LOCUS       NM_001359127            2123 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus cysteine sulfinic acid decarboxylase (Csad),
            transcript variant 3, mRNA.
ACCESSION   NM_001359127 XM_011245643
VERSION     NM_001359127.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2123)
  AUTHORS   Tan,R., Li,J., Liu,L., Wu,Q., Fan,L., Ma,N., Yu,C., Lu,H.,
            Zhang,X., Chen,J., Gong,L. and Ren,J.
  TITLE     CSAD Ameliorates Lipid Accumulation in High-Fat Diet-Fed Mice
  JOURNAL   Int J Mol Sci 23 (24), 15931 (2022)
   PUBMED   36555571
  REMARK    GeneRIF: CSAD Ameliorates Lipid Accumulation in High-Fat Diet-Fed
            Mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2123)
  AUTHORS   Park,E., Elidrissi,A., Schuller-Levis,G. and Chadman,K.K.
  TITLE     Taurine Partially Improves Abnormal Anxiety in Taurine-Deficient
            Mice
  JOURNAL   Adv Exp Med Biol 1155, 905-921 (2019)
   PUBMED   31468456
REFERENCE   3  (bases 1 to 2123)
  AUTHORS   Winge,I., Teigen,K., Fossbakk,A., Mahootchi,E., Kleppe,R.,
            Skoldberg,F., Kampe,O. and Haavik,J.
  TITLE     Mammalian CSAD and GADL1 have distinct biochemical properties and
            patterns of brain expression
  JOURNAL   Neurochem Int 90, 173-184 (2015)
   PUBMED   26327310
  REMARK    GeneRIF: taurine biosynthesis in vertebrates involves two
            structurally related PLP-dependent decarboxylases (cysteine
            sulfinic acid decarboxylase and glutamic acid decarboxylase like 1)
REFERENCE   4  (bases 1 to 2123)
  AUTHORS   Ma,Q., Zhao,J., Cao,W., Liu,J. and Cui,S.
  TITLE     Estradiol decreases taurine level by reducing cysteine sulfinic
            acid decarboxylase via the estrogen receptor-alpha in female mice
            liver
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 308 (4), G277-G286 (2015)
   PUBMED   25394658
  REMARK    GeneRIF: Estradiol decreases taurine concentration mainly via the
            reduction of cysteine sulfinic acid decarboxylase expression level
            through the ER-alpha.
REFERENCE   5  (bases 1 to 2123)
  AUTHORS   Park,E., Park,S.Y., Dobkin,C. and Schuller-Levis,G.
  TITLE     Development of a novel cysteine sulfinic Acid decarboxylase
            knockout mouse: dietary taurine reduces neonatal mortality
  JOURNAL   J Amino Acids 2014, 346809 (2014)
   PUBMED   24639894
REFERENCE   6  (bases 1 to 2123)
  AUTHORS   Li,J.H., Ling,Y.Q., Fan,J.J., Zhang,X.P. and Cui,S.
  TITLE     Expression of cysteine sulfinate decarboxylase (CSD) in male
            reproductive organs of mice
  JOURNAL   Histochem Cell Biol 125 (6), 607-613 (2006)
   PUBMED   16252094
  REMARK    GeneRIF: The results show that CSD is expressed both at the mRNA
            and protein levels in the testis, epididymis and ductus deferens.
REFERENCE   7  (bases 1 to 2123)
  AUTHORS   Kim,H.W., Yoon,S.H., Park,T., Kim,B.K., Park,K.K. and Lee,D.H.
  TITLE     Gene expressions of taurine transporter and taurine biosynthetic
            enzyme during mouse and chicken embryonic development
  JOURNAL   Adv Exp Med Biol 583, 69-77 (2006)
   PUBMED   17153590
REFERENCE   8  (bases 1 to 2123)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2123)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2123)
  AUTHORS   Park,E., Park,S.Y., Wang,C., Xu,J., LaFauci,G. and
            Schuller-Levis,G.
  TITLE     Cloning of murine cysteine sulfinic acid decarboxylase and its mRNA
            expression in murine tissues
  JOURNAL   Biochim Biophys Acta 1574 (3), 403-406 (2002)
   PUBMED   11997111
  REMARK    GeneRIF: cDNA sequence that predicts a polypeptide of 493 amino
            acids - both sequences given
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123791.4.
