LOCUS       NM_001037859            3875 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus colony stimulating factor 1 receptor (Csf1r), mRNA.
ACCESSION   NM_001037859
VERSION     NM_001037859.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3875)
  AUTHORS   Konig,J., Rokavec,M., Oner-Ziegler,M.G., Fei,Y. and Hermeking,H.
  TITLE     Myeloid Mir34a suppresses colitis-associated colon cancer:
            characterization of mediators by single-cell RNA sequencing
  JOURNAL   Cell Death Differ 32 (2), 225-241 (2025)
   PUBMED   39425000
REFERENCE   2  (bases 1 to 3875)
  AUTHORS   Brandao,W., Jain,N., Yin,Z., Kleemann,K.L., Carpenter,M., Bao,X.,
            Serrano,J.R., Tycksen,E., Durao,A., Barry,J.L., Baufeld,C.,
            Guneykaya,D., Zhang,X., Litvinchuk,A., Jiang,H., Rosenzweig,N.,
            Pitts,K.M., Aronchik,M., Yahya,T., Cao,T., Takahashi,M.K.,
            Krishnan,R., Davtyan,H., Ulrich,J.D., Blurton-Jones,M., Ilin,I.,
            Weiner,H.L., Holtzman,D.M. and Butovsky,O.
  TITLE     Inhaled xenon modulates microglia and ameliorates disease in mouse
            models of amyloidosis and tauopathy
  JOURNAL   Sci Transl Med 17 (781), eadk3690 (2025)
   PUBMED   39813317
REFERENCE   3  (bases 1 to 3875)
  AUTHORS   Gallerand,A., Dolfi,B., Stunault,M.I., Caillot,Z., Castiglione,A.,
            Strazzulla,A., Chen,C., Heo,G.S., Luehmann,H., Batoul,F.,
            Vaillant,N., Dumont,A., Pilot,T., Merlin,J., Zair,F.N.,
            Gilleron,J., Bertola,A., Carmeliet,P., Williams,J.W.,
            Arguello,R.J., Masson,D., Dombrowicz,D., Yvan-Charvet,L., Doyen,D.,
            Haschemi,A., Liu,Y., Guinamard,R.R. and Ivanov,S.
  TITLE     Glucose metabolism controls monocyte homeostasis and migration but
            has no impact on atherosclerosis development in mice
  JOURNAL   Nat Commun 15 (1), 9027 (2024)
   PUBMED   39424804
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3875)
  AUTHORS   Meng,J., Pan,P., Guo,G., Chen,A., Meng,X. and Liu,H.
  TITLE     Transient CSF1R inhibition ameliorates behavioral deficits in
            Cntnap2 knockout and valproic acid-exposed mouse models of autism
  JOURNAL   J Neuroinflammation 21 (1), 262 (2024)
   PUBMED   39425203
  REMARK    GeneRIF: Transient CSF1R inhibition ameliorates behavioral deficits
            in Cntnap2 knockout and valproic acid-exposed mouse models of
            autism.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3875)
  AUTHORS   Profaci,C.P., Harvey,S.S., Bajc,K., Zhang,T.Z., Jeffrey,D.A.,
            Zhang,A.Z., Nemec,K.M., Davtyan,H., O'Brien,C.A., McKinsey,G.L.,
            Longworth,A., McMullen,T.P., Capocchi,J.K., Gonzalez,J.G.,
            Lawson,D.A., Arnold,T.D., Davalos,D., Blurton-Jones,M.,
            Dabertrand,F., Bennett,F.C. and Daneman,R.
  TITLE     Microglia are not necessary for maintenance of blood-brain barrier
            properties in health, but PLX5622 alters brain endothelial
            cholesterol metabolism
  JOURNAL   Neuron 112 (17), 2910-2921 (2024)
   PUBMED   39142282
REFERENCE   6  (bases 1 to 3875)
  AUTHORS   Kaupmann,K., Becker-Follmann,J., Scherer,G., Jockusch,H. and
            Starzinski-Powitz,A.
  TITLE     The gene for the cell adhesion molecule M-cadherin maps to mouse
            chromosome 8 and human chromosome 16q24.1-qter and is near the
            E-cadherin (uvomorulin) locus in both species
  JOURNAL   Genomics 14 (2), 488-490 (1992)
   PUBMED   1427864
REFERENCE   7  (bases 1 to 3875)
  AUTHORS   Justice,M.J., Gilbert,D.J., Kinzler,K.W., Vogelstein,B.,
            Buchberg,A.M., Ceci,J.D., Matsuda,Y., Chapman,V.M., Patriotis,C.,
            Makris,A. et al.
