LOCUS       NM_009965                819 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus crystallin, beta A1 (Cryba1), transcript variant 1,
            mRNA.
ACCESSION   NM_009965
VERSION     NM_009965.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 819)
  AUTHORS   Joseph,R., Robinson,M.L., Lambert,L. and Srivastava,O.P.
  TITLE     Lens-specific betaA3/A1-conditional knockout mice: Phenotypic
            characteristics and calpain activation causing protein degradation
            and insolubilization
  JOURNAL   PLoS One 18 (3), e0281386 (2023)
   PUBMED   36989286
  REMARK    GeneRIF: Lens-specific betaA3/A1-conditional knockout mice:
            Phenotypic characteristics and calpain activation causing protein
            degradation and insolubilization.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 819)
  AUTHORS   Shang,P., Stepicheva,N., Teel,K., McCauley,A., Fitting,C.S.,
            Hose,S., Grebe,R., Yazdankhah,M., Ghosh,S., Liu,H., Strizhakova,A.,
            Weiss,J., Bhutto,I.A., Lutty,G.A., Jayagopal,A., Qian,J.,
            Sahel,J.A., Samuel Zigler,J. Jr., Handa,J.T., Sergeev,Y.,
            Rajala,R.V.S., Watkins,S. and Sinha,D.
  TITLE     betaA3/A1-crystallin regulates apical polarity and EGFR endocytosis
            in retinal pigmented epithelial cells
  JOURNAL   Commun Biol 4 (1), 850 (2021)
   PUBMED   34239035
  REMARK    GeneRIF: betaA3/A1-crystallin regulates apical polarity and EGFR
            endocytosis in retinal pigmented epithelial cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 819)
  AUTHORS   Ghosh,S., Liu,H., Yazdankhah,M., Stepicheva,N., Shang,P.,
            Vaidya,T., Hose,S., Gupta,U., Calderon,M.J., Hu,M.W., Nair,A.P.,
            Weiss,J., Fitting,C.S., Bhutto,I.A., Gadde,S.G.K., Naik,N.K.,
            Jaydev,C., Lutty,G.A., Handa,J.T., Jayagopal,A., Qian,J.,
            Sahel,J.A., Rajasundaram,D., Sergeev,Y., Zigler,J.S. Jr., Sethu,S.,
            Watkins,S., Ghosh,A. and Sinha,D.
  TITLE     betaA1-crystallin regulates glucose metabolism and mitochondrial
            function in mouse retinal astrocytes by modulating PTP1B activity
  JOURNAL   Commun Biol 4 (1), 248 (2021)
   PUBMED   33627831
  REMARK    GeneRIF: betaA1-crystallin regulates glucose metabolism and
            mitochondrial function in mouse retinal astrocytes by modulating
            PTP1B activity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 819)
  AUTHORS   Yu,W., Yu,Z., Wu,D., Zhang,J., Zhu,Y., Zhang,Y., Ning,H., Wang,M.,
            Zhang,J. and Zhao,J.
  TITLE     Lens-specific conditional knockout of Msx2 in mice leads to ocular
            anterior segment dysgenesis via activation of a calcium signaling
            pathway
  JOURNAL   Lab Invest 99 (11), 1714-1727 (2019)
   PUBMED   30683901
REFERENCE   5  (bases 1 to 819)
  AUTHORS   Ghosh,S., Padmanabhan,A., Vaidya,T., Watson,A.M., Bhutto,I.A.,
            Hose,S., Shang,P., Stepicheva,N., Yazdankhah,M., Weiss,J., Das,M.,
            Gopikrishna,S., Aishwarya, Yadav,N., Berger,T., Mak,T.W., Xia,S.,
            Qian,J., Lutty,G.A., Jayagopal,A., Zigler,J.S. Jr., Sethu,S.,
            Handa,J.T., Watkins,S.C., Ghosh,A. and Sinha,D.
  TITLE     Neutrophils homing into the retina trigger pathology in early
            age-related macular degeneration
  JOURNAL   Commun Biol 2, 348 (2019)
   PUBMED   31552301
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 819)
  AUTHORS   Griffin,C.S. and Muggleton-Harris,A.L.
  TITLE     Localisation of the beta crystallin Cryb gene to mouse Chromosome
            2B-->C1 by in situ hybridisation
  JOURNAL   Cytogenet Cell Genet 61 (2), 141-142 (1992)
   PUBMED   1395724
REFERENCE   7  (bases 1 to 819)
  AUTHORS   Piatigorsky,J. and Wistow,G.J.
  TITLE     Enzyme/crystallins: gene sharing as an evolutionary strategy
  JOURNAL   Cell 57 (2), 197-199 (1989)
   PUBMED   2649248
  REMARK    Review article
REFERENCE   8  (bases 1 to 819)
  AUTHORS   Schurr,E., Skamene,E., Nesbitt,M., Hynes,R. and Gros,P.
  TITLE     Identification of a linkage group including the Bcg gene by
            restriction fragment length polymorphism analysis
  JOURNAL   Curr Top Microbiol Immunol 137, 310-315 (1988)
   PUBMED   2901325
REFERENCE   9  (bases 1 to 819)
  AUTHORS   Peterson,C.A. and Piatigorsky,J.
