LOCUS       NM_016669               1278 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus crystallin, mu (Crym), mRNA.
ACCESSION   NM_016669
VERSION     NM_016669.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1278)
  AUTHORS   Ollivier,M., Soto,J.S., Linker,K.E., Moye,S.L., Jami-Alahmadi,Y.,
            Jones,A.E., Divakaruni,A.S., Kawaguchi,R., Wohlschlegel,J.A. and
            Khakh,B.S.
  TITLE     Crym-positive striatal astrocytes gate perseverative behaviour
  JOURNAL   Nature 627 (8003), 358-366 (2024)
   PUBMED   38418885
  REMARK    GeneRIF: Crym-positive striatal astrocytes gate perseverative
            behaviour.
REFERENCE   2  (bases 1 to 1278)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1278)
  AUTHORS   Galazo,M.J., Sweetser,D.A. and Macklis,J.D.
  TITLE     Tle4 controls both developmental acquisition and early post-natal
            maturation of corticothalamic projection neuron identity
  JOURNAL   Cell Rep 42 (8), 112957 (2023)
   PUBMED   37561632
REFERENCE   4  (bases 1 to 1278)
  AUTHORS   Xie,Z., Ma,X.H., Bai,Q.F., Tang,J., Sun,J.H., Jiang,F., Guo,W.,
            Wang,C.M., Yang,R., Wen,Y.C., Wang,F.Y., Chen,Y.X., Zhang,H.,
            He,D.Z., Kelley,M.W., Yang,S. and Zhang,W.J.
  TITLE     ZBTB20 is essential for cochlear maturation and hearing in mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (24), e2220867120 (2023)
   PUBMED   37279265
REFERENCE   5  (bases 1 to 1278)
  AUTHORS   Doherty,R., MacLeod,B.L., Nelson,M.M., Ibrahim,M.M.H., Borges,B.C.,
            Jaradat,N.W., Finneran,M.C., Giger,R.J. and Corfas,G.
  TITLE     Identification of in vivo roles of ErbB4-JMa and its direct nuclear
            signaling using a novel isoform-specific knock out mouse
  JOURNAL   Sci Rep 12 (1), 17267 (2022)
   PUBMED   36241655
  REMARK    Erratum:[Sci Rep. 2022 Dec 1;12(1):20748. doi:
            10.1038/s41598-022-25021-8.. PMID: 36456684]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1278)
  AUTHORS   Arlotta,P., Molyneaux,B.J., Chen,J., Inoue,J., Kominami,R. and
            Macklis,J.D.
  TITLE     Neuronal subtype-specific genes that control corticospinal motor
            neuron development in vivo
  JOURNAL   Neuron 45 (2), 207-221 (2005)
   PUBMED   15664173
REFERENCE   7  (bases 1 to 1278)
  AUTHORS   Takasato,M., Osafune,K., Matsumoto,Y., Kataoka,Y., Yoshida,N.,
            Meguro,H., Aburatani,H., Asashima,M. and Nishinakamura,R.
  TITLE     Identification of kidney mesenchymal genes by a combination of
            microarray analysis and Sall1-GFP knockin mice
  JOURNAL   Mech Dev 121 (6), 547-557 (2004)
   PUBMED   15172686
REFERENCE   8  (bases 1 to 1278)
  AUTHORS   Diaz,E., Yang,Y.H., Ferreira,T., Loh,K.C., Okazaki,Y.,
            Hayashizaki,Y., Tessier-Lavigne,M., Speed,T.P. and Ngai,J.
  TITLE     Analysis of gene expression in the developing mouse retina
  JOURNAL   Proc Natl Acad Sci U S A 100 (9), 5491-5496 (2003)
   PUBMED   12702772
REFERENCE   9  (bases 1 to 1278)
  AUTHORS   Doggett,N.A. and Callen,D.F.
  TITLE     Report and abstracts of the third international workshop on human
            chromosome 16 mapping 1994. Pittsburgh, Pennsylvania, May 7-9, 1994
  JOURNAL   Cytogenet Cell Genet 68 (3-4), 165-184 (1995)
   PUBMED   7842732
REFERENCE   10 (bases 1 to 1278)
  AUTHORS   Chen,H., Phillips,H.A., Callen,D.F., Kim,R.Y., Wistow,G.J. and
            Antonarakis,S.E.
  TITLE     Localization of the human gene for mu-crystallin to chromosome 16p
  JOURNAL   Genomics 14 (4), 1115-1116 (1992)
   PUBMED   1478656
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX237353.1, AK143116.1 and BE944232.1.
