LOCUS       NM_001312893             881 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus crystallin, beta B1 (Crybb1), transcript variant 3,
            mRNA.
ACCESSION   NM_001312893
VERSION     NM_001312893.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 881)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 881)
  AUTHORS   Brioschi,S., Belk,J.A., Peng,V., Molgora,M., Rodrigues,P.F.,
            Nguyen,K.M., Wang,S., Du,S., Wang,W.L., Grajales-Reyes,G.E.,
            Ponce,J.M., Yuede,C.M., Li,Q., Baer,J.M., DeNardo,D.G.,
            Gilfillan,S., Cella,M., Satpathy,A.T. and Colonna,M.
  TITLE     A Cre-deleter specific for embryo-derived brain macrophages reveals
            distinct features of microglia and border macrophages
  JOURNAL   Immunity 56 (5), 1027-1045 (2023)
   PUBMED   36791722
REFERENCE   3  (bases 1 to 881)
  AUTHORS   Yu,W., Yu,Z., Wu,D., Zhang,J., Zhu,Y., Zhang,Y., Ning,H., Wang,M.,
            Zhang,J. and Zhao,J.
  TITLE     Lens-specific conditional knockout of Msx2 in mice leads to ocular
            anterior segment dysgenesis via activation of a calcium signaling
            pathway
  JOURNAL   Lab Invest 99 (11), 1714-1727 (2019)
   PUBMED   30683901
REFERENCE   4  (bases 1 to 881)
  AUTHORS   Limi,S., Zhao,Y., Guo,P., Lopez-Jones,M., Zheng,D., Singer,R.H.,
            Skoultchi,A.I. and Cvekl,A.
  TITLE     Bidirectional Analysis of Cryba4-Crybb1 Nascent Transcription and
            Nuclear Accumulation of Crybb3 mRNAs in Lens Fibers
  JOURNAL   Invest Ophthalmol Vis Sci 60 (1), 234-244 (2019)
   PUBMED   30646012
  REMARK    GeneRIF: The current study shows for the first time that two highly
            expressed lens crystallin genes, Cryba4 and Crybb1, can be
            simultaneously transcribed from adjacent bidirectional promoters
            and do not show nuclear accumulation.
REFERENCE   5  (bases 1 to 881)
  AUTHORS   Logan,C.M., Rajakaruna,S., Bowen,C., Radice,G.L., Robinson,M.L. and
            Menko,A.S.
  TITLE     N-cadherin regulates signaling mechanisms required for lens fiber
            cell elongation and lens morphogenesis
  JOURNAL   Dev Biol 428 (1), 118-134 (2017)
   PUBMED   28552735
REFERENCE   6  (bases 1 to 881)
  AUTHORS   Lovicu,F.J. and Overbeek,P.A.
  TITLE     Overlapping effects of different members of the FGF family on lens
            fiber differentiation in transgenic mice
  JOURNAL   Development 125 (17), 3365-3377 (1998)
   PUBMED   9693140
REFERENCE   7  (bases 1 to 881)
  AUTHORS   Liao,X., Du,Y., Morse,H.C. 3rd, Jenkins,N.A. and Copeland,N.G.
  TITLE     Proviral integrations at the Evi5 locus disrupt a novel 90 kDa
            protein with homology to the Tre2 oncogene and cell-cycle
            regulatory proteins
  JOURNAL   Oncogene 14 (9), 1023-1029 (1997)
   PUBMED   9070650
REFERENCE   8  (bases 1 to 881)
  AUTHORS   Reneker,L.W. and Overbeek,P.A.
  TITLE     Lens-specific expression of PDGF-A alters lens growth and
            development
  JOURNAL   Dev Biol 180 (2), 554-565 (1996)
   PUBMED   8954727
REFERENCE   9  (bases 1 to 881)
  AUTHORS   Duncan,M.K., Li,X., Ogino,H., Yasuda,K. and Piatigorsky,J.
  TITLE     Developmental regulation of the chicken beta B1-crystallin promoter
            in transgenic mice
  JOURNAL   Mech Dev 57 (1), 79-89 (1996)
   PUBMED   8817455
REFERENCE   10 (bases 1 to 881)
  AUTHORS   Hulsebos,T.J., Gilbert,D.J., Delattre,O., Smink,L.J., Dunham,I.,
            Westerveld,A., Thomas,G., Jenkins,N.A. and Copeland,N.G.
  TITLE     Assignment of the beta B1 crystallin gene (CRYBB1) to human
            chromosome 22 and mouse chromosome 5
  JOURNAL   Genomics 29 (3), 712-718 (1995)
   PUBMED   8575764
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK014012.1, CX767595.1 and
            CA452040.1.
