LOCUS       NM_001404415            5778 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus CREB regulated transcription coactivator 1 (Crtc1),
            transcript variant 1, mRNA.
ACCESSION   NM_001404415 XM_011242311
VERSION     NM_001404415.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5778)
  AUTHORS   Wang,Y., Liu,L., Gu,J.H., Wang,C.N., Guan,W., Liu,Y., Tang,W.Q.,
            Ji,C.H., Chen,Y.M., Huang,J., Li,W.Y., Shi,T.S., Chen,W.J.,
            Zhu,B.L. and Jiang,B.
  TITLE     Salt-inducible kinase 1-CREB-regulated transcription coactivator 1
            signalling in the paraventricular nucleus of the hypothalamus plays
            a role in depression by regulating the
            hypothalamic-pituitary-adrenal axis
  JOURNAL   Mol Psychiatry 29 (6), 1660-1670 (2024)
   PUBMED   36434056
  REMARK    GeneRIF: Salt-inducible kinase 1-CREB-regulated transcription
            coactivator 1 signalling in the paraventricular nucleus of the
            hypothalamus plays a role in depression by regulating the
            hypothalamic-pituitary-adrenal axis.
REFERENCE   2  (bases 1 to 5778)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5778)
  AUTHORS   Li,M.Y., Liu,L.Z., Xin,Q., Zhou,J., Zhang,X., Zhang,R., Wu,Z.,
            Yi,J. and Dong,M.
  TITLE     Downregulation of mTORC1 and Mcl-1 by lipid-oversupply contributes
            to islet beta-cell apoptosis and dysfunction
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1868 (7), 159332 (2023)
   PUBMED   37196823
  REMARK    GeneRIF: Downregulation of mTORC1 and Mcl-1 by lipid-oversupply
            contributes to islet beta-cell apoptosis and dysfunction.
REFERENCE   4  (bases 1 to 5778)
  AUTHORS   Matsumura,S., Miyakita,M., Miyamori,H., Kyo,S., Ishikawa,F.,
            Sasaki,T., Jinno,T., Tanaka,J., Fujita,K., Yokokawa,T., Goto,T.,
            Momma,K., Takenaka,S. and Inoue,K.
  TITLE     CRTC1 deficiency, specifically in melanocortin-4
            receptor-expressing cells, induces hyperphagia, obesity, and
            insulin resistance
  JOURNAL   FASEB J 36 (12), e22645 (2022)
   PUBMED   36349991
  REMARK    GeneRIF: CRTC1 deficiency, specifically in melanocortin-4
            receptor-expressing cells, induces hyperphagia, obesity, and
            insulin resistance.
REFERENCE   5  (bases 1 to 5778)
  AUTHORS   Cherix,A., Poitry-Yamate,C., Lanz,B., Zanoletti,O., Grosse,J.,
            Sandi,C., Gruetter,R. and Cardinaux,J.R.
  TITLE     Deletion of Crtc1 leads to hippocampal neuroenergetic impairments
            associated with depressive-like behavior
  JOURNAL   Mol Psychiatry 27 (11), 4485-4501 (2022)
   PUBMED   36224260
  REMARK    GeneRIF: Deletion of Crtc1 leads to hippocampal neuroenergetic
            impairments associated with depressive-like behavior.
REFERENCE   6  (bases 1 to 5778)
  AUTHORS   Hayashi,A.A. and Proud,C.G.
  TITLE     The rapid activation of protein synthesis by growth hormone
            requires signaling through mTOR
  JOURNAL   Am J Physiol Endocrinol Metab 292 (6), E1647-E1655 (2007)
   PUBMED   17284572
REFERENCE   7  (bases 1 to 5778)
  AUTHORS   Kovacs,K.A., Steullet,P., Steinmann,M., Do,K.Q., Magistretti,P.J.,
            Halfon,O. and Cardinaux,J.R.
  TITLE     TORC1 is a calcium- and cAMP-sensitive coincidence detector
            involved in hippocampal long-term synaptic plasticity
  JOURNAL   Proc Natl Acad Sci U S A 104 (11), 4700-4705 (2007)
   PUBMED   17360587
  REMARK    GeneRIF: TORC1 is involved in L-LTP maintenance at the Schaffer
            collateral-CA1 synapses in the hippocampus
REFERENCE   8  (bases 1 to 5778)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   9  (bases 1 to 5778)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 5778)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158553.13.