            
            On Dec 21, 2017 this sequence version replaced XM_011245643.2.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and has
            multiple coding region differences, compared to variant 1. This
            results in a frameshift and an early stop codon, compared to
            variant 1. The encoded isoform (2) is shorter, compared to isoform
            1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784643.1676086.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               AC123791.4         81859-82015         c
            158-294             AC123791.4         81515-81651         c
            295-421             AC123791.4         81154-81280         c
            422-512             AC123791.4         80979-81069         c
            513-619             AC123791.4         80538-80644         c
            620-735             AC123791.4         80026-80141         c
            736-815             AC123791.4         79366-79445         c
            816-870             AC123791.4         78970-79024         c
            871-987             AC123791.4         72943-73059         c
            988-1052            AC123791.4         72801-72865         c
            1053-1134           AC123791.4         72493-72574         c
            1135-1334           AC123791.4         71933-72132         c
            1335-2123           AC123791.4         69970-70758         c
FEATURES             Location/Qualifiers
     source          1..2123
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.35 cM"
     gene            1..2123
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /note="cysteine sulfinic acid decarboxylase"
                     /db_xref="GeneID:246277"
                     /db_xref="MGI:MGI:2180098"
     exon            1..157
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            158..294
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1365
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /EC_number="4.1.1.11"
                     /EC_number="4.1.1.29"
                     /note="isoform 2 is encoded by transcript variant 3;
                     sulfinoalanine decarboxylase; cysteine-sulfinate
                     decarboxylase; aspartate 1-decarboxylase"
                     /codon_start=1
                     /product="cysteine sulfinic acid decarboxylase isoform 2"
                     /protein_id="NP_001346056.1"
                     /db_xref="GeneID:246277"
                     /db_xref="MGI:MGI:2180098"
                     /translation="MADSKPLRTLDGDPVAVEALLQDVFGIVVDEAILKGTSASEKVC
                     EWKEPEELKQLLDLELQSQGESREQILERCRTVIHYSVKTGHPRFFNQLFSGLDPHAL
                     AGRIITESLNTSQYTYEIAPVFVLMEEEVLKKLRALVGWNSGDGVFCPGGSISNMYAM
                     NLARFQRYPDCKQRGLRALPPLALFTSKECHYSITKGAAFLGLGTDSVRVVKADERGR
                     MIPEDLERQIILAEAEGSVPFLVSATSGTTVLGAFDPLDAIADVCQRHGLWFHVDAAW
                     GGSVLLSRTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLRDTSNLLKRCHGSQAS
                     YLFQQDKFYDVALDTGDKVVQCGRRVDCLKLWLMWKAQGGQGLERRIDQAFALTRWPL
                     CSRSAW"
     exon            295..421
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            422..512
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            513..619
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            620..735
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            736..815
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            816..870
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            871..987
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1052
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1134
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1334
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..2123
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2101..2106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /note="hexamer: AATAAA"
     polyA_site      2122
                     /gene="Csad"
                     /gene_synonym="Csd"
                     /note="major polyA site"
ORIGIN      
        1 ctctttcggg caagggtcat gagagtaatg ccactgccat gtgactctgg ctttatcctg
       61 ctccctctgc ttctgtctta gccctattct gaaaagtcca ttgtgtacct tgtcaccagc
      121 tcgtctgatc cttctctgag ccctcctgag ctggaagatt tcatcctgat ggctgactca
      181 aaaccactca ggaccctgga tggggacccc gtggctgtgg aggccttgct ccaggacgtg
      241 tttgggattg ttgtagatga ggccattctg aaggggacca gtgcctctga gaaggtctgc
      301 gaatggaagg agcctgaaga actcaagcag ctgctggact tggagctgca gagccagggc
      361 gagtcccggg agcagatcct ggagcgctgc cggactgtga ttcactacag tgtcaagact
      421 ggtcaccccc ggttcttcaa ccagctcttc tcagggttag atccccatgc tctggctggg
      481 cgcatcatca cggagagcct caacactagc cagtacacat atgagattgc ccccgtgttt
      541 gtgctcatgg aagaggaggt gctgaagaaa ctccgtgccc tggtgggctg gaactctggg
      601 gatggggtct tctgtcctgg tggctccatc tccaacatgt acgccatgaa cctggcccgc
      661 tttcagcgct acccagactg caagcagagg ggcctccggg ccctgccgcc cttggctctc
      721 ttcacttcaa aggagtgtca ctactccatc accaagggag ctgcttttct gggacttggc
      781 accgacagtg tccgagtggt caaggctgat gagagaggga ggatgatccc tgaggacctg
      841 gagaggcaga tcattctggc agaggctgag ggctctgtgc catttctggt cagtgccacc
      901 tctggtacca ccgtgctagg ggcctttgac cccctggatg caattgccga tgtttgccag
      961 cgacacggac tgtggttcca tgtggatgct gcctggggtg ggagcgtcct gctgtctcgg
     1021 acacacaggc atctcctgga tgggatccag agggctgact ctgtggcctg gaaccctcac
     1081 aagcttctcg ccgcagggct gcagtgctcc gctcttcttc tccgggacac ctcgaacctg
     1141 ctcaagcgct gccatggatc ccaggccagc tacctcttcc agcaagacaa gttctacgat
     1201 gtggctctgg acaccggaga caaagtggtg cagtgtggcc gccgcgtgga ctgtctgaag
     1261 ctatggctca tgtggaaggc acagggtggg caggggttgg agcggcgcat cgaccaggcc
     1321 tttgctctca cccggtggcc cctgtgctca aggagcgcat ggtgaagaag gggaccatga
     1381 tgattggcta ccagccccat gggacccggg ccaacttctt ccgaatggtg gtggccaacc
     1441 ccatactggc ccaggccgat atagatttcc ttctgggcga gctggagctc ctgggccagg
     1501 acctgtgagc tgcttctgct ctctgcccca cccaagctct gcgtagtctc ctgggttctc
     1561 aaaatcgacc tttctaggaa acagtggcct tgactgtgtg tgctcccaca cactcactct
     1621 cccagctaag tattggctgt caggaaggtg tctaaacaca ctacagtatg ttcttacgaa
     1681 atatgctttt attaagttgg gcacaggggc acacaccttt actaccagca ttggggggac
     1741 agaagcagcc agtttgaggc cagcctggac tacagagctg ggctacacag agaaactgtc
     1801 tcaaaaagaa aaaaagaaaa gaaaaaaaga aatatttttc attaaaatta tgtttataaa
     1861 gaatttttat taatatgaga gaaatggtac aatgtattga aaagctggat atgagtttat
     1921 gaatcacagt atctgagtta ggctaaaaat cacataggaa aaggctgtcg gtggaactgt
     1981 gccaaaggtc agcagttttc cctggaacgg gatattaggt tattcccaaa tcaacctctc
     2041 agaccttttg tgcttcccca ttttattgtg taacaacatc acatacttct gaaataggac
     2101 aataaagctg cggtttccat tat
//
