LOCUS       NM_178629               2818 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus CDP-L-ribitol pyrophosphorylase A (Crppa), transcript
            variant 1, mRNA.
ACCESSION   NM_178629
VERSION     NM_178629.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2818)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2818)
  AUTHORS   Tokuoka,H., Imae,R., Nakashima,H., Manya,H., Masuda,C., Hoshino,S.,
            Kobayashi,K., Lefeber,D.J., Matsumoto,R., Okada,T., Endo,T.,
            Kanagawa,M. and Toda,T.
  TITLE     CDP-ribitol prodrug treatment ameliorates ISPD-deficient muscular
            dystrophy mouse model
  JOURNAL   Nat Commun 13 (1), 1847 (2022)
   PUBMED   35422047
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2818)
  AUTHORS   Clements,R. and Wright,K.M.
  TITLE     Retinal ganglion cell axon sorting at the optic chiasm requires
            dystroglycan
  JOURNAL   Dev Biol 442 (2), 210-219 (2018)
   PUBMED   30149005
REFERENCE   4  (bases 1 to 2818)
  AUTHORS   Clements,R., Turk,R., Campbell,K.P. and Wright,K.M.
  TITLE     Dystroglycan Maintains Inner Limiting Membrane Integrity to
            Coordinate Retinal Development
  JOURNAL   J Neurosci 37 (35), 8559-8574 (2017)
   PUBMED   28760865
REFERENCE   5  (bases 1 to 2818)
  AUTHORS   Lee,A.Y. and Lloyd,K.C.
  TITLE     Conditional targeting of Ispd using paired Cas9 nickase and a
            single DNA template in mice
  JOURNAL   FEBS Open Bio 4, 637-642 (2014)
   PUBMED   25161872
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2818)
  AUTHORS   Yagi,H., Nakagawa,N., Saito,T., Kiyonari,H., Abe,T., Toda,T.,
            Wu,S.W., Khoo,K.H., Oka,S. and Kato,K.
  TITLE     AGO61-dependent GlcNAc modification primes the formation of
            functional glycans on alpha-dystroglycan
  JOURNAL   Sci Rep 3, 3288 (2013)
   PUBMED   24256719
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2818)
  AUTHORS   Rakowski,L.A., Garagiola,D.D., Li,C.M., Decker,M., Caruso,S.,
            Jones,M., Kuick,R., Cierpicki,T., Maillard,I. and Chiang,M.Y.
  TITLE     Convergence of the ZMIZ1 and NOTCH1 pathways at C-MYC in acute T
            lymphoblastic leukemias
  JOURNAL   Cancer Res 73 (2), 930-941 (2013)
   PUBMED   23161489
  REMARK    GeneRIF: we show that activated NOTCH1 and ZMIZ1 collaborate to
            induce T-ALL in mice
REFERENCE   8  (bases 1 to 2818)
  AUTHORS   Wright,K.M., Lyon,K.A., Leung,H., Leahy,D.J., Ma,L. and Ginty,D.D.
  TITLE     Dystroglycan organizes axon guidance cue localization and axonal
            pathfinding
  JOURNAL   Neuron 76 (5), 931-944 (2012)
   PUBMED   23217742
  REMARK    GeneRIF: This study demonistrated that the axonal guidance defects
            observed in ispd mutant mice.
REFERENCE   9  (bases 1 to 2818)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK045940.1, BC086665.1, BC050993.1 and AK051322.1.
