURES             Location/Qualifiers
     source          1..1033
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 32.13 cM"
     gene            1..1033
                     /gene="Csf2"
                     /gene_synonym="CSF; Csfgm; Gm-CSf; GMCSF; MGI-IGM"
                     /note="colony stimulating factor 2
                     (granulocyte-macrophage)"
                     /db_xref="GeneID:12981"
                     /db_xref="MGI:MGI:1339752"
     exon            1..439
                     /gene="Csf2"
                     /gene_synonym="CSF; Csfgm; Gm-CSf; GMCSF; MGI-IGM"
                     /inference="alignment:Splign:2.1.0"
     exon            440..481
                     /gene="Csf2"
                     /gene_synonym="CSF; Csfgm; Gm-CSf; GMCSF; MGI-IGM"
                     /inference="alignment:Splign:2.1.0"
     exon            482..607
                     /gene="Csf2"
                     /gene_synonym="CSF; Csfgm; Gm-CSf; GMCSF; MGI-IGM"
                     /inference="alignment:Splign:2.1.0"
     exon            608..1033
                     /gene="Csf2"
                     /gene_synonym="CSF; Csfgm; Gm-CSf; GMCSF; MGI-IGM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1014..1019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csf2"
                     /gene_synonym="CSF; Csfgm; Gm-CSf; GMCSF; MGI-IGM"
                     /note="hexamer: AATAAA"
     polyA_site      1032
                     /gene="Csf2"
                     /gene_synonym="CSF; Csfgm; Gm-CSf; GMCSF; MGI-IGM"
                     /note="major polyA site"
ORIGIN      
        1 ggtcagactg cccaggcagg gtgggaaagg cctttaaagc agcccgcagg tgggctgcca
       61 gttcttggaa gggcttatta atgaaaaccc cccaagcctg acaacctggg ggaaggctca
      121 ctggccccat gtatagctga taagggccag gagattccac aactcaggta gttcccccgc
      181 ccccctggag ttctgtggtc accattaatc atttcctcta actgtgtata taagagctct
      241 tttgcagtga gcccagtact cagagagaaa ggctaaggtc ctgaggagga tgtggctgca
      301 gaatttactt ttcctgggca ttgtggtcta cagcctctca gcacccaccc gctcacccat
      361 cactgtcacc cggccttgga agcatgtaga ggccatcaaa gaagccctga acctcctgga
      421 tgacatgcct gtcacgttga atgaagaggt agaagtcgtc tctaacgagt tctccttcaa
      481 gaagctaaca tgtgtgcaga cccgcctgaa gatattcgag cagggtctac ggggcaattt
      541 caccaaactc aagggcgcct tgaacatgac agccagctac taccagacat actgcccccc
      601 aactccggaa acggactgtg aaacacaagt taccacctat gcggatttca tagacagcct
      661 taaaaccttt ctgactgata tcccctttga atgcaaaaaa ccaggccaaa aatgaggaag
      721 cccaggccag ctctgaatcc agcttctcag actgctgctt ttgtgcctgc gtaatgagcc
      781 aggaacttgg aatttctgcc ttaaagggac caagagatgt ggcacagcca cagttggaag
      841 gcagtatagc cctctgaaaa cgctgactca gcttggacag cggaagacaa acgagagata
      901 ttttctactg atagggacca ttatatttat ttatatattt atatttttta aatatttatt
      961 tatttattta tttatttttg caactctatt tattgagaat gtcttaccag aataataaat
     1021 tattaaaact ttt
//
