LOCUS       NM_001281954            5044 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus cytotoxic and regulatory T cell molecule (Crtam),
            transcript variant 1, mRNA.
ACCESSION   NM_001281954
VERSION     NM_001281954.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5044)
  AUTHORS   Vazquez-Martinez,J.A., Gomez-Lim,M.A., Morales-Rios,E.,
            Gonzalez-Y-Merchand,J.A. and Ortiz-Navarrete,V.
  TITLE     Short Disordered Epitope of CRTAM Ig-Like V Domain as a Potential
            Target for Blocking Antibodies
  JOURNAL   Int J Mol Sci 21 (22), 8798 (2020)
   PUBMED   33233764
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5044)
  AUTHORS   Perez-Lopez,A., Nuccio,S.P., Ushach,I., Edwards,R.A., Pahu,R.,
            Silva,S., Zlotnik,A. and Raffatellu,M.
  TITLE     CRTAM Shapes the Gut Microbiota and Enhances the Severity of
            Infection
  JOURNAL   J Immunol 203 (2), 532-543 (2019)
   PUBMED   31142601
REFERENCE   3  (bases 1 to 5044)
  AUTHORS   Cervantes-Barragan,L., Cortez,V.S., Wang,Q., McDonald,K.G.,
            Chai,J.N., Di Luccia,B., Gilfillan,S., Hsieh,C.S., Newberry,R.D.,
            Sibley,L.D. and Colonna,M.
  TITLE     CRTAM Protects Against Intestinal Dysbiosis During Pathogenic
            Parasitic Infection by Enabling Th17 Maturation
  JOURNAL   Front Immunol 10, 1423 (2019)
   PUBMED   31312200
  REMARK    GeneRIF: Class I-restricted T cell-associated molecule (CRTAM)
            expression on T cells is required for an optimal IL-17 production
            during Toxoplasma gondii infection.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5044)
  AUTHORS   Takeuchi,A., Badr Mel,S., Miyauchi,K., Ishihara,C., Onishi,R.,
            Guo,Z., Sasaki,Y., Ike,H., Takumi,A., Tsuji,N.M., Murakami,Y.,
            Katakai,T., Kubo,M. and Saito,T.
  TITLE     CRTAM determines the CD4+ cytotoxic T lymphocyte lineage
  JOURNAL   J Exp Med 213 (1), 123-138 (2016)
   PUBMED   26694968
  REMARK    GeneRIF: These results reveal that CRTAM is critical to instruct
            the differentiation of CD4(+)CTL through the induction of Eomes and
            CTL-related gene.
REFERENCE   5  (bases 1 to 5044)
  AUTHORS   Cortez,V.S., Cervantes-Barragan,L., Song,C., Gilfillan,S.,
            McDonald,K.G., Tussiwand,R., Edelson,B.T., Murakami,Y.,
            Murphy,K.M., Newberry,R.D., Sibley,L.D. and Colonna,M.
  TITLE     CRTAM controls residency of gut CD4+CD8+ T cells in the steady
            state and maintenance of gut CD4+ Th17 during parasitic infection
  JOURNAL   J Exp Med 211 (4), 623-633 (2014)
   PUBMED   24687959
  REMARK    GeneRIF: During pathogenic infection, Crtam-Cadm1 interactions
            regulate the dynamic equilibrium between newly formed CD4(+) T
            cells and their retention in the gut.
REFERENCE   6  (bases 1 to 5044)
  AUTHORS   Arase,N., Takeuchi,A., Unno,M., Hirano,S., Yokosuka,T., Arase,H.
            and Saito,T.
  TITLE     Heterotypic interaction of CRTAM with Necl2 induces cell adhesion
            on activated NK cells and CD8+ T cells
  JOURNAL   Int Immunol 17 (9), 1227-1237 (2005)
   PUBMED   16091383
REFERENCE   7  (bases 1 to 5044)
  AUTHORS   Boles,K.S., Barchet,W., Diacovo,T., Cella,M. and Colonna,M.
  TITLE     The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell
            responses through the cell-surface receptor CRTAM
  JOURNAL   Blood 106 (3), 779-786 (2005)
   PUBMED   15811952
  REMARK    GeneRIF: NK cells and T8 cells recognize Necl-2 through CRTAM,
            expressed only on activated cells. CRTAM-Necl-2 interactions
            promote cytotoxicity of NK cells and IFN-gamma secretion of T8
            cells as well as NK cell-mediated rejection of tumors expressing
            Necl-2
REFERENCE   8  (bases 1 to 5044)
  AUTHORS   Galibert,L., Diemer,G.S., Liu,Z., Johnson,R.S., Smith,J.L.,
            Walzer,T., Comeau,M.R., Rauch,C.T., Wolfson,M.F., Sorensen,R.A.,
            Van der Vuurst de Vries,A.R., Branstetter,D.G., Koelling,R.M.,
            Scholler,J., Fanslow,W.C., Baum,P.R., Derry,J.M. and Yan,W.