            
            On Jan 23, 2014 this sequence version replaced NM_178629.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086665.1, SRR7652917.171279.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AK045940.1         2-70
            70-2759             BC086665.1         1-2690
            2760-2764           BC050993.1         2598-2602
            2765-2818           AK051322.1         2310-2363
FEATURES             Location/Qualifiers
     source          1..2818
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 16.84 cM"
     gene            1..2818
                     /gene="Crppa"
                     /gene_synonym="4930579E17Rik; Ispd"
                     /note="CDP-L-ribitol pyrophosphorylase A"
                     /db_xref="GeneID:75847"
                     /db_xref="MGI:MGI:1923097"
     exon            1..575
                     /gene="Crppa"
                     /gene_synonym="4930579E17Rik; Ispd"
                     /inference="alignment:Splign:2.1.0"
     CDS             325..1668
                     /gene="Crppa"
                     /gene_synonym="4930579E17Rik; Ispd"
                     /EC_number="2.7.7.40"
                     /note="isoform 1 is encoded by transcript variant 1;
                     2-C-methyl-D-erythritol 4-phosphate
                     cytidylyltransferase-like protein; notch1-induced protein;
                     isoprenoid synthase domain-containing protein;
                     D-ribitol-5-phosphate cytidylyltransferase; isoprenoid
                     synthase domain containing"
                     /codon_start=1
                     /product="D-ribitol-5-phosphate cytidylyltransferase
                     isoform 1"
                     /protein_id="NP_848744.2"
                     /db_xref="CCDS:CCDS49051.1"
                     /db_xref="GeneID:75847"
                     /db_xref="MGI:MGI:1923097"
                     /translation="MEPGPCSRPAEPGHCVSGPAGAGSAFPESPLSVAGAEPGNRPGT
                     VAAVLPAGGCGERMGVRTPKQFCRVLERPLISYTLQAMERVCWIKDIVVTVTGENMEA
                     MRSIIQRYGHKRISLAEAGATRHRSIFNGLKALAEDQPDCKLTKPEVVIIHDAVRPFV
                     EEDILLRVVLAAKEHGAAGAIRPLVSTVISPSADGHLDHSLDRAKHRASEMPQAFLFD
                     VIYEAYQQCSDFDLEFGTECLQLALKYCHRKAKLVEGPPALWKVTYKQDLCAAEAMIK
                     EKISQEICVVMNTKDEESVGHLLEEALRKELNCMKITSTVMDHIGGDIRNFIEQCYSF
                     ICVNVVSPDSQETRKLLRILEESSLPLLYPVVVVLVHCFDFTSVPLAQKMESLVWIRG
                     LAKEVKERNILLSGLLLNYSQDEQKLQESLGQSAAIIAALVKERNSALVGQLLVA"
     exon            576..852
                     /gene="Crppa"
                     /gene_synonym="4930579E17Rik; Ispd"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1002
                     /gene="Crppa"
                     /gene_synonym="4930579E17Rik; Ispd"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1107
                     /gene="Crppa"
                     /gene_synonym="4930579E17Rik; Ispd"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1153
                     /gene="Crppa"
                     /gene_synonym="4930579E17Rik; Ispd"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1248
                     /gene="Crppa"
                     /gene_synonym="4930579E17Rik; Ispd"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1338
                     /gene="Crppa"
                     /gene_synonym="4930579E17Rik; Ispd"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1431
                     /gene="Crppa"
                     /gene_synonym="4930579E17Rik; Ispd"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1563
                     /gene="Crppa"
                     /gene_synonym="4930579E17Rik; Ispd"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..2818
                     /gene="Crppa"
                     /gene_synonym="4930579E17Rik; Ispd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2741..2746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crppa"
