LOCUS       NM_153076                609 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus crystallin, gamma N (Crygn), mRNA.
ACCESSION   NM_153076 XM_906621
VERSION     NM_153076.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 609)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 609)
  AUTHORS   Aoki,H., Ogino,H., Tomita,H., Hara,A. and Kunisada,T.
  TITLE     Disruption of Rest Leads to the Early Onset of Cataracts with the
            Aberrant Terminal Differentiation of Lens Fiber Cells
  JOURNAL   PLoS One 11 (9), e0163042 (2016)
   PUBMED   27631609
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 609)
  AUTHORS   Hartwich,H., Rosengauer,E., Ruttiger,L., Wilms,V., Waterholter,S.K.
            and Nothwang,H.G.
  TITLE     Functional Role of gamma-Crystallin N in the Auditory Hindbrain
  JOURNAL   PLoS One 11 (8), e0161140 (2016)
   PUBMED   27517863
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 609)
  AUTHORS   Jin,C., Chen,J., Meng,Q., Carreira,V., Tam,N.N., Geh,E.,
            Karyala,S., Ho,S.M., Zhou,X., Medvedovic,M. and Xia,Y.
  TITLE     Deciphering gene expression program of MAP3K1 in mouse eyelid
            morphogenesis
  JOURNAL   Dev Biol 374 (1), 96-107 (2013)
   PUBMED   23201579
REFERENCE   5  (bases 1 to 609)
  AUTHORS   Yoshimoto,A., Saigou,Y., Higashi,Y. and Kondoh,H.
  TITLE     Regulation of ocular lens development by Smad-interacting protein 1
            involving Foxe3 activation
  JOURNAL   Development 132 (20), 4437-4448 (2005)
   PUBMED   16162653
REFERENCE   6  (bases 1 to 609)
  AUTHORS   Wistow,G., Wyatt,K., David,L., Gao,C., Bateman,O., Bernstein,S.,
            Tomarev,S., Segovia,L., Slingsby,C. and Vihtelic,T.
  TITLE     gammaN-crystallin and the evolution of the betagamma-crystallin
            superfamily in vertebrates
  JOURNAL   FEBS J 272 (9), 2276-2291 (2005)
   PUBMED   15853812
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137938.12, AF445456.1 and CF738166.1.
            
            On Jun 19, 2019 this sequence version replaced NM_153076.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF738166.1, BY710056.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC137938.12        72593-72597         c
            6-493               AF445456.1         1-488
            494-609             CF738166.1         480-595
FEATURES             Location/Qualifiers
     source          1..609
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 11.93 cM"
     gene            1..609
                     /gene="Crygn"
                     /note="crystallin, gamma N"
                     /db_xref="GeneID:214301"
                     /db_xref="MGI:MGI:2449167"
     exon            1..26
                     /gene="Crygn"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..557
                     /gene="Crygn"
                     /note="gamma-N-crystallin"
                     /codon_start=1
                     /product="gamma-crystallin N"
                     /protein_id="NP_694716.2"
                     /db_xref="CCDS:CCDS19129.1"
                     /db_xref="GeneID:214301"
                     /db_xref="MGI:MGI:2449167"
                     /translation="MAQRSGKITLYEGKHFTGRKLEVFGDCDNFQDQGFMNRVNSIRV
                     ESGAWVCFDHPDFRGQQFILEHGDYPEFFRWNGHNDHMGSCRPVGMHGEHFRIDIFEG
                     CNFTGQCLEFVEDCPFLQSRGWAKSCVNAIKVYGDGAWVLYEEPNYRGRMYVLERGDY
                     RCFSDWGAHSARVQSLRRVLNFF"
     exon            27..275
                     /gene="Crygn"
                     /inference="alignment:Splign:2.1.0"
     exon            276..421
                     /gene="Crygn"
                     /inference="alignment:Splign:2.1.0"
     exon            422..609
                     /gene="Crygn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      589..594
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crygn"
                     /note="hexamer: AATAAA"
     polyA_site      609
                     /gene="Crygn"
                     /note="major polyA site"
ORIGIN      
        1 acaccatggc gcaacgctcg ggaaagatca ctctgtacga gggcaagcac ttcacagggc
       61 ggaagctgga ggtgtttggg gactgtgaca acttccagga ccaaggcttt atgaaccggg
      121 tgaattccat ccgtgtggag agcggagcct gggtctgctt tgatcaccct gacttccgcg
      181 gccagcagtt cattttggag catggtgact accctgaatt cttccgctgg aatggccaca
      241 acgaccacat gggctcctgt cggcctgtgg gcatgcatgg agagcatttc cgcatagaca
      301 tcttcgaggg ctgcaacttc acgggccagt gcctagagtt cgtggaggac tgccccttcc
      361 tgcagagccg gggctgggcc aagagctgtg tcaacgccat caaggtgtat ggggacggag
      421 cgtgggtcct ctatgaggag ccaaactacc gcggccgcat gtacgtgttg gagagaggag
      481 actaccgctg cttctccgac tggggggccc acagcgcacg cgtgcagtcg ctccgccggg
      541 tgctcaactt cttctagtcc caactgcgta cgtgcgaccc acggaggcaa taaatatcca
      601 gaaagcgga
//
