LOCUS       NM_001416454            2219 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus cysteine sulfinic acid decarboxylase (Csad),
            transcript variant 8, mRNA.
ACCESSION   NM_001416454 XM_036159420
VERSION     NM_001416454.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2219)
  AUTHORS   Tan,R., Li,J., Liu,L., Wu,Q., Fan,L., Ma,N., Yu,C., Lu,H.,
            Zhang,X., Chen,J., Gong,L. and Ren,J.
  TITLE     CSAD Ameliorates Lipid Accumulation in High-Fat Diet-Fed Mice
  JOURNAL   Int J Mol Sci 23 (24), 15931 (2022)
   PUBMED   36555571
  REMARK    GeneRIF: CSAD Ameliorates Lipid Accumulation in High-Fat Diet-Fed
            Mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2219)
  AUTHORS   Park,E., Elidrissi,A., Schuller-Levis,G. and Chadman,K.K.
  TITLE     Taurine Partially Improves Abnormal Anxiety in Taurine-Deficient
            Mice
  JOURNAL   Adv Exp Med Biol 1155, 905-921 (2019)
   PUBMED   31468456
REFERENCE   3  (bases 1 to 2219)
  AUTHORS   Winge,I., Teigen,K., Fossbakk,A., Mahootchi,E., Kleppe,R.,
            Skoldberg,F., Kampe,O. and Haavik,J.
  TITLE     Mammalian CSAD and GADL1 have distinct biochemical properties and
            patterns of brain expression
  JOURNAL   Neurochem Int 90, 173-184 (2015)
   PUBMED   26327310
  REMARK    GeneRIF: taurine biosynthesis in vertebrates involves two
            structurally related PLP-dependent decarboxylases (cysteine
            sulfinic acid decarboxylase and glutamic acid decarboxylase like 1)
REFERENCE   4  (bases 1 to 2219)
  AUTHORS   Ma,Q., Zhao,J., Cao,W., Liu,J. and Cui,S.
  TITLE     Estradiol decreases taurine level by reducing cysteine sulfinic
            acid decarboxylase via the estrogen receptor-alpha in female mice
            liver
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 308 (4), G277-G286 (2015)
   PUBMED   25394658
  REMARK    GeneRIF: Estradiol decreases taurine concentration mainly via the
            reduction of cysteine sulfinic acid decarboxylase expression level
            through the ER-alpha.
REFERENCE   5  (bases 1 to 2219)
  AUTHORS   Park,E., Park,S.Y., Dobkin,C. and Schuller-Levis,G.
  TITLE     Development of a novel cysteine sulfinic Acid decarboxylase
            knockout mouse: dietary taurine reduces neonatal mortality
  JOURNAL   J Amino Acids 2014, 346809 (2014)
   PUBMED   24639894
REFERENCE   6  (bases 1 to 2219)
  AUTHORS   Li,J.H., Ling,Y.Q., Fan,J.J., Zhang,X.P. and Cui,S.
  TITLE     Expression of cysteine sulfinate decarboxylase (CSD) in male
            reproductive organs of mice
  JOURNAL   Histochem Cell Biol 125 (6), 607-613 (2006)
   PUBMED   16252094
  REMARK    GeneRIF: The results show that CSD is expressed both at the mRNA
            and protein levels in the testis, epididymis and ductus deferens.
REFERENCE   7  (bases 1 to 2219)
  AUTHORS   Kim,H.W., Yoon,S.H., Park,T., Kim,B.K., Park,K.K. and Lee,D.H.
  TITLE     Gene expressions of taurine transporter and taurine biosynthetic
            enzyme during mouse and chicken embryonic development
  JOURNAL   Adv Exp Med Biol 583, 69-77 (2006)
   PUBMED   17153590
REFERENCE   8  (bases 1 to 2219)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2219)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2219)
  AUTHORS   Park,E., Park,S.Y., Wang,C., Xu,J., LaFauci,G. and
            Schuller-Levis,G.