  TITLE     Nectin-like protein 2 defines a subset of T-cell zone dendritic
            cells and is a ligand for class-I-restricted T-cell-associated
            molecule
  JOURNAL   J Biol Chem 280 (23), 21955-21964 (2005)
   PUBMED   15781451
  REMARK    GeneRIF: Necl2/CRTAM molecular pair could regulate a large panel of
            cell/cell interactions both within and outside of the immune system
REFERENCE   9  (bases 1 to 5044)
  AUTHORS   Sundberg,J.P., Silva,K.A., Li,R., Cox,G.A. and King,L.E.
  TITLE     Adult-onset Alopecia areata is a complex polygenic trait in the
            C3H/HeJ mouse model
  JOURNAL   J Invest Dermatol 123 (2), 294-297 (2004)
   PUBMED   15245428
REFERENCE   10 (bases 1 to 5044)
  AUTHORS   Kennedy,J., Vicari,A.P., Saylor,V., Zurawski,S.M., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A. and Zlotnik,A.
  TITLE     A molecular analysis of NKT cells: identification of a class-I
            restricted T cell-associated molecule (CRTAM)
  JOURNAL   J Leukoc Biol 67 (5), 725-734 (2000)
   PUBMED   10811014
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159820.2.
            
            On Nov 1, 2022 this sequence version replaced NM_001281954.1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC117716.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AC159820.2         127049-127134       c
            87-227              AC159820.2         116953-117093       c
            228-380             AC159820.2         115070-115222       c
            381-524             AC159820.2         112653-112796       c
            525-686             AC159820.2         110289-110450       c
            687-779             AC159820.2         106798-106890       c
            780-863             AC159820.2         103664-103747       c
            864-1010            AC159820.2         100616-100762       c
            1011-1097           AC159820.2         98143-98229         c
            1098-5044           AC159820.2         92199-96145         c
FEATURES             Location/Qualifiers
     source          1..5044
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 21.79 cM"
     gene            1..5044
                     /gene="Crtam"
                     /note="cytotoxic and regulatory T cell molecule"
                     /db_xref="GeneID:54698"
                     /db_xref="MGI:MGI:1859822"
     exon            1..86
                     /gene="Crtam"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1222
                     /gene="Crtam"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; class-I MHC-restricted T-cell-associated
                     molecule; class I-restricted T cell-associated molecule"
                     /codon_start=1
                     /product="cytotoxic and regulatory T-cell molecule isoform
                     1 precursor"
                     /protein_id="NP_001268883.1"
                     /db_xref="CCDS:CCDS72216.1"
                     /db_xref="GeneID:54698"
                     /db_xref="MGI:MGI:1859822"
                     /translation="MWWGALSLLFWVPVQAAFLKMETVTVEEGQTLTLTCVTSQTKNV
                     SLQWLAPSGFTIFLNQHPALKSSKYQLLHHSATQLSISVSNVTLREEGVYTCLHYGSS
                     VKTKQVRVTVLVTPFQPTVEALVLRRQNGEKSVVLKCSTERSKPPPQITWLLGEGLEI
                     YGELNHEFEADGKICNTSSMLIARAYGKNSTVHCIIQHEGLHGRKLVAPFQFEDLVAD
                     QETSDQETSDAPEQSSLSSQALQQPTSTVSMMENSSIPETDKEEKEHATQDPGLSTEA
                     SAQHTGLARRKSGILLLTLVSFLIFILFIIVQLFIMKLRKAHVVWKKESEISEQALES
                     YRSRSNNEETSSQENSSQAPQSKRCMNYITRLYSGAKTKKSAQHWKLGGKHSRVPESI
                     V"
     exon            87..227
                     /gene="Crtam"
                     /inference="alignment:Splign:2.1.0"
     exon            228..380
                     /gene="Crtam"
