LOCUS       NM_019922               1672 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus cartilage associated protein (Crtap), mRNA.
ACCESSION   NM_019922 XM_980814
VERSION     NM_019922.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1672)
  AUTHORS   Grol,M.W., Haelterman,N.A., Lim,J., Munivez,E.M., Archer,M.,
            Hudson,D.M., Tufa,S.F., Keene,D.R., Lei,K., Park,D., Kuzawa,C.D.,
            Ambrose,C.G., Eyre,D.R. and Lee,B.H.
  TITLE     Tendon and motor phenotypes in the Crtap-/- mouse model of
            recessive osteogenesis imperfecta
  JOURNAL   Elife 10, e63488 (2021)
   PUBMED   34036937
  REMARK    GeneRIF: Tendon and motor phenotypes in the Crtap(-/-) mouse model
            of recessive osteogenesis imperfecta.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1672)
  AUTHORS   Xu,H., Lenhart,S.A., Chu,E.Y., Chavez,M.B., Wimer,H.F., Dimori,M.,
            Somerman,M.J., Morello,R., Foster,B.L. and Hatch,N.E.
  TITLE     Dental and craniofacial defects in the Crtap-/- mouse model of
            osteogenesis imperfecta type VII
  JOURNAL   Dev Dyn 249 (7), 884-897 (2020)
   PUBMED   32133710
  REMARK    GeneRIF: Dental and craniofacial defects in the Crtap(-/-) mouse
            model of osteogenesis imperfecta type VII.
REFERENCE   3  (bases 1 to 1672)
  AUTHORS   Dimori,M., Heard-Lipsmeyer,M.E., Byrum,S.D., Mackintosh,S.G.,
            Kurten,R.C., Carroll,J.L. and Morello,R.
  TITLE     Respiratory defects in the CrtapKO mouse model of osteogenesis
            imperfecta
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 318 (4), L592-L605 (2020)
   PUBMED   32022592
  REMARK    GeneRIF: Pressure-volume curves showed significant differences in
            lung volumes and in the shape of the curves between CrtapKO mice.
REFERENCE   4  (bases 1 to 1672)
  AUTHORS   Brommage,R., Liu,J., Hansen,G.M., Kirkpatrick,L.L., Potter,D.G.,
            Sands,A.T., Zambrowicz,B., Powell,D.R. and Vogel,P.
  TITLE     High-throughput screening of mouse gene knockouts identifies
            established and novel skeletal phenotypes
  JOURNAL   Bone Res 2, 14034 (2014)
   PUBMED   26273529
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1672)
  AUTHORS   Grafe,I., Yang,T., Alexander,S., Homan,E.P., Lietman,C.,
            Jiang,M.M., Bertin,T., Munivez,E., Chen,Y., Dawson,B., Ishikawa,Y.,
            Weis,M.A., Sampath,T.K., Ambrose,C., Eyre,D., Bachinger,H.P. and
            Lee,B.
  TITLE     Excessive transforming growth factor-beta signaling is a common
            mechanism in osteogenesis imperfecta
  JOURNAL   Nat Med 20 (6), 670-675 (2014)
   PUBMED   24793237
REFERENCE   6  (bases 1 to 1672)
  AUTHORS   Morello,R., Bertin,T.K., Chen,Y., Hicks,J., Tonachini,L.,
            Monticone,M., Castagnola,P., Rauch,F., Glorieux,F.H., Vranka,J.,
            Bachinger,H.P., Pace,J.M., Schwarze,U., Byers,P.H., Weis,M.,
            Fernandes,R.J., Eyre,D.R., Yao,Z., Boyce,B.F. and Lee,B.
  TITLE     CRTAP is required for prolyl 3- hydroxylation and mutations cause
            recessive osteogenesis imperfecta
  JOURNAL   Cell 127 (2), 291-304 (2006)
   PUBMED   17055431
  REMARK    GeneRIF: CRTAP mutations are associated with the clinical spectrum
            of recessive osteogenesis imperfecta, including the type II and VII
            forms
REFERENCE   7  (bases 1 to 1672)
  AUTHORS   Desai,J., Shannon,M.E., Johnson,M.D., Ruff,D.W., Hughes,L.A.,
            Kerley,M.K., Carpenter,D.A., Johnson,D.K., Rinchik,E.M. and
            Culiat,C.T.
