LOCUS       NM_009968               2519 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus crystallin, zeta (Cryz), transcript variant 1, mRNA.
ACCESSION   NM_009968
VERSION     NM_009968.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2519)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2519)
  AUTHORS   Alam,G., Luan,Z., Gul,A., Lu,H., Zhou,Y., Huo,X., Li,Y., Du,C.,
            Luo,Z., Zhang,H., Xu,H., Zheng,F., Guan,Y. and Zhang,X.
  TITLE     Activation of farnesoid X receptor (FXR) induces crystallin zeta
            expression in mouse medullary collecting duct cells
  JOURNAL   Pflugers Arch 472 (11), 1631-1641 (2020)
   PUBMED   32914211
  REMARK    GeneRIF: Activation of farnesoid X receptor (FXR) induces
            crystallin zeta expression in mouse medullary collecting duct
            cells.
REFERENCE   3  (bases 1 to 2519)
  AUTHORS   Szutkowska,M., Vernimmen,C., Debaix,H., Devuyst,O., Friedlander,G.
            and Karim,Z.
  TITLE     Zeta-crystallin mediates the acid pH-induced increase of BSC1
            cotransporter mRNA stability
  JOURNAL   Kidney Int 76 (7), 730-738 (2009)
   PUBMED   19657324
  REMARK    GeneRIF: induction of zeta-crystallin by an acid pH plays an
            important role in preventing BSC1 mRNA decay
REFERENCE   4  (bases 1 to 2519)
  AUTHORS   Graw,J.
  TITLE     Genetics of crystallins: cataract and beyond
  JOURNAL   Exp Eye Res 88 (2), 173-189 (2009)
   PUBMED   19007775
  REMARK    Review article
REFERENCE   5  (bases 1 to 2519)
  AUTHORS   Wheeler,F.C., Fernandez,L., Carlson,K.M., Wolf,M.J., Rockman,H.A.
            and Marchuk,D.A.
  TITLE     QTL mapping in a mouse model of cardiomyopathy reveals an ancestral
            modifier allele affecting heart function and survival
  JOURNAL   Mamm Genome 16 (6), 414-423 (2005)
   PUBMED   16075368
REFERENCE   6  (bases 1 to 2519)
  AUTHORS   Wakana,S., Sugaya,E., Naramoto,F., Yokote,N., Maruyama,C., Jin,W.,
            Ohguchi,H., Tsuda,T., Sugaya,A. and Kajiwara,K.
  TITLE     Gene mapping of SEZ group genes and determination of
            pentylenetetrazol susceptible quantitative trait loci in the mouse
            chromosome
  JOURNAL   Brain Res 857 (1-2), 286-290 (2000)
   PUBMED   10700579
REFERENCE   7  (bases 1 to 2519)
  AUTHORS   Rao,P.V., Gonzalez,P., Persson,B., Jornvall,H., Garland,D. and
            Zigler,J.S. Jr.
  TITLE     Guinea pig and bovine zeta-crystallins have distinct functional
            characteristics highlighting replacements in otherwise similar
            structures
  JOURNAL   Biochemistry 36 (18), 5353-5362 (1997)
   PUBMED   9154917
REFERENCE   8  (bases 1 to 2519)
  AUTHORS   Kajiwara,K., Nagawawa,H., Shimizu-Nishikawa,S., Ookuri,T.,
            Kimura,M. and Sugaya,E.
  TITLE     Molecular characterization of seizure-related genes isolated by
            differential screening
  JOURNAL   Biochem Biophys Res Commun 219 (3), 795-799 (1996)
   PUBMED   8645260
REFERENCE   9  (bases 1 to 2519)
  AUTHORS   Gonzalez,P., Hernandez-Calzadilla,C., Rao,P.V., Rodriguez,I.R.,
            Zigler,J.S. Jr. and Borras,T.
  TITLE     Comparative analysis of the zeta-crystallin/quinone reductase gene
            in guinea pig and mouse
  JOURNAL   Mol Biol Evol 11 (2), 305-315 (1994)
   PUBMED   8170370
REFERENCE   10 (bases 1 to 2519)
  AUTHORS   Wistow,G. and Piatigorsky,J.
