LOCUS       NM_009967                708 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus crystallin, gamma S (Crygs), mRNA.
ACCESSION   NM_009967
VERSION     NM_009967.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 708)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 708)
  AUTHORS   Aoki,H., Ogino,H., Tomita,H., Hara,A. and Kunisada,T.
  TITLE     Disruption of Rest Leads to the Early Onset of Cataracts with the
            Aberrant Terminal Differentiation of Lens Fiber Cells
  JOURNAL   PLoS One 11 (9), e0163042 (2016)
   PUBMED   27631609
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 708)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 708)
  AUTHORS   Fan,J., Dong,L., Mishra,S., Chen,Y., FitzGerald,P. and Wistow,G.
  TITLE     A role for gammaS-crystallin in the organization of actin and fiber
            cell maturation in the mouse lens
  JOURNAL   FEBS J 279 (16), 2892-2904 (2012)
   PUBMED   22715935
  REMARK    GeneRIF: gammaS may have a functional role related to actin,
            perhaps in 'shepherding' filaments to maintain the optical
            properties of the lens cytoplasm and normal fiber cell maturation
REFERENCE   5  (bases 1 to 708)
  AUTHORS   Wende,H., Lechner,S.G., Cheret,C., Bourane,S., Kolanczyk,M.E.,
            Pattyn,A., Reuter,K., Munier,F.L., Carroll,P., Lewin,G.R. and
            Birchmeier,C.
  TITLE     The transcription factor c-Maf controls touch receptor development
            and function
  JOURNAL   Science 335 (6074), 1373-1376 (2012)
   PUBMED   22345400
REFERENCE   6  (bases 1 to 708)
  AUTHORS   Schibler,L., Vaiman,D., Oustry,A., Giraud-Delville,C. and
            Cribiu,E.P.
  TITLE     Comparative gene mapping: a fine-scale survey of chromosome
            rearrangements between ruminants and humans
  JOURNAL   Genome Res 8 (9), 901-915 (1998)
   PUBMED   9750190
REFERENCE   7  (bases 1 to 708)
  AUTHORS   Sinha,D., Esumi,N., Jaworski,C., Kozak,C.A., Pierce,E. and
            Wistow,G.
  TITLE     Cloning and mapping the mouse Crygs gene and non-lens expression of
            [gamma]S-crystallin
  JOURNAL   Mol Vis 4, 8 (1998)
   PUBMED   9565648
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 708)
  AUTHORS   Kerscher,S., Glenister,P.H., Favor,J. and Lyon,M.F.
  TITLE     Two new cataract loci, Ccw and To3, and further mapping of the Npp
            and Opj cataracts in the mouse
  JOURNAL   Genomics 36 (1), 17-21 (1996)
   PUBMED   8812411
REFERENCE   9  (bases 1 to 708)
  AUTHORS   Everett,C.A., Glenister,P.H., Taylor,D.M., Lyon,M.F.,
            Kratochvilova-Loester,J. and Favor,J.
  TITLE     Mapping of six dominant cataract genes in the mouse
  JOURNAL   Genomics 20 (3), 429-434 (1994)
   PUBMED   8034315
REFERENCE   10 (bases 1 to 708)
  AUTHORS   Favor,J.
  TITLE     A comparison of the dominant cataract and recessive specific-locus
            mutation rates induced by treatment of male mice with
            ethylnitrosourea
  JOURNAL   Mutat Res 110 (2), 367-382 (1983)
   PUBMED   6877261
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT571248.10 and AK143060.1.
            
            On Mar 18, 2010 this sequence version replaced NM_009967.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB845195.2, AK143060.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 CT571248.10        115799-115801       c
            4-702               AK143060.1         1-699
            703-708             CT571248.10        109594-109599       c
FEATURES             Location/Qualifiers
     source          1..708
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 13.66 cM"
     gene            1..708
                     /gene="Crygs"
                     /gene_synonym="Opj; rncat"
                     /note="crystallin, gamma S"
                     /db_xref="GeneID:12970"
                     /db_xref="MGI:MGI:1298216"
     exon            1..76
                     /gene="Crygs"
                     /gene_synonym="Opj; rncat"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..592
                     /gene="Crygs"
                     /gene_synonym="Opj; rncat"
                     /note="beta-crystallin S; opacity due to poor secondary
                     fiber cell junction; recessive nuclear cataract"
                     /codon_start=1
                     /product="gamma-crystallin S"
                     /protein_id="NP_034097.1"
                     /db_xref="CCDS:CCDS28069.1"
                     /db_xref="GeneID:12970"
                     /db_xref="MGI:MGI:1298216"
                     /translation="MSKTGGKISFYEDRNFQGRRYDCDCDCADFRSYLSRCNSIRVEG
                     GTWAVYERPNFSGHMYILPQGEYPEYQRWMGLNDRLGSCRAVHLSSGGQAKIQVFEKG
                     DFNGQMYETTEDCPSIMEQFHLREIHSCKVVEGTWIFYELPNYRGRQYLLDKKEYRKP
                     VDWGAASPAIQSFRRIVE"
     exon            77..319
                     /gene="Crygs"
                     /gene_synonym="Opj; rncat"
                     /inference="alignment:Splign:2.1.0"
     exon            320..708
                     /gene="Crygs"
                     /gene_synonym="Opj; rncat"
                     /inference="alignment:Splign:2.1.0"
     regulatory      684..689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crygs"
                     /gene_synonym="Opj; rncat"
                     /note="hexamer: AATAAA"
     polyA_site      703
                     /gene="Crygs"
                     /gene_synonym="Opj; rncat"
                     /note="major polyA site"
ORIGIN      
        1 ctggagctgc cctggatctc tctcagtagt gcgggaatca acctttgcac atacaatgtc
       61 taaaactgga ggcaagatta gtttctacga agaccgaaat tttcaaggcc gccgctatga
      121 ctgcgactgc gactgcgcag acttccgctc gtacctaagt cgctgcaact ccattagagt
      181 agagggaggc acctgggctg tgtatgaaag gcccaacttc tccgggcaca tgtacatctt
      241 accccagggc gagtaccctg aataccagcg ttggatgggc cttaatgacc gcctgggctc
      301 ttgccgagct gttcatctgt ctagcggagg ccaggctaag attcaggtct ttgaaaaggg
      361 cgacttcaac ggtcagatgt acgaaaccac ggaagactgt ccttctatca tggagcagtt
      421 tcacctgcga gagattcatt cctgtaaggt ggtagaaggc acctggattt tctatgagct
      481 acccaactac cgtggcagac agtatcttct ggataagaag gagtaccgga agcccgtcga
      541 ttggggtgcg gcatcccccg ctatccagtc gttccgccgc attgtggagt gatggcctgg
      601 agtgggacca tagagttctc cctgagggct gaacttgagg gctgaactct gctgtctggc
      661 ttgtggtcca aatagacaac gtaaataaaa gcattggaat gcatccca
//
