LOCUS       NM_174848              10522 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus beta-gamma crystallin domain containing 3 (Crybg3),
            mRNA.
ACCESSION   NM_174848 XM_006522095
VERSION     NM_174848.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10522)
  AUTHORS   Mori,M., Liu,C., Yoshizawa,T., Miyahara,H., Dai,J., Igarashi,Y.,
            Cui,X., Li,Y., Kang,X. and Higuchi,K.
  TITLE     Polygenic control of the wavy coat of the NCT mouse: involvement of
            an intracisternal A particle insertional mutation of the protease,
            serine 53 (Prss53) gene, and a modifier gene
  JOURNAL   Mamm Genome 33 (3), 451-464 (2022)
   PUBMED   35067752
REFERENCE   2  (bases 1 to 10522)
  AUTHORS   Mori,M., Gotoh,S., Taketani,S., Hiai,H. and Higuchi,K.
  TITLE     Hereditary cataract of the Nakano mouse: Involvement of a
            hypomorphic mutation in the coproporphyrinogen oxidase gene
  JOURNAL   Exp Eye Res 112, 45-50 (2013)
   PUBMED   23631845
REFERENCE   3  (bases 1 to 10522)
  AUTHORS   Rajanikanth,V., Srivastava,S.S., Singh,A.K., Rajyalakshmi,M.,
            Chandra,K., Aravind,P., Sankaranarayanan,R. and Sharma,Y.
  TITLE     Aggregation-prone near-native intermediate formation during
            unfolding of a structurally similar nonlenticular
            betagamma-crystallin domain
  JOURNAL   Biochemistry 51 (43), 8502-8513 (2012)
   PUBMED   23043265
  REMARK    GeneRIF: The crystal structure determined at 1.86 A demonstrates
            that the beta-gamma crystallin domain of Crybg3 resembles more
            closely the lens beta-gamma crystallins than the microbial
            crystallins do.
REFERENCE   4  (bases 1 to 10522)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154473.2 and AC154854.2.
            
            On or before Feb 20, 2019 this sequence version replaced
            XM_006522095.3, NM_174848.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-303               AC154473.2         80386-80688
            304-370             AC154473.2         103569-103635
            371-801             AC154473.2         115790-116220
            802-6937            AC154473.2         121191-127326
            6938-6982           AC154473.2         128859-128903
            6983-7098           AC154473.2         129146-129261
            7099-7246           AC154473.2         130884-131031
            7247-7383           AC154473.2         137268-137404
            7384-7498           AC154473.2         138143-138257
            7499-7534           AC154473.2         139338-139373
            7535-7668           AC154473.2         141495-141628
            7669-7795           AC154473.2         144609-144735
            7796-7941           AC154473.2         150957-151102
            7942-8068           AC154473.2         151203-151329
            8069-8101           AC154473.2         152178-152210
            8102-8211           AC154473.2         156463-156572
            8212-8341           AC154473.2         159220-159349
            8342-8481           AC154854.2         198698-198837       c
            8482-8605           AC154854.2         195642-195765       c
            8606-8764           AC154854.2         188127-188285       c
