LOCUS       NM_028881               2603 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus CREB regulated transcription coactivator 2 (Crtc2),
            transcript variant 1, mRNA.
ACCESSION   NM_028881 XM_110709 XM_359307
VERSION     NM_028881.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2603)
  AUTHORS   Morgan,H.J.N., Delfino,H.B.P., Schavinski,A.Z., Malone,S.A.,
            Charoy,C., Reis,N.G., Assis,A.P., Lautherbach,N., Silveira,W.A.,
            Heck,L.C., Guton,D., Domingos,A.I., Kettelhut,I.C., Montminy,M. and
            Navegantes,L.C.C.
  TITLE     Hepatic noradrenergic innervation acts via CREB/CRTC2 to activate
            gluconeogenesis during cold
  JOURNAL   Metabolism 157, 155940 (2024)
   PUBMED   38878857
  REMARK    GeneRIF: Hepatic noradrenergic innervation acts via CREB/CRTC2 to
            activate gluconeogenesis during cold.
REFERENCE   2  (bases 1 to 2603)
  AUTHORS   Li,Y., Zhang,Y., Shi,H., Liu,X., Li,Z., Zhang,J., Wang,X., Wang,W.
            and Tong,X.
  TITLE     CRTC2 activates the epithelial-mesenchymal transition of diabetic
            kidney disease through the CREB-Smad2/3 pathway
  JOURNAL   Mol Med 29 (1), 146 (2023)
   PUBMED   37884902
  REMARK    GeneRIF: CRTC2 activates the epithelial-mesenchymal transition of
            diabetic kidney disease through the CREB-Smad2/3 pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2603)
  AUTHORS   Wang,W., Tan,J., Liu,X., Guo,W., Li,M., Liu,X., Liu,Y., Dai,W.,
            Hu,L., Wang,Y., Lu,Q., Lee,W.X., Tang,H.W. and Zhou,Q.
  TITLE     Cytoplasmic Endonuclease G promotes nonalcoholic fatty liver
            disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress
  JOURNAL   Nat Commun 14 (1), 6201 (2023)
   PUBMED   37794041
  REMARK    GeneRIF: Cytoplasmic Endonuclease G promotes nonalcoholic fatty
            liver disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress.
            Erratum:[Nat Commun. 2024 Aug 21;15(1):7167. doi:
            10.1038/s41467-024-51312-x.. PMID: 39168977]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2603)
  AUTHORS   Han,H.S., Ahn,E., Park,E.S., Huh,T., Choi,S., Kwon,Y., Choi,B.H.,
            Lee,J., Choi,Y.H., Jeong,Y.L., Lee,G.B., Kim,M., Seong,J.K.,
            Shin,H.M., Kim,H.R., Moon,M.H., Kim,J.K., Hwang,G.S. and Koo,S.H.
  TITLE     Impaired BCAA catabolism in adipose tissues promotes age-associated
            metabolic derangement
  JOURNAL   Nat Aging 3 (8), 982-1000 (2023)
   PUBMED   37488415
REFERENCE   5  (bases 1 to 2603)
  AUTHORS   Gao,L., Liu,G., Wu,X., Liu,C., Wang,Y., Ma,M., Ma,Y. and Hao,Z.
  TITLE     Osteocytes autophagy mediated by mTORC2 activation controls
            osteoblasts differentiation and osteoclasts activities under
            mechanical loading
  JOURNAL   Arch Biochem Biophys 742, 109634 (2023)
   PUBMED   37164247
  REMARK    GeneRIF: Osteocytes autophagy mediated by mTORC2 activation
            controls osteoblasts differentiation and osteoclasts activities
            under mechanical loading.
REFERENCE   6  (bases 1 to 2603)
  AUTHORS   Xu,W., Kasper,L.H., Lerach,S., Jeevan,T. and Brindle,P.K.