            
            On Apr 9, 2022 this sequence version replaced XM_011242311.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.50750.1,
                                           SRR9219382.238702.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               AC158553.13        25054-25211
            159-275             AC158553.13        55633-55749
            276-413             AC158553.13        58429-58566
            414-475             AC158553.13        59324-59385
            476-570             AC158553.13        62119-62213
            571-656             AC158553.13        63940-64025
            657-697             AC158553.13        66308-66348
            698-987             AC158553.13        66609-66898
            988-1121            AC158553.13        71589-71722
            1122-1424           AC158553.13        72481-72783
            1425-1526           AC158553.13        73341-73442
            1527-1613           AC158553.13        76483-76569
            1614-1794           AC158553.13        76923-77103
            1795-5778           AC158553.13        78309-82292
FEATURES             Location/Qualifiers
     source          1..5778
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.15 cM"
     gene            1..5778
                     /gene="Crtc1"
                     /gene_synonym="Mect1; mKIAA0616; TORC-1; TORC1"
                     /note="CREB regulated transcription coactivator 1"
                     /db_xref="GeneID:382056"
                     /db_xref="MGI:MGI:2142523"
     exon            1..158
                     /gene="Crtc1"
                     /gene_synonym="Mect1; mKIAA0616; TORC-1; TORC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..2006
                     /gene="Crtc1"
                     /gene_synonym="Mect1; mKIAA0616; TORC-1; TORC1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mucoepidermoid carcinoma translocated 1; transducer of
                     CREB protein 1; mucoepidermoid carcinoma translocated
                     protein 1 homolog; transducer of regulated cAMP response
                     element-binding protein 1"
                     /codon_start=1
                     /product="CREB-regulated transcription coactivator 1
                     isoform 1"
                     /protein_id="NP_001391344.1"
                     /db_xref="GeneID:382056"
                     /db_xref="MGI:MGI:2142523"
                     /translation="MATSNNPRKFSEKIALHNQKQAEETAAFEEVMKDLSLTRAARLQ
                     LQKSQYLQLGPSRGQYYGGSLPNVNQIGSSSVDLAFQTPFQSSGLDTSRTTRHHGLVD
                     RVYRERGRLGSPHRRPLSVDKHGRQADSCPYGTVYLSPPADTSWRRTNSDSALHQSTM
                     TPSQAESFTGGSQDAHQKRVLLLTVPGMEDTGAETDKTLSKQSWDSKKAGSRPKSCEV
                     PGINCPGLAGLACLSLSPDLMSCPPHLVFPSIFPSADQENTTALIPATHNTGGSLPDL
                     TNIHFPSPLPTPLDPEEPPFPALTSSSSTGSLAHLGVGGAGQGMNTPSSSPQHRPAVV
                     SPLSLSTEARRQQAQQVSPTLSPLSPITQAVAMDALSLEQQLPYAFFTQTGSQQPPPQ
                     PQPPPPPPPVSQQQPPPPQVSVGLPQGGPLLPSASLTRGPQLPPLSVTVPSTLPQSPT
                     ENPGQSPMGIDATSAPALQYRTSAGSPATQSPTSPVSNQGFSPGSSPQHTSTLGSVFG
                     DAYYEQQMTARQANALSRQLEQFNMMENAISSSSLYNPGSTLNYSQAAMMGLSGSHGG
                     LQDPQQLGYTGHGGIPNIILTVTGESPPSLSKELSSTLAGVSDVSFDSDHQFPLDELK
                     IDPLTLDGLHMLNDPDMVLADPATEDTFRMDRL"
     exon            159..275
                     /gene="Crtc1"