            8765-8924           AC154854.2         187184-187343       c
            8925-10522          AC154854.2         184605-186202       c
FEATURES             Location/Qualifiers
     source          1..10522
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 34.83 cM"
     gene            1..10522
                     /gene="Crybg3"
                     /gene_synonym="5031404N19; Gm9581"
                     /note="beta-gamma crystallin domain containing 3"
                     /db_xref="GeneID:224273"
                     /db_xref="MGI:MGI:2676311"
     exon            1..303
                     /gene="Crybg3"
                     /gene_synonym="5031404N19; Gm9581"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..9013
                     /gene="Crybg3"
                     /gene_synonym="5031404N19; Gm9581"
                     /codon_start=1
                     /product="beta/gamma crystallin domain-containing protein
                     3"
                     /protein_id="NP_777273.3"
                     /db_xref="CCDS:CCDS28258.2"
                     /db_xref="GeneID:224273"
                     /db_xref="MGI:MGI:2676311"
                     /translation="MSGGRRRGSAPWHSFSRFFAPRNPSRDKEEEEEEKPGTGQPAGV
                     SRSAASVENEPVSTSQKKENALSSEAVKIPQAEDRRNHAEQPAILPMVDDLPKPKDLP
                     DSTPEAKTGESDRQPKESFFQFLGNLFNISGKSSLGEVKQSSFKDDQEKPEKDPQTPW
                     GPPEEGSQREEEAASHPARTQVLLGGQQESTSSELSDAFSLDSTQDSEQETTEMPKKD
                     TVGKPEKPSVTYATYRGATQIRKYLQQQPVLETMNHLDGEDGSSDSSPQAHAGSRSIR
                     DTVTVPLSTDSKDVATKGYLLGGPLEASGYSQINTNRESHQESVPGLQDIASSKCILN
                     KNSHGGLRSSWASPSSVSNPSYVVGEPDSQTESVLVCSSVFRGSKSSQGPCPEFQRKT
                     PTDSPPRVNSSAVTDGLPSVPGEEPARPQRPSVPDFSRSKSDGSDTTKMESTNLSSPH
                     KSIRHEDARLPEHKCGDKPAVDNPSRRTVNHACIMALQGHAVTDSELVNEGKKLPARD
                     SQKNMVSEILKETECASGREPTTLSHVRTPEVRIESLPKETEPPEPPCETETKRLGLE
                     LHVKTPHEMGKTQEDPGSVKGVSDSVVVACTESETAHELKSELNRNPTSESPFLLENS
                     QQGGVASDAEAPLHLDCKTSDYSASPPTLASRINRLGQLGFSGLKGERSSSSKTGQGK
                     VFSHPNECQEEGVGTHSEATDRENPPALYLGHASSTLESKEFLPHGEKCQSPSGPETA
                     GTQLAGVALNFEHGDTSEDLNSVPSHGPKKEELMSSNAKARKSTVEKSDSFPLETQTA
                     KMLGKGEVCDQSSFPVESSSGRRKALSTPSVSQAEPRDVPQCNISSSQVTVAEKLAET
                     VLSELNYLGMEKDEDVQPVDRKEIKQLCFSGGFKENHQTGISPASEHHGGQETEMNTP
                     DRSAAVLTSNLPGILPLPPEEESTRHRPQNCEASTCLITPSLAICVTKKSSSISETEG
                     LSLDNIFPKFQETDNTRVYTSFLSSDAHLEKNVFAPEGSSSLTVPSLLGLEKEASSRR
                     DNAYFQSAGTGNTSPSFCHTKGESTAVNSHDLPSNFESLKVTVNLTCEGASVIDPLGH
                     NSFYLALDTPSPKEAEVTSLQGCVGTHTRKACLDSPTTAYFDNLMKAETGTVAGAPVS
                     VNRSCQQCSEASADQTDSRRRARDPLLLRSGLPKRADTLTEEILSSVREELKSKHTVG
                     TCQEHLAQEDVMNPGTVKEAIPSEVVLAGIQLKESLDEKGVDSMSGVKEEEETSVSSA
                     VGETSLLFDFDRGNSSWMLEERARELVNEVIYAAQENLIRDAFDEIEDTRVSEPQANT
                     SKNWNGSGGGNPHAVVREFLVSEQAVNQSTCEISENEVLSKLSSVSYLVSGTESIKGR
                     EIVPYQECPDFGSGAGQSASVKLETLETVFQGEGVPRTRLDAKVKTGFLVSEDYKKVA
                     ETECVDNHKMAAADTRTLVLNFNLPFARDDIHVPSTSKNSFSDSLVCISEKSFPGHNK
