LOCUS       NM_001416468            2148 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus cysteine sulfinic acid decarboxylase (Csad),
            transcript variant 22, mRNA.
ACCESSION   NM_001416468
VERSION     NM_001416468.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2148)
  AUTHORS   Tan,R., Li,J., Liu,L., Wu,Q., Fan,L., Ma,N., Yu,C., Lu,H.,
            Zhang,X., Chen,J., Gong,L. and Ren,J.
  TITLE     CSAD Ameliorates Lipid Accumulation in High-Fat Diet-Fed Mice
  JOURNAL   Int J Mol Sci 23 (24), 15931 (2022)
   PUBMED   36555571
  REMARK    GeneRIF: CSAD Ameliorates Lipid Accumulation in High-Fat Diet-Fed
            Mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2148)
  AUTHORS   Park,E., Elidrissi,A., Schuller-Levis,G. and Chadman,K.K.
  TITLE     Taurine Partially Improves Abnormal Anxiety in Taurine-Deficient
            Mice
  JOURNAL   Adv Exp Med Biol 1155, 905-921 (2019)
   PUBMED   31468456
REFERENCE   3  (bases 1 to 2148)
  AUTHORS   Winge,I., Teigen,K., Fossbakk,A., Mahootchi,E., Kleppe,R.,
            Skoldberg,F., Kampe,O. and Haavik,J.
  TITLE     Mammalian CSAD and GADL1 have distinct biochemical properties and
            patterns of brain expression
  JOURNAL   Neurochem Int 90, 173-184 (2015)
   PUBMED   26327310
  REMARK    GeneRIF: taurine biosynthesis in vertebrates involves two
            structurally related PLP-dependent decarboxylases (cysteine
            sulfinic acid decarboxylase and glutamic acid decarboxylase like 1)
REFERENCE   4  (bases 1 to 2148)
  AUTHORS   Ma,Q., Zhao,J., Cao,W., Liu,J. and Cui,S.
  TITLE     Estradiol decreases taurine level by reducing cysteine sulfinic
            acid decarboxylase via the estrogen receptor-alpha in female mice
            liver
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 308 (4), G277-G286 (2015)
   PUBMED   25394658
  REMARK    GeneRIF: Estradiol decreases taurine concentration mainly via the
            reduction of cysteine sulfinic acid decarboxylase expression level
            through the ER-alpha.
REFERENCE   5  (bases 1 to 2148)
  AUTHORS   Park,E., Park,S.Y., Dobkin,C. and Schuller-Levis,G.
  TITLE     Development of a novel cysteine sulfinic Acid decarboxylase
            knockout mouse: dietary taurine reduces neonatal mortality
  JOURNAL   J Amino Acids 2014, 346809 (2014)
   PUBMED   24639894
REFERENCE   6  (bases 1 to 2148)
  AUTHORS   Li,J.H., Ling,Y.Q., Fan,J.J., Zhang,X.P. and Cui,S.
  TITLE     Expression of cysteine sulfinate decarboxylase (CSD) in male
            reproductive organs of mice
  JOURNAL   Histochem Cell Biol 125 (6), 607-613 (2006)
   PUBMED   16252094
  REMARK    GeneRIF: The results show that CSD is expressed both at the mRNA
            and protein levels in the testis, epididymis and ductus deferens.
REFERENCE   7  (bases 1 to 2148)
  AUTHORS   Kim,H.W., Yoon,S.H., Park,T., Kim,B.K., Park,K.K. and Lee,D.H.
  TITLE     Gene expressions of taurine transporter and taurine biosynthetic
            enzyme during mouse and chicken embryonic development
  JOURNAL   Adv Exp Med Biol 583, 69-77 (2006)
   PUBMED   17153590
REFERENCE   8  (bases 1 to 2148)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2148)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2148)
  AUTHORS   Park,E., Park,S.Y., Wang,C., Xu,J., LaFauci,G. and
            Schuller-Levis,G.
  TITLE     Cloning of murine cysteine sulfinic acid decarboxylase and its mRNA
            expression in murine tissues
  JOURNAL   Biochim Biophys Acta 1574 (3), 403-406 (2002)
   PUBMED   11997111
  REMARK    GeneRIF: cDNA sequence that predicts a polypeptide of 493 amino
            acids - both sequences given
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123791.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253014.4296486.1,
                                           SRR17253011.9035483.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AC123791.4         97111-97222         c
            113-188             AC123791.4         81859-81934         c
            189-325             AC123791.4         81515-81651         c
            326-452             AC123791.4         81154-81280         c
            453-543             AC123791.4         80979-81069         c
            544-650             AC123791.4         80538-80644         c
            651-766             AC123791.4         80026-80141         c
            767-846             AC123791.4         79366-79445         c
            847-901             AC123791.4         78970-79024         c
            902-1018            AC123791.4         72943-73059         c
            1019-1218           AC123791.4         71933-72132         c
            1219-1270           AC123791.4         71753-71804         c
            1271-1360           AC123791.4         71499-71588         c
            1361-2148           AC123791.4         69971-70758         c
FEATURES             Location/Qualifiers
     source          1..2148
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.35 cM"
     gene            1..2148
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /note="cysteine sulfinic acid decarboxylase"
                     /db_xref="GeneID:246277"