            
            Summary: This gene encodes a member of the crystallin family of
            proteins that contribute to the transparency and refractive
            properties of the ocular lens. The encoded protein associates with
            other beta crystallin proteins to form dimers, tetramers and other
            higher-order complexes. This gene is located adjacent to a related
            crystallin gene on chromosome 5. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Aug 2015].
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            compared to variant 1. Variants 1 - 4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CX767595.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AK014012.1         2-18
            18-860              CX767595.1         1-843
            861-881             CA452040.1         631-651
FEATURES             Location/Qualifiers
     source          1..881
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 54.63 cM"
     gene            1..881
                     /gene="Crybb1"
                     /gene_synonym="3110006K12Rik; BB1CRY"
                     /note="crystallin, beta B1"
                     /db_xref="GeneID:12960"
                     /db_xref="MGI:MGI:104992"
     exon            1..28
                     /gene="Crybb1"
                     /gene_synonym="3110006K12Rik; BB1CRY"
                     /inference="alignment:Splign:2.1.0"
     exon            29..207
                     /gene="Crybb1"
                     /gene_synonym="3110006K12Rik; BB1CRY"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..786
                     /gene="Crybb1"
                     /gene_synonym="3110006K12Rik; BB1CRY"
                     /codon_start=1
                     /product="beta-crystallin B1"
                     /protein_id="NP_001299822.1"
                     /db_xref="CCDS:CCDS19537.1"
                     /db_xref="GeneID:12960"
                     /db_xref="MGI:MGI:104992"
                     /translation="MSQAAKASATTAVNPGPDGKGKGAPSTGPAPAPGPTPVPASVPR
                     PAAKVGDLPPGSYRLIVFEQENFQGRRVEFSGECLNLGDRGFDRVRSLIVVSGPWVAF
                     EQSAFRGEMFVLEKGEYPRWDTWTSSYRSDRLMSFRPIRMDSQEHKICLFEGANFKGN
                     TMEIQEDDVPSLWVYGFCDRVGSITVSGGTWVGYQYPGYRGYQYLLEPGDFRHWNEWG
                     AFQPQMQAVRRLRDRQWHQEGCFPVLTAEPPK"
     exon            208..326
                     /gene="Crybb1"
                     /gene_synonym="3110006K12Rik; BB1CRY"
                     /inference="alignment:Splign:2.1.0"
     exon            327..459
                     /gene="Crybb1"
                     /gene_synonym="3110006K12Rik; BB1CRY"
                     /inference="alignment:Splign:2.1.0"
     exon            460..602
                     /gene="Crybb1"
                     /gene_synonym="3110006K12Rik; BB1CRY"
                     /inference="alignment:Splign:2.1.0"
     exon            603..871
                     /gene="Crybb1"
                     /gene_synonym="3110006K12Rik; BB1CRY"
                     /inference="alignment:Splign:2.1.0"
     regulatory      847..852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crybb1"
                     /gene_synonym="3110006K12Rik; BB1CRY"
                     /note="hexamer: AATAAA"
     polyA_site      866
                     /gene="Crybb1"
                     /gene_synonym="3110006K12Rik; BB1CRY"
                     /note="major polyA site"
ORIGIN      
        1 cacagcaccc gcctgtccac caatacagga accatgtccc aggctgccaa ggcttcagcc
       61 accacagcgg tgaacccagg gcctgatggc aagggaaaag gggccccatc cacagggcca
      121 gcccctgccc ctggccccac tcctgtccca gcttctgtgc ccaggcccgc tgccaaagta
      181 ggggacctgc ctcctgggag ctacaggctg atcgtcttcg agcaggaaaa ctttcagggc
      241 cgccgggtgg aattctcggg ggagtgcctg aatctggggg accgtggctt cgacagagtg
      301 cgcagcctga tcgtcgtctc gggaccctgg gtggcctttg agcaatctgc cttccgtgga
      361 gagatgtttg tcctggagaa gggcgagtac ccacgctggg acacctggac cagcagttac
      421 cgcagtgacc ggctcatgtc cttccggccc atcaggatgg attcccagga acataagatc
      481 tgcctgttcg aaggggccaa cttcaagggc aacaccatgg agatccaaga ggatgatgtg
      541 cccagcctct gggtttatgg cttctgtgac cgtgtgggca gcataaccgt ctctggtggc
      601 acatgggtcg gctaccagta cccaggttac cgtggctacc agtatctgct ggagcctggc
      661 gacttccggc actggaacga gtggggcgcc ttccagccgc agatgcaggc tgtgcggcgc
      721 ctgcgggacc gccagtggca ccaagagggc tgcttcccgg tgctgacagc cgagcccccc
      781 aagtgagaca agctcccggc ctcccttcta cagcccgccc tgcctcacgt cccatcttcc
      841 cctactaata aagttcttat agccgatact aaaaaaaaaa a
//