  TITLE     Individual CREB-target genes dictate usage of distinct
            cAMP-responsive coactivation mechanisms
  JOURNAL   EMBO J 26 (12), 2890-2903 (2007)
   PUBMED   17525731
REFERENCE   7  (bases 1 to 2603)
  AUTHORS   Ohmae,S., Takemoto-Kimura,S., Okamura,M., Adachi-Morishima,A.,
            Nonaka,M., Fuse,T., Kida,S., Tanji,M., Furuyashiki,T., Arakawa,Y.,
            Narumiya,S., Okuno,H. and Bito,H.
  TITLE     Molecular identification and characterization of a family of
            kinases with homology to Ca2+/calmodulin-dependent protein kinases
            I/IV
  JOURNAL   J Biol Chem 281 (29), 20427-20439 (2006)
   PUBMED   16684769
REFERENCE   8  (bases 1 to 2603)
  AUTHORS   Shaw,R.J., Lamia,K.A., Vasquez,D., Koo,S.H., Bardeesy,N.,
            Depinho,R.A., Montminy,M. and Cantley,L.C.
  TITLE     The kinase LKB1 mediates glucose homeostasis in liver and
            therapeutic effects of metformin
  JOURNAL   Science 310 (5754), 1642-1646 (2005)
   PUBMED   16308421
REFERENCE   9  (bases 1 to 2603)
  AUTHORS   Koo,S.H., Flechner,L., Qi,L., Zhang,X., Screaton,R.A., Jeffries,S.,
            Hedrick,S., Xu,W., Boussouar,F., Brindle,P., Takemori,H. and
            Montminy,M.
  TITLE     The CREB coactivator TORC2 is a key regulator of fasting glucose
            metabolism
  JOURNAL   Nature 437 (7062), 1109-1111 (2005)
   PUBMED   16148943
  REMARK    GeneRIF: hormonal and energy-sensing pathways converge on the
            coactivator TORC2 (transducer of regulated CREB activity 2) to
            modulate glucose output
REFERENCE   10 (bases 1 to 2603)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119825.11.
            
            On Oct 5, 2022 this sequence version replaced NM_028881.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023831.1, AK156192.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               AC119825.11        149745-150001
            258-359             AC119825.11        152560-152661
            360-476             AC119825.11        152738-152854
            477-538             AC119825.11        153908-153969
            539-607             AC119825.11        154597-154665
            608-714             AC119825.11        154829-154935
            715-744             AC119825.11        155026-155055
            745-809             AC119825.11        155206-155270
            810-859             AC119825.11        155397-155446
            860-1104            AC119825.11        155569-155813
            1105-1511           AC119825.11        156140-156546
            1512-1775           AC119825.11        157894-158157
            1776-1962           AC119825.11        158614-158800
            1963-2603           AC119825.11        158923-159563
FEATURES             Location/Qualifiers
     source          1..2603
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.21 cM"
     gene            1..2603
                     /gene="Crtc2"
                     /gene_synonym="4632407F12Rik; Torc2"
                     /note="CREB regulated transcription coactivator 2"
                     /db_xref="GeneID:74343"
                     /db_xref="MGI:MGI:1921593"
     exon            1..257
                     /gene="Crtc2"
                     /gene_synonym="4632407F12Rik; Torc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..2183
                     /gene="Crtc2"
                     /gene_synonym="4632407F12Rik; Torc2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     TORC-2; transducer of CREB protein 2; transducer of
                     regulated cAMP response element-binding protein 2"
