LOCUS       NM_007778               4192 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus colony stimulating factor 1 (macrophage) (Csf1),
            transcript variant 1, mRNA.
ACCESSION   NM_007778
VERSION     NM_007778.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4192)
  AUTHORS   Alkaslasi,M.R., Lloyd,E.Y.H., Gable,A.S., Silberberg,H.,
            Yarur,H.E., Tsai,V.S., Sohn,M., Margolin,G., Tejeda,H.A. and Le
            Pichon,C.E.
  TITLE     The transcriptional response of cortical neurons to concussion
            reveals divergent fates after injury
  JOURNAL   Nat Commun 16 (1), 1097 (2025)
   PUBMED   39870620
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4192)
  AUTHORS   Brandao,W., Jain,N., Yin,Z., Kleemann,K.L., Carpenter,M., Bao,X.,
            Serrano,J.R., Tycksen,E., Durao,A., Barry,J.L., Baufeld,C.,
            Guneykaya,D., Zhang,X., Litvinchuk,A., Jiang,H., Rosenzweig,N.,
            Pitts,K.M., Aronchik,M., Yahya,T., Cao,T., Takahashi,M.K.,
            Krishnan,R., Davtyan,H., Ulrich,J.D., Blurton-Jones,M., Ilin,I.,
            Weiner,H.L., Holtzman,D.M. and Butovsky,O.
  TITLE     Inhaled xenon modulates microglia and ameliorates disease in mouse
            models of amyloidosis and tauopathy
  JOURNAL   Sci Transl Med 17 (781), eadk3690 (2025)
   PUBMED   39813317
REFERENCE   3  (bases 1 to 4192)
  AUTHORS   Baligacs,N., Albertini,G., Borrie,S.C., Serneels,L., Pridans,C.,
            Balusu,S. and De Strooper,B.
  TITLE     Homeostatic microglia initially seed and activated microglia later
            reshape amyloid plaques in Alzheimer's Disease
  JOURNAL   Nat Commun 15 (1), 10634 (2024)
   PUBMED   39639016
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4192)
  AUTHORS   Houchen,C.J., Ghanem,S., Kaartinen,V. and Bumann,E.E.
  TITLE     TGF-beta signaling in the cranial neural crest affects late-stage
            mandibular bone resorption and length
  JOURNAL   Front Physiol 15, 1435594 (2024)
   PUBMED   39473613
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4192)
  AUTHORS   Thierry,G.R., Baudon,E.M., Bijnen,M., Bellomo,A., Lagueyrie,M.,
            Mondor,I., Simonnet,L., Carrette,F., Fenouil,R., Keshvari,S.,
            Hume,D.A., Dombrowicz,D. and Bajenoff,M.
  TITLE     Non-classical monocytes scavenge the growth factor CSF1 from
            endothelial cells in the peripheral vascular tree to ensure
            survival and homeostasis
  JOURNAL   Immunity 57 (9), 2108-2121 (2024)
   PUBMED   39089257
  REMARK    GeneRIF: Non-classical monocytes scavenge the growth factor CSF1
            from endothelial cells in the peripheral vascular tree to ensure
            survival and homeostasis.
REFERENCE   6  (bases 1 to 4192)
  AUTHORS   Kiso,Y., Pollard,J.W. and Croy,B.A.
  TITLE     A study of granulated metrial gland cell differentiation in
            pregnant, macrophage-deficient, osteopetrotic (op/op) mice
  JOURNAL   Experientia 48 (10), 973-975 (1992)
   PUBMED   1426147
REFERENCE   7  (bases 1 to 4192)
  AUTHORS   Wiktor-Jedrzejczak,W., Ansari,A.A., Szperl,M. and Urbanowska,E.
  TITLE     Distinct in vivo functions of two macrophage subpopulations as
            evidenced by studies using macrophage-deficient op/op mouse
  JOURNAL   Eur J Immunol 22 (7), 1951-1954 (1992)
   PUBMED   1378025
REFERENCE   8  (bases 1 to 4192)
  AUTHORS   Arceci,R.J., Pampfer,S. and Pollard,J.W.
  TITLE     Expression of CSF-1/c-fms and SF/c-kit mRNA during preimplantation
            mouse development
  JOURNAL   Dev Biol 151 (1), 1-8 (1992)
   PUBMED   1374350
REFERENCE   9  (bases 1 to 4192)
  AUTHORS   Lane,P.W. and Eicher,E.M.
