LOCUS       NM_001416456            3018 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus cysteine sulfinic acid decarboxylase (Csad),
            transcript variant 10, mRNA.
ACCESSION   NM_001416456 XM_036159416
VERSION     NM_001416456.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3018)
  AUTHORS   Tan,R., Li,J., Liu,L., Wu,Q., Fan,L., Ma,N., Yu,C., Lu,H.,
            Zhang,X., Chen,J., Gong,L. and Ren,J.
  TITLE     CSAD Ameliorates Lipid Accumulation in High-Fat Diet-Fed Mice
  JOURNAL   Int J Mol Sci 23 (24), 15931 (2022)
   PUBMED   36555571
  REMARK    GeneRIF: CSAD Ameliorates Lipid Accumulation in High-Fat Diet-Fed
            Mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3018)
  AUTHORS   Park,E., Elidrissi,A., Schuller-Levis,G. and Chadman,K.K.
  TITLE     Taurine Partially Improves Abnormal Anxiety in Taurine-Deficient
            Mice
  JOURNAL   Adv Exp Med Biol 1155, 905-921 (2019)
   PUBMED   31468456
REFERENCE   3  (bases 1 to 3018)
  AUTHORS   Winge,I., Teigen,K., Fossbakk,A., Mahootchi,E., Kleppe,R.,
            Skoldberg,F., Kampe,O. and Haavik,J.
  TITLE     Mammalian CSAD and GADL1 have distinct biochemical properties and
            patterns of brain expression
  JOURNAL   Neurochem Int 90, 173-184 (2015)
   PUBMED   26327310
  REMARK    GeneRIF: taurine biosynthesis in vertebrates involves two
            structurally related PLP-dependent decarboxylases (cysteine
            sulfinic acid decarboxylase and glutamic acid decarboxylase like 1)
REFERENCE   4  (bases 1 to 3018)
  AUTHORS   Ma,Q., Zhao,J., Cao,W., Liu,J. and Cui,S.
  TITLE     Estradiol decreases taurine level by reducing cysteine sulfinic
            acid decarboxylase via the estrogen receptor-alpha in female mice
            liver
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 308 (4), G277-G286 (2015)
   PUBMED   25394658
  REMARK    GeneRIF: Estradiol decreases taurine concentration mainly via the
            reduction of cysteine sulfinic acid decarboxylase expression level
            through the ER-alpha.
REFERENCE   5  (bases 1 to 3018)
  AUTHORS   Park,E., Park,S.Y., Dobkin,C. and Schuller-Levis,G.
  TITLE     Development of a novel cysteine sulfinic Acid decarboxylase
            knockout mouse: dietary taurine reduces neonatal mortality
  JOURNAL   J Amino Acids 2014, 346809 (2014)
   PUBMED   24639894
REFERENCE   6  (bases 1 to 3018)
  AUTHORS   Li,J.H., Ling,Y.Q., Fan,J.J., Zhang,X.P. and Cui,S.
  TITLE     Expression of cysteine sulfinate decarboxylase (CSD) in male
            reproductive organs of mice
  JOURNAL   Histochem Cell Biol 125 (6), 607-613 (2006)
   PUBMED   16252094
  REMARK    GeneRIF: The results show that CSD is expressed both at the mRNA
            and protein levels in the testis, epididymis and ductus deferens.
REFERENCE   7  (bases 1 to 3018)
  AUTHORS   Kim,H.W., Yoon,S.H., Park,T., Kim,B.K., Park,K.K. and Lee,D.H.
  TITLE     Gene expressions of taurine transporter and taurine biosynthetic
            enzyme during mouse and chicken embryonic development
  JOURNAL   Adv Exp Med Biol 583, 69-77 (2006)
   PUBMED   17153590
REFERENCE   8  (bases 1 to 3018)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3018)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3018)
  AUTHORS   Park,E., Park,S.Y., Wang,C., Xu,J., LaFauci,G. and
            Schuller-Levis,G.
  TITLE     Cloning of murine cysteine sulfinic acid decarboxylase and its mRNA
            expression in murine tissues
  JOURNAL   Biochim Biophys Acta 1574 (3), 403-406 (2002)
   PUBMED   11997111
  REMARK    GeneRIF: cDNA sequence that predicts a polypeptide of 493 amino
            acids - both sequences given
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123791.4.
