LOCUS       NM_173863               5110 bp    mRNA    linear   ROD 11-OCT-2023
DEFINITION  Mus musculus CREB regulated transcription coactivator 3 (Crtc3),
            mRNA.
ACCESSION   NM_173863
VERSION     NM_173863.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5110)
  AUTHORS   Park JS, Heo H, Kim MS, Lee SE, Park S, Kim KH, Kang YH, Kim JS,
            Sung YH, Shim WH, Kim DH, Song Y and Yoon SY.
  TITLE     Amphiregulin normalizes altered circuit connectivity for social
            dominance of the CRTC3 knockout mouse
  JOURNAL   Mol Psychiatry (2023) In press
   PUBMED   37730843
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 5110)
  AUTHORS   Yoon YS, Liu W, Van de Velde S, Matsumura S, Wiater E, Huang L and
            Montminy M.
  TITLE     Activation of the adipocyte CREB/CRTC pathway in obesity
  JOURNAL   Commun Biol 4 (1), 1214 (2021)
   PUBMED   34686752
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5110)
  AUTHORS   Yoo H, Lee HR, Kim KH, Kim MA, Bang S, Kang YH, Kim WH, Song Y and
            Chang SE.
  TITLE     CRTC3, a sensor and key regulator for melanogenesis, as a tunable
            therapeutic target for pigmentary disorders
  JOURNAL   Theranostics 11 (20), 9918-9936 (2021)
   PUBMED   34815795
  REMARK    GeneRIF: CRTC3, a sensor and key regulator for melanogenesis, as a
            tunable therapeutic target for pigmentary disorders.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5110)
  AUTHORS   Ostojic J, Yoon YS, Sonntag T, Nguyen B, Vaughan JM, Shokhirev M
            and Montminy M.
  TITLE     Transcriptional co-activator regulates melanocyte differentiation
            and oncogenesis by integrating cAMP and MAPK/ERK pathways
  JOURNAL   Cell Rep 35 (7), 109136 (2021)
   PUBMED   34010639
REFERENCE   5  (bases 1 to 5110)
  AUTHORS   Sonntag T, Ostojic J, Vaughan JM, Moresco JJ, Yoon YS, Yates JR 3rd
            and Montminy M.
  TITLE     Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A
            Recruitment
  JOURNAL   iScience 11, 134-145 (2019)
   PUBMED   30611118
REFERENCE   6  (bases 1 to 5110)
  AUTHORS   Luan B, Goodarzi MO, Phillips NG, Guo X, Chen YD, Yao J, Allison M,
            Rotter JI, Shaw R and Montminy M.
  TITLE     Leptin-mediated increases in catecholamine signaling reduce adipose
            tissue inflammation via activation of macrophage HDAC4
  JOURNAL   Cell Metab 19 (6), 1058-1065 (2014)
   PUBMED   24768298
REFERENCE   7  (bases 1 to 5110)
  AUTHORS   Bruno NE, Kelly KA, Hawkins R, Bramah-Lawani M, Amelio AL,
            Nwachukwu JC, Nettles KW and Conkright MD.
  TITLE     Creb coactivators direct anabolic responses and enhance performance
            of skeletal muscle
  JOURNAL   EMBO J 33 (9), 1027-1043 (2014)
   PUBMED   24674967
  REMARK    GeneRIF: beta-agonists or catecholamines released during intense
            exercise induce Creb-mediated transcriptional programs through
            activation of its obligate coactivators Crtc2 and Crtc3.
REFERENCE   8  (bases 1 to 5110)
  AUTHORS   Ravnskjaer,K., Hogan,M.F., Lackey,D., Tora,L., Dent,S.Y.,
            Olefsky,J. and Montminy,M.
  TITLE     Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated
            epigenetic effects
  JOURNAL   J Clin Invest 123 (10), 4318-4328 (2013)
   PUBMED   24051374
REFERENCE   9  (bases 1 to 5110)
  AUTHORS   Than TA, Lou H, Ji C, Win S and Kaplowitz N.
  TITLE     Role of cAMP-responsive element-binding protein (CREB)-regulated
            transcription coactivator 3 (CRTC3) in the initiation of
            mitochondrial biogenesis and stress response in liver cells
  JOURNAL   J Biol Chem 286 (25), 22047-22054 (2011)
   PUBMED   21536665
  REMARK    GeneRIF: CRTC3 plays a selective role in mitochondrial biogenesis
            in response to rotenone
REFERENCE   10 (bases 1 to 5110)
  AUTHORS   Song Y, Altarejos J, Goodarzi MO, Inoue H, Guo X, Berdeaux R, Kim
            JH, Goode J, Igata M, Paz JC, Hogan MF, Singh PK, Goebel N, Vera L,
            Miller N, Cui J, Jones MR, Chen YD, Taylor KD, Hsueh WA, Rotter JI
            and Montminy M.