  TITLE     Nell1-deficient mice have reduced expression of extracellular
            matrix proteins causing cranial and vertebral defects
  JOURNAL   Hum Mol Genet 15 (8), 1329-1341 (2006)
   PUBMED   16537572
REFERENCE   8  (bases 1 to 1672)
  AUTHORS   Pang,A.L., Taylor,H.C., Johnson,W., Alexander,S., Chen,Y., Su,Y.A.,
            Li,X., Ravindranath,N., Dym,M., Rennert,O.M. and Chan,W.Y.
  TITLE     Identification of differentially expressed genes in mouse
            spermatogenesis
  JOURNAL   J Androl 24 (6), 899-911 (2003)
   PUBMED   14581517
REFERENCE   9  (bases 1 to 1672)
  AUTHORS   Morello,R., Tonachini,L., Monticone,M., Viggiano,L., Rocchi,M.,
            Cancedda,R. and Castagnola,P.
  TITLE     cDNA cloning, characterization and chromosome mapping of Crtap
            encoding the mouse cartilage associated protein
  JOURNAL   Matrix Biol 18 (3), 319-324 (1999)
   PUBMED   10429950
REFERENCE   10 (bases 1 to 1672)
  AUTHORS   Tonachini,L., Morello,R., Monticone,M., Skaug,J., Scherer,S.W.,
            Cancedda,R. and Castagnola,P.
  TITLE     cDNA cloning, characterization and chromosome mapping of the gene
            encoding human cartilage associated protein (CRTAP)
  JOURNAL   Cytogenet Cell Genet 87 (3-4), 191-194 (1999)
   PUBMED   10702664
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156499.2.
            
            On Feb 4, 2022 this sequence version replaced NM_019922.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK017797.1, AK007624.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-544               AC156499.2         85789-86332
            545-694             AC156499.2         90113-90262
            695-866             AC156499.2         91597-91768
            867-995             AC156499.2         94750-94878
            996-1141            AC156499.2         96409-96554
            1142-1225           AC156499.2         98341-98424
            1226-1672           AC156499.2         100882-101328
FEATURES             Location/Qualifiers
     source          1..1672
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 64.39 cM"
     gene            1..1672
                     /gene="Crtap"
                     /gene_synonym="5730529N23Rik; CASP; Leprel3; P3h5"
                     /note="cartilage associated protein"
                     /db_xref="GeneID:56693"
                     /db_xref="MGI:MGI:1891221"
     exon            1..544
                     /gene="Crtap"
                     /gene_synonym="5730529N23Rik; CASP; Leprel3; P3h5"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1279
                     /gene="Crtap"
                     /gene_synonym="5730529N23Rik; CASP; Leprel3; P3h5"
                     /codon_start=1
                     /product="cartilage-associated protein precursor"
                     /protein_id="NP_064306.2"
                     /db_xref="CCDS:CCDS23592.1"
                     /db_xref="GeneID:56693"
                     /db_xref="MGI:MGI:1891221"
                     /translation="MGPRSPTAALLVLLCVGCAPTPGRGQYERYSFRSFPRDELMPLE
                     SAYRHALDQYSGEHWAESVGYLEVSLRLHRLLRDSEAFCHRNCSAATPAPAPAGPASH
                     AELRLFGSVLRRAQCLKRCKQGLPAFRQSQPSRSVLADFQQREPYKFLQFAYFKANDL
                     PKAIAAAHTYLLKHPDDEMMKRNMEYYKSLPGAEDHIKDLETKSYESLFVRAVRAYNG
                     ENWRTSISDMELALPDFLKAFYECLAACEGSREIKDFKDFYLSIADHYVEVLECKIRC
