LOCUS       NM_007771               3035 bp    mRNA    linear   ROD 01-FEB-2024
DEFINITION  Mus musculus cryptochrome circadian regulator 1 (Cry1), mRNA.
ACCESSION   NM_007771
VERSION     NM_007771.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3035)
  AUTHORS   De Virgiliis,F., Mueller,F., Palmisano,I., Chadwick,J.S.,
            Luengo-Gutierrez,L., Giarrizzo,A., Yan,Y., Danzi,M.C.,
            Picon-Munoz,C., Zhou,L., Kong,G., Serger,E., Hutson,T.H.,
            Maldonado-Lasuncion,I., Song,Y., Scheiermann,C., Brancaccio,M. and
            Di Giovanni,S.
  TITLE     The circadian clock time tunes axonal regeneration
  JOURNAL   Cell Metab 35 (12), 2153-2164 (2023)
   PUBMED   37951214
REFERENCE   2  (bases 1 to 3035)
  AUTHORS   Lin,L., Huang,Y., Wang,J., Guo,X., Yu,F., He,D., Wu,C., Guo,L. and
            Wu,B.
  TITLE     CRY1/2 regulate rhythmic CYP2A5 in mouse liver through repression
            of E4BP4
  JOURNAL   Biochem Pharmacol 217, 115843 (2023)
   PUBMED   37797722
  REMARK    GeneRIF: CRY1/2 regulate rhythmic CYP2A5 in mouse liver through
            repression of E4BP4.
REFERENCE   3  (bases 1 to 3035)
  AUTHORS   Sato,S., Hishida,T., Kinouchi,K., Hatanaka,F., Li,Y., Nguyen,Q.,
            Chen,Y., Wang,P.H., Kessenbrock,K., Li,W., Izpisua Belmonte,J.C.
            and Sassone-Corsi,P.
  TITLE     The circadian clock CRY1 regulates pluripotent stem cell identity
            and somatic cell reprogramming
  JOURNAL   Cell Rep 42 (6), 112590 (2023)
   PUBMED   37261952
  REMARK    GeneRIF: The circadian clock CRY1 regulates pluripotent stem cell
            identity and somatic cell reprogramming.
REFERENCE   4  (bases 1 to 3035)
  AUTHORS   Schirmer,A.E., Kumar,V., Schook,A., Song,E.J., Marshall,M.S. and
            Takahashi,J.S.
  TITLE     Cry1 expression during postnatal development is critical for the
            establishment of normal circadian period
  JOURNAL   Front Neurosci 17, 1166137 (2023)
   PUBMED   37389366
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3035)
  AUTHORS   Hitrec,T., Petit,C., Cryer,E., Muir,C., Tal,N., Fustin,J.M.,
            Hughes,A.T.L. and Piggins,H.D.
  TITLE     Timed exercise stabilizes behavioral rhythms but not molecular
            programs in the brain's suprachiasmatic clock
  JOURNAL   iScience 26 (2), 106002 (2023)
   PUBMED   36866044
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3035)
  AUTHORS   van der Horst,G.T., Muijtjens,M., Kobayashi,K., Takano,R.,
            Kanno,S., Takao,M., de Wit,J., Verkerk,A., Eker,A.P., van
            Leenen,D., Buijs,R., Bootsma,D., Hoeijmakers,J.H. and Yasui,A.
  TITLE     Mammalian Cry1 and Cry2 are essential for maintenance of circadian
            rhythms
  JOURNAL   Nature 398 (6728), 627-630 (1999)
   PUBMED   10217146
REFERENCE   7  (bases 1 to 3035)
  AUTHORS   Thresher,R.J., Vitaterna,M.H., Miyamoto,Y., Kazantsev,A., Hsu,D.S.,
            Petit,C., Selby,C.P., Dawut,L., Smithies,O., Takahashi,J.S. and
            Sancar,A.
  TITLE     Role of mouse cryptochrome blue-light photoreceptor in circadian
            photoresponses
  JOURNAL   Science 282 (5393), 1490-1494 (1998)
   PUBMED   9822380
REFERENCE   8  (bases 1 to 3035)
  AUTHORS   Kobayashi,K., Kanno,S., Smit,B., van der Horst,G.T., Takao,M. and
            Yasui,A.
  TITLE     Characterization of photolyase/blue-light receptor homologs in
            mouse and human cells
  JOURNAL   Nucleic Acids Res 26 (22), 5086-5092 (1998)
   PUBMED   9801304
REFERENCE   9  (bases 1 to 3035)
  AUTHORS   Miyamoto,Y. and Sancar,A.