                     /db_xref="MGI:MGI:2180098"
     exon            1..112
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            113..188
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            189..325
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..1534
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /EC_number="4.1.1.11"
                     /EC_number="4.1.1.29"
                     /note="isoform 4 is encoded by transcript variant 22;
                     sulfinoalanine decarboxylase; cysteine-sulfinate
                     decarboxylase; aspartate 1-decarboxylase"
                     /codon_start=1
                     /product="cysteine sulfinic acid decarboxylase isoform 4"
                     /protein_id="NP_001403397.1"
                     /db_xref="GeneID:246277"
                     /db_xref="MGI:MGI:2180098"
                     /translation="MADSKPLRTLDGDPVAVEALLQDVFGIVVDEAILKGTSASEKVC
                     EWKEPEELKQLLDLELQSQGESREQILERCRTVIHYSVKTGHPRFFNQLFSGLDPHAL
                     AGRIITESLNTSQYTYEIAPVFVLMEEEVLKKLRALVGWNSGDGVFCPGGSISNMYAM
                     NLARFQRYPDCKQRGLRALPPLALFTSKECHYSITKGAAFLGLGTDSVRVVKADERGR
                     MIPEDLERQIILAEAEGSVPFLVSATSGTTVLGAFDPLDAIADVCQRHGLWFHVDNLL
                     KRCHGSQASYLFQQDKFYDVALDTGDKVVQCGRRVDCLKLWLMWKAQGGQGLERRIDQ
                     AFALTRYLVEEIKKREGFELVMEPEFVNVCFWFVPPSLRGKKESPDYSQRLSQVAPVL
                     KERMVKKGTMMIGYQPHGTRANFFRMVVANPILAQADIDFLLGELELLGQDL"
     exon            326..452
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            453..543
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            544..650
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            651..766
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            767..846
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            847..901
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1018
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1218
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1270
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1360
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..2148
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2127..2132
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /note="hexamer: AATAAA"
     polyA_site      2148
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /note="major polyA site"
ORIGIN      
        1 actccacaga cgagggcaga actgtgttgg aaggaagctc gggaggcctc cgccgagcgc
       61 cggggtggct ggcagtgccc gcacgtgagc gtcgctcgga gtccgcccga agccctattc
      121 tgaaaagtcc attgtgtacc ttgtcaccag ctcgtctgat ccttctctga gccctcctga
      181 gctggaagat ttcatcctga tggctgactc aaaaccactc aggaccctgg atggggaccc
      241 cgtggctgtg gaggccttgc tccaggacgt gtttgggatt gttgtagatg aggccattct
      301 gaaggggacc agtgcctctg agaaggtctg cgaatggaag gagcctgaag aactcaagca
      361 gctgctggac ttggagctgc agagccaggg cgagtcccgg gagcagatcc tggagcgctg
      421 ccggactgtg attcactaca gtgtcaagac tggtcacccc cggttcttca accagctctt
      481 ctcagggtta gatccccatg ctctggctgg gcgcatcatc acggagagcc tcaacactag
      541 ccagtacaca tatgagattg cccccgtgtt tgtgctcatg gaagaggagg tgctgaagaa
      601 actccgtgcc ctggtgggct ggaactctgg ggatggggtc ttctgtcctg gtggctccat
      661 ctccaacatg tacgccatga acctggcccg ctttcagcgc tacccagact gcaagcagag
      721 gggcctccgg gccctgccgc ccttggctct cttcacttca aaggagtgtc actactccat
      781 caccaaggga gctgcttttc tgggacttgg caccgacagt gtccgagtgg tcaaggctga
      841 tgagagaggg aggatgatcc ctgaggacct ggagaggcag atcattctgg cagaggctga
      901 gggctctgtg ccatttctgg tcagtgccac ctctggtacc accgtgctag gggcctttga
      961 ccccctggat gcaattgccg atgtttgcca gcgacacgga ctgtggttcc atgtggataa
     1021 cctgctcaag cgctgccatg gatcccaggc cagctacctc ttccagcaag acaagttcta
     1081 cgatgtggct ctggacaccg gagacaaagt ggtgcagtgt ggccgccgcg tggactgtct
     1141 gaagctatgg ctcatgtgga aggcacaggg tgggcagggg ttggagcggc gcatcgacca
     1201 ggcctttgct ctcacccggt acttggtgga ggagattaaa aagcgggaag gatttgagtt
     1261 ggtaatggag cccgagttcg tcaacgtgtg cttctggttt gtgcctccca gccttcgggg
     1321 gaagaaggag agtccagatt acagccaaag gctgtctcag gtggcccctg tgctcaagga
     1381 gcgcatggtg aagaagggga ccatgatgat tggctaccag ccccatggga cccgggccaa
     1441 cttcttccga atggtggtgg ccaaccccat actggcccag gccgatatag atttccttct
     1501 gggcgagctg gagctcctgg gccaggacct gtgagctgct tctgctctct gccccaccca
     1561 agctctgcgt agtctcctgg gttctcaaaa tcgacctttc taggaaacag tggccttgac
     1621 tgtgtgtgct cccacacact cactctccca gctaagtatt ggctgtcagg aaggtgtcta
     1681 aacacactac agtatgttct tacgaaatat gcttttatta agttgggcac aggggcacac
     1741 acctttacta ccagcattgg ggggacagaa gcagccagtt tgaggccagc ctggactaca
     1801 gagctgggct acacagagaa actgtctcaa aaagaaaaaa agaaaagaaa aaaagaaata
     1861 tttttcatta aaattatgtt tataaagaat ttttattaat atgagagaaa tggtacaatg
     1921 tattgaaaag ctggatatga gtttatgaat cacagtatct gagttaggct aaaaatcaca
     1981 taggaaaagg ctgtcggtgg aactgtgcca aaggtcagca gttttccctg gaacgggata
     2041 ttaggttatt cccaaatcaa cctctcagac cttttgtgct tccccatttt attgtgtaac
     2101 aacatcacat acttctgaaa taggacaata aagctgcggt ttccatta
//