  TITLE     Gene order in linkage group XVI of the house mouse
  JOURNAL   J Hered 70 (4), 239-244 (1979)
   PUBMED   489953
REFERENCE   10 (bases 1 to 4192)
  AUTHORS   Marks,S.C. Jr. and Lane,P.W.
  TITLE     Osteopetrosis, a new recessive skeletal mutation on chromosome 12
            of the mouse
  JOURNAL   J Hered 67 (1), 11-18 (1976)
   PUBMED   1262696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140786.3, BC066187.1, AK160995.1 and AI844210.1.
            
            On Jan 24, 2008 this sequence version replaced NM_007778.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Variants 1 and 3
            encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154261.1, AK160995.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               AC140786.3         113456-113701       c
            247-2242            BC066187.1         1-1996
            2243-4166           AK160995.1         2017-3940
            4167-4192           AI844210.1         1-26                c
FEATURES             Location/Qualifiers
     source          1..4192
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3"
     gene            1..4192
                     /gene="Csf1"
                     /gene_synonym="BAP025; Csfm; MCSF; Mhdabap25; op;
                     PG-M-CSF"
                     /note="colony stimulating factor 1 (macrophage)"
                     /db_xref="GeneID:12977"
                     /db_xref="MGI:MGI:1339753"
     exon            1..445
                     /gene="Csf1"
                     /gene_synonym="BAP025; Csfm; MCSF; Mhdabap25; op;
                     PG-M-CSF"
                     /inference="alignment:Splign:2.1.0"
     CDS             407..2065
                     /gene="Csf1"
                     /gene_synonym="BAP025; Csfm; MCSF; Mhdabap25; op;
                     PG-M-CSF"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; osteopetrosis; proteoglycan macrophage
                     colony-stimulating factor"
                     /codon_start=1
                     /product="macrophage colony-stimulating factor 1 isoform 1
                     precursor"
                     /protein_id="NP_031804.3"
                     /db_xref="CCDS:CCDS17740.1"
                     /db_xref="GeneID:12977"
                     /db_xref="MGI:MGI:1339753"
                     /translation="MTARGAAGRCPSSTWLGSRLLLVCLLMSRSIAKEVSEHCSHMIG
                     NGHLKVLQQLIDSQMETSCQIAFEFVDQEQLDDPVCYLKKAFFLVQDIIDETMRFKDN
                     TPNANATERLQELSNNLNSCFTKDYEEQNKACVRTFHETPLQLLEKIKNFFNETKNLL
                     EKDWNIFTKNCNNSFAKCSSRDVVTKPDCNCLYPKATPSSDPASASPHQPPAPSMAPL
                     AGLAWDDSQRTEGSSLLPSELPLRIEDPGSAKQRPPRSTCQTLESTEQPNHGDRLTED
                     SQPHPSAGGPVPGVEDILESSLGTNWVLEEASGEASEGFLTQEAKFSPSTPVGGSIQA
                     ETDRPRALSASPFPKSTEDQKPVDITDRPLTEVNPMRPIGQTQNNTPEKTDGTSTLRE
                     DHQEPGSPHIATPNPQRVSNSATPVAQLLLPKSHSWGIVLPLGELEGKRSTRDRRSPA
                     ELEGGSASEGAARPVARFNSIPLTDTGHVEQHEGSSDPQIPESVFHLLVPGIILVLLT
                     VGGLLFYKWKWRSHRDPQTLDSSVGRPEDSSLTQDEDRQVELPV"
     exon            446..568
                     /gene="Csf1"
                     /gene_synonym="BAP025; Csfm; MCSF; Mhdabap25; op;
                     PG-M-CSF"
                     /inference="alignment:Splign:2.1.0"
     exon            569..631
                     /gene="Csf1"
                     /gene_synonym="BAP025; Csfm; MCSF; Mhdabap25; op;
                     PG-M-CSF"
                     /inference="alignment:Splign:2.1.0"
     exon            632..802
                     /gene="Csf1"
