LOCUS       NM_001312895             940 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus crystallin, beta B1 (Crybb1), transcript variant 4,
            mRNA.
ACCESSION   NM_001312895
VERSION     NM_001312895.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 940)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 940)
  AUTHORS   Brioschi,S., Belk,J.A., Peng,V., Molgora,M., Rodrigues,P.F.,
            Nguyen,K.M., Wang,S., Du,S., Wang,W.L., Grajales-Reyes,G.E.,
            Ponce,J.M., Yuede,C.M., Li,Q., Baer,J.M., DeNardo,D.G.,
            Gilfillan,S., Cella,M., Satpathy,A.T. and Colonna,M.
  TITLE     A Cre-deleter specific for embryo-derived brain macrophages reveals
            distinct features of microglia and border macrophages
  JOURNAL   Immunity 56 (5), 1027-1045 (2023)
   PUBMED   36791722
REFERENCE   3  (bases 1 to 940)
  AUTHORS   Yu,W., Yu,Z., Wu,D., Zhang,J., Zhu,Y., Zhang,Y., Ning,H., Wang,M.,
            Zhang,J. and Zhao,J.
  TITLE     Lens-specific conditional knockout of Msx2 in mice leads to ocular
            anterior segment dysgenesis via activation of a calcium signaling
            pathway
  JOURNAL   Lab Invest 99 (11), 1714-1727 (2019)
   PUBMED   30683901
REFERENCE   4  (bases 1 to 940)
  AUTHORS   Limi,S., Zhao,Y., Guo,P., Lopez-Jones,M., Zheng,D., Singer,R.H.,
            Skoultchi,A.I. and Cvekl,A.
  TITLE     Bidirectional Analysis of Cryba4-Crybb1 Nascent Transcription and
            Nuclear Accumulation of Crybb3 mRNAs in Lens Fibers
  JOURNAL   Invest Ophthalmol Vis Sci 60 (1), 234-244 (2019)
   PUBMED   30646012
  REMARK    GeneRIF: The current study shows for the first time that two highly
            expressed lens crystallin genes, Cryba4 and Crybb1, can be
            simultaneously transcribed from adjacent bidirectional promoters
            and do not show nuclear accumulation.
REFERENCE   5  (bases 1 to 940)
  AUTHORS   Logan,C.M., Rajakaruna,S., Bowen,C., Radice,G.L., Robinson,M.L. and
            Menko,A.S.
  TITLE     N-cadherin regulates signaling mechanisms required for lens fiber
            cell elongation and lens morphogenesis
  JOURNAL   Dev Biol 428 (1), 118-134 (2017)
   PUBMED   28552735
REFERENCE   6  (bases 1 to 940)
  AUTHORS   Lovicu,F.J. and Overbeek,P.A.
  TITLE     Overlapping effects of different members of the FGF family on lens
            fiber differentiation in transgenic mice
  JOURNAL   Development 125 (17), 3365-3377 (1998)
   PUBMED   9693140
REFERENCE   7  (bases 1 to 940)
  AUTHORS   Liao,X., Du,Y., Morse,H.C. 3rd, Jenkins,N.A. and Copeland,N.G.
  TITLE     Proviral integrations at the Evi5 locus disrupt a novel 90 kDa
            protein with homology to the Tre2 oncogene and cell-cycle
            regulatory proteins
  JOURNAL   Oncogene 14 (9), 1023-1029 (1997)
   PUBMED   9070650
REFERENCE   8  (bases 1 to 940)
  AUTHORS   Reneker,L.W. and Overbeek,P.A.
  TITLE     Lens-specific expression of PDGF-A alters lens growth and
            development
  JOURNAL   Dev Biol 180 (2), 554-565 (1996)
   PUBMED   8954727
REFERENCE   9  (bases 1 to 940)
  AUTHORS   Duncan,M.K., Li,X., Ogino,H., Yasuda,K. and Piatigorsky,J.
  TITLE     Developmental regulation of the chicken beta B1-crystallin promoter
            in transgenic mice
  JOURNAL   Mech Dev 57 (1), 79-89 (1996)
   PUBMED   8817455
REFERENCE   10 (bases 1 to 940)
  AUTHORS   Hulsebos,T.J., Gilbert,D.J., Delattre,O., Smink,L.J., Dunham,I.,
            Westerveld,A., Thomas,G., Jenkins,N.A. and Copeland,N.G.
  TITLE     Assignment of the beta B1 crystallin gene (CRYBB1) to human
            chromosome 22 and mouse chromosome 5
  JOURNAL   Genomics 29 (3), 712-718 (1995)
   PUBMED   8575764
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC123795.4, CX767799.1 and
            CX767857.1.
            
            Summary: This gene encodes a member of the crystallin family of
            proteins that contribute to the transparency and refractive
            properties of the ocular lens. The encoded protein associates with
            other beta crystallin proteins to form dimers, tetramers and other
            higher-order complexes. This gene is located adjacent to a related
            crystallin gene on chromosome 5. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Aug 2015].