                     STPLAMSDLGKAHKNDNEVNVGKMALTPSMLEIGKTNKRDVELNIMKHEAAPLMPHRE
                     KACKVDPELNSMKAEPEANVFARGSVYQMDAQMYVEKPEELPITLGMEKAFKTDSEGD
                     IGKAEVMPAMSELKTVHLKDAEGAIVKTEVAPISIEMESFYQKRAEGDVGKAGVASVM
                     PEVEIFYQSDGVGSASEAEATTVTLGMEDTYQKDEESTVAETDVIDMVPAELEMESIY
                     PKDSEGDTDSISEGMPAKLDVVNAYQKYSDRVTGRIERPVSPLRDAEDVLGNAETVPF
                     VLDVKETYQETVYPPLDILEKRIQRDTEESNGTTEPVPSKIEMEVMAPEDSSGSTENR
                     ELLPMEVAMERTNGTTPGVTIMQTDALGPAFENTKDPREYMEKSIGEIEEPPGEVKKG
                     LILHDDRLASHFRGYESPTLSKDYEGYPASAIPDVQEEDTVVRLKKIMSVPVVYDKRR
                     NLDCREEKEESNLAFVSQDEQDSSSFTILYEEPLQEEDRYTSAELRGSQSLLFPDTSS
                     MPGLACERSESRTDLVHHFEKEGKLGEAFDGDNSEMFLSVEAKRYKIYPLALSPIYED
                     DSSQEDVLSSEVSPGHHGSSKSRESANQPSSVLSLLQSVSERLQRNFDGDDRQEAEEE
                     EEEAVASGKDWRTEKREHVTFHLPDPSIPFYPEDNQEHAGIFKSYVEFSEPTTSSLQH
                     GRWSEKELFLQKSDMTSKLHSSLKSAYHQYLQTSRTHSSETGTRFGGTLQEPVSKYFR
                     VQDHAGRLSPYVENVDKQTLKCNPRPGKMIIYDLHGSKYKQEVYCNIPDATTWSFPNG
                     ALIKVVRGCWILYEKPHFQGQKCVLEEGERVLDRDWLLQNRKHPERNFVLGSIKRVLK
                     DCSIPVIELCPKTDPGCSPIYIHRSVPNVEELNIPKSTSVTVKSGVWLAYPDIHFKGQ
                     ATILEEDQGLFEISAAEMKSLHPLQMGGLKVEMPMNLKVILYEKPHFLGHTKEFSEHI
                     DSVPTFLKSDKDFHGIGSIRVIGGVWVAYEKEHFKGQQFLLEEGDFEDSSACGALSGP
                     IMSFRYLQANFIESSITLFESSHLESGKFIDITNQEISDLEEIGFGSETRSIHVKSGV
                     WVAYHQKFFCGDQYILEKGKYKCFFDWGGSSNTILSIRPIQLEPLGINEPTHLLKAFS
                     KAGFQGECIDFVKECADLTSFTPASFKVLRGCWLLLYYQEDGFYHQCVLEEGLYVDLT
                     SCGCPSARIRALQPIDYVFEEPSISLFALEHCEGRELHLEDAVNSVLNKDLHFYTQSV
                     WIKSGLWIAYEGSNFLGRQILLTPKEIPNWTAFSGWKTIGSVRPMKQPAVYIRIRNRA
                     QDEYLTVTGNPADARTMSVCISPYSGKDTQIWHYCRGLFKSKASHTCLDVIGGRDTPG
                     AKVALWTEHGQLRQKWRMSRNGTISSYLSDELVLDVKGGNYYDKTHVIVNQPLEGEET
                     QKWDIEIL"
     exon            304..370
                     /gene="Crybg3"
                     /gene_synonym="5031404N19; Gm9581"
                     /inference="alignment:Splign:2.1.0"
     exon            371..801
                     /gene="Crybg3"
                     /gene_synonym="5031404N19; Gm9581"
                     /inference="alignment:Splign:2.1.0"
     exon            802..6937
                     /gene="Crybg3"
                     /gene_synonym="5031404N19; Gm9581"
                     /inference="alignment:Splign:2.1.0"
     exon            6938..6982
                     /gene="Crybg3"
                     /gene_synonym="5031404N19; Gm9581"
                     /inference="alignment:Splign:2.1.0"
     exon            6983..7098
                     /gene="Crybg3"
                     /gene_synonym="5031404N19; Gm9581"
                     /inference="alignment:Splign:2.1.0"
     exon            7099..7246
                     /gene="Crybg3"
                     /gene_synonym="5031404N19; Gm9581"
                     /inference="alignment:Splign:2.1.0"
     exon            7247..7383
                     /gene="Crybg3"
                     /gene_synonym="5031404N19; Gm9581"
