LOCUS       NM_007777                662 bp    mRNA    linear   ROD 17-DEC-2022
DEFINITION  Mus musculus crystallin, gamma E (Cryge), mRNA.
ACCESSION   NM_007777
VERSION     NM_007777.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 662)
  AUTHORS   Zhang X, Wang D, Dongye M, Zhu Y, Chen C, Wang R, Long E, Liu Z, Wu
            X, Lin D, Chen J, Lin Z, Wang J, Li W, Li Y, Li D and Lin H.
  TITLE     Loss-of-function mutations in FREM2 disrupt eye morphogenesis
  JOURNAL   Exp Eye Res 181, 302-312 (2019)
   PUBMED   30802441
REFERENCE   2  (bases 1 to 662)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 662)
  AUTHORS   Xie Q and Cvekl A.
  TITLE     The orchestration of mammalian tissue morphogenesis through a
            series of coherent feed-forward loops
  JOURNAL   J Biol Chem 286 (50), 43259-43271 (2011)
   PUBMED   21998302
REFERENCE   4  (bases 1 to 662)
  AUTHORS   Campos Y, Qiu X, Zanoteli E, Moshiach S, Vergani N, Bongiovanni A,
            Harris AJ and d'Azzo A.
  TITLE     Ozz-E3 ubiquitin ligase targets sarcomeric embryonic myosin heavy
            chain during muscle development
  JOURNAL   PLoS One 5 (3), e9866 (2010)
   PUBMED   20352047
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 662)
  AUTHORS   Takeuchi T, Kudo T, Ogata K, Hamada M, Nakamura M, Kito K, Abe Y,
            Ueda N, Yamamoto M, Engel JD and Takahashi S.
  TITLE     Neither MafA/L-Maf nor MafB is essential for lens development in
            mice
  JOURNAL   Genes Cells 14 (8), 941-947 (2009)
   PUBMED   19624757
REFERENCE   6  (bases 1 to 662)
  AUTHORS   Cartier M, Breitman ML and Tsui LC.
  TITLE     A frameshift mutation in the gamma E-crystallin gene of the Elo
            mouse
  JOURNAL   Nat Genet 2 (1), 42-45 (1992)
   PUBMED   1303247
  REMARK    Erratum:[Nat Genet 1992 Dec;2(4):343]
REFERENCE   7  (bases 1 to 662)
  AUTHORS   Sato H, Sakai Y, Koiwai O and Watanabe T.
  TITLE     Mapping of the mouse bilirubin UDP-glucuronosyltransferase gene
            (Gnt-1) to chromosome 1 by restriction fragment length variations
  JOURNAL   Biochem Genet 30 (7-8), 347-352 (1992)
   PUBMED   1359870
REFERENCE   8  (bases 1 to 662)
  AUTHORS   Kratochvilova J and Favor J.
  TITLE     Allelism tests of 15 dominant cataract mutations in mice
  JOURNAL   Genet Res 59 (3), 199-203 (1992)
   PUBMED   1511869
REFERENCE   9  (bases 1 to 662)
  AUTHORS   Goring DR, Breitman ML and Tsui LC.
  TITLE     Temporal regulation of six crystallin transcripts during mouse lens
            development
  JOURNAL   Exp Eye Res 54 (5), 785-795 (1992)
   PUBMED   1623964
REFERENCE   10 (bases 1 to 662)
  AUTHORS   Yoshiki A, Hanazono M, Oda S, Wakasugi N, Sakakura T and Kusakabe
            M.
  TITLE     Developmental analysis of the eye lens obsolescence (Elo) gene in
            the mouse: cell proliferation and Elo gene expression in the
            aggregation chimera
  JOURNAL   Development 113 (4), 1293-1304 (1991)
   PUBMED   1811943
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC132506.1 and BC078417.1.
            
            [WARNING] On Apr 25, 2023 this sequence was replaced by
            NM_007777.4.
            
            On Mar 30, 2007 this sequence version replaced NM_007777.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF739564.1, CB841023.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               BC132506.1         1-203
            204-662             BC078417.1         179-637
FEATURES             Location/Qualifiers
     source          1..662
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 32.8 cM"
     gene            1..662
                     /gene="Cryge"
                     /gene_synonym="Cryg-2; Cryg-6; DGcry-2; Elo"
                     /note="crystallin, gamma E"
                     /db_xref="GeneID:12968"
                     /db_xref="MGI:MGI:88525"
     exon            1..59
                     /gene="Cryge"
                     /gene_synonym="Cryg-2; Cryg-6; DGcry-2; Elo"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..575
                     /gene="Cryge"
                     /gene_synonym="Cryg-2; Cryg-6; DGcry-2; Elo"
                     /note="gamma-E-crystallin; eye lens obsolescence"
                     /codon_start=1
                     /product="gamma-crystallin E"
                     /protein_id="NP_031803.3"
                     /db_xref="CCDS:CCDS35598.1"
                     /db_xref="GeneID:12968"
                     /db_xref="MGI:MGI:88525"
                     /translation="MGKITFYEDRGFQGRHYECSTDHSNLQPYFSRCNSVRVDSGCWM
                     LYEQPNFAGCQYFLRRGDYPDYQQWMGFSDSVRSCRLIPHSSSHRIKIYEREDYRGQM
                     VEITDDCSHLQDRFHFSDFHSFHVMEGYWVLYEMPNYRGRQYLLRPGEYRRYHDWGAM
                     NARVGSLRRIMDFY"
     exon            60..302
                     /gene="Cryge"
                     /gene_synonym="Cryg-2; Cryg-6; DGcry-2; Elo"
                     /inference="alignment:Splign:2.1.0"
     exon            303..642
                     /gene="Cryge"
                     /gene_synonym="Cryg-2; Cryg-6; DGcry-2; Elo"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccccacac actcaacagc actatcccat ccgacctgcc aacaccagcc atggggaaga
       61 tcaccttcta tgaggaccgc ggcttccagg gccgccacta tgagtgcagc accgaccact
      121 ccaacctgca gccctacttc agccgctgca actctgtgcg cgtggacagt ggctgctgga
      181 tgctctatga gcagcccaac ttcgcaggct gccagtactt cctgcgtcgc ggggactacc
      241 ctgactacca gcagtggatg ggtttcagtg actctgtccg ctcctgccgc ctcatccccc
      301 actccagttc tcacaggatc aagatctacg agcgagagga ctacagaggc caaatggtgg
      361 agatcacaga cgactgctcc cacctgcagg accgcttcca cttcagtgac ttccactcct
      421 tccacgtgat ggagggctac tgggtcctct acgagatgcc caactaccgg gggcggcagt
      481 acctgctcag gcctggggag tacaggcgct accacgactg gggcgccatg aatgccaggg
      541 tgggctctct gaggagaatc atggatttct attgaaatat ttttactcta ccattttctc
      601 catctggaca gtaataaaat atttcctgtg tgtttcatgc aaaaaaaaaa aaaaaaaaaa
      661 aa
//