  TITLE     Cloning of murine cysteine sulfinic acid decarboxylase and its mRNA
            expression in murine tissues
  JOURNAL   Biochim Biophys Acta 1574 (3), 403-406 (2002)
   PUBMED   11997111
  REMARK    GeneRIF: cDNA sequence that predicts a polypeptide of 493 amino
            acids - both sequences given
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123791.4.
            
            On Feb 3, 2023 this sequence version replaced XM_036159420.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.1594632.1,
                                           SRR13422598.1587160.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AC123791.4         97111-97222         c
            113-249             AC123791.4         81515-81651         c
            250-376             AC123791.4         81154-81280         c
            377-467             AC123791.4         80979-81069         c
            468-574             AC123791.4         80538-80644         c
            575-690             AC123791.4         80026-80141         c
            691-770             AC123791.4         79366-79445         c
            771-825             AC123791.4         78970-79024         c
            826-942             AC123791.4         72943-73059         c
            943-1007            AC123791.4         72801-72865         c
            1008-1089           AC123791.4         72493-72574         c
            1090-1289           AC123791.4         71933-72132         c
            1290-1341           AC123791.4         71753-71804         c
            1342-1431           AC123791.4         71499-71588         c
            1432-2219           AC123791.4         69971-70758         c
FEATURES             Location/Qualifiers
     source          1..2219
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.35 cM"
     gene            1..2219
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /note="cysteine sulfinic acid decarboxylase"
                     /db_xref="GeneID:246277"
                     /db_xref="MGI:MGI:2180098"
     exon            1..112
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            113..249
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1605
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /EC_number="4.1.1.11"
                     /EC_number="4.1.1.29"
                     /note="isoform 1 is encoded by transcript variant 8;
                     sulfinoalanine decarboxylase; cysteine-sulfinate
                     decarboxylase; aspartate 1-decarboxylase"
                     /codon_start=1
                     /product="cysteine sulfinic acid decarboxylase isoform 1"
                     /protein_id="NP_001403383.1"
                     /db_xref="GeneID:246277"
                     /db_xref="MGI:MGI:2180098"
                     /translation="MADSKPLRTLDGDPVAVEALLQDVFGIVVDEAILKGTSASEKVC
                     EWKEPEELKQLLDLELQSQGESREQILERCRTVIHYSVKTGHPRFFNQLFSGLDPHAL
                     AGRIITESLNTSQYTYEIAPVFVLMEEEVLKKLRALVGWNSGDGVFCPGGSISNMYAM
                     NLARFQRYPDCKQRGLRALPPLALFTSKECHYSITKGAAFLGLGTDSVRVVKADERGR
                     MIPEDLERQIILAEAEGSVPFLVSATSGTTVLGAFDPLDAIADVCQRHGLWFHVDAAW
                     GGSVLLSRTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLRDTSNLLKRCHGSQAS
                     YLFQQDKFYDVALDTGDKVVQCGRRVDCLKLWLMWKAQGGQGLERRIDQAFALTRYLV
                     EEIKKREGFELVMEPEFVNVCFWFVPPSLRGKKESPDYSQRLSQVAPVLKERMVKKGT
                     MMIGYQPHGTRANFFRMVVANPILAQADIDFLLGELELLGQDL"
     exon            250..376
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            377..467
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            468..574