                     /gene_synonym="Mect1; mKIAA0616; TORC-1; TORC1"
                     /inference="alignment:Splign:2.1.0"
     exon            276..413
                     /gene="Crtc1"
                     /gene_synonym="Mect1; mKIAA0616; TORC-1; TORC1"
                     /inference="alignment:Splign:2.1.0"
     exon            414..475
                     /gene="Crtc1"
                     /gene_synonym="Mect1; mKIAA0616; TORC-1; TORC1"
                     /inference="alignment:Splign:2.1.0"
     exon            476..570
                     /gene="Crtc1"
                     /gene_synonym="Mect1; mKIAA0616; TORC-1; TORC1"
                     /inference="alignment:Splign:2.1.0"
     exon            571..656
                     /gene="Crtc1"
                     /gene_synonym="Mect1; mKIAA0616; TORC-1; TORC1"
                     /inference="alignment:Splign:2.1.0"
     exon            657..697
                     /gene="Crtc1"
                     /gene_synonym="Mect1; mKIAA0616; TORC-1; TORC1"
                     /inference="alignment:Splign:2.1.0"
     exon            698..987
                     /gene="Crtc1"
                     /gene_synonym="Mect1; mKIAA0616; TORC-1; TORC1"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1121
                     /gene="Crtc1"
                     /gene_synonym="Mect1; mKIAA0616; TORC-1; TORC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1424
                     /gene="Crtc1"
                     /gene_synonym="Mect1; mKIAA0616; TORC-1; TORC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1526
                     /gene="Crtc1"
                     /gene_synonym="Mect1; mKIAA0616; TORC-1; TORC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1613
                     /gene="Crtc1"
                     /gene_synonym="Mect1; mKIAA0616; TORC-1; TORC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1794
                     /gene="Crtc1"
                     /gene_synonym="Mect1; mKIAA0616; TORC-1; TORC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..5778
                     /gene="Crtc1"
                     /gene_synonym="Mect1; mKIAA0616; TORC-1; TORC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2568..2573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crtc1"
                     /gene_synonym="Mect1; mKIAA0616; TORC-1; TORC1"
                     /note="hexamer: AATAAA"
     polyA_site      2589
                     /gene="Crtc1"
                     /gene_synonym="Mect1; mKIAA0616; TORC-1; TORC1"
                     /note="major polyA site"
     regulatory      5753..5758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crtc1"
                     /gene_synonym="Mect1; mKIAA0616; TORC-1; TORC1"
                     /note="hexamer: AATAAA"
     polyA_site      5778
                     /gene="Crtc1"
                     /gene_synonym="Mect1; mKIAA0616; TORC-1; TORC1"
ORIGIN      
        1 gaggagtagg agtaggagga ggcggcgaga agatggcgac ttcgaacaat ccgcggaaat
       61 ttagcgagaa gatcgcactg cacaaccaga agcaggcgga ggagacggcg gccttcgagg
      121 aggtcatgaa ggacctgagc ctgacgcggg ccgcgcggct tcagctgcag aagtcccagt
      181 acctgcagct gggccccagc cgtggccagt actacggtgg gtccctgccc aacgtgaacc
      241 agattggaag cagcagcgtg gacctggcct tccagacccc atttcagtcc tcaggcctgg
      301 acacgagtcg gaccacacga catcatgggc ttgtggacag agtatatcgt gagcgtggca
