LOCUS       NM_145123               2623 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus cartilage acidic protein 1 (Crtac1), transcript
            variant 1, mRNA.
ACCESSION   NM_145123
VERSION     NM_145123.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2623)
  AUTHORS   Kurihara,Y., Kawaguchi,Y., Ohta,Y., Kawasaki,N., Fujita,Y. and
            Takei,K.
  TITLE     Nogo Receptor Antagonist LOTUS Promotes Neurite Outgrowth through
            Its Interaction with Teneurin-4
  JOURNAL   Cells 13 (16), 1369 (2024)
   PUBMED   39195260
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2623)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2623)
  AUTHORS   Kawaguchi,Y., Matsubayashi,J., Kawakami,Y., Nishida,R., Kurihara,Y.
            and Takei,K.
  TITLE     LOTUS suppresses amyloid beta-induced dendritic spine elimination
            through the blockade of amyloid beta binding to PirB
  JOURNAL   Mol Med 28 (1), 154 (2022)
   PUBMED   36510132
  REMARK    GeneRIF: LOTUS suppresses amyloid beta-induced dendritic spine
            elimination through the blockade of amyloid beta binding to PirB.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2623)
  AUTHORS   Ito,S., Nagoshi,N., Kamata,Y., Kojima,K., Nori,S., Matsumoto,M.,
            Takei,K., Nakamura,M. and Okano,H.
  TITLE     LOTUS overexpression via ex vivo gene transduction further promotes
            recovery of motor function following human iPSC-NS/PC
            transplantation for contusive spinal cord injury
  JOURNAL   Stem Cell Reports 16 (11), 2703-2717 (2021)
   PUBMED   34653401
  REMARK    GeneRIF: LOTUS overexpression via ex vivo gene transduction further
            promotes recovery of motor function following human iPSC-NS/PC
            transplantation for contusive spinal cord injury.
REFERENCE   5  (bases 1 to 2623)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2623)
  AUTHORS   Tan,S.L., Nishi,M., Ohtsuka,T., Matsui,T., Takemoto,K.,
            Kamio-Miura,A., Aburatani,H., Shinkai,Y. and Kageyama,R.
  TITLE     Essential roles of the histone methyltransferase ESET in the
            epigenetic control of neural progenitor cells during development
  JOURNAL   Development 139 (20), 3806-3816 (2012)
   PUBMED   22991445
REFERENCE   7  (bases 1 to 2623)
  AUTHORS   Oeschger,F.M., Wang,W.Z., Lee,S., Garcia-Moreno,F., Goffinet,A.M.,
            Arbones,M.L., Rakic,S. and Molnar,Z.
  TITLE     Gene expression analysis of the embryonic subplate
  JOURNAL   Cereb Cortex 22 (6), 1343-1359 (2012)
   PUBMED   21862448
REFERENCE   8  (bases 1 to 2623)
  AUTHORS   Kurihara,Y., Arie,Y., Iketani,M., Ito,H., Nishiyama,K., Sato,Y.,
            Nakamura,F., Mizuki,N., Goshima,Y. and Takei,K.
  TITLE     The carboxyl-terminal region of Crtac1B/LOTUS acts as a functional
            domain in endogenous antagonism to Nogo receptor-1
  JOURNAL   Biochem Biophys Res Commun 418 (2), 390-395 (2012)
   PUBMED   22281491
  REMARK    GeneRIF: These findings suggest that the UA/EC region is a
            functional domain of LOTUS serving for an antagonistic action to
            NgR1.
REFERENCE   9  (bases 1 to 2623)
  AUTHORS   Sato,Y., Iketani,M., Kurihara,Y., Yamaguchi,M., Yamashita,N.,
            Nakamura,F., Arie,Y., Kawasaki,T., Hirata,T., Abe,T., Kiyonari,H.,
            Strittmatter,S.M., Goshima,Y. and Takei,K.
  TITLE     Cartilage acidic protein-1B (LOTUS), an endogenous Nogo receptor
            antagonist for axon tract formation
  JOURNAL   Science 333 (6043), 769-773 (2011)
   PUBMED   21817055
  REMARK    GeneRIF: found CRTAC1-B(LOTUS)is key molecule for lateral olfactory
            tract(LOT)formation; NgR1 is LOTUS-binding protein;LOTUS suppressed
            Nogo-NgR1 binding and Nogo-induced growth cone collapse;suggest
            endogenous antagonism of NgR1 by LOTUS crucial for LOT formation
REFERENCE   10 (bases 1 to 2623)
  AUTHORS   Desai,J., Shannon,M.E., Johnson,M.D., Ruff,D.W., Hughes,L.A.,
            Kerley,M.K., Carpenter,D.A., Johnson,D.K., Rinchik,E.M. and
            Culiat,C.T.
  TITLE     Nell1-deficient mice have reduced expression of extracellular
            matrix proteins causing cranial and vertebral defects
  JOURNAL   Hum Mol Genet 15 (8), 1329-1341 (2006)
   PUBMED   16537572
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK149020.1, AK149069.1 and AK032328.1.