                     /inference="alignment:Splign:2.1.0"
     exon            7384..7498
                     /gene="Crybg3"
                     /gene_synonym="5031404N19; Gm9581"
                     /inference="alignment:Splign:2.1.0"
     exon            7499..7534
                     /gene="Crybg3"
                     /gene_synonym="5031404N19; Gm9581"
                     /inference="alignment:Splign:2.1.0"
     exon            7535..7668
                     /gene="Crybg3"
                     /gene_synonym="5031404N19; Gm9581"
                     /inference="alignment:Splign:2.1.0"
     exon            7669..7795
                     /gene="Crybg3"
                     /gene_synonym="5031404N19; Gm9581"
                     /inference="alignment:Splign:2.1.0"
     exon            7796..7941
                     /gene="Crybg3"
                     /gene_synonym="5031404N19; Gm9581"
                     /inference="alignment:Splign:2.1.0"
     exon            7942..8068
                     /gene="Crybg3"
                     /gene_synonym="5031404N19; Gm9581"
                     /inference="alignment:Splign:2.1.0"
     exon            8069..8101
                     /gene="Crybg3"
                     /gene_synonym="5031404N19; Gm9581"
                     /inference="alignment:Splign:2.1.0"
     exon            8102..8211
                     /gene="Crybg3"
                     /gene_synonym="5031404N19; Gm9581"
                     /inference="alignment:Splign:2.1.0"
     exon            8212..8341
                     /gene="Crybg3"
                     /gene_synonym="5031404N19; Gm9581"
                     /inference="alignment:Splign:2.1.0"
     exon            8342..8481
                     /gene="Crybg3"
                     /gene_synonym="5031404N19; Gm9581"
                     /inference="alignment:Splign:2.1.0"
     exon            8482..8605
                     /gene="Crybg3"
                     /gene_synonym="5031404N19; Gm9581"
                     /inference="alignment:Splign:2.1.0"
     exon            8606..8764
                     /gene="Crybg3"
                     /gene_synonym="5031404N19; Gm9581"
                     /inference="alignment:Splign:2.1.0"
     exon            8765..8924
                     /gene="Crybg3"
                     /gene_synonym="5031404N19; Gm9581"
                     /inference="alignment:Splign:2.1.0"
     exon            8925..10522
                     /gene="Crybg3"
                     /gene_synonym="5031404N19; Gm9581"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10496..10501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crybg3"
                     /gene_synonym="5031404N19; Gm9581"
                     /note="hexamer: AATAAA"
     polyA_site      10522
                     /gene="Crybg3"
                     /gene_synonym="5031404N19; Gm9581"
                     /note="major polyA site"
ORIGIN      
        1 gcacggggag cgctcgtgcc ggccgggctg gaggagccgc gccggcggcc cgggccgact
       61 ctcgctgcgc tcagcgagcc agggctgcgg ccaccctcgc tccggccagc ggctcgtcgg
      121 ggcccgcgga cggcgcggcc gagccggtgg ggagatgtcc ggcggccgca ggaggggcag
      181 cgccccctgg cacagcttct ctcggttctt cgctccgcgg aacccttctc gggacaagga