                     /codon_start=1
                     /product="CREB-regulated transcription coactivator 2
                     isoform 1"
                     /protein_id="NP_083157.1"
                     /db_xref="CCDS:CCDS38501.1"
                     /db_xref="GeneID:74343"
                     /db_xref="MGI:MGI:1921593"
                     /translation="MATSGANGPGSATASASNPRKFSEKIALQKQRQAEETAAFEEVM
                     MDIGSTRLQAQKLRLAYTRSSHYGGSLPNVNQIGCGLAEFQSPLHSPLDSSRSTRHHG
                     LVERVQRDARRMVSPLRRYPRHIDSSPYSPAYLSPPPESGWRRMMPWGNLPAEKGQLF
                     RLPSALNRTSSDSALHTSVMNPNPQDTYPGPTPPSVLPSRRGGGFLDGEMDAKVPAIE
                     ENVVDDKHLLKPWDAKKLSSSSSRPRSCEVPGINIFPSPDQPANVPVLPPAMNTGGSL
                     PDLTNLHFPPPLPTPLDPEETVYPSLSGGNSTTNLTHTMTHLGISGGLGLGPSYDVPG
                     LHSPLSHPSLQSSLSNPNLQASLSSPQPQLQGSHSHPSLPASSLAHHALPTTSLGHPS
                     LSAPALSSSSSSSSTSSPVLSAPPYPASTPGASPRHRRVPLSPLSLPAGPADARRSQQ
                     QLPKQFSPTMSPTLSSITQGVPLDTSKLPTDQRLPPYPYSPPSLVIPTHPPTPKSLQQ
                     LPSQACLVQPSGGQPPGRQPHYGALYPPGSSGHGQQPYHRPINDFSLGNLEQFNMESP
                     STSLVLDPPAFSEGPGFLGSEGSMSGPQDPHVLNHQNLTHCSRHGSGPNIILTGDSSP
                     GFSKEIAAALAGVPGFEVSASGLELGLGLEDELRMEPLGLEGLTMLSDPCALLPDPAV
                     EDSFRSDRLQ"
     exon            258..359
                     /gene="Crtc2"
                     /gene_synonym="4632407F12Rik; Torc2"
                     /inference="alignment:Splign:2.1.0"
     exon            360..476
                     /gene="Crtc2"
                     /gene_synonym="4632407F12Rik; Torc2"
                     /inference="alignment:Splign:2.1.0"
     exon            477..538
                     /gene="Crtc2"
                     /gene_synonym="4632407F12Rik; Torc2"
                     /inference="alignment:Splign:2.1.0"
     exon            539..607
                     /gene="Crtc2"
                     /gene_synonym="4632407F12Rik; Torc2"
                     /inference="alignment:Splign:2.1.0"
     exon            608..714
                     /gene="Crtc2"
                     /gene_synonym="4632407F12Rik; Torc2"
                     /inference="alignment:Splign:2.1.0"
     exon            715..744
                     /gene="Crtc2"
                     /gene_synonym="4632407F12Rik; Torc2"
                     /inference="alignment:Splign:2.1.0"
     exon            745..809
                     /gene="Crtc2"
                     /gene_synonym="4632407F12Rik; Torc2"
                     /inference="alignment:Splign:2.1.0"
     exon            810..859
                     /gene="Crtc2"
                     /gene_synonym="4632407F12Rik; Torc2"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1104
                     /gene="Crtc2"
                     /gene_synonym="4632407F12Rik; Torc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1511
                     /gene="Crtc2"
                     /gene_synonym="4632407F12Rik; Torc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1775
                     /gene="Crtc2"
                     /gene_synonym="4632407F12Rik; Torc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1962
                     /gene="Crtc2"
                     /gene_synonym="4632407F12Rik; Torc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2603
                     /gene="Crtc2"
                     /gene_synonym="4632407F12Rik; Torc2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2585..2590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crtc2"