      361 gacttggctc cccgcaccgt cgacccctgt cagtagacaa gcatgggcga caggctgaca
      421 gctgccccta tggcaccgtg tacctctcgc ctcctgcgga caccagctgg aggaggacca
      481 actctgactc tgccctgcac cagagcacaa tgacacccag ccaggcagag tccttcacag
      541 gcgggtccca ggatgcgcac cagaagagag tcttactgct aactgtccca ggaatggagg
      601 acaccggggc tgagacagac aagacccttt ctaagcagtc atgggactca aagaaggcgg
      661 gttccaggcc caagtcctgt gaggtccccg gaatcaattg tcctgggttg gcagggctgg
      721 cctgcttgtc actgtcccca gaccttatgt cctgtcctcc ccatctggtc tttcccagca
      781 tctttccgtc tgcagaccag gagaacacaa cagccctgat ccctgccacc cacaacacag
      841 ggggctccct tcctgacctc accaacatcc acttcccctc cccactcccg acaccactgg
      901 accctgagga gcctccgttc cctgctctca ccagctccag cagcaccggc agccttgcac
      961 atctgggcgt tggcggcgca ggccagggta tgaacacccc cagctcttct ccacagcacc
     1021 ggccagcagt cgtcagcccc ctgtccctga gcacagaggc caggcggcag caggcccagc
     1081 aggtgtcacc caccctgtct ccgttgtcac ccatcactca ggccgtggct atggatgccc
     1141 tgtccttgga gcagcagctg ccctatgcct tcttcaccca gactggctcc cagcagcctc
     1201 ccccacagcc ccagccaccg cctccacctc caccggtatc ccagcagcag ccaccacctc
     1261 cacaggtgtc tgtgggcctc ccccagggtg gtccactgct gcccagtgcc agcctgactc
     1321 gggggcccca gctgccacca ctctcagtta ctgtaccatc cactcttccc cagtccccta
     1381 cagagaaccc aggccagtca ccaatgggga tcgatgccac ttcggcacca gctctgcagt
     1441 accgcacgag tgcagggtca cctgccaccc agtctcccac ctctccggtc tccaaccaag
     1501 gcttctcccc tggaagctcc ccacagcaca cgtccaccct gggcagcgtg tttggggatg
     1561 cgtactatga gcagcagatg acagccaggc aggccaatgc tctgtcccgc cagctggagc
     1621 agttcaacat gatggagaac gccatcagct ccagcagcct atacaacccg ggctccacac
     1681 tcaactattc ccaggctgcc atgatgggtc tgagcgggag ccacgggggc ctacaggacc
     1741 cgcagcagct cggctacaca ggccacggtg gaatccccaa catcatcctc acggtgacag
     1801 gagagtcacc accgagcctc tctaaggaac tgagcagcac actggcagga gtcagtgatg
     1861 tcagctttga ttcagaccat cagtttccac tggacgagct gaagattgac cctctgaccc
     1921 tggacggact ccatatgttg aatgacccag acatggtttt agccgaccca gccaccgagg
     1981 acaccttccg aatggaccgc ctgtgagtgg ctgtgcccac cagccgccgc tggtcagtct
     2041 ccaacggcgc tgccccaaac ctggggacgg caatggcgtc cccctttgcc aacggccaag
     2101 cttgtggttc tgagcttgca atgctgccca gtgcccctgc cagccccccg ccaccccggt
     2161 cgttcacctc ccatgatgcc tggcgtgtgt gaggccgctg tgtactaggc tggctatctg
     2221 tctgtccatc catctacctg gggtcaggct gatggccgag gctgtgagtg cctggccccc
     2281 atggatgttc cccgtgctcg ctccctcacc cctcactggg gatgtgagag ccctcatcag
     2341 atacccaaag tgtcactcac ttccagatgt gctgtgcaag gagggccggg gcgtgggtgt
     2401 ggagcgccca gaggcttagg tgcgccatcc attcgactgt tgtcagctgt cactgccttc
     2461 ctccatcctg cccccctccc caccgccatc cccagccctg gtcaggtcat gcatgcccac
     2521 cgagcccagg gcaaagacag cagagtgacg gggccgacct ggaccagaat aaacactgtt
     2581 tggatggctg ccttttatat tcctgagcgc tcttgcagcg tgacaatcga cctatggccg
     2641 aatgtggtat ggacagagcc actgaagcag ccagtgcccc tccttggctc attctcacca
     2701 tccttgcccc ctgttggaca aaggtcagta tggtggcact gggatggagg gtcacgggcc
     2761 acctgcacat tctcctcact cttccagcct cgtgacctgt ccctcctgct gtttaggatc
     2821 tggggctcgg gaggcagcag ccctggtggt tctgcttttc cttccgtttc tgttggcatt
     2881 tggtagctga cccccccccc ccagacttgc ctggcagcat gtgttaacta tcccccagtc
     2941 cctcctttac ctttttaaaa gttaactgga atactagcct ggagcacttg caagctgggg
     3001 cacctgggct gctcaccctg gacctgggcg tactggcatt tagtctcaac tccagagagc