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            575..690
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            691..770
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            771..825
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            826..942
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1007
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1089
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1289
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1341
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1431
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..2219
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2198..2203
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /note="hexamer: AATAAA"
     polyA_site      2219
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /note="major polyA site"
ORIGIN      
        1 actccacaga cgagggcaga actgtgttgg aaggaagctc gggaggcctc cgccgagcgc
       61 cggggtggct ggcagtgccc gcacgtgagc gtcgctcgga gtccgcccga agatttcatc
      121 ctgatggctg actcaaaacc actcaggacc ctggatgggg accccgtggc tgtggaggcc
      181 ttgctccagg acgtgtttgg gattgttgta gatgaggcca ttctgaaggg gaccagtgcc
      241 tctgagaagg tctgcgaatg gaaggagcct gaagaactca agcagctgct ggacttggag
      301 ctgcagagcc agggcgagtc ccgggagcag atcctggagc gctgccggac tgtgattcac
      361 tacagtgtca agactggtca cccccggttc ttcaaccagc tcttctcagg gttagatccc
      421 catgctctgg ctgggcgcat catcacggag agcctcaaca ctagccagta cacatatgag
      481 attgcccccg tgtttgtgct catggaagag gaggtgctga agaaactccg tgccctggtg
      541 ggctggaact ctggggatgg ggtcttctgt cctggtggct ccatctccaa catgtacgcc
      601 atgaacctgg cccgctttca gcgctaccca gactgcaagc agaggggcct ccgggccctg
      661 ccgcccttgg ctctcttcac ttcaaaggag tgtcactact ccatcaccaa gggagctgct
      721 tttctgggac ttggcaccga cagtgtccga gtggtcaagg ctgatgagag agggaggatg
      781 atccctgagg acctggagag gcagatcatt ctggcagagg ctgagggctc tgtgccattt
      841 ctggtcagtg ccacctctgg taccaccgtg ctaggggcct ttgaccccct ggatgcaatt
      901 gccgatgttt gccagcgaca cggactgtgg ttccatgtgg atgctgcctg gggtgggagc
      961 gtcctgctgt ctcggacaca caggcatctc ctggatggga tccagagggc tgactctgtg
     1021 gcctggaacc ctcacaagct tctcgccgca gggctgcagt gctccgctct tcttctccgg
     1081 gacacctcga acctgctcaa gcgctgccat ggatcccagg ccagctacct cttccagcaa
     1141 gacaagttct acgatgtggc tctggacacc ggagacaaag tggtgcagtg tggccgccgc
     1201 gtggactgtc tgaagctatg gctcatgtgg aaggcacagg gtgggcaggg gttggagcgg
     1261 cgcatcgacc aggcctttgc tctcacccgg tacttggtgg aggagattaa aaagcgggaa
     1321 ggatttgagt tggtaatgga gcccgagttc gtcaacgtgt gcttctggtt tgtgcctccc
     1381 agccttcggg ggaagaagga gagtccagat tacagccaaa ggctgtctca ggtggcccct
     1441 gtgctcaagg agcgcatggt gaagaagggg accatgatga ttggctacca gccccatggg
     1501 acccgggcca acttcttccg aatggtggtg gccaacccca tactggccca ggccgatata
     1561 gatttccttc tgggcgagct ggagctcctg ggccaggacc tgtgagctgc ttctgctctc
     1621 tgccccaccc aagctctgcg tagtctcctg ggttctcaaa atcgaccttt ctaggaaaca
     1681 gtggccttga ctgtgtgtgc tcccacacac tcactctccc agctaagtat tggctgtcag
     1741 gaaggtgtct aaacacacta cagtatgttc ttacgaaata tgcttttatt aagttgggca
     1801 caggggcaca cacctttact accagcattg gggggacaga agcagccagt ttgaggccag
     1861 cctggactac agagctgggc tacacagaga aactgtctca aaaagaaaaa aagaaaagaa
     1921 aaaaagaaat atttttcatt aaaattatgt ttataaagaa tttttattaa tatgagagaa
     1981 atggtacaat gtattgaaaa gctggatatg agtttatgaa tcacagtatc tgagttaggc
     2041 taaaaatcac ataggaaaag gctgtcggtg gaactgtgcc aaaggtcagc agttttccct
     2101 ggaacgggat attaggttat tcccaaatca acctctcaga ccttttgtgc ttccccattt
     2161 tattgtgtaa caacatcaca tacttctgaa ataggacaat aaagctgcgg tttccatta
//