                     /gene_synonym="4930579E17Rik; Ispd"
                     /note="hexamer: AATAAA"
     polyA_site      2764
                     /gene="Crppa"
                     /gene_synonym="4930579E17Rik; Ispd"
                     /note="major polyA site"
ORIGIN      
        1 agaatggggc ccatgactgt gctgtgcata gctgcctgtg tgtgactgtc aaatctgtaa
       61 ggactgctac tgcagcctcg gctcgacctg cccggaggga tagagggaag agcaggaaga
      121 gcattgctgc ctaggggcgc tgggcccagg ctgggaagac aaggcttgct ggcttcctcc
      181 gcgatcagca cccgaggcca ctttccccga gtccgctcgg cgccgttcct ggcccagtgc
      241 gacccttgat ctcgtcccag ggccggtgct ggcgtctcgc tctcggtttc catctgcacc
      301 tcgagcttct gcgctctgcc tgctatggag cctgggccgt gcagcaggcc cgctgagcct
      361 gggcattgcg tgagcggccc cgcgggcgcg ggctcagcgt tcccggagtc cccgttgtcc
      421 gtcgctgggg cggagcccgg gaaccgccct ggaaccgtgg ccgccgtgct gccggctggg
      481 ggttgcgggg aaaggatggg cgtccgcacc ccgaagcagt tctgccgggt tctggaaagg
      541 ccgctcatca gctacacttt gcaggctatg gagagagtat gctggataaa ggacattgtt
      601 gtgacagtga caggggagaa catggaagca atgagaagta tcatccagag gtatgggcat
      661 aagcgcatct cactagctga ggctggagcc acgcgccaca gatcaatttt caatggactg
      721 aaagccctgg cagaagatca gccagactgt aaactcacta agccagaagt ggtgattatc
      781 catgacgccg tgagaccttt tgttgaggaa gatatcctcc tgagagttgt cttagcagct
      841 aaggaacatg gggcagcagg agcaattcga cctctggtgt ccactgtcat cagtccctct
      901 gctgatggtc acttagacca ctcactggac cgtgccaagc atagggcaag cgaaatgccc
      961 caggcttttc tctttgatgt catctatgaa gcgtatcagc agtgtagtga ttttgacttg
     1021 gaatttggaa cagagtgctt gcagttggct ctaaaatact gtcacaggaa agcaaaactt
     1081 gtagaagggc cccctgccct ctggaaggtg acctacaaac aagacctgtg tgcagctgaa
     1141 gccatgatta aagagaaaat ttcacaagag atttgtgtgg tcatgaacac aaaagatgaa
     1201 gaatctgtag gacatcttct tgaggaagcg ctaagaaagg aactaaattg tatgaaaatc
     1261 acatctacag ttatggatca cataggcgga gacattagga acttcataga gcaatgttac
     1321 agtttcatct gtgtgaatgt tgtgtcccct gatagtcaag aaaccaggaa gttactgcgt
     1381 atcctcgaag agagcagcct tcctcttctg tatcctgtag ttgttgtttt ggtacactgc
     1441 tttgacttca cgtcagtgcc actcgctcag aagatggaaa gcctggtgtg gattaggggg
     1501 ttagcaaagg aagtgaaaga aaggaatatt ctcctaagtg gactcctcct aaactactca
     1561 caggatgagc agaagctaca agagagttta ggacaaagtg cagccatcat agctgcctta
     1621 gttaaggaaa gaaattctgc acttgttggg cagctcctgg tggcatgaag aacacagaca
     1681 aaaatcatct ctaagcttcc aaagatactt ccctaaggca ccaccttccc catcttgatg
     1741 ccccctcctt gtgcatacaa cattttagtt gttttcttta tcttgccatt tattgaatat
     1801 gatgcttagg ttgtggaaat gcataaatgt ttgtgtccat gagataatgt gtctaataaa
     1861 aatggctcca cccagaaaag gataaataaa tggaaaatac taatttcatg taaagaatct
     1921 gttcactact gcagcaagtg aaattgaaac gctcaggtga gccgttcttg tttagacagc
     1981 ttgactgtta tgtaagtcta tgctaatatc agtcataata tgcttcagaa ctagtcctaa
     2041 ttctaaaatc atcctcttac catgtgataa tgtatctttt ttgccttgtt ttggaattca
     2101 ctacacctta taaagaggaa gagagctggg acattggctt agtgggcaaa ctcttgccta
     2161 gtatggatag agcgacatcc cagaagaaaa cgaaaaccat gctggtaaac actgggcaga
     2221 aacaggaaag gggatgtctc caggtttctt ccccttggtc tcctattgct ctcaatctct
     2281 acagatctct aaagagaatg agatcccttt tatcagtttt aaactgtatc ttctctttgt
     2341 cttatgaggt gttatgctga cattatttta aagagtctct acttcttctg ggttcgtttc
     2401 agcagtgtct ggagagcctc ctgaaagttg agtcgcttca gtccatccat cccatggtct
     2461 tctgaaaagc agggatgcca gtgctatgga gttagctaat cttaatgctg gaatggcggc
     2521 cttgctaaat caagatttca ttccctttca ttcctattgg ccatacatac tactgttctt
     2581 tatgttgcac ttaataattt tatatgcata cagttgttaa aatgcctttg gttatataca
     2641 tacatttttt attgaaatat gttaaatcag aacactctag aatttacact ggatgaagaa
     2701 attataaaag ctgcatgaag tgtgtttact caggattgtc aataaatatg tctactttct
     2761 gaaatgtctc ctacaacatg ttaaataaat tcctctatat ttttgagttt caatacac
//