  TITLE     Preferential conservation of the globular domains of the beta
            A3/A1-crystallin polypeptide of the chicken eye lens
  JOURNAL   Gene 45 (2), 139-147 (1986)
   PUBMED   3803920
REFERENCE   10 (bases 1 to 819)
  AUTHORS   Inana,G., Piatigorsky,J., Norman,B., Slingsby,C. and Blundell,T.
  TITLE     Gene and protein structure of a beta-crystallin polypeptide in
            murine lens: relationship of exons and structural motifs
  JOURNAL   Nature 302 (5906), 310-315 (1983)
   PUBMED   6835368
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AJ239052.1 and CN539082.1.
            
            On Sep 14, 2015 this sequence version replaced NM_009965.2.
            
            Summary: Mammalian lens crystallins are divided into alpha, beta,
            and gamma families. Alpha and beta families are further divided
            into acidic and basic groups. Seven protein regions exist in
            crystallins: four homologous motifs, a connecting peptide, and N-
            and C-terminal extensions. Beta-crystallins, the most
            heterogeneous, differ by the presence of the C-terminal extension
            (present in the basic group, none in the acidic group).
            Beta-crystallins form aggregates of different sizes and are able to
            self-associate to form dimers or to form heterodimers with other
            beta-crystallins. This gene, a beta acidic group member, encodes
            two proteins (crystallin, beta A3 and crystallin, beta A1) from a
            single mRNA. Two transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CN539082.1, CB848756.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-683               AJ239052.1         1-683
            684-819             CN539082.1         657-792
FEATURES             Location/Qualifiers
     source          1..819
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     gene            1..819
                     /gene="Cryba1"
                     /gene_synonym="BA3/A1; Cryb"
                     /note="crystallin, beta A1"
                     /db_xref="GeneID:12957"
                     /db_xref="MGI:MGI:88518"
     exon            1..43
                     /gene="Cryba1"
                     /gene_synonym="BA3/A1; Cryb"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..660
                     /gene="Cryba1"
                     /gene_synonym="BA3/A1; Cryb"
                     /note="isoform 1 is encoded by transcript variant 1;
                     beta-crystallin A1; beta-A3/A1-crystallin;
                     beta-A1-crystallin"
                     /codon_start=1
                     /product="beta-crystallin A1 isoform 1"
                     /protein_id="NP_034095.1"
                     /db_xref="CCDS:CCDS25084.1"
                     /db_xref="GeneID:12957"
                     /db_xref="MGI:MGI:88518"
                     /translation="METQTVQRELETLPTTKMAQTNPMPGSLGPWKITIYDQENFQGK
                     RMEFTSSCPNVSERNFDNVRSLKVECGAWIGYEHTSFCGQQFILERGEYPRWDAWSGS
                     NAYHIERLMSFRPICSANHKESKITIFEKENFIGRQWEICDDYPSLQAMGWFNNEVGS
                     MKIQCGAWVCYQYPGYRGYQYILECDHHGGDYKHWPEWGSHAQTSQIQSIRRIQQ"
     exon            44..108
                     /gene="Cryba1"
                     /gene_synonym="BA3/A1; Cryb"
                     /inference="alignment:Splign:2.1.0"
     exon            109..227
                     /gene="Cryba1"
                     /gene_synonym="BA3/A1; Cryb"
                     /inference="alignment:Splign:2.1.0"
     exon            228..369
                     /gene="Cryba1"
                     /gene_synonym="BA3/A1; Cryb"
                     /inference="alignment:Splign:2.1.0"
     exon            370..512
                     /gene="Cryba1"
                     /gene_synonym="BA3/A1; Cryb"
                     /inference="alignment:Splign:2.1.0"
     exon            513..801
                     /gene="Cryba1"
                     /gene_synonym="BA3/A1; Cryb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      764..769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cryba1"
                     /gene_synonym="BA3/A1; Cryb"
     polyA_site      801
                     /gene="Cryba1"
                     /gene_synonym="BA3/A1; Cryb"
ORIGIN      
        1 aagctgcacc agatggagac ccagactgtg cagcgggagt tggaaactct tccaaccacc
       61 aagatggctc agaccaaccc tatgccagga tccttggggc catggaagat aaccatctac
      121 gatcaagaga acttccaggg caagaggatg gagttcacca gctcctgccc aaatgtctct
      181 gaacgtaatt ttgataatgt ccggtcactt aaggtggagt gtggcgcctg gattggttat
      241 gaacacacca gcttctgtgg gcaacagttc atcctggaaa gaggagaata ccctcgatgg
      301 gatgcctgga gcgggagcaa tgcctatcat attgagcgtc tcatgtcctt ccgacccatc
      361 tgttccgcta atcataaaga gtctaagatt accatcttcg agaaagagaa ctttattgga
      421 cgccagtggg aaatctgtga tgactaccct tccttgcaag ccatgggttg gttcaacaat
      481 gaagttggtt ccatgaagat acaatgtggg gcctgggttt gctaccagta ccctggatat
      541 cgtggttatc agtatatctt ggagtgtgac caccatggag gagactacaa gcactggcca
      601 gagtggggat ctcacgccca gacttcccag atccaatcaa ttcgccgaat acaacaatag
      661 agcaaaagtt ccaaaaatcc ctcaagcatg acatcttgct aagcactcta gaatttcatg
      721 ttctgcccag acactgcttc caaatgttag cgctaaaatc cacaataaat gtcatttaaa
      781 aaaaagtacc ttggaaacgg aaaaaaaaaa aaaaaaaaa
//
