LOCUS       NP_031803                174 aa            linear   ROD 02-MAY-2024
DEFINITION  gamma-crystallin E isoform 1 [Mus musculus].
ACCESSION   NP_031803
VERSION     NP_031803.3
DBSOURCE    REFSEQ: accession NM_007777.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 174)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 174)
  AUTHORS   Zhang,X., Wang,D., Dongye,M., Zhu,Y., Chen,C., Wang,R., Long,E.,
            Liu,Z., Wu,X., Lin,D., Chen,J., Lin,Z., Wang,J., Li,W., Li,Y.,
            Li,D. and Lin,H.
  TITLE     Loss-of-function mutations in FREM2 disrupt eye morphogenesis
  JOURNAL   Exp Eye Res 181, 302-312 (2019)
   PUBMED   30802441
REFERENCE   3  (residues 1 to 174)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (residues 1 to 174)
  AUTHORS   Xie,Q. and Cvekl,A.
  TITLE     The orchestration of mammalian tissue morphogenesis through a
            series of coherent feed-forward loops
  JOURNAL   J Biol Chem 286 (50), 43259-43271 (2011)
   PUBMED   21998302
REFERENCE   5  (residues 1 to 174)
  AUTHORS   Campos,Y., Qiu,X., Zanoteli,E., Moshiach,S., Vergani,N.,
            Bongiovanni,A., Harris,A.J. and d'Azzo,A.
  TITLE     Ozz-E3 ubiquitin ligase targets sarcomeric embryonic myosin heavy
            chain during muscle development
  JOURNAL   PLoS One 5 (3), e9866 (2010)
   PUBMED   20352047
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 174)
  AUTHORS   Cartier,M., Breitman,M.L. and Tsui,L.C.
  TITLE     A frameshift mutation in the gamma E-crystallin gene of the Elo
            mouse
  JOURNAL   Nat Genet 2 (1), 42-45 (1992)
   PUBMED   1303247
  REMARK    Erratum:[Nat Genet 1992 Dec;2(4):343]
REFERENCE   7  (residues 1 to 174)
  AUTHORS   Sato,H., Sakai,Y., Koiwai,O. and Watanabe,T.
  TITLE     Mapping of the mouse bilirubin UDP-glucuronosyltransferase gene
            (Gnt-1) to chromosome 1 by restriction fragment length variations
  JOURNAL   Biochem Genet 30 (7-8), 347-352 (1992)
   PUBMED   1359870
REFERENCE   8  (residues 1 to 174)
  AUTHORS   Kratochvilova,J. and Favor,J.
  TITLE     Allelism tests of 15 dominant cataract mutations in mice
  JOURNAL   Genet Res 59 (3), 199-203 (1992)
   PUBMED   1511869
REFERENCE   9  (residues 1 to 174)
  AUTHORS   Goring,D.R., Breitman,M.L. and Tsui,L.C.
  TITLE     Temporal regulation of six crystallin transcripts during mouse lens
            development
  JOURNAL   Exp Eye Res 54 (5), 785-795 (1992)
   PUBMED   1623964
REFERENCE   10 (residues 1 to 174)
  AUTHORS   Yoshiki,A., Hanazono,M., Oda,S., Wakasugi,N., Sakakura,T. and
            Kusakabe,M.
  TITLE     Developmental analysis of the eye lens obsolescence (Elo) gene in
            the mouse: cell proliferation and Elo gene expression in the
            aggregation chimera
  JOURNAL   Development 113 (4), 1293-1304 (1991)
   PUBMED   1811943
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158958.4.
            
            On Mar 30, 2007 this sequence version replaced NP_031803.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY713264.1, CF739564.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..174
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 32.8 cM"
     Protein         1..174
                     /product="gamma-crystallin E isoform 1"
                     /note="gamma-crystallin E; gamma-E-crystallin; eye lens
                     obsolescence"
                     /calculated_mol_wt=21065
     Region          3..82
                     /region_name="XTALbg"
                     /note="Beta/gamma crystallins; smart00247"
                     /db_xref="CDD:214583"
     Region          84..87
                     /region_name="Connecting peptide"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03740.4)"
     Region          89..170
                     /region_name="Crystall"
                     /note="Beta/Gamma crystallin; pfam00030"
                     /db_xref="CDD:459639"
     CDS             1..174
                     /gene="Cryge"
                     /gene_synonym="Cryg-2; Cryg-6; DGcry-2; Elo"
                     /coded_by="NM_007777.4:37..561"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS35598.1"
                     /db_xref="GeneID:12968"
                     /db_xref="MGI:MGI:88525"
ORIGIN      
        1 mgkitfyedr gfqgrhyecs tdhsnlqpyf srcnsvrvds gcwmlyeqpn fagcqyflrr
       61 gdypdyqqwm gfsdsvrscr liphssshri kiyeredyrg qmveitddcs hlqdrfhfsd
      121 fhsfhvmegy wvlyempnyr grqyllrpge yrryhdwgam narvgslrri mdfy
//
