LOCUS       NM_007774                621 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus crystallin, gamma A (Cryga), mRNA.
ACCESSION   NM_007774
VERSION     NM_007774.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 621)
  AUTHORS   Garg,A., Hannan,A., Wang,Q., Makrides,N., Zhong,J., Li,H., Yoon,S.,
            Mao,Y. and Zhang,X.
  TITLE     Etv transcription factors functionally diverge from their upstream
            FGF signaling in lens development
  JOURNAL   Elife 9, e51915 (2020)
   PUBMED   32043969
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 621)
  AUTHORS   Martynova,E., Zhao,Y., Xie,Q., Zheng,D. and Cvekl,A.
  TITLE     Transcriptomic analysis and novel insights into lens fibre cell
            differentiation regulated by Gata3
  JOURNAL   Open Biol 9 (12), 190220 (2019)
   PUBMED   31847788
REFERENCE   3  (bases 1 to 621)
  AUTHORS   Limi,S., Senecal,A., Coleman,R., Lopez-Jones,M., Guo,P.,
            Polumbo,C., Singer,R.H., Skoultchi,A.I. and Cvekl,A.
  TITLE     Transcriptional burst fraction and size dynamics during lens fiber
            cell differentiation and detailed insights into the denucleation
            process
  JOURNAL   J Biol Chem 293 (34), 13176-13190 (2018)
   PUBMED   29959226
REFERENCE   4  (bases 1 to 621)
  AUTHORS   Aoki,H., Ogino,H., Tomita,H., Hara,A. and Kunisada,T.
  TITLE     Disruption of Rest Leads to the Early Onset of Cataracts with the
            Aberrant Terminal Differentiation of Lens Fiber Cells
  JOURNAL   PLoS One 11 (9), e0163042 (2016)
   PUBMED   27631609
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 621)
  AUTHORS   Cheng,M.H., Tam,C.N., Choy,K.W., Tsang,W.H., Tsang,S.L., Pang,C.P.,
            Song,Y.Q. and Sham,M.H.
  TITLE     A gammaA-Crystallin Mouse Mutant Secc with Small Eye, Cataract and
            Closed Eyelid
  JOURNAL   PLoS One 11 (8), e0160691 (2016)
   PUBMED   27513760
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 621)
  AUTHORS   Goring,D.R., Breitman,M.L. and Tsui,L.C.
  TITLE     Temporal regulation of six crystallin transcripts during mouse lens
            development
  JOURNAL   Exp Eye Res 54 (5), 785-795 (1992)
   PUBMED   1623964
REFERENCE   7  (bases 1 to 621)
  AUTHORS   Levan,G., Szpirer,J., Szpirer,C., Klinga,K., Hanson,C. and
            Islam,M.Q.
  TITLE     The gene map of the Norway rat (Rattus norvegicus) and comparative
            mapping with mouse and man
  JOURNAL   Genomics 10 (3), 699-718 (1991)
   PUBMED   1889815
REFERENCE   8  (bases 1 to 621)
  AUTHORS   Masaki,S. and Watanabe,T.
  TITLE     Linkage analysis of the mutation locus in the eye lens obsolescence
            (Elo) mouse
  JOURNAL   Genomics 5 (2), 259-263 (1989)
   PUBMED   2571575
REFERENCE   9  (bases 1 to 621)
  AUTHORS   Skow,L.C., Donner,M.E., Huang,S.M., Gardner,J.M., Taylor,B.A.,
            Beamer,W.G. and Lalley,P.A.
  TITLE     Mapping of mouse gamma crystallin genes on chromosome 1
  JOURNAL   Biochem Genet 26 (9-10), 557-570 (1988)
   PUBMED   3242494
REFERENCE   10 (bases 1 to 621)
  AUTHORS   Zneimer,S.M. and Womack,J.E.
  TITLE     Regional localization of the fibronectin and gamma crystallin genes
            to mouse chromosome 1 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 48 (4), 238-241 (1988)
   PUBMED   3248380
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC101869.13.
            
            On Nov 10, 2022 this sequence version replaced NM_007774.3.
            
            Summary: Three main families of major soluble proteins, the alpha,
            beta and gamma crystallins, are ubiquitously expressed in
            vertebrate lenses. This gene encodes a member of the
            gamma-crystallin family of proteins which may function as a
            structural component of the eye lens. Gamma-crystallins are a
            homogeneous group of highly symmetrical, monomeric proteins
            typically lacking connecting peptides and terminal extensions. They
            are differentially regulated after early development. Five
            gamma-crystallin genes (gamma-A through gamma-E) are tandemly
            organized in a genomic segment as a gene cluster in the mouse.
            Another gamma-crystallin gene (gamma-F) is found some distance
            upstream of the cluster on the same chromosome. Whether due to
            aging or mutations in specific genes, gamma-crystallins have been
            involved in cataract formation. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CO045983.1, CF738355.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AC101869.13        69126-69170
            46-288              AC101869.13        69276-69518
            289-621             AC101869.13        71774-72106
FEATURES             Location/Qualifiers
     source          1..621
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 32.84 cM"
     gene            1..621
                     /gene="Cryga"
                     /gene_synonym="Cryg-4; DGcry-4; Secc"
                     /note="crystallin, gamma A"
                     /db_xref="GeneID:12964"
                     /db_xref="MGI:MGI:88521"
     exon            1..45
                     /gene="Cryga"
                     /gene_synonym="Cryg-4; DGcry-4; Secc"
                     /inference="alignment:Splign:2.1.0"
     exon            46..288
                     /gene="Cryga"
                     /gene_synonym="Cryg-4; DGcry-4; Secc"
                     /inference="alignment:Splign:2.1.0"
     exon            289..621
                     /gene="Cryga"
                     /gene_synonym="Cryg-4; DGcry-4; Secc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      598..603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cryga"
                     /gene_synonym="Cryg-4; DGcry-4; Secc"
                     /note="hexamer: AATAAT"
     polyA_site      621
                     /gene="Cryga"
                     /gene_synonym="Cryg-4; DGcry-4; Secc"
                     /note="major polyA site"
ORIGIN      
        1 atcatactca acactgacca tttgctgtca acaacgatgg gaaagatcac cttctacgag
       61 gaccgcggct tccagggccg ctgctatgag tgcagcagcg actgccccaa cctgcagacc
      121 tacttcagcc gctgcaactc catccgtgtg gacagtggct gctggatgct ctatgagcgc
      181 cccaactacc agggctacca gtacttcctg cgtcgcgggg actaccctga ctaccagcag
      241 tggatgggtt tcagcgactc catccgctcc tgccgttcca ttccatacac cagctctcac
      301 aggataaggc tttatgagag agatgactac cggggccttg tgtctgagct catggacgac
      361 tgttcctgca tccacgatcg cttccgcctc catgagatct actccatgca cgtgctggag
      421 ggctgctggg tcctctatga gatgcccaac taccgaggcc gccaatacct gctcaggcct
      481 ggagactaca ggcgctacca cgactggggc gccatggatg ccaaggtcgg ctctctgaga
      541 cgggtcatgg atttgtacta agcctccttt tgcttgttac agcccatata tgcaataaat
      601 aatcaacctg tgttcctggc a
//