                     /gene_synonym="BAP025; Csfm; MCSF; Mhdabap25; op;
                     PG-M-CSF"
                     /inference="alignment:Splign:2.1.0"
     exon            803..950
                     /gene="Csf1"
                     /gene_synonym="BAP025; Csfm; MCSF; Mhdabap25; op;
                     PG-M-CSF"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1966
                     /gene="Csf1"
                     /gene_synonym="BAP025; Csfm; MCSF; Mhdabap25; op;
                     PG-M-CSF"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2019
                     /gene="Csf1"
                     /gene_synonym="BAP025; Csfm; MCSF; Mhdabap25; op;
                     PG-M-CSF"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2078
                     /gene="Csf1"
                     /gene_synonym="BAP025; Csfm; MCSF; Mhdabap25; op;
                     PG-M-CSF"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..4176
                     /gene="Csf1"
                     /gene_synonym="BAP025; Csfm; MCSF; Mhdabap25; op;
                     PG-M-CSF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3881..3886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csf1"
                     /gene_synonym="BAP025; Csfm; MCSF; Mhdabap25; op;
                     PG-M-CSF"
                     /note="hexamer: ATTAAA"
     polyA_site      3905
                     /gene="Csf1"
                     /gene_synonym="BAP025; Csfm; MCSF; Mhdabap25; op;
                     PG-M-CSF"
     regulatory      4145..4150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csf1"
                     /gene_synonym="BAP025; Csfm; MCSF; Mhdabap25; op;
                     PG-M-CSF"
                     /note="hexamer: AATAAA"
     polyA_site      4169
                     /gene="Csf1"
                     /gene_synonym="BAP025; Csfm; MCSF; Mhdabap25; op;
                     PG-M-CSF"
                     /note="major polyA site"
ORIGIN      
        1 acagagcgac ggggaagaga gctagcgggg acgaccaggc ggcccgcttg ggggaaggga
       61 gtcggcggct cagtgggcct ctggggtgta gtatgtgtca gtgcctgtga gtgtgtttgt
      121 gtgtgtgtat gtctgtgtgt gtctggcgga gagccagggt gatttcccat aaaccacatg
      181 ccccgccagc ccgcccgctt aaaaggctgt gccgagggct ggccagcgaa gctcggccag
      241 gggaaagtga aagtttgcct cggtgctctc ggtgtcgctg cggctctctg catcccagga
      301 cagcggcgtg gccctcgacc ggggcgcggg ctcttcagcc actagcgagc aagggagcga
      361 gcgaaccagg gcggccaaca cgccgtgccg ggacccagct gcccgtatga ccgcgcgggg
      421 cgccgcgggg cgctgccctt cttcgacatg gctgggctcc cggctgctgc tggtctgtct
      481 cctcatgagc aggagtattg ccaaggaggt gtcagaacac tgtagccaca tgattgggaa
      541 tggacacctg aaggtcctgc agcagttgat cgacagtcaa atggagactt catgccagat
      601 tgcctttgaa tttgtagacc aggaacagct ggatgatcct gtttgctacc taaagaaggc
      661 cttttttctg gtacaagaca taatagatga gaccatgcgc tttaaagaca acacccccaa
      721 tgctaacgcc accgagaggc tccaggaact ctccaataac ctgaacagct gcttcaccaa
      781 ggactatgag gagcagaaca aggcctgtgt ccgaactttc catgagactc ctctccagct
      841 gctggagaag atcaagaact tctttaatga aacaaagaat ctccttgaaa aggactggaa
      901 catttttacc aagaactgca acaacagctt tgctaagtgc tctagccgag atgtggtgac
      961 caagcctgat tgcaactgcc tgtaccctaa agccacccct agcagtgacc cggcctctgc
     1021 ctcccctcac cagccccccg ccccctccat ggcccctctg gctggcttgg cttgggatga
     1081 ttctcagagg acagagggca gctccctctt gcccagtgag cttccccttc gcatagagga
     1141 cccaggcagt gccaagcagc gaccacccag gagtacctgc cagaccctcg agtcaacaga
     1201 gcaaccaaac catggggaca gactcactga ggactcacaa cctcatcctt ctgcgggggg
     1261 gcccgtccct ggggtggaag acattcttga atcttcactg ggcactaact gggtcctaga