  CONSRTM   CHARGE Consortium; GIANT Consortium
  TITLE     CRTC3 links catecholamine signalling to energy balance
  JOURNAL   Nature 468 (7326), 933-939 (2010)
   PUBMED   21164481
  REMARK    GeneRIF: the cAMP response element binding (CREB) coactivator Crtc3
            promotes obesity by attenuating beta-adrenergic receptor signalling
            in adipose tissue
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK144840.1 and AC127594.3.
            
            [WARNING] On Jan 16, 2024 this sequence was replaced by
            NM_173863.3.
            
            On Apr 5, 2007 this sequence version replaced NM_173863.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144840.1, BC011210.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-861               AK144840.1         2-862
            862-1697            AK144840.1         864-1699
            1698-2796           AK144840.1         1701-2799
            2797-5110           AC127594.3         136892-139205
FEATURES             Location/Qualifiers
     source          1..5110
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.65 cM"
     gene            1..5110
                     /gene="Crtc3"
                     /gene_synonym="2610312F20Rik; 6332415K15Rik; TORC3"
                     /note="CREB regulated transcription coactivator 3"
                     /db_xref="GeneID:70461"
                     /db_xref="MGI:MGI:1917711"
     exon            1..271
                     /gene="Crtc3"
                     /gene_synonym="2610312F20Rik; 6332415K15Rik; TORC3"
                     /inference="alignment:Splign:2.1.0"
     exon            272..370
                     /gene="Crtc3"
                     /gene_synonym="2610312F20Rik; 6332415K15Rik; TORC3"
                     /inference="alignment:Splign:2.1.0"
     exon            371..490
                     /gene="Crtc3"
                     /gene_synonym="2610312F20Rik; 6332415K15Rik; TORC3"
                     /inference="alignment:Splign:2.1.0"
     exon            491..552
                     /gene="Crtc3"
                     /gene_synonym="2610312F20Rik; 6332415K15Rik; TORC3"
                     /inference="alignment:Splign:2.1.0"
     exon            553..615
                     /gene="Crtc3"
                     /gene_synonym="2610312F20Rik; 6332415K15Rik; TORC3"
                     /inference="alignment:Splign:2.1.0"
     exon            616..716
                     /gene="Crtc3"
                     /gene_synonym="2610312F20Rik; 6332415K15Rik; TORC3"
                     /inference="alignment:Splign:2.1.0"
     exon            717..752
                     /gene="Crtc3"
                     /gene_synonym="2610312F20Rik; 6332415K15Rik; TORC3"
                     /inference="alignment:Splign:2.1.0"
     exon            753..838
                     /gene="Crtc3"
                     /gene_synonym="2610312F20Rik; 6332415K15Rik; TORC3"
                     /inference="alignment:Splign:2.1.0"
     exon            839..888
                     /gene="Crtc3"
                     /gene_synonym="2610312F20Rik; 6332415K15Rik; TORC3"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1106
                     /gene="Crtc3"
                     /gene_synonym="2610312F20Rik; 6332415K15Rik; TORC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1405
                     /gene="Crtc3"
                     /gene_synonym="2610312F20Rik; 6332415K15Rik; TORC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1606
                     /gene="Crtc3"