            
            On Oct 11, 2017 this sequence version replaced NM_145123.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032328.1, AK149069.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AK149020.1         2-6
            6-2621              AK149069.1         2-2617
            2622-2623           AK032328.1         2482-2483
FEATURES             Location/Qualifiers
     source          1..2623
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 36.07 cM"
     gene            1..2623
                     /gene="Crtac1"
                     /gene_synonym="2810454P21Rik; Crtac1B; Lotus"
                     /note="cartilage acidic protein 1"
                     /db_xref="GeneID:72832"
                     /db_xref="MGI:MGI:1920082"
     exon            1..179
                     /gene="Crtac1"
                     /gene_synonym="2810454P21Rik; Crtac1B; Lotus"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..2096
                     /gene="Crtac1"
                     /gene_synonym="2810454P21Rik; Crtac1B; Lotus"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; ASPIC; CEP-68; protein CRTAC1-B; 68 kDa
                     chondrocyte-expressed protein"
                     /codon_start=1
                     /product="cartilage acidic protein 1 isoform 1 precursor"
                     /protein_id="NP_660105.3"
                     /db_xref="CCDS:CCDS29828.1"
                     /db_xref="GeneID:72832"
                     /db_xref="MGI:MGI:1920082"
                     /translation="MAPSADPGMVRMALLLLPPLWLLPLTGGSQRAEPMFTAVTNSVL
                     PPDYDSNPTQLNYGVAVTDVDHDGDFEIVVAGYTGPNLVLKYNRAQNRLVNIAVDERS
                     SPYYALRDRQGNAIGVTACDIDGDGREEIYFLNTNNAFSGVATYTDKLFKFRNNRWED
                     ILSDDVNVARGVASLFAGRSVACVDRTGSGRYSIYIANYAYGDVGPDALIEMDPEASD
                     LSRGILALRDVAAEAGVSKYTAGRGVSVGPILSSSASDIFCDNENGPNFLFHNQGNGT
                     FVDTAASAGVDDPHQHGRGVALADFNRDGKVDIVYGNWNGPHRLYLQMSAHGKVRFRD
                     IASPKFSTPSPVRTVIAADFDNDQELEVFFNNIAYRSSSANRLFRVIRREHGDPLIEE
                     LNPGDALEPEGRGTGGVVTDFDGDGMLDLILSHGESMAQPLSVFRGNQGFSNNWLRVV
                     PRTRFGAFARGAKVVLYTKKSGAHLRIIDGGSGYLCEMEPVAHFGLGRDEASSVEVTW
                     PDGKMVSRSVASEEMNSVLEILYPQDEDKLQNTAPLECGQGFSQQDNGHCMDTNECIQ
                     FPFVCPRDKPVCVNTYGSYRCRTNKRCNRGYEPNEDGTACVAQVAFLGGYSSAAFRLS
                     EPLSQASYLSLGLGLCLQLYAL"
     exon            180..382
                     /gene="Crtac1"
                     /gene_synonym="2810454P21Rik; Crtac1B; Lotus"
                     /inference="alignment:Splign:2.1.0"
     exon            383..579
                     /gene="Crtac1"
                     /gene_synonym="2810454P21Rik; Crtac1B; Lotus"
                     /inference="alignment:Splign:2.1.0"
     exon            580..716
                     /gene="Crtac1"
                     /gene_synonym="2810454P21Rik; Crtac1B; Lotus"
                     /inference="alignment:Splign:2.1.0"
     exon            717..873
                     /gene="Crtac1"
                     /gene_synonym="2810454P21Rik; Crtac1B; Lotus"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1008
                     /gene="Crtac1"
                     /gene_synonym="2810454P21Rik; Crtac1B; Lotus"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1154
                     /gene="Crtac1"
                     /gene_synonym="2810454P21Rik; Crtac1B; Lotus"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1291
                     /gene="Crtac1"
                     /gene_synonym="2810454P21Rik; Crtac1B; Lotus"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1374
                     /gene="Crtac1"
                     /gene_synonym="2810454P21Rik; Crtac1B; Lotus"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1475
                     /gene="Crtac1"
                     /gene_synonym="2810454P21Rik; Crtac1B; Lotus"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1644
                     /gene="Crtac1"
                     /gene_synonym="2810454P21Rik; Crtac1B; Lotus"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1790
                     /gene="Crtac1"