  TITLE     A molecular genetic linkage map of mouse chromosome 18 reveals
            extensive linkage conservation with human chromosomes 5 and 18
  JOURNAL   Genomics 13 (4), 1281-1288 (1992)
   PUBMED   1354644
REFERENCE   8  (bases 1 to 3875)
  AUTHORS   Johnson,K.R. and Davisson,M.T.
  TITLE     A multipoint genetic linkage map of mouse chromosome 18
  JOURNAL   Genomics 13 (4), 1143-1149 (1992)
   PUBMED   1354640
REFERENCE   9  (bases 1 to 3875)
  AUTHORS   Arceci,R.J., Pampfer,S. and Pollard,J.W.
  TITLE     Expression of CSF-1/c-fms and SF/c-kit mRNA during preimplantation
            mouse development
  JOURNAL   Dev Biol 151 (1), 1-8 (1992)
   PUBMED   1374350
REFERENCE   10 (bases 1 to 3875)
  AUTHORS   Wilkie,T.M., Gilbert,D.J., Olsen,A.S., Chen,X.N., Amatruda,T.T.,
            Korenberg,J.R., Trask,B.J., de Jong,P., Reed,R.R., Simon,M.I. et
            al.
  TITLE     Evolution of the mammalian G protein alpha subunit multigene family
  JOURNAL   Nat Genet 1 (2), 85-91 (1992)
   PUBMED   1302014
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146069.1, BC066863.1 and BB738990.1.
            
            On Mar 8, 2007 this sequence version replaced NM_001037859.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146069.1, BC066863.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2263              AK146069.1         2-2264
            2264-3263           BC066863.1         2173-3172
            3264-3873           AK146069.1         3265-3874
            3874-3875           BB738990.1         413-414
FEATURES             Location/Qualifiers
     source          1..3875
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 34.41 cM"
     gene            1..3875
                     /gene="Csf1r"
                     /gene_synonym="CD115; CSF-1R; Csfmr; Fim-2; Fim2; Fms;
                     M-CSF-R; M-CSFR"
                     /note="colony stimulating factor 1 receptor"
                     /db_xref="GeneID:12978"
                     /db_xref="MGI:MGI:1339758"
     exon            1..113
                     /gene="Csf1r"
                     /gene_synonym="CD115; CSF-1R; Csfmr; Fim-2; Fim2; Fms;
                     M-CSF-R; M-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            114..331
                     /gene="Csf1r"
                     /gene_synonym="CD115; CSF-1R; Csfmr; Fim-2; Fim2; Fms;
                     M-CSF-R; M-CSFR"
                     /inference="alignment:Splign:2.1.0"
     CDS             283..3216
                     /gene="Csf1r"
                     /gene_synonym="CD115; CSF-1R; Csfmr; Fim-2; Fim2; Fms;
                     M-CSF-R; M-CSFR"
                     /EC_number="2.7.10.1"
                     /note="macrophage colony-stimulating factor 1 receptor;
                     c-fms; CSF-1-R; proto-oncogene fms; proto-oncogene c-Fms;
                     CSF-1 receptor"
                     /codon_start=1
                     /product="macrophage colony-stimulating factor 1 receptor
                     precursor"
                     /protein_id="NP_001032948.2"
                     /db_xref="CCDS:CCDS29280.1"
                     /db_xref="GeneID:12978"
                     /db_xref="MGI:MGI:1339758"
                     /translation="MELGPPLVLLLATVWHGQGAPVIEPSGPELVVEPGETVTLRCVS
                     NGSVEWDGPISPYWTLDPESPGSTLTTRNATFKNTGTYRCTELEDPMAGSTTIHLYVK
                     DPAHSWNLLAQEVTVVEGQEAVLPCLITDPALKDSVSLMREGGRQVLRKTVYFFSPWR
                     GFIIRKAKVLDSNTYVCKTMVNGRESTSTGIWLKVNRVHPEPPQIKLEPSKLVRIRGE