                     /gene_synonym="2610312F20Rik; 6332415K15Rik; TORC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1687
                     /gene="Crtc3"
                     /gene_synonym="2610312F20Rik; 6332415K15Rik; TORC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1790
                     /gene="Crtc3"
                     /gene_synonym="2610312F20Rik; 6332415K15Rik; TORC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..5110
                     /gene="Crtc3"
                     /gene_synonym="2610312F20Rik; 6332415K15Rik; TORC3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggcggctc ctctgccggg tcgcgccgga ggacaggttt cgggcggcgg cttgggcggc
       61 ctgcggacag accgggtggg ccgagcagcg gaaccccgcg cctgccgtgt gcctagcccg
      121 ctagcgccgg gcgcgcgcca tggccgcctc gcccggttcg ggcagcgcca acccgcggaa
      181 gttcagtgag aagatcgccc tgcacacgca gcggcaggcc gaggagacgc gggccttcga
      241 gcagctcatg accgacctca ccctgtcccg ggttcagttt cagaagcttc agcagctgcg
      301 ccttacccag taccacgggg gatccttacc caacgtgagc cagctgcgga acagcgcgcc
      361 agagttccag ccatcacttc atcaagccga taatgttcgt ggaacccgcc accatgggct
      421 ggtggagagg ccagcccgga accgcttcca cccccttcac cgaaggtctg gggacaagcc
      481 agggagacag tttgatggga atgctttcgc agccagttat tcttcacagc acctggatga
      541 gagctggcca cggcaacagc ctccttggaa agaagagaag catcctggat tcaggctaac
      601 atctgcactt aacaggacca attctgattc tgctcttcac acgagtgctc tgagcaccaa
      661 accccaggac ccctatggag gaggaggcca gtcagcctgg cctgccccat acatgggttt
      721 ctgtgatggt gaaaacgatg gccatgcgga agtagccgcc ttcccgggtc cgctgaaaga
      781 agagaatctg ttaaatgtcc cgaagccact gcctaaacac ctgtgggaga gcaaggagat
      841 ccagtccctg tctgggcgcc ctcgatcctg tgatgttggg ggcggcaatg ctttcccaca
      901 taatggccag aacacaggcc tctcaccgtt cctgggcacc ctgaacaccg gagggtcgtt
      961 accagatcta accaacctcc actactcagc acccctgcca gcctccctgg acaccagcga
     1021 ccacctcttt ggtagcatga gtgtggggaa cagcgtgggc aaccttccag ctgccatgac
     1081 tcacctgggg ataagaacct cctctggtct ccaaagttct cgaagtaacc cttccatcca
     1141 agccacactc agtaagatgg cactctcctc gtccctcaag tgccacccgc agccgtctgt
     1201 ggccaacgcc tctgctctgc acccctccct ccggctcttc tcccttagca acccgtctct
     1261 ttccaccaca aacctgagtg gcccctctcg gcgcaggcag cctccagtca gccctctcac
     1321 gctctctcct ggccctgaag cacatcaagg cttcagcaga cagctctctg cgaccagccc
     1381 actgaacccg tatcctgcct cccagatggt gacctcagag cagagcccac tttccttcct
     1441 gcccacagac gctcaagccc aagtgtcccc accaccccct taccccacac cccaggagct
     1501 gcctcagcca ctcctacagc agccccatgc ccaggagccc ccaactcagc agccccaggc
     1561 agccccctcc ctgccacagt cagacttcca gctcctcact gcccagggct cagctttgac
     1621 cagcttcttc ccggatgtgc gctttgacca acagcccatg aggcccagcc ctgcctttcc
     1681 tcagcaggtg cctttggtac agcagagcca ccgagaacca caggactcat tccacttgag
     1741 accaaaccca tattccagct gtggcagctt cccaggcacc atcctgacag aagatacaaa
     1801 cagcaacctg ttcaaaggcc ttagcggggg gctgtcgggc atgccagagg tcagcctgga
     1861 catggacacc ccgttccctc tggaagagga gctgcagatc gaacccttga gcctcgatgg
     1921 actcaacatg ctaagtgact ccagcatggg cctgctggac ccctctgtgg aggagacgtt
     1981 tcgagctgac cggctatgag cacagtgcag tggaactggg gaactgaaat ggccagagaa
     2041 agctggggtg gagccagcaa acaccctgcc ggtggtcaca gccagcaaac accctgacag
     2101 tggtcacagc cagcaaacac cttgacggtg gttacagcat agagggagcc gctgccccgg
     2161 gctctccact gagctcagcc aaggctttgc tagacacagc tgcactcttc ggcccatggc
     2221 accagttgta ctgctgcagg ccagctgctt tggagcttcc ggtgaccagg aagctgacca
     2281 tgtcaccctt aattctcttt attggccatc cagtcagtca gtgtgtaaat gtagaaaatg