                     /inference="alignment:Splign:2.1.0"
     exon            381..524
                     /gene="Crtam"
                     /inference="alignment:Splign:2.1.0"
     exon            525..686
                     /gene="Crtam"
                     /inference="alignment:Splign:2.1.0"
     exon            687..779
                     /gene="Crtam"
                     /inference="alignment:Splign:2.1.0"
     exon            780..863
                     /gene="Crtam"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1010
                     /gene="Crtam"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1097
                     /gene="Crtam"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..5044
                     /gene="Crtam"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1891..1896
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crtam"
                     /note="hexamer: AATAAA"
     polyA_site      1916
                     /gene="Crtam"
                     /note="major polyA site"
     regulatory      5022..5027
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crtam"
                     /note="hexamer: ATTAAA"
     polyA_site      5044
                     /gene="Crtam"
ORIGIN      
        1 aggaagctgt cagagactcc ctccgttcag cacagccagc atgtggtggg gagccctcag
       61 tttgctgttc tgggtgccgg tgcaagcagc ctttctgaaa atggagaccg tcacggtaga
      121 ggaaggccaa acgctcactc taacgtgtgt tacttctcag acaaaaaacg tctctctcca
      181 gtggctggct ccctctgggt tcaccatttt tttaaaccag catcctgctt taaaaagctc
      241 caaataccag cttcttcacc attcagctac acaactctcc attagtgtgt ccaatgtaac
      301 tctccgagag gaaggtgtgt atacatgctt gcactacggg agttctgtga agacgaagca
      361 agtgagagtg accgtgttag tgactccttt ccagccaacc gtggaagctt tggttctcag
      421 aaggcagaat ggagagaaat cggttgtgct gaaatgttcc acagagagaa gcaagccccc
      481 gccacaaatc acctggctgc tgggggaagg tctggagatc tatggtgaac tcaaccatga
      541 atttgaagct gatgggaaaa tatgtaacac cagcagcatg ctcatcgccc gcgcatacgg
      601 caaaaactca accgtgcact gcattatcca gcacgagggc ttgcacggga gaaagctggt
      661 tgcccccttc cagtttgaag atttggttgc agatcaagaa acttcagatc aagaaacttc
      721 agatgcccct gagcagagct ctctctcctc ccaagccctc cagcagccca caagtacagt
      781 ctcaatgatg gaaaattcca gtataccaga gactgacaag gaagagaaag aacatgccac
      841 tcaagaccct ggcttgtcca ctgaagccag tgctcagcat acaggactgg cccggaggaa
      901 gagtggtatc ctgctgctca cactggtgtc cttcctcatt ttcatccttt tcatcatcgt
      961 tcagctcttc atcatgaagc tgcgtaaagc acacgtggta tggaagaagg aaagtgaaat
     1021 ttcagagcaa gctctagaaa gttacagatc aagatccaac aacgaggaga catcttccca
     1081 ggagaatagc agccaggctc cccagtctaa gcgttgcatg aactacatca cgcggttata
     1141 ctcgggagcc aaaacaaaga agagtgccca gcactggaag ctcggaggca agcacagccg
     1201 tgtcccggag agtattgtgt agtgttccct gcaatagaag ataggatttc agggcagccg
     1261 catcaggccc tggaaaggat cgtaagtact gtgacatgaa aaaaaataga atgtccattg
     1321 agtacaattc aagacagtgt ccattgagcc agggcagcca catgaggacc aagccatgga
     1381 cagaaagctc ctcgctgaaa ggaaaacata gaaagaacct attatgactg acactacctc
     1441 agagctggag aactctgcta agtcgttttg gatcagggtc aaaatgacca gtgagcagct
     1501 gacctcgaag ggaacagctt tttagacctg gggctggagt ggaactgttt gaattggttt
     1561 aaaatctttc cttctggtca agaagaactt aagcatgaga agtaccccaa ggagacctga
     1621 gatgccagca gcctgctttc aagacagcct ctcagaagag gcctggtggg caacagagaa
     1681 atgtgggatg ttacagcacg cagtggacat gatgccccag agagccacaa ctctcaactg
     1741 agttcaactg acaagaggct tcctgactaa ccatgagcca acctgacggg ccacttttat
     1801 cctaattaca ccatggtaaa agtagggaca gaagcaaacc gtgagtttgg ttgacagact
     1861 gttgaatttg tgactggctt ttagaatttt aataaagacc agaatgtgtc tttttagagg
     1921 ctgtcatgcc cattgattat ctgtgtgaaa agtcctttat gttaaaaaaa aaaaagaaag
     1981 aaagaaaagg aaaaaagaaa agaaaaattt agacgaaata gcaaactgac ttcatagaaa