      241 agaggaagag gaggagaagc cggggaccgg ccagccggcg ggagtgagcc ggagtgcagc
      301 cagtgttgaa aatgagcccg tgagtacaag tcagaaaaag gaaaatgcgc tttcatcaga
      361 agcagtgaag attccccaag cggaggacag aaggaaccat gctgaacagc cggccatcct
      421 ccccatggtg gacgatctcc caaagccaaa ggaccttccg gattccaccc cagaggccaa
      481 aacaggagag agcgaccggc agccaaaaga aagctttttt cagttcctcg ggaacttatt
      541 caacatctcg ggaaagtcgt ctcttggaga ggttaagcag tcttccttca aagatgacca
      601 ggagaaacct gagaaggacc cacagactcc ctggggccct cctgaggagg ggagccaaag
      661 ggaggaggag gctgccagcc acccagcgag gactcaggta cttcttgggg gccaacagga
      721 atccacctcc tcagaactct ccgatgcctt ttctttggat tcaacacaag acagcgaaca
      781 ggaaaccact gagatgccca aaaaagacac ggtcggtaag ccagagaagc cttcagtgac
      841 atacgcaaca taccgaggcg ccacacaaat caggaagtat ttgcagcaac agcctgtgtt
      901 ggagactatg aatcacttag acggagaaga tggaagctct gactcaagtc cccaggcaca
      961 tgctggctcc agaagcataa gggacactgt gacggtccca ttgtcaacag acagcaaaga
     1021 cgtagccaca aaaggatatt tgcttggagg tccattagaa gcctctggtt atagccaaat
     1081 aaataccaac cgagaaagcc atcaggaaag cgtcccagga ctgcaggata ttgcttcatc
     1141 taagtgcatt ttaaataaaa atagccatgg aggcctcagg agcagttggg cctccccctc
     1201 ttccgtgtct aaccccagct atgttgttgg agagcctgac tcacaaacgg agagtgtttt
     1261 agtatgctca tcagtgttta gaggaagcaa aagtagccaa ggcccttgtc cagaatttca
     1321 gaggaaaact ccaaccgaca gtccaccgag agtaaacagc tctgcggtga ctgatgggct
     1381 gccatcagtg ccgggagagg agccggctcg gcctcagagg ccttctgttc ctgacttctc
     1441 ccgcagtaaa tctgatggga gtgacactac caaaatggaa agtacaaatt tgtcaagtcc
     1501 acataaatca attaggcatg aagatgcacg gttgccagag cataagtgtg gtgacaagcc
     1561 agctgtagat aacccatcaa ggcggactgt caatcacgcc tgcattatgg ctctccaggg
     1621 acatgctgtg acagactcag aacttgtaaa tgaaggaaag aagttacctg cccgagactc
     1681 gcagaaaaat atggtttcag aaatcttgaa agaaacagaa tgtgcctcag gcagggagcc
     1741 cacaacttta agtcatgtaa gaactcccga agtcagaatt gagtccttac ccaaagaaac
     1801 ggagccaccg gagccaccgt gtgaaacaga aaccaaaagg cttggtttgg aactacatgt
     1861 caaaactcct cacgagatgg gaaaaactca agaggaccct gggtctgtga agggtgtcag
     1921 tgactcggtg gttgtcgcat gcacagaaag tgaaacagca catgaactaa aatctgaact
     1981 gaacagaaat cctacttctg aatctccttt tctcttagag aattctcaac aaggcggcgt
     2041 tgcctctgat gctgaggcac ctcttcacct tgactgtaaa acgtctgatt acagtgcctc
     2101 acctcctacc ttggcttcta gaatcaacag gcttggccag ttgggtttct cgggcttaaa
     2161 gggagagaga tcttcgtcca gtaaaactgg acagggcaag gttttttctc accctaacga
     2221 gtgtcaagaa gaaggtgtgg gaactcattc tgaggctaca gacagggaga atcctcctgc
     2281 gctttacctt ggacatgcgt cctcaaccct tgaatccaag gaatttcttc ctcatggtga
     2341 aaaatgccaa tctccttcag gtcctgaaac tgctggcact cagttagctg gggtagcttt
     2401 aaactttgag catggagata cctctgagga tctcaattct gttccgtctc acggtcctaa
     2461 gaaagaagag ttaatgtcct caaatgcgaa agctagaaag agcactgtag agaagtctga
     2521 ttcttttccc ttggaaactc aaactgctaa aatgttagga aaaggagagg tttgtgatca
     2581 gagcagcttc cctgttgagt cgagttctgg aagacgaaaa gccttgtcca caccctctgt
     2641 ttctcaggca gaacccagag atgttcctca gtgcaacatt tcctcttctc aagtaacagt
     2701 tgcggaaaag ctagcagaga ctgttttatc ggagttaaat tatctaggta tggaaaagga
     2761 cgaagatgtt cagccagtgg atcgcaaaga gatcaaacag ttgtgtttca gcggtggttt