  TITLE     Vitamin B2-based blue-light photoreceptors in the
            retinohypothalamic tract as the photoactive pigments for setting
            the circadian clock in mammals
  JOURNAL   Proc Natl Acad Sci U S A 95 (11), 6097-6102 (1998)
   PUBMED   9600923
REFERENCE   10 (bases 1 to 3035)
  AUTHORS   van der Spek,P.J., Kobayashi,K., Bootsma,D., Takao,M., Eker,A.P.
            and Yasui,A.
  TITLE     Cloning, tissue expression, and mapping of a human photolyase
            homolog with similarity to plant blue-light receptors
  JOURNAL   Genomics 37 (2), 177-182 (1996)
   PUBMED   8921389
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC085499.1.
            
            [WARNING] On Mar 12, 2024 this sequence was replaced by
            NM_007771.4.
            
            On Nov 15, 2004 this sequence version replaced NM_007771.2.
            
            Summary: This gene encodes a flavin adenine dinucleotide-binding
            protein that is a key component of the circadian core oscillator
            complex, which regulates the circadian clock. This gene is
            upregulated by Clock/Arntl heterodimers but then represses this
            upregulation in a feedback loop using Per/Cry heterodimers to
            interact with Clock/Arntl. Polymorphisms in this gene have been
            associated with altered sleep patterns. The encoded protein is
            widely conserved across plants and animals. Loss of this gene
            results in a shortened circadian cycle in complete darkness.
            [provided by RefSeq, Feb 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085499.1, AK162460.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3035
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 41.63 cM"
     gene            1..3035
                     /gene="Cry1"
                     /gene_synonym="Phll1"
                     /note="cryptochrome circadian regulator 1"
                     /db_xref="GeneID:12952"
                     /db_xref="MGI:MGI:1270841"
     exon            1..741
                     /gene="Cry1"
                     /gene_synonym="Phll1"
                     /inference="alignment:Splign:2.1.0"
     exon            742..850
                     /gene="Cry1"
                     /gene_synonym="Phll1"
                     /inference="alignment:Splign:2.1.0"
     exon            851..993
                     /gene="Cry1"
                     /gene_synonym="Phll1"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1178
                     /gene="Cry1"
                     /gene_synonym="Phll1"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1267
                     /gene="Cry1"
                     /gene_synonym="Phll1"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1408
                     /gene="Cry1"
                     /gene_synonym="Phll1"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1720
                     /gene="Cry1"
                     /gene_synonym="Phll1"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1872
                     /gene="Cry1"
                     /gene_synonym="Phll1"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..2075
                     /gene="Cry1"
                     /gene_synonym="Phll1"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2228
                     /gene="Cry1"
                     /gene_synonym="Phll1"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2300
                     /gene="Cry1"
                     /gene_synonym="Phll1"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2408
                     /gene="Cry1"
                     /gene_synonym="Phll1"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..3016
                     /gene="Cry1"
                     /gene_synonym="Phll1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggagtcacc cgggcagcct cgggaccggt gaccggcagg cgagcgtccc gcggcctgga