  TITLE     Recruitment of enzymes as lens structural proteins
  JOURNAL   Science 236 (4808), 1554-1556 (1987)
   PUBMED   3589669
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB618817.1, BC043076.1 and AK134281.1.
            
            On Nov 4, 2017 this sequence version replaced NM_009968.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: S70056.1, AK098082.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-539               BB618817.1         2-540
            540-1241            BC043076.1         1-702
            1242-2505           AK134281.1         727-1990
            2506-2519           BC043076.1         1967-1980
FEATURES             Location/Qualifiers
     source          1..2519
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 79.25 cM"
     gene            1..2519
                     /gene="Cryz"
                     /gene_synonym="Sez9"
                     /note="crystallin, zeta"
                     /db_xref="GeneID:12972"
                     /db_xref="MGI:MGI:88527"
     exon            1..574
                     /gene="Cryz"
                     /gene_synonym="Sez9"
                     /inference="alignment:Splign:2.1.0"
     exon            575..698
                     /gene="Cryz"
                     /gene_synonym="Sez9"
                     /inference="alignment:Splign:2.1.0"
     CDS             588..1583
                     /gene="Cryz"
                     /gene_synonym="Sez9"
                     /EC_number="1.6.5.5"
                     /note="zeta-crystallin; NADPH:quinone reductase"
                     /codon_start=1
                     /product="quinone oxidoreductase"
                     /protein_id="NP_034098.1"
                     /db_xref="CCDS:CCDS17927.1"
                     /db_xref="GeneID:12972"
                     /db_xref="MGI:MGI:88527"
                     /translation="MATGQKLMRAIRVFEFGGPEVLKLQSDVVVPVPQSHQVLIKVHA
                     CGVNPVETYIRSGAYSRKPALPYTPGSDVAGIIESVGDKVSAFKKGDRVFCYSTVSGG
                     YAEFALAADDTIYPLPETLNFRQGAALGIPYFTACRALFHSARARAGESVLVHGASGG
                     VGLATCQIARAHGLKVLGTAGSEEGKKLVLQNGAHEVFNHKEANYIDKIKMSVGDKDK
                     GVDVIIEMLANENLSNDLKLLSHGGRVVVVGCRGPIEINPRDTMAKETSIIGVSLSSS
                     TKEEFQQFAGLLQAGIEKGWVKPVIGSEYPLEKAAQAHEDIIHGSGKTGKMILLL"
     exon            699..851
                     /gene="Cryz"
                     /gene_synonym="Sez9"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1015
                     /gene="Cryz"
                     /gene_synonym="Sez9"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1067
                     /gene="Cryz"
                     /gene_synonym="Sez9"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1217
                     /gene="Cryz"
                     /gene_synonym="Sez9"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1325
                     /gene="Cryz"
                     /gene_synonym="Sez9"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1421
                     /gene="Cryz"
                     /gene_synonym="Sez9"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..2507
                     /gene="Cryz"
                     /gene_synonym="Sez9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2485..2490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cryz"
                     /gene_synonym="Sez9"