     2821 taaagagaat caccagactg ggatttctcc tgcctctgaa catcacggtg gacaagaaac
     2881 ggagatgaac accccagatc gctctgctgc tgttctcacg agtaatctgc ctgggattct
     2941 gccgctgcct ccagaggagg aatccacaag gcacaggcca cagaactgtg aagctagcac
     3001 ttgccttatc actccctctt tggctatttg tgtgacgaaa aagagttcta gcatctctga
     3061 aacggaaggg ctgagcttag acaacatttt tccaaaattc caagaaactg acaacacacg
     3121 cgtatataca tcttttctga gttctgatgc ccatctggag aaaaatgtgt ttgcacctga
     3181 gggctccagc tcactgactg tgccttctct cctgggttta gaaaaggaag cctcatcacg
     3241 cagagacaac gcttatttcc agagcgctgg tactggtaac acatctccct ccttttgtca
     3301 cactaaggga gagagcacag ctgtaaattc acatgatctc ccaagtaatt ttgagtcttt
     3361 aaaagttact gtaaatctca catgtgaagg tgcttctgtt attgacccac tgggccataa
     3421 tagcttttat ttggcattag atacacctag cccaaaagaa gcagaggtga cctcactcca
     3481 aggatgtgtg ggcactcata ctaggaaggc atgtcttgat tccccaacca ctgcctactt
     3541 tgacaatctc atgaaagcag agaccggaac agttgctggg gcaccggtgt cagttaaccg
     3601 atcatgccag cagtgttctg aggcatctgc tgaccagacg gattcaagga gaagagcacg
     3661 tgacccactt ttactcagaa gtggtttacc caaaagagct gatacattga ctgaggagat
     3721 tttaagttct gtcagagaag aactaaaatc caaacacacg gttggtacct gccaggagca
     3781 tctagcccaa gaggatgtaa tgaatccagg tactgtgaaa gaagctatcc catcagaagt
     3841 ggtgttagca gggattcaac tgaaagagag tttggacgag aaaggtgtgg acagtatgtc
     3901 aggagtcaaa gaggaagaag agaccagtgt ttcatctgca gttggtgaga caagtctcct
     3961 ttttgatttt gatagaggga atagctcttg gatgttagaa gaacgggcca gggaattagt
     4021 caatgaggtt atttatgcag cccaagaaaa tttgataagg gatgcttttg acgagattga
     4081 agatacccgg gtttctgaac ctcaggctaa cacttcaaaa aactggaatg gtagcggtgg
     4141 tggtaatcca cacgccgtag ttagggagtt cttggtatca gaacaggcag taaatcaaag
     4201 cacatgtgaa attagtgaaa atgaagtatt aagtaaactc tcctccgtga gttacttagt
     4261 tagtggcacc gaatcaatta aaggaagaga aattgttccc tatcaagagt gcccagattt
     4321 tggaagtggg gctggacagt ctgctagtgt caagttggag acattagaga ctgttttcca
     4381 aggtgaaggt gtaccccgga caaggttaga tgctaaagtg aagactggct tccttgtcag
     4441 tgaggactat aaaaaggtag cagaaacaga gtgtgtggat aatcacaaga tggcagcagc
     4501 agatactaga actcttgtat taaatttcaa cttgcctttt gcaagggatg acatccatgt
     4561 gcctagcacc tccaaaaaca gtttttctga tagccttgta tgcatatctg aaaaaagttt
     4621 tccaggacat aataaaagca caccccttgc gatgtcggac ttagggaaag cgcacaaaaa
     4681 cgataatgaa gtaaatgtag ggaaaatggc acttacacct tccatgttag agataggaaa
     4741 gacgaataaa agggatgttg aattgaatat tatgaaacat gaagcagccc ctcttatgcc
     4801 acatagagaa aaggcatgta aagtggaccc tgaattgaac agtatgaaag ctgagccaga
     4861 ggctaacgtt ttcgcaagag gaagtgtata ccaaatggat gctcagatgt atgttgaaaa
     4921 acccgaggaa ttgcccatca ctttgggaat ggaaaaagct tttaagacgg atagcgaggg
     4981 ggacattggc aaagctgagg tgatgcctgc tatgtcagaa ttgaaaactg tccatctaaa
     5041 agatgctgag ggagctatcg taaagaccga ggtggcacct atttcaattg agatggaaag
     5101 tttttatcaa aaacgtgctg aaggggatgt tggcaaggcg ggggttgcat ctgtgatgcc
     5161 agaagtggaa attttctacc aaagcgatgg tgtggggagt gcttcagagg ctgaagcgac
     5221 aactgtgaca ttaggaatgg aagacactta ccagaaggat gaagaaagta ctgttgcaga
     5281 gactgatgtg atagacatgg tacctgccga actagaaatg gaaagtattt atcctaagga
     5341 ctctgaagga gatactgaca gtatctctga ggggatgcct gccaagctag atgtggtaaa