     1321 agaagcttct ggagaggcta gtgagggatt tttgacccag gaagcaaagt tttccccctc
     1381 cacgcctgta gggggcagca tccaggcaga gactgacaga cccagggccc tctcagcatc
     1441 tccattccct aaatcaacag aggaccaaaa gccagtggat ataacagaca ggccgttgac
     1501 agaggtgaac cctatgagac ccattggcca gacacagaat aatactcctg agaagactga
     1561 tggtacatcc acgctgcgtg aagaccacca ggagccaggc tctccccata ttgcgacacc
     1621 gaatccccaa cgagtcagca actcagccac ccccgttgct cagttactgc ttcccaaaag
     1681 ccactcttgg ggcattgtgc tgccccttgg ggagcttgag ggcaagagaa gtaccaggga
     1741 tcgaaggagc cccgcagagc tggaaggagg atcagcaagt gagggggcag ccaggcctgt
     1801 ggcccgtttt aattccattc ctttgactga cacaggccat gtggagcagc atgagggatc
     1861 ctctgacccc cagatccctg agtctgtctt ccacctgctg gtgccgggca tcatcctagt
     1921 cttgctgact gttgggggcc tcctgttcta caagtggaag tggaggagcc atcgagaccc
     1981 tcagacattg gattcttctg tggggcgacc agaggacagc tccctgaccc aggatgagga
     2041 cagacaggtg gaactgccag tatagaaagg attctatgct gggcacacag gactatctct
     2101 ttatggaagg agacatatgg gaacatccac cactaccctc tcctaccatc ttcctgggaa
     2161 tgtggcctac cactaccaga gctcctgcct accaagactg gatgaaagaa gcagctttga
     2221 tggggtcttt ccatcctcac ccttagactc tcaaccaaag agaaagggct ggaggatgcc
     2281 ccccacatac tgccactatt tattgtgggc cctggaggct ccctgcattg gaggaagggc
     2341 agctcagcag ctcaggaccc tttcccttag gggctgcttc ctcccctcaa aaccagaacc
     2401 tggcaaggga ctcactagcc tggatggccc atgggagacc aggacagatg agaaggagca
     2461 gaagagccct gtgcccagaa gacccaactg gtgccaagga atcccagcat ggacaggcag
     2521 ggacctgttt cccaagaaga gagcctgata ttcaaagggt gggacagcat ctgcccgact
     2581 tcccgtaaag gcataaaggc acgcagccca aaagacggga agaggaggcc tttggctgct
     2641 tgtgttgaca gcttaaaggg gtctacaccc tcaacttgct taagtgccct ctgctgatag
     2701 ccaggaagga gggagaccag ccctgcccct caggacctga cctggctcat gatgccaaga
     2761 ggaagacaga gctctagcct cgtcttctcc tgcccacagc ccctgccaga gttcttttgc
     2821 ccagcagagg cacccctcat gaaggaagcc attgcactgt gaatactgaa cctgcctgct
     2881 gaacagcctg tcccatccat ccctatgagt gaccatccgt ccgaatgttc tcccacttcc
     2941 ttcagcctct cctcggcttc ttgcactgag ctggcctcac gtgttgactg agggagcccc
     3001 tgagccccaa ccttcccctg cctcagcctt tgattgtcca gggtgaagct gtgggagaac
     3061 cgcctgggct accagtcaga gctggtcttt gggctgtgtt ccttgcccag gtttctgcat
     3121 cttgcacttt gacattccca ggagggaagt gactagtgga agggagagag gaaggggagg
     3181 cagagacaaa ggccacaggc agagctatga atgagaatgg gtcttgaaaa tatgtgtgca
     3241 cccctaagct tgaaattgat ctctatactc tagcccctca gccagcctcc ttcctgttgt
     3301 ctgaaacctg gagctaagca ggttgtcctg tcacaagctc tggggactga gctccatgct
     3361 ccaaccccac cctcttctga cctttgttct ccagacctga cccaggtagg caagggtacc
     3421 ctcccagtct cacctaccat actgtgccat ctctagccaa gcaagccagg tttagagaag
     3481 ggtcaaaaaa aaaaaaaagg gttgtttact tccaacttgt tctgatgccc tctgtttccc
     3541 aggccaggct tgtctgtggt gacctgggca tgggtgacag ggctctcatt tgccccttgg
     3601 tctctttatg ctgctgagtc cccctttcct gccctccctg gctactgggt caataatctt
     3661 tcaggccatg aatctgggag gagagtggtc tgtaagctcc atcagccctg tcctgagaca
     3721 gcagggggga aggacactgg agactttctt gtggggctta cttagccttc tggttacaga
     3781 ctatttccat gctagaaaat acatatttta aaatagaagg aaaaacacag aaacaaaaca
     3841 aaacaaggca ttctctaccc ctccacctta aacatatatt attaaagaca gaagagaaaa
     3901 tccaacccat tgcaagaagc tctttgtggg tgcctggtta catcggagca ggggagcctc
     3961 aaatccacct ttggagccgc ccctgtgtgc attaggaacc cttctctcct ctgagaaagc
     4021 tcagagggag cactgcctca caaactgtga gactgcgttt tttatacttg gaagtggtga
     4081 attattttat ataaggtcat ttaaatatct atttaaaaaa taggaagctg cttttatatt
     4141 taataataaa agaagtgcac aagctgccac gtgtgaaaaa aaaaaaaaaa aa
//