            
            Transcript Variant: This variant (4) differs in the 5' UTR,
            compared to variant 1. Variants 1 - 4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CX767799.1, CX767920.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN02415128, SAMN02415133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AC123795.4         28225-28278         c
            55-828              CX767799.1         1-774
            829-940             CX767857.1         705-816
FEATURES             Location/Qualifiers
     source          1..940
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 54.63 cM"
     gene            1..940
                     /gene="Crybb1"
                     /gene_synonym="3110006K12Rik; BB1CRY"
                     /note="crystallin, beta B1"
                     /db_xref="GeneID:12960"
                     /db_xref="MGI:MGI:104992"
     exon            1..81
                     /gene="Crybb1"
                     /gene_synonym="3110006K12Rik; BB1CRY"
                     /inference="alignment:Splign:2.1.0"
     exon            82..266
                     /gene="Crybb1"
                     /gene_synonym="3110006K12Rik; BB1CRY"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..845
                     /gene="Crybb1"
                     /gene_synonym="3110006K12Rik; BB1CRY"
                     /codon_start=1
                     /product="beta-crystallin B1"
                     /protein_id="NP_001299824.1"
                     /db_xref="CCDS:CCDS19537.1"
                     /db_xref="GeneID:12960"
                     /db_xref="MGI:MGI:104992"
                     /translation="MSQAAKASATTAVNPGPDGKGKGAPSTGPAPAPGPTPVPASVPR
                     PAAKVGDLPPGSYRLIVFEQENFQGRRVEFSGECLNLGDRGFDRVRSLIVVSGPWVAF
                     EQSAFRGEMFVLEKGEYPRWDTWTSSYRSDRLMSFRPIRMDSQEHKICLFEGANFKGN
                     TMEIQEDDVPSLWVYGFCDRVGSITVSGGTWVGYQYPGYRGYQYLLEPGDFRHWNEWG
                     AFQPQMQAVRRLRDRQWHQEGCFPVLTAEPPK"
     exon            267..385
                     /gene="Crybb1"
                     /gene_synonym="3110006K12Rik; BB1CRY"
                     /inference="alignment:Splign:2.1.0"
     exon            386..518
                     /gene="Crybb1"
                     /gene_synonym="3110006K12Rik; BB1CRY"
                     /inference="alignment:Splign:2.1.0"
     exon            519..661
                     /gene="Crybb1"
                     /gene_synonym="3110006K12Rik; BB1CRY"
                     /inference="alignment:Splign:2.1.0"
     exon            662..930
                     /gene="Crybb1"
                     /gene_synonym="3110006K12Rik; BB1CRY"
                     /inference="alignment:Splign:2.1.0"
     regulatory      906..911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crybb1"
                     /gene_synonym="3110006K12Rik; BB1CRY"
                     /note="hexamer: AATAAA"
     polyA_site      925
                     /gene="Crybb1"
                     /gene_synonym="3110006K12Rik; BB1CRY"
                     /note="major polyA site"
ORIGIN      
        1 cacagcaccc gcctgtccac caatacaggt aagaggggac tgccacacca ccagagaact
       61 gagaggagga cagaaacaga gcaccaggaa ccatgtccca ggctgccaag gcttcagcca
      121 ccacagcggt gaacccaggg cctgatggca agggaaaagg ggccccatcc acagggccag
      181 cccctgcccc tggccccact cctgtcccag cttctgtgcc caggcccgct gccaaagtag
      241 gggacctgcc tcctgggagc tacaggctga tcgtcttcga gcaggaaaac tttcagggcc
      301 gccgggtgga attctcgggg gagtgcctga atctggggga ccgtggcttc gacagagtgc
      361 gcagcctgat cgtcgtctcg ggaccctggg tggcctttga gcaatctgcc ttccgtggag
      421 agatgtttgt cctggagaag ggcgagtacc cacgctggga cacctggacc agcagttacc
      481 gcagtgaccg gctcatgtcc ttccggccca tcaggatgga ttcccaggaa cataagatct
      541 gcctgttcga aggggccaac ttcaagggca acaccatgga gatccaagag gatgatgtgc
      601 ccagcctctg ggtttatggc ttctgtgacc gtgtgggcag cataaccgtc tctggtggca
      661 catgggtcgg ctaccagtac ccaggttacc gtggctacca gtatctgctg gagcctggcg
      721 acttccggca ctggaacgag tggggcgcct tccagccgca gatgcaggct gtgcggcgcc
      781 tgcgggaccg ccagtggcac caagagggct gcttcccggt gctgacagcc gagcccccca
      841 agtgagacaa gctcccggcc tcccttctac agcccgccct gcctcacgtc ccatcttccc
      901 ctactaataa agttcttata gccgatacta aaaaaaaaaa
//