            
            On Feb 3, 2023 this sequence version replaced XM_036159416.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422601.2065028.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               AC123791.4         96668-96862         c
            196-319             AC123791.4         96109-96232         c
            320-450             AC123791.4         95416-95546         c
            451-835             AC123791.4         93670-94054         c
            836-911             AC123791.4         81859-81934         c
            912-1048            AC123791.4         81515-81651         c
            1049-1175           AC123791.4         81154-81280         c
            1176-1266           AC123791.4         80979-81069         c
            1267-1373           AC123791.4         80538-80644         c
            1374-1489           AC123791.4         80026-80141         c
            1490-1569           AC123791.4         79366-79445         c
            1570-1624           AC123791.4         78970-79024         c
            1625-1741           AC123791.4         72943-73059         c
            1742-1806           AC123791.4         72801-72865         c
            1807-1888           AC123791.4         72493-72574         c
            1889-2088           AC123791.4         71933-72132         c
            2089-2140           AC123791.4         71753-71804         c
            2141-2230           AC123791.4         71499-71588         c
            2231-3018           AC123791.4         69971-70758         c
FEATURES             Location/Qualifiers
     source          1..3018
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.35 cM"
     gene            1..3018
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /note="cysteine sulfinic acid decarboxylase"
                     /db_xref="GeneID:246277"
                     /db_xref="MGI:MGI:2180098"
     exon            1..195
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            196..319
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            320..450
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            451..835
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            836..911
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1048
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     CDS             923..2404
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /EC_number="4.1.1.11"
                     /EC_number="4.1.1.29"
                     /note="isoform 1 is encoded by transcript variant 10;
                     sulfinoalanine decarboxylase; cysteine-sulfinate
                     decarboxylase; aspartate 1-decarboxylase"
                     /codon_start=1
                     /product="cysteine sulfinic acid decarboxylase isoform 1"
                     /protein_id="NP_001403385.1"
                     /db_xref="GeneID:246277"
                     /db_xref="MGI:MGI:2180098"
                     /translation="MADSKPLRTLDGDPVAVEALLQDVFGIVVDEAILKGTSASEKVC
                     EWKEPEELKQLLDLELQSQGESREQILERCRTVIHYSVKTGHPRFFNQLFSGLDPHAL
                     AGRIITESLNTSQYTYEIAPVFVLMEEEVLKKLRALVGWNSGDGVFCPGGSISNMYAM
                     NLARFQRYPDCKQRGLRALPPLALFTSKECHYSITKGAAFLGLGTDSVRVVKADERGR
                     MIPEDLERQIILAEAEGSVPFLVSATSGTTVLGAFDPLDAIADVCQRHGLWFHVDAAW
                     GGSVLLSRTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLRDTSNLLKRCHGSQAS
                     YLFQQDKFYDVALDTGDKVVQCGRRVDCLKLWLMWKAQGGQGLERRIDQAFALTRYLV
                     EEIKKREGFELVMEPEFVNVCFWFVPPSLRGKKESPDYSQRLSQVAPVLKERMVKKGT
                     MMIGYQPHGTRANFFRMVVANPILAQADIDFLLGELELLGQDL"
     exon            1049..1175
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1266
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1373
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1489
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1569
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1624
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1741
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1806
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1888
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2088