                     /note="hexamer: AGTAAA"
     polyA_site      2507
                     /gene="Cryz"
                     /gene_synonym="Sez9"
                     /note="major polyA site"
ORIGIN      
        1 gagcgtgacc gaagggactt ggagactcga gctcctccag cgctctgtaa atccaatccc
       61 cagccttcgc cacttaagct agctccacca tcacccggag gacgcattag cattgcacag
      121 cctcccccgg cccgggcctc accccgtcca gaaggaggat gcgccctgcg caggagctgg
      181 tggtgaaaaa ctcttcccgc gagttcagga gctccaccac ctccaccgcg tcctcgtcca
      241 cactgccctt gcggctaagg tccgccttgc tcagactctg cgccttccac cggccgaact
      301 ccgcgctacg gtccatgagc gagcgagcga gctggggtcg gctttctgct ctggaatgcg
      361 ccttcttctc catgggcgca gccatattgc cgccacggtg gccggagagg accaaagttc
      421 cccattggcg caaccaggag caagacgtgc gccgccagac cgtacaggcg taaaccgaga
      481 gggggagcct agcgaagtta gggaaagcca gcccacctct ttccccacag accttctgga
      541 gcttaggagg ttttgtttcc tactctagag gaggcctcta ggtcgccatg gcaactgggc
      601 agaagttgat gagggctatt cgagtgtttg agtttggtgg accagaagtg ctgaagctcc
      661 agtcggatgt ggtcgtgcct gttccacaga gccatcaggt cctaatcaaa gtccacgcct
      721 gcggtgtcaa cccagtagag acatacattc gctctggggc ctacagtcga aaacctgccc
      781 taccctacac tccaggctct gatgtggctg ggatcataga atccgttgga gacaaagtgt
      841 ctgctttcaa gaaaggcgac agggtcttct gctacagcac cgtctctggt ggctacgcgg
      901 aatttgctct tgcagccgat gacactatct accccctgcc cgagacactg aacttcaggc
      961 agggggctgc cctggggatc ccgtacttca cggcctgccg agctctgttc cacagtgccc
     1021 gtgctcgagc tggcgaaagc gttttggttc atggggccag tggaggagtt ggattagcta
     1081 catgccagat tgccagagct catggcttaa aggttttggg cacagctggt tctgaggaag
     1141 gaaaaaagct tgttctgcaa aacggagccc acgaagtgtt taatcacaaa gaagccaact
     1201 atattgataa aatcaagatg tctgttggtg acaaggacaa gggggttgat gtgattattg
     1261 agatgctggc gaatgagaac cttagcaatg acctgaagct tctgtcccac ggaggacggg
     1321 tcgtcgttgt tggctgtcga ggtcccattg agataaaccc aagggacacc atggcaaaag
     1381 aaacaagcat cattggggtc tctctctctt cttccaccaa ggaggaattt caacaattcg
     1441 caggccttct ccaagcagga atagaaaaag gttgggtgaa acctgtgata ggttctgagt
     1501 atccattgga gaaagcagcc caggcccacg aagatatcat tcacggcagt gggaagacgg
     1561 ggaaaatgat tctcctctta tgagacctgt gtcactgggc tccttcttcc tcaagtctct
     1621 gcaccaccat ctttaaacag tgttatttga ttgaggttca cgtattaaaa acaggacttt
     1681 agggagtaga cacagtgagt gacataattg cagagagcag gtgtgcccaa tggggtctgc
     1741 gtgcatcaca aaactctttt cttccttttt cttcattttc ttagtttggt tggatgtttt
     1801 tgttttgtgc ttgagacagg atcattctct gtagttcatg ctggccgtga actcacagtg
     1861 atctttctgc ctcagccgtc taaatgctgg gataatcagt agtgatgcac actaccacac
     1921 acagcttcat ctcagacctt cttgtctgat taagttcaga cctttgaata aaatgtacaa
     1981 gttcaaaatg gtcctctact gaccttcctg ggctcccaag cctgctactc tttagggagt
     2041 cacctgcccc ctcagccatg gctgtcttgg gccctgaaga ctttctgggc tgaaaaatat
     2101 ccttttaaaa ctaatgtcat ctcagtctgt aagcctctgg aaagcttcgg caaaaatgag
     2161 caatacttgg gagacctccc agtcagcttt cctaacattt ttgagaatat cagaatactg
     2221 catgccggtc accagccacc tgtagtctgg ggggtcagca gccacctgta gtctgggagg
     2281 tcaccagcta cctgtagtct gggaggtcag cagccttatc ctgggtctgt ggtcttcagt
     2341 atggtcaccc atcaaatgct tcatggtcac ttatagtttg ctgtatatgt gacatgagtc
     2401 tcatagtttc acttaaaatt gtaagttcac aaatttaaca tgttaagacc tgtctgcttt
     2461 ggttttcata gtatcttaac ctggagtaaa ttctgtagaa cactgaaaaa aaaaaaaaa
//
