LOCUS       NM_001416466            2288 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus cysteine sulfinic acid decarboxylase (Csad),
            transcript variant 20, mRNA.
ACCESSION   NM_001416466 XM_011245638
VERSION     NM_001416466.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2288)
  AUTHORS   Tan,R., Li,J., Liu,L., Wu,Q., Fan,L., Ma,N., Yu,C., Lu,H.,
            Zhang,X., Chen,J., Gong,L. and Ren,J.
  TITLE     CSAD Ameliorates Lipid Accumulation in High-Fat Diet-Fed Mice
  JOURNAL   Int J Mol Sci 23 (24), 15931 (2022)
   PUBMED   36555571
  REMARK    GeneRIF: CSAD Ameliorates Lipid Accumulation in High-Fat Diet-Fed
            Mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2288)
  AUTHORS   Park,E., Elidrissi,A., Schuller-Levis,G. and Chadman,K.K.
  TITLE     Taurine Partially Improves Abnormal Anxiety in Taurine-Deficient
            Mice
  JOURNAL   Adv Exp Med Biol 1155, 905-921 (2019)
   PUBMED   31468456
REFERENCE   3  (bases 1 to 2288)
  AUTHORS   Winge,I., Teigen,K., Fossbakk,A., Mahootchi,E., Kleppe,R.,
            Skoldberg,F., Kampe,O. and Haavik,J.
  TITLE     Mammalian CSAD and GADL1 have distinct biochemical properties and
            patterns of brain expression
  JOURNAL   Neurochem Int 90, 173-184 (2015)
   PUBMED   26327310
  REMARK    GeneRIF: taurine biosynthesis in vertebrates involves two
            structurally related PLP-dependent decarboxylases (cysteine
            sulfinic acid decarboxylase and glutamic acid decarboxylase like 1)
REFERENCE   4  (bases 1 to 2288)
  AUTHORS   Ma,Q., Zhao,J., Cao,W., Liu,J. and Cui,S.
  TITLE     Estradiol decreases taurine level by reducing cysteine sulfinic
            acid decarboxylase via the estrogen receptor-alpha in female mice
            liver
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 308 (4), G277-G286 (2015)
   PUBMED   25394658
  REMARK    GeneRIF: Estradiol decreases taurine concentration mainly via the
            reduction of cysteine sulfinic acid decarboxylase expression level
            through the ER-alpha.
REFERENCE   5  (bases 1 to 2288)
  AUTHORS   Park,E., Park,S.Y., Dobkin,C. and Schuller-Levis,G.
  TITLE     Development of a novel cysteine sulfinic Acid decarboxylase
            knockout mouse: dietary taurine reduces neonatal mortality
  JOURNAL   J Amino Acids 2014, 346809 (2014)
   PUBMED   24639894
REFERENCE   6  (bases 1 to 2288)
  AUTHORS   Li,J.H., Ling,Y.Q., Fan,J.J., Zhang,X.P. and Cui,S.
  TITLE     Expression of cysteine sulfinate decarboxylase (CSD) in male
            reproductive organs of mice
  JOURNAL   Histochem Cell Biol 125 (6), 607-613 (2006)
   PUBMED   16252094
  REMARK    GeneRIF: The results show that CSD is expressed both at the mRNA
            and protein levels in the testis, epididymis and ductus deferens.
REFERENCE   7  (bases 1 to 2288)
  AUTHORS   Kim,H.W., Yoon,S.H., Park,T., Kim,B.K., Park,K.K. and Lee,D.H.
  TITLE     Gene expressions of taurine transporter and taurine biosynthetic
            enzyme during mouse and chicken embryonic development
  JOURNAL   Adv Exp Med Biol 583, 69-77 (2006)
   PUBMED   17153590
REFERENCE   8  (bases 1 to 2288)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2288)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2288)
  AUTHORS   Park,E., Park,S.Y., Wang,C., Xu,J., LaFauci,G. and
            Schuller-Levis,G.