                     AAQIVCSATNAEVGFNVILKRGDTKLEIPLNSDFQDNYYKKVRALSLNAVDFQDAGIY
                     SCVASNDVGTRTATMNFQVVESAYLNLTSEQSLLQEVSVGDSLILTVHADAYPSIQHY
                     NWTYLGPFFEDQRKLEFITQRAIYRYTFKLFLNRVKASEAGQYFLMAQNKAGWNNLTF
                     ELTLRYPPEVSVTWMPVNGSDVLFCDVSGYPQPSVTWMECRGHTDRCDEAQALQVWND
                     THPEVLSQKPFDKVIIQSQLPIGTLKHNMTYFCKTHNSVGNSSQYFRAVSLGQSKQLP
                     DESLFTPVVVACMSVMSLLVLLLLLLLYKYKQKPKYQVRWKIIERYEGNSYTFIDPTQ
                     LPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADE
                     KEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLG
                     PSLSPGQDSEGDSSYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSSDSFFKQDL
                     DKEASRPLELWDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGHVAKIGDFGLA
                     RDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPG
                     ILVNNKFYKLVKDGYQMAQPVFAPKNIYSIMQSCWDLEPTRRPTFQQICFLLQEQARL
                     ERRDQDYANLPSSGGSSGSDSGGGSSGGSSSEPEEESSSEHLACCEPGDIAQPLLQPN
                     NYQFC"
     exon            332..589
                     /gene="Csf1r"
                     /gene_synonym="CD115; CSF-1R; Csfmr; Fim-2; Fim2; Fms;
                     M-CSF-R; M-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            590..874
                     /gene="Csf1r"
                     /gene_synonym="CD115; CSF-1R; Csfmr; Fim-2; Fim2; Fms;
                     M-CSF-R; M-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1011
                     /gene="Csf1r"
                     /gene_synonym="CD115; CSF-1R; Csfmr; Fim-2; Fim2; Fms;
                     M-CSF-R; M-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1171
                     /gene="Csf1r"
                     /gene_synonym="CD115; CSF-1R; Csfmr; Fim-2; Fim2; Fms;
                     M-CSF-R; M-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1358
                     /gene="Csf1r"
                     /gene_synonym="CD115; CSF-1R; Csfmr; Fim-2; Fim2; Fms;
                     M-CSF-R; M-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1474
                     /gene="Csf1r"
                     /gene_synonym="CD115; CSF-1R; Csfmr; Fim-2; Fim2; Fms;
                     M-CSF-R; M-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1595
                     /gene="Csf1r"
                     /gene_synonym="CD115; CSF-1R; Csfmr; Fim-2; Fim2; Fms;
                     M-CSF-R; M-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1786
                     /gene="Csf1r"
                     /gene_synonym="CD115; CSF-1R; Csfmr; Fim-2; Fim2; Fms;
                     M-CSF-R; M-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1902
                     /gene="Csf1r"
                     /gene_synonym="CD115; CSF-1R; Csfmr; Fim-2; Fim2; Fms;
                     M-CSF-R; M-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2029
                     /gene="Csf1r"
                     /gene_synonym="CD115; CSF-1R; Csfmr; Fim-2; Fim2; Fms;
                     M-CSF-R; M-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2134
                     /gene="Csf1r"
                     /gene_synonym="CD115; CSF-1R; Csfmr; Fim-2; Fim2; Fms;
                     M-CSF-R; M-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2245
                     /gene="Csf1r"
                     /gene_synonym="CD115; CSF-1R; Csfmr; Fim-2; Fim2; Fms;
                     M-CSF-R; M-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2408
