LOCUS       NM_027010                647 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus crystallin, gamma F (Crygf), transcript variant 1,
            mRNA.
ACCESSION   NM_027010
VERSION     NM_027010.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 647)
  AUTHORS   Xie,Q. and Cvekl,A.
  TITLE     The orchestration of mammalian tissue morphogenesis through a
            series of coherent feed-forward loops
  JOURNAL   J Biol Chem 286 (50), 43259-43271 (2011)
   PUBMED   21998302
REFERENCE   2  (bases 1 to 647)
  AUTHORS   Takeuchi,T., Kudo,T., Ogata,K., Hamada,M., Nakamura,M., Kito,K.,
            Abe,Y., Ueda,N., Yamamoto,M., Engel,J.D. and Takahashi,S.
  TITLE     Neither MafA/L-Maf nor MafB is essential for lens development in
            mice
  JOURNAL   Genes Cells 14 (8), 941-947 (2009)
   PUBMED   19624757
REFERENCE   3  (bases 1 to 647)
  AUTHORS   Cheong,C., Sung,Y.H., Lee,J., Choi,Y.S., Song,J., Kee,C. and
            Lee,H.W.
  TITLE     Role of INK4a locus in normal eye development and cataract genesis
  JOURNAL   Mech Ageing Dev 127 (7), 633-638 (2006)
   PUBMED   16620915
REFERENCE   4  (bases 1 to 647)
  AUTHORS   Yoshimoto,A., Saigou,Y., Higashi,Y. and Kondoh,H.
  TITLE     Regulation of ocular lens development by Smad-interacting protein 1
            involving Foxe3 activation
  JOURNAL   Development 132 (20), 4437-4448 (2005)
   PUBMED   16162653
REFERENCE   5  (bases 1 to 647)
  AUTHORS   Min,J.N., Zhang,Y., Moskophidis,D. and Mivechi,N.F.
  TITLE     Unique contribution of heat shock transcription factor 4 in ocular
            lens development and fiber cell differentiation
  JOURNAL   Genesis 40 (4), 205-217 (2004)
   PUBMED   15593327
REFERENCE   6  (bases 1 to 647)
  AUTHORS   Barton,C.H., Ajioka,J.W., Roach,T.I. and Blackwell,J.M.
  TITLE     Mapping Creb-1 to chromosome 1 in the mouse
  JOURNAL   Genomics 14 (3), 790-792 (1992)
   PUBMED   1358811
REFERENCE   7  (bases 1 to 647)
  AUTHORS   Vidal,S.M., Epstein,D.J., Malo,D., Weith,A., Vekemans,M. and
            Gros,P.
  TITLE     Identification and mapping of six microdissected genomic DNA probes
            to the proximal region of mouse chromosome 1
  JOURNAL   Genomics 14 (1), 32-37 (1992)
   PUBMED   1358796
REFERENCE   8  (bases 1 to 647)
  AUTHORS   Goring,D.R., Breitman,M.L. and Tsui,L.C.
  TITLE     Temporal regulation of six crystallin transcripts during mouse lens
            development
  JOURNAL   Exp Eye Res 54 (5), 785-795 (1992)
   PUBMED   1623964
REFERENCE   9  (bases 1 to 647)
  AUTHORS   Graw,J., Coban,L., Liebstein,A. and Werner,T.
  TITLE     Murine gamma E-crystallin is distinct from murine gamma
            2-crystallin
  JOURNAL   Gene 104 (2), 265-270 (1991)
   PUBMED   1916296
REFERENCE   10 (bases 1 to 647)
  AUTHORS   Schurr,E., Skamene,E., Morgan,K., Chu,M.L. and Gros,P.
  TITLE     Mapping of Col3a1 and Col6a3 to proximal murine chromosome 1
            identifies conserved linkage of structural protein genes between
            murine chromosome 1 and human chromosome 2q
  JOURNAL   Genomics 8 (3), 477-486 (1990)
   PUBMED   1981051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK013953.1 and CA326162.1.
            
            On Feb 13, 2018 this sequence version replaced NM_027010.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA326162.1, BC056453.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-622               AK013953.1         2-623
            623-647             CA326162.1         613-637
FEATURES             Location/Qualifiers
     source          1..647
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 33.31 cM"
     gene            1..647
                     /gene="Crygf"
                     /gene_synonym="3110001K11Rik; Cryg-2; DGcry-2; Len-2"
                     /note="crystallin, gamma F"
                     /db_xref="GeneID:12969"
                     /db_xref="MGI:MGI:88526"
     exon            1..45
                     /gene="Crygf"
                     /gene_synonym="3110001K11Rik; Cryg-2; DGcry-2; Len-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..561
                     /gene="Crygf"
                     /gene_synonym="3110001K11Rik; Cryg-2; DGcry-2; Len-2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     gamma-crystallin F; gamma-F-crystallin"
                     /codon_start=1
                     /product="gamma-crystallin F isoform 1"
                     /protein_id="NP_081286.1"
                     /db_xref="CCDS:CCDS15018.1"
                     /db_xref="GeneID:12969"
                     /db_xref="MGI:MGI:88526"
                     /translation="MGKITFYEDRSFQGRHYECSTDHSNLQPYFSRCNSVRVDSGCWM
                     LYEQPNFAGCQYFLRRGDYPDYQQWMGFSDSVRSCHLIPHSTSHRIRIYEREDYRGQM
                     VEITDDCSHLQDRFHFSDFHSFHVMEGYWVLYEMPNYRGRQYLLRPGEYRRYHDWGAM
                     NARVGSLRRIMDFY"
     exon            46..288
                     /gene="Crygf"
                     /gene_synonym="3110001K11Rik; Cryg-2; DGcry-2; Len-2"
                     /inference="alignment:Splign:2.1.0"
     exon            289..629
                     /gene="Crygf"
                     /gene_synonym="3110001K11Rik; Cryg-2; DGcry-2; Len-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      597..602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crygf"
                     /gene_synonym="3110001K11Rik; Cryg-2; DGcry-2; Len-2"
                     /note="hexamer: AATAAA"
     polyA_site      629
                     /gene="Crygf"
                     /gene_synonym="3110001K11Rik; Cryg-2; DGcry-2; Len-2"
                     /note="major polyA site"
ORIGIN      
        1 aacagcacca tcccatctga cctgccaaca ccagccatgg ggaagatcac cttctatgag
       61 gaccgcagct tccagggccg ccactatgag tgcagcaccg accactccaa cctgcagccc
      121 tacttcagcc gctgcaactc tgtgcgagtg gacagtggct gctggatgct ctatgagcag
      181 cccaacttcg caggctgcca gtacttcctg cgtcgcgggg actaccctga ctaccagcag
      241 tggatgggtt tcagtgactc tgtccgctcc tgccacctca tcccccactc cacttctcac
      301 aggatcagga tctacgagcg agaggactac agaggccaga tggtggagat cacagacgac
      361 tgctcccacc tgcaggaccg cttccacttc agtgacttcc actccttcca cgtgatggag
      421 ggctactggg tcctctacga gatgcccaac taccgggggc ggcagtacct gctgaggcca
      481 ggggagtata ggcgctacca cgattggggc gccatgaatg ccagggtggg ctctctgagg
      541 agaatcatgg atttctattg aattttctta ctctgccctt tcatcatttg gaagttaata
      601 aaatatttcc tatgtgttcc atgcattaaa aaaaaaaaaa aaaaaaa
//