  TITLE     Cloning of murine cysteine sulfinic acid decarboxylase and its mRNA
            expression in murine tissues
  JOURNAL   Biochim Biophys Acta 1574 (3), 403-406 (2002)
   PUBMED   11997111
  REMARK    GeneRIF: cDNA sequence that predicts a polypeptide of 493 amino
            acids - both sequences given
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123791.4.
            
            On Feb 3, 2023 this sequence version replaced XM_011245638.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1728342.1,
                                           SRR13422597.587299.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               AC123791.4         96668-96862         c
            196-271             AC123791.4         81859-81934         c
            272-408             AC123791.4         81515-81651         c
            409-535             AC123791.4         81154-81280         c
            536-626             AC123791.4         80979-81069         c
            627-733             AC123791.4         80538-80644         c
            734-849             AC123791.4         80026-80141         c
            850-929             AC123791.4         79366-79445         c
            930-984             AC123791.4         78970-79024         c
            985-1101            AC123791.4         72943-73059         c
            1102-1166           AC123791.4         72801-72865         c
            1167-1248           AC123791.4         72493-72574         c
            1249-1448           AC123791.4         71933-72132         c
            1449-1500           AC123791.4         71753-71804         c
            1501-2288           AC123791.4         69971-70758         c
FEATURES             Location/Qualifiers
     source          1..2288
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.35 cM"
     gene            1..2288
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /note="cysteine sulfinic acid decarboxylase"
                     /db_xref="GeneID:246277"
                     /db_xref="MGI:MGI:2180098"
     exon            1..195
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            196..271
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            272..408
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     CDS             283..1674
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /EC_number="4.1.1.11"
                     /EC_number="4.1.1.29"
                     /note="isoform 3 is encoded by transcript variant 20;
                     sulfinoalanine decarboxylase; cysteine-sulfinate
                     decarboxylase; aspartate 1-decarboxylase"
                     /codon_start=1
                     /product="cysteine sulfinic acid decarboxylase isoform 3"
                     /protein_id="NP_001403395.1"
                     /db_xref="GeneID:246277"
                     /db_xref="MGI:MGI:2180098"
                     /translation="MADSKPLRTLDGDPVAVEALLQDVFGIVVDEAILKGTSASEKVC
                     EWKEPEELKQLLDLELQSQGESREQILERCRTVIHYSVKTGHPRFFNQLFSGLDPHAL
                     AGRIITESLNTSQYTYEIAPVFVLMEEEVLKKLRALVGWNSGDGVFCPGGSISNMYAM
                     NLARFQRYPDCKQRGLRALPPLALFTSKECHYSITKGAAFLGLGTDSVRVVKADERGR
                     MIPEDLERQIILAEAEGSVPFLVSATSGTTVLGAFDPLDAIADVCQRHGLWFHVDAAW
                     GGSVLLSRTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLRDTSNLLKRCHGSQAS
                     YLFQQDKFYDVALDTGDKVVQCGRRVDCLKLWLMWKAQGGQGLERRIDQAFALTRYLV
                     EEIKKREGFELVMEVAPVLKERMVKKGTMMIGYQPHGTRANFFRMVVANPILAQADID
                     FLLGELELLGQDL"
     exon            409..535
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            536..626
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            627..733