                     /gene="Csf1r"
                     /gene_synonym="CD115; CSF-1R; Csfmr; Fim-2; Fim2; Fms;
                     M-CSF-R; M-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2497
                     /gene="Csf1r"
                     /gene_synonym="CD115; CSF-1R; Csfmr; Fim-2; Fim2; Fms;
                     M-CSF-R; M-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..2595
                     /gene="Csf1r"
                     /gene_synonym="CD115; CSF-1R; Csfmr; Fim-2; Fim2; Fms;
                     M-CSF-R; M-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2718
                     /gene="Csf1r"
                     /gene_synonym="CD115; CSF-1R; Csfmr; Fim-2; Fim2; Fms;
                     M-CSF-R; M-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2719..2830
                     /gene="Csf1r"
                     /gene_synonym="CD115; CSF-1R; Csfmr; Fim-2; Fim2; Fms;
                     M-CSF-R; M-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..2930
                     /gene="Csf1r"
                     /gene_synonym="CD115; CSF-1R; Csfmr; Fim-2; Fim2; Fms;
                     M-CSF-R; M-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2931..3039
                     /gene="Csf1r"
                     /gene_synonym="CD115; CSF-1R; Csfmr; Fim-2; Fim2; Fms;
                     M-CSF-R; M-CSFR"
                     /inference="alignment:Splign:2.1.0"
     exon            3040..3875
                     /gene="Csf1r"
                     /gene_synonym="CD115; CSF-1R; Csfmr; Fim-2; Fim2; Fms;
                     M-CSF-R; M-CSFR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3848..3853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csf1r"
                     /gene_synonym="CD115; CSF-1R; Csfmr; Fim-2; Fim2; Fms;
                     M-CSF-R; M-CSFR"
                     /note="hexamer: ATTAAA"
     polyA_site      3874
                     /gene="Csf1r"
                     /gene_synonym="CD115; CSF-1R; Csfmr; Fim-2; Fim2; Fms;
                     M-CSF-R; M-CSFR"
                     /note="major polyA site"
ORIGIN      
        1 gggtatgact cctctcctaa gtgtccttag aggtggtttc ctaagtctct caaactccat
       61 catctccctt caggatcagt tgagcctggc cccagattct gcctcttcct ctgttccctt
      121 tcaggcaacc taaaaaaaaa aaaaaaaaaa aaggggaaga ggagccagtg caacagacag
      181 gaacgtgttc atctgttccc gtcctcacag aactagcagc tgggagcccc gtgcccagcc
      241 gactctccaa cctgcatcgg ctcacgctat cccctggagg ctatggagtt ggggcctcct
      301 ctggtcctgc tgctggccac agtttggcat ggtcaggggg cccctgtcat cgagcctagt
      361 ggcccagaac tggttgtaga gccgggtgaa acggtgaccc tgcgatgtgt gagcaatggc
      421 agtgtggaat gggatggccc catctctccc tactggacct tggaccctga atctcccgga
      481 agcaccctga ccacaagaaa cgcgaccttc aaaaacactg ggacctaccg ttgtaccgag
      541 cttgaagacc ccatggcagg cagtaccacc atccacttgt atgtcaaaga tccggcccac
      601 tcttggaatt tgctggcaca ggaggtgaca gtggttgagg gccaggaagc tgtgctgccc
      661 tgtctgatca ctgaccctgc actgaaggac agtgtctcac tgatgcgtga ggggggcagg
      721 caggtcttac gcaaaacggt ctacttcttc tcgccatggc gagggttcat tatccgcaag
      781 gctaaagtcc ttgacagcaa tacctacgtg tgcaagacca tggtgaatgg tagggaatcc
      841 acctccactg gcatctggct taaggtgaat cgagtccacc cagagccccc acagataaaa
      901 ttggagccta gcaagctggt gcggattcga ggggaggctg cgcagatcgt gtgctcggcc
      961 actaacgccg aagtgggatt caacgttatc ctcaaacgtg gagacaccaa gctggaaatc
     1021 cccctaaaca gtgacttcca agataactat tataaaaaag tccgggctct cagtctcaac
