LOCUS       NM_001416453            2419 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus cysteine sulfinic acid decarboxylase (Csad),
            transcript variant 7, mRNA.
ACCESSION   NM_001416453 XM_030248578
VERSION     NM_001416453.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2419)
  AUTHORS   Tan,R., Li,J., Liu,L., Wu,Q., Fan,L., Ma,N., Yu,C., Lu,H.,
            Zhang,X., Chen,J., Gong,L. and Ren,J.
  TITLE     CSAD Ameliorates Lipid Accumulation in High-Fat Diet-Fed Mice
  JOURNAL   Int J Mol Sci 23 (24), 15931 (2022)
   PUBMED   36555571
  REMARK    GeneRIF: CSAD Ameliorates Lipid Accumulation in High-Fat Diet-Fed
            Mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2419)
  AUTHORS   Park,E., Elidrissi,A., Schuller-Levis,G. and Chadman,K.K.
  TITLE     Taurine Partially Improves Abnormal Anxiety in Taurine-Deficient
            Mice
  JOURNAL   Adv Exp Med Biol 1155, 905-921 (2019)
   PUBMED   31468456
REFERENCE   3  (bases 1 to 2419)
  AUTHORS   Winge,I., Teigen,K., Fossbakk,A., Mahootchi,E., Kleppe,R.,
            Skoldberg,F., Kampe,O. and Haavik,J.
  TITLE     Mammalian CSAD and GADL1 have distinct biochemical properties and
            patterns of brain expression
  JOURNAL   Neurochem Int 90, 173-184 (2015)
   PUBMED   26327310
  REMARK    GeneRIF: taurine biosynthesis in vertebrates involves two
            structurally related PLP-dependent decarboxylases (cysteine
            sulfinic acid decarboxylase and glutamic acid decarboxylase like 1)
REFERENCE   4  (bases 1 to 2419)
  AUTHORS   Ma,Q., Zhao,J., Cao,W., Liu,J. and Cui,S.
  TITLE     Estradiol decreases taurine level by reducing cysteine sulfinic
            acid decarboxylase via the estrogen receptor-alpha in female mice
            liver
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 308 (4), G277-G286 (2015)
   PUBMED   25394658
  REMARK    GeneRIF: Estradiol decreases taurine concentration mainly via the
            reduction of cysteine sulfinic acid decarboxylase expression level
            through the ER-alpha.
REFERENCE   5  (bases 1 to 2419)
  AUTHORS   Park,E., Park,S.Y., Dobkin,C. and Schuller-Levis,G.
  TITLE     Development of a novel cysteine sulfinic Acid decarboxylase
            knockout mouse: dietary taurine reduces neonatal mortality
  JOURNAL   J Amino Acids 2014, 346809 (2014)
   PUBMED   24639894
REFERENCE   6  (bases 1 to 2419)
  AUTHORS   Li,J.H., Ling,Y.Q., Fan,J.J., Zhang,X.P. and Cui,S.
  TITLE     Expression of cysteine sulfinate decarboxylase (CSD) in male
            reproductive organs of mice
  JOURNAL   Histochem Cell Biol 125 (6), 607-613 (2006)
   PUBMED   16252094
  REMARK    GeneRIF: The results show that CSD is expressed both at the mRNA
            and protein levels in the testis, epididymis and ductus deferens.
REFERENCE   7  (bases 1 to 2419)
  AUTHORS   Kim,H.W., Yoon,S.H., Park,T., Kim,B.K., Park,K.K. and Lee,D.H.
  TITLE     Gene expressions of taurine transporter and taurine biosynthetic
            enzyme during mouse and chicken embryonic development
  JOURNAL   Adv Exp Med Biol 583, 69-77 (2006)
   PUBMED   17153590
REFERENCE   8  (bases 1 to 2419)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2419)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2419)
  AUTHORS   Park,E., Park,S.Y., Wang,C., Xu,J., LaFauci,G. and
            Schuller-Levis,G.
