LOCUS       NM_007775                626 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus crystallin, gamma C (Crygc), transcript variant 1,
            mRNA.
ACCESSION   NM_007775
VERSION     NM_007775.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 626)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 626)
  AUTHORS   Minogue,P.J., Gao,J., Mathias,R.T., Williams,J.C. Jr.,
            Bledsoe,S.B., Sommer,A.J., Beyer,E.C. and Berthoud,V.M.
  TITLE     A crystallin mutant cataract with mineral deposits
  JOURNAL   J Biol Chem 299 (8), 104935 (2023)
   PUBMED   37331601
REFERENCE   3  (bases 1 to 626)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 626)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 626)
  AUTHORS   Wu,Y., Liang,D., Wang,Y., Bai,M., Tang,W., Bao,S., Yan,Z., Li,D.
            and Li,J.
  TITLE     Correction of a genetic disease in mouse via use of CRISPR-Cas9
  JOURNAL   Cell Stem Cell 13 (6), 659-662 (2013)
   PUBMED   24315440
REFERENCE   6  (bases 1 to 626)
  AUTHORS   Graw,J., Liebstein,A., Pietrowski,D., Schmitt-John,T. and Werner,T.
  TITLE     Genomic sequences of murine gamma B- and gamma
            C-crystallin-encoding genes: promoter analysis and complete
            evolutionary pattern of mouse, rat and human gamma-crystallins
  JOURNAL   Gene 136 (1-2), 145-156 (1993)
   PUBMED   8293998
REFERENCE   7  (bases 1 to 626)
  AUTHORS   Goring,D.R., Breitman,M.L. and Tsui,L.C.
  TITLE     Temporal regulation of six crystallin transcripts during mouse lens
            development
  JOURNAL   Exp Eye Res 54 (5), 785-795 (1992)
   PUBMED   1623964
REFERENCE   8  (bases 1 to 626)
  AUTHORS   Levan,G., Szpirer,J., Szpirer,C., Klinga,K., Hanson,C. and
            Islam,M.Q.
  TITLE     The gene map of the Norway rat (Rattus norvegicus) and comparative
            mapping with mouse and man
  JOURNAL   Genomics 10 (3), 699-718 (1991)
   PUBMED   1889815
REFERENCE   9  (bases 1 to 626)
  AUTHORS   Quinlan,P., Oda,S., Breitman,M.L. and Tsui,L.C.
  TITLE     The mouse eye lens obsolescence (Elo) mutant: studies on crystallin
            gene expression and linkage analysis between the mutant locus and
            the gamma-crystallin genes
  JOURNAL   Genes Dev 1 (7), 637-644 (1987)
   PUBMED   3428594
REFERENCE   10 (bases 1 to 626)
  AUTHORS   Murer-Orlando,M., Paterson,R.C., Lok,S., Tsui,L.C. and
            Breitman,M.L.
  TITLE     Differential regulation of gamma-crystallin genes during mouse lens
            development
  JOURNAL   Dev Biol 119 (1), 260-267 (1987)
   PUBMED   3792630
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ066821.1, EF426301.1 and CK627566.1.
            
            On Sep 28, 2012 this sequence version replaced NM_007775.1.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA452042.1, CJ066821.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                CJ066821.1         2-12
            12-620              EF426301.1         1-609
            621-626             CK627566.1         219-224
FEATURES             Location/Qualifiers
     source          1..626
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 32.81 cM"
     gene            1..626
                     /gene="Crygc"
                     /gene_synonym="Cryg-5"
                     /note="crystallin, gamma C"
                     /db_xref="GeneID:12966"
                     /db_xref="MGI:MGI:88523"
     exon            1..36
                     /gene="Crygc"
                     /gene_synonym="Cryg-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..552
                     /gene="Crygc"
                     /gene_synonym="Cryg-5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     gamma-crystallin C; gammaC-crystallin; gamma-C-crystallin"
                     /codon_start=1
                     /product="gamma-crystallin C isoform 1"
                     /protein_id="NP_031801.1"
                     /db_xref="CCDS:CCDS15012.1"
                     /db_xref="GeneID:12966"
                     /db_xref="MGI:MGI:88523"
                     /translation="MGKITFFEDRSFQGRCYECSSDCPNLQTYFSRCNSVRVDSGCWM
                     LYERPNYQGHQYFLRRGEYPDYQQWMGFSDSIRSCRLIPHAGSHRMRLYEKEDHKGVM
                     MELSEDCSCIQDRFHLSEVRSLQVLEGCWVLYEMPNYRGRQYLLRPQEYRRFQDWGSV
                     DAKAGSLRRVVDLY"
     exon            37..279
                     /gene="Crygc"
                     /gene_synonym="Cryg-5"
                     /inference="alignment:Splign:2.1.0"
     exon            280..626
                     /gene="Crygc"
                     /gene_synonym="Cryg-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      590..595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crygc"
                     /gene_synonym="Cryg-5"
                     /note="hexamer: AATAAA"
     polyA_site      620
                     /gene="Crygc"
                     /gene_synonym="Cryg-5"
                     /note="major polyA site"
ORIGIN      
        1 actgaactca ccacgggtca gccagccatg gggaagatca ccttcttcga ggaccgcagc
       61 ttccagggcc gctgctatga gtgcagcagc gactgcccca acctgcagac ctacttcagc
      121 cgctgcaatt ctgtccgcgt ggacagtggc tgctggatgc tctatgagcg ccccaactac
      181 cagggccacc agtacttcct gagacgtgga gagtaccctg actaccagca gtggatgggt
      241 ttcagcgact ccatccgctc ctgccgcctc atcccccatg caggttccca cagaatgcgg
      301 ctgtatgaga aagaagatca caaaggtgtc atgatggagc tgagcgagga ttgctcctgc
      361 atccaggatc gcttccacct cagtgaggtg cgctcgctgc aagtgctgga aggctgctgg
      421 gttctctatg agatgcctaa ctaccgaggc cgccagtatc tgctgaggcc tcaagagtac
      481 cggcgcttcc aggactgggg ctctgtagat gctaaggcgg gctctttgcg gagggtggta
      541 gatttatact aaaataggtt aacgctacca ttttctcatt ttggaaccta ataaagtatt
      601 tagtctgtat tgttggcaaa ccctga
//