     5401 tgcttatcaa aaatacagtg acagagttac tggaaggatc gagagacctg tgtctcccct
     5461 aagggatgct gaagatgtcc taggaaatgc tgaaacagtc ccatttgtgc tagatgtgaa
     5521 agaaacctac caggagacag tatatcctcc cttggacatc ttggaaaaac gaatccaaag
     5581 agacactgaa gagtcaaatg gaacaacaga gcctgtgcct tctaagatag aaatggaagt
     5641 aatggctcca gaggattcca gtggcagcac tgagaaccgt gaactgttac ctatggaggt
     5701 agctatggag cgcaccaatg gaacaacacc aggggtgacc attatgcaaa cggacgccct
     5761 aggtcctgcc tttgaaaata caaaggatcc tcgggagtac atggagaaga gcattggaga
     5821 aatagaagaa ccgcctggtg aggtaaaaaa aggcttgatc ttgcacgatg acagacttgc
     5881 ttcgcatttc aggggctatg agtcgcctac attaagtaag gattatgagg gctacccagc
     5941 ctcagcaata ccagatgtcc aagaggagga cacagtagta aggctcaaga aaataatgtc
     6001 tgtccctgta gtatatgaca agaggagaaa tctggattgt agagaagaaa aggaagagtc
     6061 caacttagcc tttgtctctc aagacgaaca agacagttct tcctttacca tattgtatga
     6121 ggaacccctt caagaggagg acaggtacac ctctgcagag ttacgagggt cacagtctct
     6181 cctgtttccc gacacctcca gcatgcctgg cctggcctgc gaaaggtctg agagcagaac
     6241 tgacctggtc catcattttg aaaaagaagg taaactgggt gaggcatttg atggagacaa
     6301 ttcagagatg ttcttatcgg tggaagccaa gaggtacaaa atctatccct tagccctgag
     6361 ccccatctat gaggatgaca gttcgcagga ggatgttctg tccagtgagg tctcgcctgg
     6421 tcaccatggc tcttccaagt caagggagag tgcaaaccag ccctcttctg tcttatccct
     6481 cctacagtca gtgtcagagc gcttacagag aaacttcgat ggagatgaca gacaggaggc
     6541 cgaggaagag gaggaggaag ctgtagcttc gggcaaagat tggagaactg aaaagaggga
     6601 gcatgttacc ttccacttgc cagatccttc catccccttt taccctgaag acaaccagga
     6661 acacgctgga attttcaagt cttatgtaga gttcagtgaa ccaacgacct ccagtctgca
     6721 gcatggccgg tggtcagaaa aggagttgtt tctccaaaaa tccgatatga cttctaagtt
     6781 gcattcttct ctgaagagtg cctatcatca gtacttgcag acttccagga ctcactcctc
     6841 agagacgggg accagatttg gtggcaccct tcaggaacca gtgtccaagt atttccgtgt
     6901 tcaggaccat gcaggcagac tgagtccgta tgtggagaac gttgacaaac aaactctgaa
     6961 gtgtaatcca aggcctggaa agatgataat ttatgatctc catggaagta aatataaaca
     7021 agaggtctac tgtaacatcc ctgatgctac aacatggtct ttcccgaatg gggcactgat
     7081 aaaagttgta aggggctgct ggattctgta tgagaagccc catttccaag gtcagaagtg
     7141 tgtgttggaa gaaggggaaa gagtgttaga ccgggactgg cttcttcaga acaggaagca
     7201 cccagaaagg aactttgtcc tgggctctat caaacgtgtc ttaaaggatt gcagcattcc
     7261 ggtgatagag ctgtgcccca agactgaccc tgggtgcagc cccatctaca tacaccgatc
     7321 tgtccccaat gtggaagagc tgaacatccc caagtctaca tccgtcactg tgaagtcagg
     7381 cgtttggctg gcctacccag atattcattt taaggggcaa gctacaattt tggaggaaga
     7441 ccaggggctc tttgagattt ctgcagccga gatgaaatca ctgcatcctc ttcaaatggg
     7501 tggactgaaa gtggaaatgc ctatgaactt aaaggttatc ctttatgaga aacctcactt
     7561 cctcggacat accaaagagt ttagtgaaca tatagattct gtccctacgt ttttaaaaag
     7621 cgataaggac ttccatggca tcggatcgat tcgtgtcatt ggtggagtgt gggttgccta
     7681 tgaaaaggaa catttcaaag gccagcaatt cctactagaa gaaggagact ttgaagatag
     7741 cagcgcttgt ggggccttaa gtggacccat catgtctttc cggtacctac aagctaattt
     7801 tatagaatct tcgatcacac tgtttgaatc atctcacctg gaaagtggga agtttattga
     7861 catcacgaat caggaaattt ctgacttaga agaaatcggc tttggcagcg agacaagatc
     7921 cattcacgtg aagagtggag tgtgggttgc ctaccaccag aagttcttct gcggcgatca