            
            On Jun 3, 2018 this sequence version replaced NM_016669.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF039391.1, AK143116.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                CX237353.1         5-16
            13-1255             AK143116.1         2-1244
            1256-1278           BE944232.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..1278
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 64.47 cM"
     gene            1..1278
                     /gene="Crym"
                     /note="crystallin, mu"
                     /db_xref="GeneID:12971"
                     /db_xref="MGI:MGI:102675"
     exon            1..235
                     /gene="Crym"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1007
                     /gene="Crym"
                     /EC_number="1.5.1.25"
                     /note="mu-crystallin homolog; NADP-regulated
                     thyroid-hormone-binding protein;
                     thiomorpholine-carboxylate dehydrogenase"
                     /codon_start=1
                     /product="ketimine reductase mu-crystallin"
                     /protein_id="NP_057878.1"
                     /db_xref="CCDS:CCDS21794.1"
                     /db_xref="GeneID:12971"
                     /db_xref="MGI:MGI:102675"
                     /translation="MKRAPAFLSAEEVQDHLRSSSLLIPPLEAALANFSKGPDGGVMQ
                     PVRTVVPVAKHRGFLGVMPAYSAAEDALTTKLVTFYEGHSNTAVPSHQASVLLFDPSN
                     GSLLAVMDGNVITAKRTAAVSAIATKLLKPPGSDVLCILGAGVQAYSHYEIFTEQFSF
                     KEVRMWNRTRENAEKFASTVQGDVRVCSSVQEAVTGADVIITVTMATEPILFGEWVKP
                     GAHINAVGASRPDWRELDDELMRQAVLYVDSREAALKESGDVLLSGADIFAELGEVIS
                     GAKPAHCEKTTVFKSLGMAVEDLVAAKLVYDSWSSGK"
     exon            236..386
                     /gene="Crym"
                     /inference="alignment:Splign:2.1.0"
     exon            387..449
                     /gene="Crym"
                     /inference="alignment:Splign:2.1.0"
     exon            450..551
                     /gene="Crym"
                     /inference="alignment:Splign:2.1.0"
     exon            552..735
                     /gene="Crym"
                     /inference="alignment:Splign:2.1.0"
     exon            736..857
                     /gene="Crym"
                     /inference="alignment:Splign:2.1.0"
     exon            858..942
                     /gene="Crym"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1261
                     /gene="Crym"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1236..1241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crym"
                     /note="hexamer: AATAAA"
     polyA_site      1255
                     /gene="Crym"
                     /note="major polyA site"
ORIGIN      
        1 catttagggc tcagctcctg gaacgtggag tgtgtttcag cccgggttcg aaggcaggcg
       61 gcgagatgaa gcgggcgcca gcgttcctga gcgcagagga ggtgcaggat caccttcgca
      121 gctccagcct tctcatccca cccctggagg ccgcactggc caacttctcc aaaggtcccg
      181 acggaggggt catgcagcca gtgcgcaccg tggtgcctgt agccaagcac cgaggcttcc
      241 tgggagtcat gcctgcctac agtgctgctg aggatgcgct caccaccaag ttagtcacct
      301 tctatgaggg ccacagcaac acagcggtcc cctcccatca ggcatcggtg cttctctttg
      361 atcccagcaa tggctccctg ctggcggtca tggatggaaa tgtcataact gcaaagagaa
      421 cagcagcggt gtctgccatt gccacaaagc tgttgaagcc cccaggcagt gatgtgctgt
      481 gcatccttgg agcgggggtc caggcgtaca gtcactatga gatcttcaca gagcagttct
      541 ccttcaagga ggtgagaatg tggaaccgca ccagggaaaa tgctgagaag tttgcaagca
      601 cagtgcaagg agatgttcgg gtctgttcat cagtgcagga ggctgtgaca ggtgctgatg
      661 tcatcatcac agtcaccatg gcaacagagc ccattttatt tggtgaatgg gtaaagccgg
      721 gggctcacat caatgctgtt ggagccagca ggcctgactg gcgagaactg gatgacgagc
      781 tcatgaggca agcggtgctg tatgtggact cccgggaggc tgccctgaag gagtcaggag
      841 acgttctgtt gtcaggggct gacatctttg ctgagcttgg agaagtgatt tcaggagcga
      901 agcctgcaca ctgtgagaag accacagtgt tcaaatcttt ggggatggca gtggaagacc
      961 tggttgcagc caaattagta tatgattctt ggtcatctgg caagtgagtt gaaggaaccg
     1021 tgcctgagtt ggccatcaca gctcaacact gtttcacaag tgtcaaaatc aaaggaggtc
     1081 cagtccccag tgaatggtag tgattgtcat tcataagtac tgacacccct attcatgttt
     1141 gtggttggat agctaaacca ggtaaccatt tcttctgtta aggggtgatg gccacattat
     1201 ctacccttga tcttactagt cttgtatctc tctgaaataa atcatttcca cttcttctgt
     1261 gaaaaaaaaa aaaaaaaa
//