     1081 gctgtggact tccaagacgc tggcatatat tcttgtgtgg ccagcaatga tgttggcaca
     1141 cgcacggcca ccatgaactt ccaggtggtg gagagtgcct acttaaactt gacctctgag
     1201 cagagcctct tgcaggaggt gtctgtgggt gacagcctca tcctcacggt ccatgcagat
     1261 gcctacccta gcatacagca ttacaactgg acctacctag gtccattctt tgaagaccag
     1321 cgcaagcttg agtttatcac ccaaagggcc atatacaggt acacattcaa gctctttctg
     1381 aaccgtgtaa aggcctcaga ggcgggccag tacttcttaa tggcacaaaa caaggcaggc
     1441 tggaataatc tgacctttga gctcaccctg cgatatcccc cagaggtcag tgttacatgg
     1501 atgcctgtga atggctctga tgtcctgttc tgtgacgtct ctgggtaccc tcagcccagc
     1561 gtgacatgga tggagtgcag gggccacacc gataggtgtg atgaagccca ggctttgcag
     1621 gtttggaatg acacccaccc tgaagtcctg agtcagaagc ccttcgacaa agtgatcatt
     1681 cagagccagc tgcccattgg gaccttaaaa cacaacatga cttatttttg caaaacccac
     1741 aacagtgtgg gtaacagctc tcagtacttc agggccgtct ccctaggaca aagcaagcag
     1801 ctccccgatg agtccctctt cactccggtg gtggtggcct gtatgtctgt catgtctctg
     1861 ctggtgctac tgctgttgct gctcttgtac aagtacaagc agaagccgaa gtaccaggtg
     1921 cgctggaaga tcatcgagag atacgaaggc aatagctaca ccttcattga ccctactcag
     1981 ttgccctaca atgagaagtg ggagttccct cggaacaacc tgcagtttgg taagactcta
     2041 ggagccggtg cctttgggaa ggtggtggag gctacagcct ttggtctggg caaagaagat
     2101 gcagtgctga aggtggctgt gaagatgcta aagtccacgg ctcatgctga tgagaaggag
     2161 gccctgatgt cagagctgaa gatcatgagt cacctgggac agcacgagaa tatagtcaac
     2221 ctcttgggag cctgtactca cggaggacct gtcctggtca tcactgaata ctgctgctat
     2281 ggagacctac tcaactttct ccgaaggaag gccgaggcta tgctaggacc cagcctgagt
     2341 cctggtcagg actccgaggg agactccagc tacaagaaca tccacctgga gaagaaatat
     2401 gtgcgcaggg acagtggctt ctccagtcag ggtgtagaca cctacgtgga gatgaggcct
     2461 gtctcgactt cttcaagtga ctccttcttt aagcaagatc tggacaaaga ggccagccgg
     2521 cccctggagc tctgggacct gctccacttc tccagccaag tggctcaggg catggccttc
     2581 cttgcttcta aaaactgcat ccaccgggac gtagcagctc gaaacgtgct gttgaccagc
     2641 ggacatgtgg ccaagattgg ggactttgga ctggctaggg acatcatgaa tgactccaac
     2701 tatgttgtca agggcaatgc ccgcctgcct gtaaagtgga tggccccaga gagcatcttt
     2761 gactgcgtct acacagttca gagtgatgtg tggtcctacg gcatcctcct ctgggagatc
     2821 ttctcgcttg gtctgaaccc ctaccccggc atcctagtga acaacaagtt ctacaaactg
     2881 gtgaaggatg gataccaaat ggcccagcct gtatttgcac cgaagaacat atacagcatc
     2941 atgcagtcct gctgggacct ggagcctacc agaagaccca ccttccaaca gatctgcttc
     3001 ctcctccagg agcaggcccg actggagagg agagaccagg actatgctaa cctgccaagc
     3061 agcggtggca gcagcggcag tgacagtggt ggtggcagca gcggtggcag cagcagtgag
     3121 ccagaagagg agagctccag tgaacacctg gcctgctgtg agccagggga catcgcccag
     3181 cccctgctgc agcctaacaa ctaccagttc tgctgaagtg ggagggagag ccgagtcctg
     3241 ccgctctcta cgtcccagct tggcctcctc catggcacgg gcgacatggg gagaacatat
     3301 ggacttcgcc ctcagcttgg cccagctctg acacttcaga acatgagggg tctggggagg
     3361 tcagaggccc cgtttgttcc cagagcctgg gccatcactg ccagtggggt tctcacagtg
     3421 ctagcctcta tatttactat gccaactggt gcacccctag ttctctttct ccatcctatt
     3481 cccattttaa aaaacccgtc ccaaactctc gtgtttcaat ggaaagactg atttatgtct
     3541 caaaagacaa gagtctcaaa ggctgtgggt aagctgaagg cttgcctccc tgacagatgc
     3601 ttagactaca ggcttcttgg gacaggtggc cccttcctaa gctcacagga gtggccacca
     3661 ctcttgacct tcactctgtc tatagtcccg cctcatcctg gatcttgtac tgagcggcag
     3721 ctaaaagtgt tctacccagt gccctgtcac tctagactgg aaggtatggg gcctgatgca
     3781 aggctgacca caccaacaaa caccgtgtgc tcctctccaa gctgactcgt cctcattaac
     3841 tgtcaacatt aaactaacag cattaacaca gccag
//