     7981 gtacatttta gagaaaggaa aatataaatg cttttttgat tggggaggat caagtaatac
     8041 aatcttgtct atccgaccaa tccaattgga accactcggg ataaatgagc ctacacactt
     8101 gctcaaagca ttcagtaaag caggcttcca aggagagtgt atcgatttcg taaaagaatg
     8161 tgccgacctg acctcgttca cgccggcatc ctttaaggtt ctccgtggct gctggctcct
     8221 cctgtattac caagaagacg gtttctatca tcagtgtgta ctggaagagg gcctctacgt
     8281 tgacctcact tcctgcggct gcccatcagc tagaatcaga gcactccagc ccatcgacta
     8341 tgtttttgaa gaaccttcca tcagcctttt tgctctggaa cattgtgagg gaagagaact
     8401 acatcttgaa gacgccgtga attccgtttt gaacaaagac ctacacttct acacccagtc
     8461 tgtgtggata aagagtggct tatggatcgc ttatgaaggt tccaatttct tgggaaggca
     8521 aatccttctt acgcctaagg agattccaaa ttggacagca ttcagtgggt ggaagacaat
     8581 cggctctgtg cgtcctatga agcagcctgc agtgtacatc agaataagga accgagccca
     8641 ggatgaatac ttgacagtca ctgggaaccc agcagatgca cggacaatgt ctgtctgcat
     8701 ctctccctac agtgggaagg acactcagat ctggcactac tgccgaggac tctttaaatc
     8761 caaggccagt catacatgtc ttgatgtgat tggaggccgg gacactcctg gagccaaggt
     8821 ggccttgtgg actgaacacg ggcagctcag gcagaagtgg agaatgagca ggaacggaac
     8881 catcagctct tatctcagtg atgaactcgt cctggatgtt aaaggaggaa actattatga
     8941 caagactcat gtcattgtga atcagcccct ggaaggggaa gagacccaga agtgggacat
     9001 tgaaatcctg tgagagaatc acaaaggcac ctccacccac tcacgtgctg tgtgcatgag
     9061 aaggaggccg ctgtgttcac actactgcac cgcaccgcac ccagaaagaa ctttctcccc
     9121 agcggtgacg actgctccat ggggaagcta aaatatcctc gccagttccg gagcaccctt
     9181 gtgaagaaaa tgtgttcttt cttccgatgg gtccagttgc agtggccaat ttcctgaaac
     9241 ctgtcttttc ctaagcgctg accgtgaact ctgcccttga tggcgctaag ctgtctggac
     9301 agtgcggtta caagcattag tgagtgtcct gctccacgcc tgtgtgaacc aggcacagga
     9361 aaacaaactc ctacaggctg tcatgctcct gcaggaagat gagtcatttt tagcaccacc
     9421 tgaagacttt tatttaaaac agctttcata ttaaactgct gctgtattaa acagacctta
     9481 gtttccatat agaaacttta taactgaaac acccttaagt atttatattc tttaattatc
     9541 tgacccacaa ggagggacct cggcttcttg aggcaaaagg cactagtact taaagtactt
     9601 tctgtggcgt gaccaatctt tactgttttt ctaactacag atgtatgaac atccttggag
     9661 tgcccaccca gcacccagtg ttgagtatta accttacatt ttacccgact taaggaggaa
     9721 tagtagtgta agagctgccc ggctccctgg agtaaagcgc tacacgcaag ttcccataaa
     9781 gcaaacaggg cttctacttt gtctgctcgg tgacagacaa ccaagttttc ctcccatttt
     9841 aaacaattac agctaagcaa aaccaggttt agaggcacta ccagtacaca cagtacctgc
     9901 acacgtacag gtcaacagcc ttctccctcc taagatggac ttaattcaga cagccactgc
     9961 tttcagcccc gattttggcc agaaagaaaa aatacttatt tttacagaaa ttctccagca
    10021 atatttttaa aaataccaac ttgtatgcac tttagaatgt aaaataacag tggatactta
    10081 agactcaaag agccaccact actttatttt ttatacactt ggtctttcca tgtatatacc
    10141 ggcctctgtt tttttttttt ccaatctctg gctcttctgt catcttccaa gcagcgtctg
    10201 agagctctgc acgggcacag atgctgggta cctcttatgg gtgtggcagt attacacgaa
    10261 acatgtttat tttaatgggg aaaggggtca tgtatgctca aagatatgta tattttcatt
    10321 gtaaagaaaa aaatccaact ttattcctaa gttttaattg ttagaaagta ttttcggagc
    10381 cagtgatgct ctttaaagga gttatttctt ccaaagaagc aagacgagcc aggttactga
    10441 cataatcttt atgacatgtg tactgcagtt gtgccttttc tacaacactg cattgaataa
    10501 acttgtccga agtatcgttt ta
//
