LOCUS       NM_023565               3604 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus chromosome segregation 1 like (Cse1l), mRNA.
ACCESSION   NM_023565
VERSION     NM_023565.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3604)
  AUTHORS   Blizzard,L.E., Menke,C., Patel,S.D., Waclaw,R.R., Lachke,S.A. and
            Stottmann,R.W.
  TITLE     A Novel Mutation in Cse1l Disrupts Brain and Eye Development with
            Specific Effects on Pax6 Expression
  JOURNAL   J Dev Biol 9 (3), 27 (2021)
   PUBMED   34287339
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3604)
  AUTHORS   Lee,W.R., Shen,S.C., Shih,Y.H., Chou,C.L., Tseng,J.T., Chin,S.Y.,
            Liu,K.H., Chen,Y.C. and Jiang,M.C.
  TITLE     Early decline in serum phospho-CSE1L levels in
            vemurafenib/sunitinib-treated melanoma and
            sorafenib/lapatinib-treated colorectal tumor xenografts
  JOURNAL   J Transl Med 13, 191 (2015)
   PUBMED   26070816
  REMARK    GeneRIF: serum phospho-CSE1L is useful for early detecting the
            efficacy of targeted therapy in initial treatment.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3604)
  AUTHORS   Jiang,M.C., Yeh,C.M., Tai,C.J., Chen,H.C., Lin,S.H., Su,T.C.,
            Shen,S.C., Lee,W.R., Liao,C.F., Li,L.T., Lee,C.H., Chen,Y.C.,
            Yeh,K.T. and Chang,C.C.
  TITLE     CSE1L modulates Ras-induced cancer cell invasion: correlation of
            K-Ras mutation and CSE1L expression in colorectal cancer
            progression
  JOURNAL   Am J Surg 206 (3), 418-427 (2013)
   PUBMED   23806821
  REMARK    GeneRIF: CSE1L knockdown reduced Ras-induced metastasis of B16F10
            melanoma cells in C57BL/6 mice. v-H-Ras expression altered the
            cellular trafficking of CSE1L and increased CSE1L secretion.
REFERENCE   4  (bases 1 to 3604)
  AUTHORS   Li,R., Yang,Y.G., Gao,Y., Wang,Z.Q. and Tong,W.M.
  TITLE     A distinct response to endogenous DNA damage in the development of
            Nbs1-deficient cortical neurons
  JOURNAL   Cell Res 22 (5), 859-872 (2012)
   PUBMED   22212482
REFERENCE   5  (bases 1 to 3604)
  AUTHORS   Lo,J.C., Jamsai,D., O'Connor,A.E., Borg,C., Clark,B.J.,
            Whisstock,J.C., Field,M.C., Adams,V., Ishikawa,T., Aitken,R.J.,
            Whittle,B., Goodnow,C.C., Ormandy,C.J. and O'Bryan,M.K.
  TITLE     RAB-like 2 has an essential role in male fertility, sperm
            intra-flagellar transport, and tail assembly
  JOURNAL   PLoS Genet 8 (10), e1002969 (2012)
   PUBMED   23055941
REFERENCE   6  (bases 1 to 3604)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 3604)
  AUTHORS   Behrens,P., Brinkmann,U. and Wellmann,A.
  TITLE     CSE1L/CAS: its role in proliferation and apoptosis
  JOURNAL   Apoptosis 8 (1), 39-44 (2003)
   PUBMED   12510150
  REMARK    GeneRIF: CSE1L/CAS has a role in proliferation and apoptosis
            [review]
            Review article
REFERENCE   8  (bases 1 to 3604)
  AUTHORS   Bera,T.K., Bera,J., Brinkmann,U., Tessarollo,L. and Pastan,I.
  TITLE     Cse1l is essential for early embryonic growth and development
  JOURNAL   Mol Cell Biol 21 (20), 7020-7024 (2001)
   PUBMED   11564884
REFERENCE   9  (bases 1 to 3604)
  AUTHORS   Brinkmann,U., Brinkmann,E., Bera,T.K., Wellmann,A. and Pastan,I.
  TITLE     Tissue-specific alternative splicing of the CSE1L/CAS (cellular
            apoptosis susceptibility) gene
  JOURNAL   Genomics 58 (1), 41-49 (1999)
   PUBMED   10331944
REFERENCE   10 (bases 1 to 3604)
  AUTHORS   de Miguel,M., Centanni,J.M., Gopalan,G., Gilbert,D.J.,
            Copeland,N.G., Jenkins,N.A. and Donovan,P.J.
  TITLE     Cellular apoptosis susceptibility gene capts maps to mouse
            chromosome 2
  JOURNAL   Mamm Genome 9 (5), 411-412 (1998)
   PUBMED   9545506
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591911.8 and AL591711.22.
