LOCUS       NM_144761                633 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus crystallin, gamma B (Crygb), mRNA.
ACCESSION   NM_144761 XM_355210
VERSION     NM_144761.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 633)
  AUTHORS   Zhang,L., Liu,X., Li,W., Liu,K., Zhang,J., Liu,X. and Wang,J.
  TITLE     Integrative transcriptomic profiling of ncRNAs and mRNAs in
            developing mouse lens
  JOURNAL   Front Genet 15, 1405715 (2024)
   PUBMED   38933921
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 633)
  AUTHORS   Minogue,P.J., Gao,J., Mathias,R.T., Williams,J.C. Jr.,
            Bledsoe,S.B., Sommer,A.J., Beyer,E.C. and Berthoud,V.M.
  TITLE     A crystallin mutant cataract with mineral deposits
  JOURNAL   J Biol Chem 299 (8), 104935 (2023)
   PUBMED   37331601
REFERENCE   3  (bases 1 to 633)
  AUTHORS   Hou,W., Pande,A. and Pande,J.
  TITLE     Oxidation of active cysteines mediates protein aggregation of S10R,
            the cataract-associated mutant of mouse GammaB-crystallin
  JOURNAL   Proteins 90 (11), 1987-2000 (2022)
   PUBMED   35726360
  REMARK    GeneRIF: Oxidation of active cysteines mediates protein aggregation
            of S10R, the cataract-associated mutant of mouse GammaB-crystallin.
REFERENCE   4  (bases 1 to 633)
  AUTHORS   Dash,S., Brastrom,L.K., Patel,S.D., Scott,C.A., Slusarski,D.C. and
            Lachke,S.A.
  TITLE     The master transcription factor SOX2, mutated in
            anophthalmia/microphthalmia, is post-transcriptionally regulated by
            the conserved RNA-binding protein RBM24 in vertebrate eye
            development
  JOURNAL   Hum Mol Genet 29 (4), 591-604 (2020)
   PUBMED   31814023
REFERENCE   5  (bases 1 to 633)
  AUTHORS   Martynova,E., Zhao,Y., Xie,Q., Zheng,D. and Cvekl,A.
  TITLE     Transcriptomic analysis and novel insights into lens fibre cell
            differentiation regulated by Gata3
  JOURNAL   Open Biol 9 (12), 190220 (2019)
   PUBMED   31847788
REFERENCE   6  (bases 1 to 633)
  AUTHORS   Kratochvilova,J. and Favor,J.
  TITLE     Allelism tests of 15 dominant cataract mutations in mice
  JOURNAL   Genet Res 59 (3), 199-203 (1992)
   PUBMED   1511869
REFERENCE   7  (bases 1 to 633)
  AUTHORS   Goring,D.R., Breitman,M.L. and Tsui,L.C.
  TITLE     Temporal regulation of six crystallin transcripts during mouse lens
            development
  JOURNAL   Exp Eye Res 54 (5), 785-795 (1992)
   PUBMED   1623964
REFERENCE   8  (bases 1 to 633)
  AUTHORS   Levan,G., Szpirer,J., Szpirer,C., Klinga,K., Hanson,C. and
            Islam,M.Q.
  TITLE     The gene map of the Norway rat (Rattus norvegicus) and comparative
            mapping with mouse and man
  JOURNAL   Genomics 10 (3), 699-718 (1991)
   PUBMED   1889815
REFERENCE   9  (bases 1 to 633)
  AUTHORS   Quinlan,P., Oda,S., Breitman,M.L. and Tsui,L.C.
  TITLE     The mouse eye lens obsolescence (Elo) mutant: studies on crystallin
            gene expression and linkage analysis between the mutant locus and
            the gamma-crystallin genes
  JOURNAL   Genes Dev 1 (7), 637-644 (1987)
   PUBMED   3428594
REFERENCE   10 (bases 1 to 633)
  AUTHORS   Murer-Orlando,M., Paterson,R.C., Lok,S., Tsui,L.C. and
            Breitman,M.L.
