LOCUS       NM_021541                740 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus crystallin, beta A2 (Cryba2), mRNA.
ACCESSION   NM_021541
VERSION     NM_021541.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 740)
  AUTHORS   Schmid,P.W.N., Lim,N.C.H., Peters,C., Back,K.C., Bourgeois,B.,
            Pirolt,F., Richter,B., Peschek,J., Puk,O., Amarie,O.V., Dalke,C.,
            Haslbeck,M., Weinkauf,S., Madl,T., Graw,J. and Buchner,J.
  TITLE     Imbalances in the eye lens proteome are linked to cataract
            formation
  JOURNAL   Nat Struct Mol Biol 28 (2), 143-151 (2021)
   PUBMED   33432246
REFERENCE   2  (bases 1 to 740)
  AUTHORS   Abdellatif,A.M., Oishi,H., Itagaki,T., Jung,Y., Shawki,H.H.,
            Okita,Y., Hasegawa,Y., Suzuki,H., El-Morsy,S.E., El-Sayed,M.A.,
            Shoaib,M.B., Sugiyama,F. and Takahashi,S.
  TITLE     beta-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine
            Cell Development
  JOURNAL   PLoS One 11 (2), e0150010 (2016)
   PUBMED   26901059
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 740)
  AUTHORS   Jin,C., Chen,J., Meng,Q., Carreira,V., Tam,N.N., Geh,E.,
            Karyala,S., Ho,S.M., Zhou,X., Medvedovic,M. and Xia,Y.
  TITLE     Deciphering gene expression program of MAP3K1 in mouse eyelid
            morphogenesis
  JOURNAL   Dev Biol 374 (1), 96-107 (2013)
   PUBMED   23201579
REFERENCE   4  (bases 1 to 740)
  AUTHORS   Wende,H., Lechner,S.G., Cheret,C., Bourane,S., Kolanczyk,M.E.,
            Pattyn,A., Reuter,K., Munier,F.L., Carroll,P., Lewin,G.R. and
            Birchmeier,C.
  TITLE     The transcription factor c-Maf controls touch receptor development
            and function
  JOURNAL   Science 335 (6074), 1373-1376 (2012)
   PUBMED   22345400
REFERENCE   5  (bases 1 to 740)
  AUTHORS   Xie,Q. and Cvekl,A.
  TITLE     The orchestration of mammalian tissue morphogenesis through a
            series of coherent feed-forward loops
  JOURNAL   J Biol Chem 286 (50), 43259-43271 (2011)
   PUBMED   21998302
REFERENCE   6  (bases 1 to 740)
  AUTHORS   Gonzalez,M., Ruggiero,F.P., Chang,Q., Shi,Y.J., Rich,M.M.,
            Kraner,S. and Balice-Gordon,R.J.
  TITLE     Disruption of Trkb-mediated signaling induces disassembly of
            postsynaptic receptor clusters at neuromuscular junctions
  JOURNAL   Neuron 24 (3), 567-583 (1999)
   PUBMED   10595510
REFERENCE   7  (bases 1 to 740)
  AUTHORS   Lovicu,F.J. and Overbeek,P.A.
  TITLE     Overlapping effects of different members of the FGF family on lens
            fiber differentiation in transgenic mice
  JOURNAL   Development 125 (17), 3365-3377 (1998)
   PUBMED   9693140
REFERENCE   8  (bases 1 to 740)
  AUTHORS   Hulsebos,T.J., Gilbert,D.J., Delattre,O., Smink,L.J., Dunham,I.,
            Westerveld,A., Thomas,G., Jenkins,N.A. and Copeland,N.G.
  TITLE     Assignment of the beta B1 crystallin gene (CRYBB1) to human
            chromosome 22 and mouse chromosome 5
  JOURNAL   Genomics 29 (3), 712-718 (1995)
   PUBMED   8575764
REFERENCE   9  (bases 1 to 740)
  AUTHORS   Hulsebos,T.J., Cerosaletti,K.M., Fournier,R.E., Sinke,R.J.,
            Rocchi,M., Marzella,R., Jenkins,N.A., Gilbert,D.J. and
            Copeland,N.G.