  TITLE     Cloning of murine cysteine sulfinic acid decarboxylase and its mRNA
            expression in murine tissues
  JOURNAL   Biochim Biophys Acta 1574 (3), 403-406 (2002)
   PUBMED   11997111
  REMARK    GeneRIF: cDNA sequence that predicts a polypeptide of 493 amino
            acids - both sequences given
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123791.4.
            
            On Feb 3, 2023 this sequence version replaced XM_030248578.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3580029.1,
                                           SRR13422598.1318227.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AC123791.4         97111-97222         c
            113-236             AC123791.4         96109-96232         c
            237-312             AC123791.4         81859-81934         c
            313-449             AC123791.4         81515-81651         c
            450-576             AC123791.4         81154-81280         c
            577-667             AC123791.4         80979-81069         c
            668-774             AC123791.4         80538-80644         c
            775-890             AC123791.4         80026-80141         c
            891-970             AC123791.4         79366-79445         c
            971-1025            AC123791.4         78970-79024         c
            1026-1142           AC123791.4         72943-73059         c
            1143-1207           AC123791.4         72801-72865         c
            1208-1289           AC123791.4         72493-72574         c
            1290-1489           AC123791.4         71933-72132         c
            1490-1541           AC123791.4         71753-71804         c
            1542-1631           AC123791.4         71499-71588         c
            1632-2419           AC123791.4         69971-70758         c
FEATURES             Location/Qualifiers
     source          1..2419
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.35 cM"
     gene            1..2419
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /note="cysteine sulfinic acid decarboxylase"
                     /db_xref="GeneID:246277"
                     /db_xref="MGI:MGI:2180098"
     exon            1..112
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            113..236
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            237..312
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            313..449
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     CDS             324..1805
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /EC_number="4.1.1.11"
                     /EC_number="4.1.1.29"
                     /note="isoform 1 is encoded by transcript variant 7;
                     sulfinoalanine decarboxylase; cysteine-sulfinate
                     decarboxylase; aspartate 1-decarboxylase"
                     /codon_start=1
                     /product="cysteine sulfinic acid decarboxylase isoform 1"
                     /protein_id="NP_001403382.1"
                     /db_xref="GeneID:246277"
                     /db_xref="MGI:MGI:2180098"
                     /translation="MADSKPLRTLDGDPVAVEALLQDVFGIVVDEAILKGTSASEKVC
                     EWKEPEELKQLLDLELQSQGESREQILERCRTVIHYSVKTGHPRFFNQLFSGLDPHAL
                     AGRIITESLNTSQYTYEIAPVFVLMEEEVLKKLRALVGWNSGDGVFCPGGSISNMYAM
                     NLARFQRYPDCKQRGLRALPPLALFTSKECHYSITKGAAFLGLGTDSVRVVKADERGR
                     MIPEDLERQIILAEAEGSVPFLVSATSGTTVLGAFDPLDAIADVCQRHGLWFHVDAAW
                     GGSVLLSRTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLRDTSNLLKRCHGSQAS
                     YLFQQDKFYDVALDTGDKVVQCGRRVDCLKLWLMWKAQGGQGLERRIDQAFALTRYLV
                     EEIKKREGFELVMEPEFVNVCFWFVPPSLRGKKESPDYSQRLSQVAPVLKERMVKKGT
                     MMIGYQPHGTRANFFRMVVANPILAQADIDFLLGELELLGQDL"
     exon            450..576
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            577..667