     2041 tgaaacattt ctcattagtt ggatctgaaa aaaacagctt gcaagtgtta catgaacaca
     2101 cctgtgcatg ctgtacacac ccatgaacac acttatacat acttacttgt acccacccct
     2161 atatacaaac aaatatacac acacacacct gtatcatgaa tgtgttattg tagaccccag
     2221 ctcttcctgg tcctatccct cctatgataa ttttttttcc atttaacaat cacaaaattg
     2281 tagcaaaata taaagacagc atagaccttc ctcgcttatt tgagagtgag tgggcctgat
     2341 actcaacacc ttttaagccc tttgattacc ccaagaaaga cacctatcac agcagagcaa
     2401 acttctaagt caggaaagca gcatcgctgt cttccactca cagtccttgg atgctgtgat
     2461 ggtttgaatg aggatggtca ccacaggctc acatgtttga atgcttggtc accagttggt
     2521 ggaaccgctt gggagggatt agaaggtatg gccttgttgg agaaggagtg tcactgggga
     2581 tgggctttga ggaatcccaa accaggccct gcctcactct ctcttcctgc tgcctaccaa
     2641 tcaagatgta aaactctcag ctactgctct agcaagatgt ctgtctgctt cctaccgtga
     2701 tgataatggc taaccctcta aaactattag caagccctca attaatggcc ttcttttata
     2761 agacttgtct tggccatgat gtctcttcat agtaatagaa cagtgactaa ggcaaacacc
     2821 aaccaagctt ttcctgttgt cccaactgtc ctgaaggccc cagctggctt ctcacttcat
     2881 cttcacctct gtctgtttct gttttcaagg cctgggtgtt tgcaatacag ggtaattatt
     2941 tcacagagca gctctcagtt gggttttgtc caatgtttct ttgagattag gttcaagtaa
     3001 cacttgtcct gggctctcaa ggaagcctgt tgagttttac tttcttgtgt attattaagg
     3061 ataacttgaa gagaagaaaa gatagccact gtggacaata caatgggggg gggcacctga
     3121 agaaaggagg ggtgtgcctt cagagaaatc acttgaacaa agccgatacc taacctttgt
     3181 gcttcggtgg gctggtggca agttctccac tatatgattt ggtctgacac agcctacatg
     3241 acaaggagcc aggtactgga taggaccata catttatctt gcagctttta ggggaatggg
     3301 ctgcaatgcc acagaatgcc acagccttat aattctatcc cagagaggaa gggctgattg
     3361 tggggagatg acaagtctcg aagagagtct gcaatggact ctggcattta ggatccagga
     3421 tttgtgatag ttgccatggc ttttgaggta tcatcattgt tggatcctct caatggacag
     3481 aactttgaat tatttctata cgtgtatgta atgtgtatat gtgtgtgcat gttggtgtat
     3541 gtttaaatct gtctattgaa accatgagct tattcttttt ttgtattcat aattccatcc
     3601 tctgagagat gtttttgtat ccccagtgta tttgccaatt tatcagttcc cttcttggag
     3661 gtcatctccc agttccacca gtgcccattg cccttagatg tccttctccg gcaaaggctc
     3721 catgtctttg cttcctccat gtaggttctc tgctccttaa acatgggttc ttcgacctca
     3781 catgtgtggc ccctctgtgt ggaagccttt gacatgcaca caggtgcaca gacactgctg
     3841 tgtgccagtc ttctcaccca ttcaaactga gagtgtgggc aagggtagct ccatgtggag
     3901 cactgactcc ttcctaggct ggggctctca tactctctct ggagctccac ttgttcctcc
     3961 tcacactcgt atggcctcct gctttgtctt catgatggaa ctgtttggga agagtgtacc
     4021 tgtagggggt tgagaggaag ggaatgagcc aggtaccctg cattccaagg gagtttcagt
     4081 gtgcaaagac atctagacgt ggcatgccat tcatagtttt gtagcatctc tgtgcccgtc
     4141 atccatcagg ccaacagcag ttttaaaaca atacagaggg aagcactctt acctcagagt
     4201 ggtgctaatc attgttgatt aagcatacgt tggccaattt tgagtctatg tttgcagcga
     4261 agcctcccgc aggttgcctc cggtgactcc cccaatttct ccaggcccat tatcaggaat
     4321 caagtgaatg taccaacaac tcagcagcat gcagagtgga gaaaagccct gagccagagt
     4381 tgtcagaatc cccctgtcag gggttcccca gttcaattcc agcggctggt gtcagaagat
     4441 tcagggaagc gtttggaatc agtattttct aaagagtcta ccgcctggta ggggaactct
     4501 ggggaagcac cagccagaca ttttcaaaga ggaagtgaac tgtgaatcct gcagtcgagg
     4561 tgatcatgga ctcctggtta tcactttaaa atattcatgc caagcttatg cgaacaacta
     4621 aggatagaca ctgtacagca atccaagact acctggcctc aatgccatgg cccctctatt
     4681 gctgtagtaa gaggactgca ggggacattt agaatggaat gaggtggtgg gagctgtgtt
     4741 taatatcttt catttgccct gggagagtga tgatttgggc tacaacgctg tgaccccttt
     4801 ccatctccct ggagagagtg tgaagtacca acagatgtga gagagcagca aacgtccagg
     4861 gttagcagga ctgactgcat tcctcaactc tagttacaat tcaggtgttt ttctctttct
     4921 ctggttctga aatttatctg cttcattctt gcatctgttt aagtggacgt tggaatatcc
     4981 tcggcaactt tttgtttccc tcaaagcttt gaatctagtt tattaaatcc cttgtattat
     5041 ccaa
//