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            734..849
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            850..929
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            930..984
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1101
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1166
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1248
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1448
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1500
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..2288
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2267..2272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /note="hexamer: AATAAA"
     polyA_site      2288
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /note="major polyA site"
ORIGIN      
        1 cctcgcgcgc ggcgccccac ggcctgcgag ctgctgtccg cccgctcgcc cgcccgctcg
       61 acgctgcctc cccgcggcgc gcgcctacct gcctggcgcg gcctcccgcc gtctcctccg
      121 ccgcgcggcg ccccctccag gccccaggca ccccgtgcca agcccgcggc cgccgctccc
      181 cgcgtcggga ccgagcccta ttctgaaaag tccattgtgt accttgtcac cagctcgtct
      241 gatccttctc tgagccctcc tgagctggaa gatttcatcc tgatggctga ctcaaaacca
      301 ctcaggaccc tggatgggga ccccgtggct gtggaggcct tgctccagga cgtgtttggg
      361 attgttgtag atgaggccat tctgaagggg accagtgcct ctgagaaggt ctgcgaatgg
      421 aaggagcctg aagaactcaa gcagctgctg gacttggagc tgcagagcca gggcgagtcc
      481 cgggagcaga tcctggagcg ctgccggact gtgattcact acagtgtcaa gactggtcac
      541 ccccggttct tcaaccagct cttctcaggg ttagatcccc atgctctggc tgggcgcatc
      601 atcacggaga gcctcaacac tagccagtac acatatgaga ttgcccccgt gtttgtgctc
      661 atggaagagg aggtgctgaa gaaactccgt gccctggtgg gctggaactc tggggatggg
      721 gtcttctgtc ctggtggctc catctccaac atgtacgcca tgaacctggc ccgctttcag
      781 cgctacccag actgcaagca gaggggcctc cgggccctgc cgcccttggc tctcttcact
      841 tcaaaggagt gtcactactc catcaccaag ggagctgctt ttctgggact tggcaccgac
      901 agtgtccgag tggtcaaggc tgatgagaga gggaggatga tccctgagga cctggagagg
      961 cagatcattc tggcagaggc tgagggctct gtgccatttc tggtcagtgc cacctctggt
     1021 accaccgtgc taggggcctt tgaccccctg gatgcaattg ccgatgtttg ccagcgacac
     1081 ggactgtggt tccatgtgga tgctgcctgg ggtgggagcg tcctgctgtc tcggacacac
     1141 aggcatctcc tggatgggat ccagagggct gactctgtgg cctggaaccc tcacaagctt
     1201 ctcgccgcag ggctgcagtg ctccgctctt cttctccggg acacctcgaa cctgctcaag
     1261 cgctgccatg gatcccaggc cagctacctc ttccagcaag acaagttcta cgatgtggct
     1321 ctggacaccg gagacaaagt ggtgcagtgt ggccgccgcg tggactgtct gaagctatgg
     1381 ctcatgtgga aggcacaggg tgggcagggg ttggagcggc gcatcgacca ggcctttgct
     1441 ctcacccggt acttggtgga ggagattaaa aagcgggaag gatttgagtt ggtaatggag
     1501 gtggcccctg tgctcaagga gcgcatggtg aagaagggga ccatgatgat tggctaccag
     1561 ccccatggga cccgggccaa cttcttccga atggtggtgg ccaaccccat actggcccag
     1621 gccgatatag atttccttct gggcgagctg gagctcctgg gccaggacct gtgagctgct
     1681 tctgctctct gccccaccca agctctgcgt agtctcctgg gttctcaaaa tcgacctttc
     1741 taggaaacag tggccttgac tgtgtgtgct cccacacact cactctccca gctaagtatt
     1801 ggctgtcagg aaggtgtcta aacacactac agtatgttct tacgaaatat gcttttatta
     1861 agttgggcac aggggcacac acctttacta ccagcattgg ggggacagaa gcagccagtt
     1921 tgaggccagc ctggactaca gagctgggct acacagagaa actgtctcaa aaagaaaaaa
     1981 agaaaagaaa aaaagaaata tttttcatta aaattatgtt tataaagaat ttttattaat
     2041 atgagagaaa tggtacaatg tattgaaaag ctggatatga gtttatgaat cacagtatct
     2101 gagttaggct aaaaatcaca taggaaaagg ctgtcggtgg aactgtgcca aaggtcagca
     2161 gttttccctg gaacgggata ttaggttatt cccaaatcaa cctctcagac cttttgtgct
     2221 tccccatttt attgtgtaac aacatcacat acttctgaaa taggacaata aagctgcggt
     2281 ttccatta
//