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            668..774
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            775..890
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            891..970
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1025
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1142
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1207
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1289
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1489
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1541
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1631
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..2419
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2398..2403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /note="hexamer: AATAAA"
     polyA_site      2419
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /note="major polyA site"
ORIGIN      
        1 actccacaga cgagggcaga actgtgttgg aaggaagctc gggaggcctc cgccgagcgc
       61 cggggtggct ggcagtgccc gcacgtgagc gtcgctcgga gtccgcccga agcttggtga
      121 ggtctgtttt tccggtgcct gctgctgtgg ggtgcagacc tgcagactga ggtcagctgg
      181 gaggagagtt gagccgttgc gcagtcctgc ggtacacact aaaccacaat ctgcatccct
      241 attctgaaaa gtccattgtg taccttgtca ccagctcgtc tgatccttct ctgagccctc
      301 ctgagctgga agatttcatc ctgatggctg actcaaaacc actcaggacc ctggatgggg
      361 accccgtggc tgtggaggcc ttgctccagg acgtgtttgg gattgttgta gatgaggcca
      421 ttctgaaggg gaccagtgcc tctgagaagg tctgcgaatg gaaggagcct gaagaactca
      481 agcagctgct ggacttggag ctgcagagcc agggcgagtc ccgggagcag atcctggagc
      541 gctgccggac tgtgattcac tacagtgtca agactggtca cccccggttc ttcaaccagc
      601 tcttctcagg gttagatccc catgctctgg ctgggcgcat catcacggag agcctcaaca
      661 ctagccagta cacatatgag attgcccccg tgtttgtgct catggaagag gaggtgctga
      721 agaaactccg tgccctggtg ggctggaact ctggggatgg ggtcttctgt cctggtggct
      781 ccatctccaa catgtacgcc atgaacctgg cccgctttca gcgctaccca gactgcaagc
      841 agaggggcct ccgggccctg ccgcccttgg ctctcttcac ttcaaaggag tgtcactact
      901 ccatcaccaa gggagctgct tttctgggac ttggcaccga cagtgtccga gtggtcaagg
      961 ctgatgagag agggaggatg atccctgagg acctggagag gcagatcatt ctggcagagg
     1021 ctgagggctc tgtgccattt ctggtcagtg ccacctctgg taccaccgtg ctaggggcct
     1081 ttgaccccct ggatgcaatt gccgatgttt gccagcgaca cggactgtgg ttccatgtgg
     1141 atgctgcctg gggtgggagc gtcctgctgt ctcggacaca caggcatctc ctggatggga
     1201 tccagagggc tgactctgtg gcctggaacc ctcacaagct tctcgccgca gggctgcagt
     1261 gctccgctct tcttctccgg gacacctcga acctgctcaa gcgctgccat ggatcccagg
     1321 ccagctacct cttccagcaa gacaagttct acgatgtggc tctggacacc ggagacaaag
     1381 tggtgcagtg tggccgccgc gtggactgtc tgaagctatg gctcatgtgg aaggcacagg
     1441 gtgggcaggg gttggagcgg cgcatcgacc aggcctttgc tctcacccgg tacttggtgg
     1501 aggagattaa aaagcgggaa ggatttgagt tggtaatgga gcccgagttc gtcaacgtgt
     1561 gcttctggtt tgtgcctccc agccttcggg ggaagaagga gagtccagat tacagccaaa
     1621 ggctgtctca ggtggcccct gtgctcaagg agcgcatggt gaagaagggg accatgatga
     1681 ttggctacca gccccatggg acccgggcca acttcttccg aatggtggtg gccaacccca
     1741 tactggccca ggccgatata gatttccttc tgggcgagct ggagctcctg ggccaggacc
     1801 tgtgagctgc ttctgctctc tgccccaccc aagctctgcg tagtctcctg ggttctcaaa
     1861 atcgaccttt ctaggaaaca gtggccttga ctgtgtgtgc tcccacacac tcactctccc
     1921 agctaagtat tggctgtcag gaaggtgtct aaacacacta cagtatgttc ttacgaaata
     1981 tgcttttatt aagttgggca caggggcaca cacctttact accagcattg gggggacaga
     2041 agcagccagt ttgaggccag cctggactac agagctgggc tacacagaga aactgtctca
     2101 aaaagaaaaa aagaaaagaa aaaaagaaat atttttcatt aaaattatgt ttataaagaa
     2161 tttttattaa tatgagagaa atggtacaat gtattgaaaa gctggatatg agtttatgaa
     2221 tcacagtatc tgagttaggc taaaaatcac ataggaaaag gctgtcggtg gaactgtgcc
     2281 aaaggtcagc agttttccct ggaacgggat attaggttat tcccaaatca acctctcaga
     2341 ccttttgtgc ttccccattt tattgtgtaa caacatcaca tacttctgaa ataggacaat
     2401 aaagctgcgg tttccatta
//