       61 gctctagccc gcgctctccg agctcgctgc ccactccggg acgcacaggc cgcgtcgcgc
      121 ggaggccgcg tgagctcgtg tccgttcgtg gaggccgcct cgggcgcgcc accgtctcct
      181 cgcgggtcgc ctcggttggg cgaggtttcc gtgacgagcc tcccggggct gctgcgacca
      241 gctcgggccg tcgtggcggc tcgggccccg cgcgctcgct tgcgctccgg gggtctcagg
      301 ccctggaagg tatgcgtgtc ctccggacgc tgggcgcggg ctcctgaagg acgtcgcgcg
      361 tggatcccgg cgcctcggca gcctccattc atctgccagc tgcgcgctcg ccacctccgc
      421 gccccgcctc ggcgtcgcct cctcccgtcc cctctctgca gccctttccc cactcctcgg
      481 gtgaggaggt tttcttggaa gcgcaggtgt cggttatgag cccggcttcc ctcccttgaa
      541 gctctcggta gaggaagtcg gggtgacccg ccgcgccccg agcatggggg tgaacgccgt
      601 gcactggttc cgaaagggac tccggctcca cgacaacccc gccctgaagg agtgcatcca
      661 gggcgccgac accatccgct gcgtctatat cctcgacccc tggttcgccg gctcttccaa
      721 cgtgggcatc aacaggtggc gatttttgct tcagtgtctt gaggatcttg atgccaatct
      781 acgaaaatta aattctcgtc tgtttgtgat tcggggacag ccagctgatg tatttcccag
      841 gcttttcaag gaatggaaca tcactaaact ctcaattgag tatgattctg agccttttgg
      901 gaaggaacga gatgcagcta tcaagaagct ggctactgag gctggcgtgg aagtcatcgt
      961 gcgcatttca catacactgt atgacctgga caagatcata gaactcaatg gcggacagcc
     1021 acctctaaca tataaaaggt ttcagactct cgtcagcaag atggagccac tggagatgcc
     1081 agcagacacc atcacatcag atgtgatagg aaagtgcatg acccctctgt ctgatgacca
     1141 tgatgagaaa tatggcgttc cttccctgga agagctcggc tttgatacag atggcctgtc
     1201 ctctgcagtg tggccaggag gagaaactga ggcacttaca cgtttggaaa ggcatttgga
     1261 aagaaaggcc tgggtggcaa actttgaacg acctcgaatg aatgcaaact ccctgcttgc
     1321 aagcccaact ggactcagtc cttatctccg ctttggttgt ttatcatgtc ggctgtttta
     1381 tttcaaacta acagatctct acaaaaaggt aaagaagaat agttcccctc ccctttctct
     1441 ttatgggcaa ctcctgtggc gtgaattttt ttatacagca gccacaaaca acccacgctt
     1501 tgacaaaatg gaagggaacc ccatctgtgt tcagatccct tgggacaaga accccgaggc
     1561 tctggccaaa tgggcagaag gccggacagg cttcccgtgg attgacgcca tcatgactca
     1621 gcttcgtcag gagggctgga tccaccattt agccagacac gcggttgcct gtttcctgac
     1681 tcgtggtgac ctgtggatca gctgggaaga agggatgaag gtctttgaag agttactgct
     1741 tgatgcagat tggagcataa atgctggaag ttggatgtgg ctgtcctgca gttccttttt
     1801 tcagcaattt tttcactgct actgccctgt gggttttggt aggaggacag atcccaatgg
     1861 agactatatt aggcgttatt tacctgtcct aagaggcttc cctgcaaaat atatctacga
     1921 tccttggaat gcaccagaag gcatccagaa ggttgccaag tgtttgatag gagttaatta
     1981 ccccaaaccg atggtgaacc atgctgaggc aagcagactg aatattgaaa gaatgaagca
     2041 gatctatcag cagctttccc ggtacagagg gctaggtctt ctcgcctcgg tcccttctaa
     2101 ctctaatggg aatggagggc tcatgggcta tgctcctgga gagaatgtcc cgagttgtag
     2161 cagcagcggg aatggagggc tcatgggcta tgctcctgga gagaacgtcc cgagctgtag
     2221 cggtggaaat tgctctcaag gaagtggtat tttacactat gctcacgggg acagtcagca
     2281 gactcactca ctcaagcaag ggagaagctc cgcgggcacc ggcctcagca gtgggaagcg
     2341 tcctagtcag gaagaggatg cccagagtgt cggccccaaa gtccagcggc agagcagtaa
     2401 ctgatacgaa agcgtgtggg aggagtcctc gcaactgaag ttggtgggaa agtcagtact
     2461 tttcatttaa attatttaaa aatgtcattc attcatggaa aacagttaca tttcaaacat
     2521 tatttctaat aatatttctg tggtttttaa ctttttaatg aatgtcatat aggacaagtg
     2581 gtaatttgta tataagatct tggtaagaga tttgcttaat gtaaatataa gccacagtta
     2641 gaatagactc atcagtatat ttttgataat ttttcatgta tggtaaaagt taaagttaac
     2701 agatattctg atataaatct caagagtttt gagagtcatt gcaggaaaat gggaagtttt
     2761 taaactttct taaaagactt tgttaaaatt ttagggcaca tttttccaga catcagtgtt
     2821 tgatctaatt ttgcagtctt tgataataat gctttagaga atacatgtaa tcaagtgcat
     2881 aggcctctgt cagcgagggc catctgtgtt acagcctcct gacttgcgca gtgcattgtg
     2941 ccgagctcct ttgtctctcc gcctctttat ttacatctac cgtgactttg ttattaaagt
     3001 atatgcaaat atggaaaaaa aaaaaaaaaa aaaaa
//