     3061 tgggtgggca aggatggggc tggatgcagg gtcctggtgg ctgggcgtgt ctgtagaacc
     3121 gcagaacata tcctgggaac agcctttact ttcactggag cctcctgaga accctctctc
     3181 tctgaggatc tttaaggcgt ctgccaggcc ttagcagtgg ctaagtgggg gctgtggacc
     3241 ggggtcacct ttggcctgga agttctgatc cccaccaccc taggtcatag cttgacatgc
     3301 cctctgcctc tgctccgtag gcccgggccg cggcttcact gtttctctgt gccgttgccc
     3361 actgcccatg ctgggggttt ggggagcaca caagctgtgt gtgtctctcc ccaagcacct
     3421 aggcagccgc ctgcatgaga aagctgccac cctttcattg ctattcccct tcccctgggt
     3481 ctgaagacac agcattgctt tgtccaagtc acctgtccag gtctcaggcc tttctgtcac
     3541 cacggtgcgg acttgaaggg aatagtggga actttatcat caccatcacc atcatcatca
     3601 aacgtatgtg gtggcacgcg tctgtcaccc cagcactggc gagctggaaa gcacacagaa
     3661 gtggggtggg actctcttcc agctgtagaa gtctgagcaa acggcctcaa cagggccgag
     3721 aggctgacag ggtacctgga gtccagttac tcactggctg tctgagttct cagtgagcca
     3781 gggcaggaca gatacagccc atggccctcc taagctggtg gcctggcttt cagtgccctg
     3841 aagccaagag tgcatgtagc tgtattaatg tgaccagttc attgccaagt cctatgatga
     3901 ggtgacacgt ccctgcctca gcgccccagg cagctgtgag catctcatga gctctctggc
     3961 ccagccagga gccagcactc gggtgcatgc atgttcccaa aggggtcacc ctcccctccc
     4021 ctgggcctag ctgctgtcag ggggactcct gggaggtgtc tttgttttct agatataggt
     4081 cacctgtccg ataatacccc tgtattgcca agacatccca agatgatagc tcaaggccgt
     4141 gggggcctca gctggtgaca tgcagatact gtgacccatt gaactgtgct gggagcagcc
     4201 accttgcaat gtgtacatag accctctgcc cacattcatg ctctctcagg acaggcttag
     4261 acacctggcc cttgagaggt cagatgcgtg agccaggcct ggttttttcc cctccacctt
     4321 acccatgtgt caccagcttc agccaagccc ctcctcagcc atgtggctgt ccagcccact
     4381 tccctgactc agaaacagga ctggggcatc ttgataactc tatgcccagc tgcctcagtt
     4441 aaccttggca atctacccaa agccccacag aacaacaatg cagctggacc cagccccttt
     4501 ctatatccta agaaatggct tgtccccttg acccaaggcc ctgtcatatc cccttcctgc
     4561 aacactatcc agtgtggctc tgggaagtcc actggtactt agcctagcct tcaactcttt
     4621 ggaagactct tacacagggg ggccccctag tgaaacccat gtgctactgc acagcaccca
     4681 aggatggctg acagctatca cactgggctt gatgtcaaga gtcctggcac tccggtcagg
     4741 acaagaacgg gcaaaaggca tggggacagc aaacctgcac cagtgtcagc tgccgttctt
     4801 ctcacagtgg gcctggggtt ttttattttg cagagattta gcacaggttg agagggctgc
     4861 tggtatcagg gtcttgatgc agctgtgtgc acaggcatgg ggttgtagag ttgtgcccta
     4921 ggtctggctg ctgtccctca gagctgtcca ggtgaggaca ccgtggcgca gtctacccca
     4981 tgtggtctgc ctctggtgtg gtggtacctg gtccttttta taccccttcc accttggctc
     5041 ccagggggcc tcttccttca gggatctggt gggtgatttg gcgaccctga tcatttctgt
     5101 ctcaggcatg gccctcagtg tggcacaaat gcctgccacc cattggtcat agccacatct
     5161 ccctgtcagg gcagaagatg gagggacttg tatcctctcg agcctgggtg ctggggtact
     5221 cccaaggcca tggggtgccc tgaacctcag ttttcctctt tctcaaccct gctgggctca
     5281 ggggcccaac ctcctggtca gggtagggat agcagcagaa cccccacaat gggaccagca
     5341 gtcccttctg cactcagcct ttccttgggg ctagggatcc atcacatggg gtaaggccta
     5401 gcctaatcca acccagcact tctggtcaca gggggacatg aggacagggc tgtggccata
     5461 actccagagg ccaggctcct gtttctcagg ccccatctca ccccttagtt ggaaaaagga
     5521 cgccatgggc tggggtgccc ctttgatata tgcaaatggc tggttccaca ttcccctccc
     5581 cgtgcccagg ctggctctgc ccccggcatg cgcactccgc tgcggatgtc tgtggatcgt
     5641 gcgcatgggc accgcagttg ggggtcaggt tgctcagggc acgcacggcc gcccgcccca
     5701 ccttctggcg cagacgcttc tttgtatttt tgcgcccttt gtaatgaaat gtaataaaaa
     5761 cccaatgttt tcgtctgg
//