                     /gene_synonym="2810454P21Rik; Crtac1B; Lotus"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1833
                     /gene="Crtac1"
                     /gene_synonym="2810454P21Rik; Crtac1B; Lotus"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1977
                     /gene="Crtac1"
                     /gene_synonym="2810454P21Rik; Crtac1B; Lotus"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2623
                     /gene="Crtac1"
                     /gene_synonym="2810454P21Rik; Crtac1B; Lotus"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2592..2597
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crtac1"
                     /gene_synonym="2810454P21Rik; Crtac1B; Lotus"
                     /note="hexamer: GATAAA"
     polyA_site      2611
                     /gene="Crtac1"
                     /gene_synonym="2810454P21Rik; Crtac1B; Lotus"
                     /note="major polyA site"
ORIGIN      
        1 gttgtataaa gcgagcgcgc ggcgtcgggg cgggaggctc gaggccagcc cgggaccagg
       61 gctgggcgct gcaaggcggc ggcgccagcg gcagaggcag catcgagcgc ccgcgctccg
      121 acgcccccaa gcggtggggc tgagagagcc agaggatggc tccgagcgct gacccgggca
      181 tggtcaggat ggctttgctc ctgctgccgc ccctgtggct tctgcctctc actgggggat
      241 cccagagggc tgagcccatg ttcactgcag tcaccaactc agtcctgccc cctgactatg
      301 acagcaaccc cacccagctc aactatggag tggcagtgac agatgtggac catgatgggg
      361 acttcgagat cgttgtggcg gggtacaccg gccccaacct ggttctgaag tacaatcgag
      421 cccagaatcg gctggtgaat attgcggtgg acgagcgcag ctcaccctac tatgctctga
      481 gggaccgtca ggggaacgcc atcggggtca cagcctgtga catcgatggg gacggccgtg
      541 aggagatcta ctttctcaac accaataacg ccttctcagg tgtggccaca tacacagaca
      601 agttgttcaa attccgaaat aaccggtggg aagacatcct gagtgatgac gtcaatgtgg
      661 cccgtggagt ggccagcctc tttgcgggac gctccgtggc ctgtgtagac aggacgggct
      721 ctggaagata ctctatctac atagccaact atgcctatgg tgatgtgggg cctgatgccc
      781 tcatcgaaat ggaccctgag gccagtgacc tgtcccgggg gatcctggca ctcagggacg
      841 tggcggctga ggctggggtc agcaagtaca cagcgggccg gggtgtcagc gtaggcccca
      901 ttctcagcag cagtgcctca gatatcttct gtgacaacga gaacgggccc aacttcctct
      961 tccacaacca aggcaacggt acctttgtgg atactgcggc cagtgccggc gtagacgacc
     1021 ctcatcagca tggccgaggt gtggccctgg cagatttcaa ccgtgacggc aaagtagaca
     1081 tcgtctatgg caactggaac ggcccacatc gcctctatct acagatgagt gctcacggga
     1141 aggtccggtt tcgggacatt gcttcgccca agttctccac gccctcccct gtccggactg
     1201 tcattgctgc cgactttgac aatgaccagg aactggaagt cttcttcaac aacattgcct
     1261 acagaagctc ctcagccaat cgcctcttcc gtgtcatccg cagggagcac ggggaccctc
     1321 tcatcgagga gctcaatcct ggtgacgccc tagagcctga gggccggggt acagggggcg
     1381 tagtgaccga cttcgatggt gatgggatgc tggatctcat cttgtcacat ggagagtcca
     1441 tggctcagcc actgtctgtc ttccggggaa atcagggctt cagcaacaac tggttgcgtg
     1501 tggtacctcg cacccggttc ggggcctttg ccaggggcgc caaggttgta ctctacacca
     1561 agaagagtgg ggcgcaccta cggatcattg atgggggttc cggctacctg tgtgaaatgg
     1621 agcctgtggc acattttggc ctgggacggg atgaagccag cagtgtggag gtgacgtggc
     1681 cagatggcaa gatggtgagc cgaagtgtgg ccagcgagga gatgaactcg gtgttggaga
     1741 tcctctaccc ccaggatgag gacaaacttc agaacacagc cccactagag tgcggccaag
     1801 gattctccca gcaggacaat ggccattgca tggacaccaa tgaatgcatc cagttcccat
     1861 ttgtgtgccc tcgagacaaa cccgtatgtg tcaacaccta tggaagctac aggtgccgga
     1921 ccaataaaag atgcaatcgg ggctatgaac ccaatgaaga cggcacagcc tgtgtggctc
     1981 aagtggcctt tttaggtggg tactcatcgg ctgcctttag actctctgag cctctctctc
     2041 aggcctcgta tctttctcta ggcctgggac tttgccttca gttatatgca ctttaaatcc
     2101 catcaataaa ggaaaaaaaa atctaacaac ctttgtggaa aactatatct ctcctgctgc
     2161 ctacctctct ccacacccca tagatcccgc catgtgctcc ttcgaacgga cagcaggggt
     2221 ggccatcttt gaaaagggaa gtttgggaga tactgatggg accttagttg ttggtgaagc
     2281 ctttctttgc atgttttctg agaaaacaga aaaaggaaaa ctatctcctc taccccaccc
     2341 ctccttccgt gagaagaacc aagagagtcc agtcatttct gtatcttcgt gagcttcttc
     2401 ttgttttgcc cttgacaaag atggctcctg ggtggttgct ggctcggttg attcagtaat
     2461 gtatcctgtg cctgctgatc cggcctgtgc tgctgctgct gctttgtaca acctgatttc
     2521 ctatgattac ggaagcctta ttggattggt ggtggcgacg gaaagggaaa gggtggccct
     2581 ttgggactgt tgataaaaaa aaaatgctta agtttgaact tgc
//