  TITLE     Differential regulation of gamma-crystallin genes during mouse lens
            development
  JOURNAL   Dev Biol 119 (1), 260-267 (1987)
   PUBMED   3792630
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EL605042.1, BC056455.1 and AC158958.4.
            
            On Aug 15, 2013 this sequence version replaced NM_144761.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EL959650.1, CO428332.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                EL605042.1         1-23
            24-628              BC056455.1         1-605
            629-633             AC158958.4         211995-211999       c
FEATURES             Location/Qualifiers
     source          1..633
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 32.82 cM"
     gene            1..633
                     /gene="Crygb"
                     /gene_synonym="Cryg-3; DGcry-3; Nop"
                     /note="crystallin, gamma B"
                     /db_xref="GeneID:12965"
                     /db_xref="MGI:MGI:88522"
     exon            1..44
                     /gene="Crygb"
                     /gene_synonym="Cryg-3; DGcry-3; Nop"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..563
                     /gene="Crygb"
                     /gene_synonym="Cryg-3; DGcry-3; Nop"
                     /note="gammaB-crystallin; gamma-B-crystallin;
                     gamma-crystallin 3; nuclear opacity"
                     /codon_start=1
                     /product="gamma-crystallin B"
                     /protein_id="NP_658906.1"
                     /db_xref="CCDS:CCDS15013.1"
                     /db_xref="GeneID:12965"
                     /db_xref="MGI:MGI:88522"
                     /translation="MGKITFFEDRSFQGRCYECSSDCPNLQTYFSRCNSVRVDSGCWM
                     LYERPNYQGHQYFLRRGEYPDYQQWMGFSDSIRSCCLIPQHSGTYRMRIYEKDDFRGQ
                     MSEITDDCLSLQDRFHFSEIHSLNVMEGCWVLYEMPSYRGRQYLLRPGEYRRYLDWGA
                     ANAKVGSFRRVMDFY"
     exon            45..287
                     /gene="Crygb"
                     /gene_synonym="Cryg-3; DGcry-3; Nop"
                     /inference="alignment:Splign:2.1.0"
     exon            288..633
                     /gene="Crygb"
                     /gene_synonym="Cryg-3; DGcry-3; Nop"
                     /inference="alignment:Splign:2.1.0"
     regulatory      600..605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crygb"
                     /gene_synonym="Cryg-3; DGcry-3; Nop"
                     /note="hexamer: AATAAA"
     polyA_site      628
                     /gene="Crygb"
                     /gene_synonym="Cryg-3; DGcry-3; Nop"
                     /note="major polyA site"
ORIGIN      
        1 tcacagctcc cagggcatct cttactctca gcgagatggg aaagatcacc ttcttcgagg
       61 accgcagctt ccagggccgc tgctatgagt gcagcagcga ctgccccaac ctgcagacct
      121 acttcagccg ctgcaattct gtccgcgtgg acagtggctg ctggatgctc tatgagcgcc
      181 ccaactacca gggccaccag tacttcctga gacgtggaga gtaccctgac taccagcagt
      241 ggatgggttt cagcgactcc attcgttcct gctgcctcat cccccaacac tctggcactt
      301 acagaatgag gatctacgaa aaagatgact tcagaggaca aatgtcagag atcacagacg
      361 attgtctctc tcttcaggat cgcttccact tcagtgaaat ccactccctc aatgtgatgg
      421 agggctgctg ggttctctat gagatgccta gctacagagg acggcagtac ctgctaaggc
      481 cgggggagta caggagatat cttgactggg gggctgcaaa tgccaaagtt ggctctttta
      541 ggcgagtcat ggatttttac tgaggcattt tgagactcta ctttcctcct ctagagccaa
      601 ataaagtatg tagcttatga ttctggcact cca
//