     2341 ctgtgtaaca cgtcagtgct ccaaacctca gattcccatc agcactgaag atggaacgct
     2401 ataggaggca gttgggggcc tcgggcccgt gtagttggct cagtgtcaca caacggtacc
     2461 agagcaccat gatgcctttc tgtctgaccg ccaaggccag gcagccctcc agctggcggg
     2521 tattctgggc ccagccatca ctctgtccaa tggctcactt aaaatgaaga agcttaccca
     2581 gccgtcccag ggcaggctta agttaggcaa actgaaggca gtttgcttcc tcccggttta
     2641 tgatctcttt gctgctgctt cctgtatgcg cacctttccc tcacagacag gaggagaggg
     2701 agacctgttt gctcactgaa aaaaatgtcc ttggaaacag gatgagccta aggaggacag
     2761 cgctcctagg agaatggagg aggaaaggga ggctacaggt gtgtcacctg cacaagatgc
     2821 cctccctctt aggcctgcca ccctccagcc cactggaagg agctgctggg actcgtatta
     2881 gtgcagggca gctgaactgc ccttctcccc agctgccctg cagacctcaa gtttaatgca
     2941 atgcccacta gactgtaagc tcccagaggg caggaactgt gccttgttct gtattgaccc
     3001 ctagtgccca ccaagtgcct ggtaggagtg catgtaccca ggatggagga gagagggact
     3061 gtgcctcgtg gtggggcggt ctaacctgca gctctctctg tcccctgcct tagctcagag
     3121 cttcaccttt cagactcact tgagtgtgcc ttaacactag gtgaccagac ctgccactag
     3181 gctcagcgcc actcctccta gggaatatgt ccctcagcag ctaggtggac atcatccagt
     3241 gcatccagca tggctgatca caccaagccc caggagtgtg gggcacctgg catccagact
     3301 gggcccccac agcaaattct tcctctcgga ccttttcctt tttttttttt tctaaattgc
     3361 ttaaaataga ggtgcaaact ttgaggttaa gaaataaggc ctggctgggc gtggtggcac
     3421 ccgcctttaa tcccagcact tgggagacag aggcagtatg atttctgagt ttgaggccag
     3481 cctggtctgc agagtgagtt ccaggatagc cagggctaca cagagaaacc ctgtctcgaa
     3541 aaaacaaaac aaaacaaaac aaacaaaaaa gaaagaaaga aggcctggtt catgggactc
     3601 ttttattcat taacgccttc tcacacagta agtaatctga gcagattcta ccagcacctg
     3661 cctcctagcc ccacatgagg aaagtgatgt ccacccagca caagggagga gccggggtgg
     3721 gtgaggaggg ccctggagga gaacttttgc ctgacgcctg ctccccttcc tgcgacatgg
     3781 gctgaagctg aggctcagtg gctgtcccca cccaggagag caagggtgga gtagaaggaa
     3841 gctgacccat ctgtgcctga ggcgaggaag cctgggaatc agaggctgct ccagctcccc
     3901 acaccgcggc tcttcagaca gccgggtgga gctgtgcggc cacgtgcccc agtctctgct
     3961 gtttaattgg aaactaaatt agaatcctct tcccctgacc atgccactgg cctggtcctg
     4021 agatcccaga gcacccgggg tgactttagt taaagtggaa gcttttcact cctctgagct
     4081 gcccagcgcc ccagcataca cactcaagcc agctcccgtg tccgtcttca ggcagagatc
     4141 gatgctgatg taaaagttga gaggaagggg tttccagcac aatctgctct ctgcgttgag
     4201 cctgatccgt gggatcatcg tgtcggtgac gcccacacac cggggaagag gcaggtgtga
     4261 ggtgacaggg tcaggagggg gaggaccctg aaggagaatc cctgcttgca cagctgctgt
     4321 cctctggtga aggcgtaacg ggagatctca ccccataccc tacgctgccc tgttcctgag
     4381 gctttctcca gccaatggga aagcgctggc tgcaggggcg gggggggggg ggggggggga
     4441 gttgaaaaaa aagaaaaccc aaaaaccaaa agagacaatg tagcactgaa ttaaatctgc
     4501 ccataggcct atcagcctga tcttttcatg tgtgtagctt taagccacta gagagcctac
     4561 cggtctacat ggtgttgagt acagcaggag actgcgttgc cctgctgcag tcgtgtgagc
     4621 ctgcactcga tgctgccttt gtgactagcc tgtcttaggc ggcagcattg aagtggctac
     4681 cggcttcccc agacctctct tcagtgtctt ctctctgtcc caccagctgc ccttccccag
     4741 cactgcaggg tggtgggttt tagcacacga gtgtggggag aagtgaggat gagctctcct
     4801 ttgccctgct cccttccccc aagtctactg tatattctct gggccgagag gtcgtgtatt
     4861 catgctcgtg cacatatctg aagacatttc ctgttgggct cttctgattt atgcacagat
     4921 ggttcccagt gttcccactg ctccagaacg gggccatccc agcagctagt cagacttccg
     4981 gccagtgtcc taactcccgg ccttttgtta agcaatattg aaagatcgga ctttgtataa
     5041 agtagcttcc aagttttata atgcatcatt ttacatcttt cataattaaa agcagcacaa
     5101 tatggttgta
//