  TITLE     Identification of the human beta A2 crystallin gene (CRYBA2):
            localization of the gene on human chromosome 2 and of the
            homologous gene on mouse chromosome 1
  JOURNAL   Genomics 28 (3), 543-548 (1995)
   PUBMED   7490092
REFERENCE   10 (bases 1 to 740)
  AUTHORS   Hulsebos,T.J., Jenkins,N.A., Gilbert,D.J. and Copeland,N.G.
  TITLE     The beta crystallin genes on human chromosome 22 define a new
            region of homology with mouse chromosome 5
  JOURNAL   Genomics 25 (2), 574-576 (1995)
   PUBMED   7789995
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF740624.1, AC139023.15 and BC052746.1.
            
            [WARNING] On Jul 22, 2024 this sequence was replaced by
            NM_021541.4.
            
            On Aug 14, 2013 this sequence version replaced NM_021541.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF740538.1, AY160973.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 CF740624.1         1-4
            5-37                AC139023.15        84406-84438         c
            38-740              BC052746.1         1-703
FEATURES             Location/Qualifiers
     source          1..740
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 38.54 cM"
     gene            1..740
                     /gene="Cryba2"
                     /gene_synonym="E130107M19Rik"
                     /note="crystallin, beta A2"
                     /db_xref="GeneID:12958"
                     /db_xref="MGI:MGI:104336"
     exon            1..67
                     /gene="Cryba2"
                     /gene_synonym="E130107M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            68..232
                     /gene="Cryba2"
                     /gene_synonym="E130107M19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..665
                     /gene="Cryba2"
                     /gene_synonym="E130107M19Rik"
                     /note="betaA2-crystallin; lens structural protein; beta-A2
                     crystallin"
                     /codon_start=1
                     /product="beta-crystallin A2"
                     /protein_id="NP_067516.1"
                     /db_xref="CCDS:CCDS15059.1"
                     /db_xref="GeneID:12958"
                     /db_xref="MGI:MGI:104336"
                     /translation="MSSAPAPGSAPVCLTLWDEEDFQGRRCRLLSDCANVCERGALRR
                     VRSVKVENGAWVAFEYPDFQGQQFILEKGDYPCWSAWSGSSGHHSNQLLSFRPVLCAN
                     HSDSRVTLFEGENFQGCKFELSDDYPSLPSMGWTSKDVGSLKVSSGAWVAYQYPGYRG
                     YQYVLERDRHSGEFRTYSDFGTQAHTGQLQSIRRVQH"
     exon            233..374
                     /gene="Cryba2"
                     /gene_synonym="E130107M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            375..517
                     /gene="Cryba2"
                     /gene_synonym="E130107M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            518..720
                     /gene="Cryba2"
                     /gene_synonym="E130107M19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      701..706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cryba2"
                     /gene_synonym="E130107M19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      720
                     /gene="Cryba2"
                     /gene_synonym="E130107M19Rik"
                     /note="major polyA site"
ORIGIN      
        1 aaagcagcga acaccaggct cgcgcgcagc ctctccattt tccgtcggtg cggtgctcac
       61 tcactcgcga catgagcagc gcccccgcgc cgggctcggc gcccgtttgc ctcacactct
      121 gggatgagga ggacttccag ggtcgtcgct gccggctact gagcgactgt gccaacgtct
      181 gtgagcgggg agccctgcgc agggtgcgct cagtcaaggt ggaaaacggc gcatgggtgg
      241 ccttcgagta ccccgacttc cagggacagc agttcattct agagaaggga gactatcctt
      301 gctggagtgc ctggagcgga agcagtggcc accacagcaa ccaattgctg tccttcaggc
      361 cagtgctctg tgcgaaccac agcgacagcc gcgtgacact gtttgagggg gaaaacttcc
      421 agggctgcaa gtttgaactc agtgatgact acccatcact gccttccatg ggctggacca
      481 gcaaagatgt gggttccctg aaagtcagct ccggagcatg ggtggcctac cagtaccctg
      541 gctaccgagg ttaccagtat gtcttagaaa gggaccggca cagcggggag tttcgaacct
      601 acagtgactt tggcacacag gcccacactg gacagctgca gtccattcga agagtccagc
      661 attaggctcc acattcccag tcatcaccag taagattctc aataaaagct ctagaatcta
      721 aaaaaaaaaa aaaaaaaaaa
//