            
            On Aug 14, 2009 this sequence version replaced NM_023565.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF301152.1, SRR1660825.152414.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AL591911.8         97781-97862
            83-177              AL591911.8         106855-106949
            178-320             AL591911.8         111298-111440
            321-422             AL591911.8         113655-113756
            423-568             AL591911.8         113840-113985
            569-659             AL591911.8         114439-114529
            660-767             AL591911.8         118036-118143
            768-860             AL591911.8         118929-119021
            861-1028            AL591911.8         119128-119295
            1029-1158           AL591911.8         119398-119527
            1159-1224           AL591911.8         120643-120708
            1225-1427           AL591711.22        2533-2735
            1428-1512           AL591711.22        3330-3414
            1513-1574           AL591711.22        4881-4942
            1575-1711           AL591711.22        7501-7637
            1712-1815           AL591711.22        8671-8774
            1816-1913           AL591711.22        10090-10187
            1914-2064           AL591711.22        12383-12533
            2065-2273           AL591711.22        12658-12866
            2274-2371           AL591711.22        13966-14063
            2372-2457           AL591711.22        14155-14240
            2458-2539           AL591711.22        14763-14844
            2540-2686           AL591711.22        15808-15954
            2687-2918           AL591711.22        17125-17356
            2919-3604           AL591711.22        18452-19137
FEATURES             Location/Qualifiers
     source          1..3604
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 87.22 cM"
     gene            1..3604
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
                     /note="chromosome segregation 1 like"
                     /db_xref="GeneID:110750"
                     /db_xref="MGI:MGI:1339951"
     exon            1..82
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
                     /inference="alignment:Splign:2.1.0"
     exon            83..177
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
                     /inference="alignment:Splign:2.1.0"
     exon            178..320
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
                     /inference="alignment:Splign:2.1.0"
     exon            321..422
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
                     /inference="alignment:Splign:2.1.0"
     exon            423..568
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
                     /inference="alignment:Splign:2.1.0"
     exon            569..659
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
                     /inference="alignment:Splign:2.1.0"
     exon            660..767
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
                     /inference="alignment:Splign:2.1.0"
     exon            768..860
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1028
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1158
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1224
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1427
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1512
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1574
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1711
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1815
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1913
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2064
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2273
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2371
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2457
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2539
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
                     /inference="alignment:Splign:2.1.0"
     exon            2540..2686
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2918
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..3604
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3455..3460
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
                     /note="hexamer: AATAAA"
     polyA_site      3482
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
                     /note="major polyA site"
     regulatory      3567..3572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
                     /note="hexamer: CATAAA"
     polyA_site      3591