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2140
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2230
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..3018
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2997..3002
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /note="hexamer: AATAAA"
     polyA_site      3018
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /note="major polyA site"
ORIGIN      
        1 cctcgcgcgc ggcgccccac ggcctgcgag ctgctgtccg cccgctcgcc cgcccgctcg
       61 acgctgcctc cccgcggcgc gcgcctacct gcctggcgcg gcctcccgcc gtctcctccg
      121 ccgcgcggcg ccccctccag gccccaggca ccccgtgcca agcccgcggc cgccgctccc
      181 cgcgtcggga ccgagcttgg tgaggtctgt ttttccggtg cctgctgctg tggggtgcag
      241 acctgcagac tgaggtcagc tgggaggaga gttgagccgt tgcgcagtcc tgcggtacac
      301 actaaaccac aatctgcatg ttaacaagcc tgctctgaca aaggtggaga ctggagaatc
      361 ccctggactt gctggattcc accttaactg agaaaattag agccccaggt tggggaagag
      421 accttgcttc taaaggaata agcagtccag gttcttactc tgtagctcac actggcttca
      481 aagtctctta cattcctcct gcctcaccct ggagtattgg gtttcaaacc cagcagatag
      541 tccatgatag atacctaagt gagttcacat tttaagaatt gtttcgtaac aaaagctgcg
      601 tgagatgatc cagacctgta gcctcagctg cccaggaggt tgaagcatga gactcacctg
      661 aacccaggaa ttcacaagcc agaacagcac agtgagactg ccccaaggtg gaaaaacaaa
      721 attaaacaaa taaaacaaac cccacccagg cagcagttcc tagtgaaggt gtgatttgag
      781 ctgggaggga gccgcaggag catctgaaac ttaaaagcta atcctcagct acaagcccta
      841 ttctgaaaag tccattgtgt accttgtcac cagctcgtct gatccttctc tgagccctcc
      901 tgagctggaa gatttcatcc tgatggctga ctcaaaacca ctcaggaccc tggatgggga
      961 ccccgtggct gtggaggcct tgctccagga cgtgtttggg attgttgtag atgaggccat
     1021 tctgaagggg accagtgcct ctgagaaggt ctgcgaatgg aaggagcctg aagaactcaa
     1081 gcagctgctg gacttggagc tgcagagcca gggcgagtcc cgggagcaga tcctggagcg
     1141 ctgccggact gtgattcact acagtgtcaa gactggtcac ccccggttct tcaaccagct
     1201 cttctcaggg ttagatcccc atgctctggc tgggcgcatc atcacggaga gcctcaacac
     1261 tagccagtac acatatgaga ttgcccccgt gtttgtgctc atggaagagg aggtgctgaa
     1321 gaaactccgt gccctggtgg gctggaactc tggggatggg gtcttctgtc ctggtggctc
     1381 catctccaac atgtacgcca tgaacctggc ccgctttcag cgctacccag actgcaagca
     1441 gaggggcctc cgggccctgc cgcccttggc tctcttcact tcaaaggagt gtcactactc
     1501 catcaccaag ggagctgctt ttctgggact tggcaccgac agtgtccgag tggtcaaggc
     1561 tgatgagaga gggaggatga tccctgagga cctggagagg cagatcattc tggcagaggc
     1621 tgagggctct gtgccatttc tggtcagtgc cacctctggt accaccgtgc taggggcctt
     1681 tgaccccctg gatgcaattg ccgatgtttg ccagcgacac ggactgtggt tccatgtgga
     1741 tgctgcctgg ggtgggagcg tcctgctgtc tcggacacac aggcatctcc tggatgggat
     1801 ccagagggct gactctgtgg cctggaaccc tcacaagctt ctcgccgcag ggctgcagtg
     1861 ctccgctctt cttctccggg acacctcgaa cctgctcaag cgctgccatg gatcccaggc
     1921 cagctacctc ttccagcaag acaagttcta cgatgtggct ctggacaccg gagacaaagt
     1981 ggtgcagtgt ggccgccgcg tggactgtct gaagctatgg ctcatgtgga aggcacaggg
     2041 tgggcagggg ttggagcggc gcatcgacca ggcctttgct ctcacccggt acttggtgga
     2101 ggagattaaa aagcgggaag gatttgagtt ggtaatggag cccgagttcg tcaacgtgtg
     2161 cttctggttt gtgcctccca gccttcgggg gaagaaggag agtccagatt acagccaaag
     2221 gctgtctcag gtggcccctg tgctcaagga gcgcatggtg aagaagggga ccatgatgat
     2281 tggctaccag ccccatggga cccgggccaa cttcttccga atggtggtgg ccaaccccat
     2341 actggcccag gccgatatag atttccttct gggcgagctg gagctcctgg gccaggacct
     2401 gtgagctgct tctgctctct gccccaccca agctctgcgt agtctcctgg gttctcaaaa
     2461 tcgacctttc taggaaacag tggccttgac tgtgtgtgct cccacacact cactctccca
     2521 gctaagtatt ggctgtcagg aaggtgtcta aacacactac agtatgttct tacgaaatat
     2581 gcttttatta agttgggcac aggggcacac acctttacta ccagcattgg ggggacagaa
     2641 gcagccagtt tgaggccagc ctggactaca gagctgggct acacagagaa actgtctcaa
     2701 aaagaaaaaa agaaaagaaa aaaagaaata tttttcatta aaattatgtt tataaagaat
     2761 ttttattaat atgagagaaa tggtacaatg tattgaaaag ctggatatga gtttatgaat
     2821 cacagtatct gagttaggct aaaaatcaca taggaaaagg ctgtcggtgg aactgtgcca
     2881 aaggtcagca gttttccctg gaacgggata ttaggttatt cccaaatcaa cctctcagac
     2941 cttttgtgct tccccatttt attgtgtaac aacatcacat acttctgaaa taggacaata
     3001 aagctgcggt ttccatta
//