                     /gene_synonym="4632407F12Rik; Torc2"
                     /note="hexamer: AATAAA"
     polyA_site      2603
                     /gene="Crtc2"
                     /gene_synonym="4632407F12Rik; Torc2"
                     /note="major polyA site"
ORIGIN      
        1 ggaggcggcg gcggctgctg ctaaggctga aggagccggg ccgggcccgc ggcagaggcc
       61 gtggctggaa ctgggaaggt ggcggggacg gacgcggggg taagatggcg acgtcagggg
      121 cgaacgggcc gggttccgcc acagcctcag cgtccaatcc acgcaagttt agtgagaaga
      181 ttgcgctgca gaagcagcgt caggccgagg agacggcggc cttcgaggag gtgatgatgg
      241 acatcggctc cacacggtta caggcccaaa aactgcgact ggcttataca aggagctccc
      301 attatggtgg ttctctgccc aatgttaacc agattggctg tggcctggct gagttccaga
      361 gcccccttca ctcacctttg gattcatctc ggagcactcg gcaccatggg ttggtggaac
      421 gggtacaacg agatgcccgc agaatggtgt ccccactccg ccgatacccc cgccacattg
      481 acagttctcc atatagccct gcctatttat ctcctccccc agagtctggc tggcgaagga
      541 tgatgccctg gggcaacctc ccagctgaga aggggcagtt gtttagactg ccgtctgcac
      601 ttaacaggac aagctctgac tctgctcttc acacaagtgt gatgaaccct aacccccaag
      661 acacttatcc aggccccaca cctcccagtg tcctgcccag ccgccgagga ggaggttttc
      721 tggatggtga gatggatgct aaagtccctg ctattgagga gaacgtggta gatgacaagc
      781 atctgctgaa accttgggat gctaagaagc tgtcctcatc ttcctctcga cctcgatcct
      841 gtgaagtccc tggaatcaac atctttccat ctcctgacca gcctgctaat gtgcctgtcc
      901 tcccacctgc catgaacaca ggaggctccc tacctgacct caccaaccta cacttccctc
      961 ctccactgcc cacacccctg gaccctgagg agacagtcta tcccagcctg agtgggggca
     1021 acagtaccac caatttgacc catactatga cccatttggg catcagtgga ggtctgggct
     1081 tgggccccag ctatgatgta ccaggacttc actcacctct tagccaccca tccctgcagt
     1141 cctccctaag caatcccaac ctccaggctt ccctaagtag tcctcaaccc cagctccagg
     1201 gctcccatag tcacccatca ctgcctgcct cctccttggc ccaccatgca ctgcccacca
     1261 cctccctggg ccacccgtca cttagtgccc cagccctttc ctcctcctct tcctcttcgt
     1321 ccacttcatc tcctgtcctg agtgctcccc cttacccagc ttctactcct ggggcctctc
     1381 cccgccaccg tcgtgtgccc ctcagccccc tgagcttgcc cgcgggccca gccgacgcca
     1441 gaaggtccca acagcagctg cccaaacagt tttcgccaac aatgtcaccc accttgtctt
     1501 ccatcactca gggcgttccc ttggatacca gtaaattgcc tactgaccag cgattgcccc
     1561 catacccata tagcccccca agtctagtta tacccaccca tccacccacc ccaaagtctc
     1621 tacagcagtt gccctctcag gcctgcttag tgcagccctc aggtggacag cctccaggca
     1681 ggcagccaca ttatggggca ctgtacccac ctgggtccag tggacatggg caacagcctt
     1741 accaccgccc aataaatgac ttcagcttgg ggaatctgga gcaattcaac atggagagcc
     1801 catcaaccag cctggtgctg gatccccctg ccttttctga aggtcctgga tttttaggga
     1861 gtgagggatc aatgagtggc ccccaggacc ctcacgtcct caaccaccag aacttgaccc
     1921 actgttcccg ccatggctca ggacctaata tcatactcac aggagactct tccccaggtt
     1981 tctctaagga gattgcagca gccctggctg gagtgcctgg ctttgaggtg tcagcatctg
     2041 ggttggagct gggcctgggg ctagaagatg agctgcgcat ggagccactg ggcctggaag
     2101 gactaactat gctgagtgac ccctgtgccc tgctgcctga ccctgctgtg gaggactcat
     2161 tccgtagtga tcggctacag tgaggggacc tcactgccat ccttcttcat ggccctgtcc
     2221 catcagtctt catcccttcc ccctggccag tagagactac tctctgcccc cagatccttt
     2281 ttctaatatg aatgaaggat cctaaaactg aggaaaggga aggggcttgg ccaggtggcc
     2341 cctgaatgct gtatgtctgg tgggcttggg ggaattcaag ggagggccta aaagcacttg
     2401 taactttgaa aaccgtctgt ctggaggtca gagcctgttg ggaagcaagg tgtagaggga
     2461 aatcttggag agagggcttg tccagaaggg atgggcacta ccagcccctc cctatttctc
     2521 ttccccttgc aatggaagag agagccagaa tggatattat tttttattaa atatattata
     2581 tgttaataaa aaatcctatt aaa
//