                     /gene="Cse1l"
                     /gene_synonym="2610100P18Rik; Capts; Cas; Xpo2"
ORIGIN      
        1 ggcggagcag cggctggagt ggggtagtgt cggctgcagc tctcgcttgg gattccctcc
       61 tcggtctcgg cgtccccacg agattcagag tcatggagct cagcgatgcg aatttacaga
      121 cactaacaga gtatttaaag aaaaccctgg atcctgatcc tgccattaga cggccagctg
      181 agaagtttct cgaatccgta gaaggaaatc agaattaccc actgttgctt ttaacattat
      241 tggaaaagtc acaggataat gtcattaaag tatgtgcttc agtaaccttc aagaactata
      301 ttaaaaggaa ttggagaatt gttgaagatg aaccaaacaa aatttgcgaa gctgatcgag
      361 tagctattaa agccaacata gtgcatctga tgctgagcag tccagagcag attcagaagc
      421 agctgagtga tgctattagc atcattggca gagaagattt ccctcagaaa tggcctgact
      481 tgttgacaga aatggtgaat cgctttcaga gtggagattt tcacgtcatt aatggagtcc
      541 ttcgtacagc gcactcacta tttaagagat accggcatga gttcaagtca aatgagctgt
      601 ggactgaaat taaacttgtc ttggatgcct ttgctttgcc tttgactaat ctattcaagg
      661 ccaccattga actgtgcagt acccatgcaa atgacgcctc tgccctgagg attctttttt
      721 cttccttgat tttgatctca aaattgttct atagtttgaa ctttcaggat ctccctgaat
      781 tctttgaaga taatatggaa acttggatga acaattttca taccctcctg acactggata
      841 ataagctctt gcagactgat gatgaagagg aagcaggctt actggagctt ttaaagtctc
      901 agatctgtga taatgccgct ctctatgcac agaaatatga cgaagagttt cagcggtacc
      961 tccctcgctt tgtcacagct atctggaact tactcgttac aacagggcga gaagttaaat
     1021 atgacttgtt ggttagcaat gcaattcagt ttctggcttc agtttgtgaa aggccacatt
     1081 ataagaatct gtttgaggac cagaacacgc tgacaagtat ctgtgaaaaa gttattgtgc
     1141 ctaacatgga atttagagct gctgatgaag aagcttttga agataattct gaggagtaca
     1201 tacggaggga tttggaaggc tctgatattg atactagacg cagggctgct tgtgatcttg
     1261 tacgaggatt atgcaaattt tttgaaggtc ctgtgacagg aatcttctct ggttatgtta
     1321 attccatgct ccaggagtat gcaaaaaacc cgtctgtcaa ctggaaacac aaagatgcag
     1381 ctatttacct tgtcacatct ttggcatcaa aagcccagac acagaagcat ggaatcacgc
     1441 aagccaatga acttgtaaac ctaactgaat ttttcgtgaa tcacatactt cctgatttaa
     1501 aatcaaataa tgtgaatgag tttcctgtgc ttaaagctga tggtatcaaa tatattatga
     1561 tttttaggaa tcaagtacca aaagagcacc tcctagtctc tattcccctc ttgatcagtc
     1621 acctggaggc tgagagtatt gtcgtccaca cttatgccgc acatgctctc gaaaggctgt
     1681 tcactatgag agggtcaaac aataccactc tttttacagc tgcagaaatc gcaccgtttg
     1741 ttgagattct gctaacaaac cttttcaaag ctctcacact tcctggctct tcagaaaatg
     1801 aatatattat gaaagctatc atgagaagtt tctccctcct gcaagaggcc atcatcccct
     1861 atatccccac tctcatcacg cagctcacac agaagctgct ggctgttagt aagaatccca
     1921 gtaaacctca tttcaatcac tacatgtttg aagcaatatg cttgtctata agaataacct
     1981 gcaaagctaa ccctgctgct gttgtgaatt ttgaggaggc tctgtttcta gtgttcactg
     2041 agatcttaca aaatgatgta caagagttta tcccatatgt ctttcaagtg atgtctttac
     2101 ttctggaaac acataaaaat gatatcccgt cttcctatat ggccttgttt ccccacctcc
     2161 ttcagccagt actgtgggaa aggacaggaa acatccctgc tctagtgagg ctgctccagg
     2221 cattcttaga acgaggctca agtacaatag caactgctgc agctgacaaa attcctggat
     2281 tactgggtgt cttccagaag ctgattgcat ccaaggcaaa cgatcaccaa ggtttctatc
     2341 ttctcaacag tataatcgaa cacatgcctc ctgaatcagt tgaccagtat aggaagcaga
     2401 tcttcattct actattccag agactgcaaa actccaagac caccaagttt atcaagagtt
     2461 tcttagtgtt tattaactta tattgcatta agtatggggc actagcatta caagaaatat
     2521 ttgatggcat acaaccaaaa atgtttggaa tggttttgga aaaaatcatt attccagaga
     2581 ttcaaaaggt atctgggaac gtggagaaaa aaatctgtgc agttggcata accaaattac
     2641 tcacagagtg tccaccaatg atggacacgg agtacactaa gctgtggact cctttgttac
     2701 aatctctcat tggcctgttt gaattacctg aagatgacag cattcctgat gaagagcatt
     2761 tcattgacat agaagataca ccaggatacc agactgcctt ctcacagctg gcatttgctg
     2821 gtaaaaagga acatgatcct gtaggtcaga tggtaaacaa ccccaaaatc catctggcac
     2881 agtcacttca caaactgtca actgcttgtc ctggaagggt tccctcgatg gtgagcacca
     2941 gcctcaatgc agaagccttg cagtatctcc aaggttacct gcaggcagcc agtgtgaccc
     3001 tgttgtgaac tccatcttcc tgaccatgca gcggctgagg atggtttctt agaaccatgt
     3061 ggacttctga gcacggccct gctgaagcaa cacaggtttc caacctcttg aacttgtcac
     3121 aaactcttac agaggacaga aaatattgct gtaagccaat gaggttgttt gtcttgatca
     3181 tcaatataac tgataacttg tctactttgt ccttaatggg acaagtattt acaatcccat
     3241 gtatggccat ggtctctgtt gaacatttgc acggtttggg ttatttcaaa tttttggcag
     3301 gccttgactg tggagactta atttctattg ttttgaagct tgtatttctc ttgtcctttg
     3361 tggattttgt ctgtttcttt aaacttttat tggacatatg aaaaagtctt gttgacttgc
     3421 aatgcacatt tcgtagttaa agtctgtaat cagcaataaa aacccaaaat gtgtatctaa
     3481 aagtgtcttc aggacaggat ttggtgcttt ctgaaacttt gatgaaatga agaatttctt
     3541 taaatctact ttccccatct ggactccata aaaatactaa tttttaaatc atttaaactc
     3601 agaa
//