                     EETLTPVIGGYPVEKFVATMYHYLQFAYYKLNDLKNAAPCAVSYLLFDQSDRVMQQNL
                     VYYQYHRDKWGLSDEHFQPRPEAVQFFNVTTLQKELYDFAQEHLMDDDEGEVVEYVDD
                     LLETEESA"
     exon            545..694
                     /gene="Crtap"
                     /gene_synonym="5730529N23Rik; CASP; Leprel3; P3h5"
                     /inference="alignment:Splign:2.1.0"
     exon            695..866
                     /gene="Crtap"
                     /gene_synonym="5730529N23Rik; CASP; Leprel3; P3h5"
                     /inference="alignment:Splign:2.1.0"
     exon            867..995
                     /gene="Crtap"
                     /gene_synonym="5730529N23Rik; CASP; Leprel3; P3h5"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1141
                     /gene="Crtap"
                     /gene_synonym="5730529N23Rik; CASP; Leprel3; P3h5"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1225
                     /gene="Crtap"
                     /gene_synonym="5730529N23Rik; CASP; Leprel3; P3h5"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1672
                     /gene="Crtap"
                     /gene_synonym="5730529N23Rik; CASP; Leprel3; P3h5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttccccgc ctcccttcct aggcctgccg cgtcgcgcgt cctcagctcg gggctctggt
       61 tcgtgggcca cgcgcgatgg ggccccgcag ccctacggcc gcgttgctgg tgctgctgtg
      121 tgtcgggtgc gcgccgaccc ccgggcgcgg gcagtacgag cgctacagct tccgcagctt
      181 cccgcgggac gagctgatgc cgctcgagtc ggcctaccgc cacgcgctcg accagtacag
      241 cggcgagcac tgggccgaga gcgtgggcta cctggaggtg agcctgcggc tgcaccgtct
      301 gctgcgcgac agcgaggcct tctgccaccg caactgcagc gcggccacgc cagcacccgc
      361 gcccgccggc ccggccagcc acgccgaact acgcctcttc ggcagcgtgc tgcgccgcgc
      421 gcagtgcctc aagcgctgca agcagggcct gcccgccttc cgccagtcgc agcccagccg
      481 ctcagtgctg gcggactttc agcagcgcga gccctacaag tttctgcagt tcgcctactt
      541 caaggccaat gacctcccga aggccatcgc tgcggctcac acctatctcc tgaagcatcc
      601 agatgacgag atgatgaaga gaaacatgga gtattataag agcttgcctg gagccgagga
      661 ccacattaaa gacttggaaa ccaagtcgta cgagagcctg tttgtccgtg cggtgcgggc
      721 ctacaacggg gagaactgga gaacgtccat ttccgacatg gagctcgcgc ttcccgactt
      781 cctcaaggcc ttctacgagt gcctggctgc ctgcgagggg tcgcgggaga tcaaggactt
      841 caaggacttc tacctgtcca tagcagatca ctatgtggaa gttctggagt gtaagattcg
      901 ttgtgaggag accctcaccc cagtcatagg aggctatccc gtggagaaat ttgtggcgac
      961 catgtaccac tatttacagt ttgcgtatta caagttgaat gatctgaaga atgcagcccc
     1021 gtgtgccgtc agctacctgc tctttgacca gagtgacagg gtcatgcaac agaacctggt
     1081 gtactatcag taccaccggg acaagtgggg cctctcggat gagcacttcc agcccagacc
     1141 cgaagcagtt cagttcttta atgtgacgac gctccagaag gaactgtacg acttcgctca
     1201 ggaacaccta atggatgacg atgagggaga ggttgtggag tatgtggacg acttgttgga
     1261 gacggaagag tctgcctagt ccacaggggc taaggaacct ctcttccgag ttcctctttc
     1321 ttcaagtgcc tgggttgttg atacctcaca gccttttctt cttaaagtaa gaaggaagcc
     1381 accatctctc cctaccaagg tcaagcctga cttccccttg ttcacactca gtattcacgc
     1441 ttgtcttcat ggttacacgt cttcatgcct gtctttccct tcacacatgt gttcccgtca
     1501 tctagtctgt cctcctcaaa gtcacgttcg tctcccctct gatcccatgt gtctccccca
     1561 tgttcagaaa gacagtcttc tgtggtctgc tttctcatcc ctgaagaaaa atcagtatta
     1621 ttttttaagt aagaaaaaca ctaaaagatg ataaatatat ttggagaatt tc
//
