LOCUS       NM_007768               1698 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus C-reactive protein, pentraxin-related (Crp), mRNA.
ACCESSION   NM_007768
VERSION     NM_007768.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1698)
  AUTHORS   He,Q., Zheng,Y., Yan,K., Tang,J., Yang,F., Tian,Y., Yang,L.,
            Dou,B., Chen,Y., Gu,J., Chen,H., Yuan,F. and Bei,W.
  TITLE     The cAMP receptor protein gene contributes to growth, stress
            resistance, and colonization of Actinobacillus pleuropneumoniae
  JOURNAL   Vet Microbiol 290, 110006 (2024)
   PUBMED   38308931
  REMARK    GeneRIF: The cAMP receptor protein gene contributes to growth,
            stress resistance, and colonization of Actinobacillus
            pleuropneumoniae.
REFERENCE   2  (bases 1 to 1698)
  AUTHORS   Jiang,J., Peng,Z., Wang,J., Chen,M., Wan,Y., Huang,H., Liu,Z.,
            Wang,J. and Hou,J.
  TITLE     C-reactive protein impairs immune response of CD8+ T cells via
            FcgammaRIIb-p38MAPK-ROS axis in multiple myeloma
  JOURNAL   J Immunother Cancer 11 (10) (2023)
   PUBMED   37844994
  REMARK    GeneRIF: C-reactive protein impairs immune response of CD8[+] T
            cells via FcgammaRIIb-p38MAPK-ROS axis in multiple myeloma.
            Erratum:[J Immunother Cancer. 2023 Dec 14;11(12):e007593corr1. doi:
            10.1136/jitc-2023-007593corr1.. PMID: 38101865]
REFERENCE   3  (bases 1 to 1698)
  AUTHORS   Fu,Y., Liu,H., Li,K., Wei,P., Alam,N., Deng,J., Li,M., Wu,H.,
            He,X., Hou,H., Xia,C., Wang,R., Wang,W., Bai,L., Xu,B., Li,Y.,
            Wu,Y., Liu,E. and Zhao,S.
  TITLE     C-reactive protein deficiency ameliorates experimental abdominal
            aortic aneurysms
  JOURNAL   Front Immunol 14, 1233807 (2023)
   PUBMED   37753091
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1698)
  AUTHORS   McCarthy,W.C., Sherlock,L.G., Grayck,M.R., Zheng,L., Lacayo,O.A.,
            Solar,M., Orlicky,D.J., Dobrinskikh,E. and Wright,C.J.
  TITLE     Innate Immune Zonation in the Liver: NF-kappaB (p50) Activation and
            C-Reactive Protein Expression in Response to Endotoxemia Are Zone
            Specific
  JOURNAL   J Immunol 210 (9), 1372-1385 (2023)
   PUBMED   36946778
  REMARK    GeneRIF: Innate Immune Zonation in the Liver: NF-kappaB (p50)
            Activation and C-Reactive Protein Expression in Response to
            Endotoxemia Are Zone Specific.
REFERENCE   5  (bases 1 to 1698)
  AUTHORS   Zhang,Z., Gao,Y., Li,L., Luo,J. and Gao,R.
  TITLE     Deficiency of C-reactive protein or human C-reactive protein
            transgenic treatment aggravates influenza A infection in mice
  JOURNAL   Front Immunol 13, 1028458 (2022)
   PUBMED   36275680
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1698)
  AUTHORS   Oakey,R.J., Watson,M.L. and Seldin,M.F.
  TITLE     Construction of a physical map on mouse and human chromosome 1:
            comparison of 13 Mb of mouse and 11 Mb of human DNA
  JOURNAL   Hum Mol Genet 1 (8), 613-620 (1992)
   PUBMED   1301170
REFERENCE   7  (bases 1 to 1698)
  AUTHORS   Hearne,C.M., McAleer,M.A., Love,J.M., Aitman,T.J., Cornall,R.J.,
            Ghosh,S., Knight,A.M., Prins,J.B. and Todd,J.A.
  TITLE     Additional microsatellite markers for mouse genome mapping
  JOURNAL   Mamm Genome 1 (4), 273-282 (1991)
   PUBMED   1794058
REFERENCE   8  (bases 1 to 1698)
  AUTHORS   Wong,Y.W., Williams,A.F., Kingsmore,S.F. and Seldin,M.F.
  TITLE     Structure, expression, and genetic linkage of the mouse BCM1 (OX45
            or Blast-1) antigen. Evidence for genetic duplication giving rise
            to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on
            mouse chromosome 3
  JOURNAL   J Exp Med 171 (6), 2115-2130 (1990)
   PUBMED   1693656
REFERENCE   9  (bases 1 to 1698)
  AUTHORS   Whitehead,A.S., Zahedi,K., Rits,M., Mortensen,R.F. and Lelias,J.M.
  TITLE     Mouse C-reactive protein. Generation of cDNA clones, structural
            analysis, and induction of mRNA during inflammation
  JOURNAL   Biochem J 266 (1), 283-290 (1990)
   PUBMED   2310378
REFERENCE   10 (bases 1 to 1698)
  AUTHORS   Yunis,I. and Whitehead,A.S.
  TITLE     The mouse C-reactive protein gene maps to distal chromosome 1 and,
            like its human counterpart, is closely linked to the serum amyloid
            P component gene
  JOURNAL   Immunogenetics 32 (5), 361-363 (1990)
   PUBMED   1979065
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131177.9.
            
            On Dec 8, 2007 this sequence version replaced NM_007768.3.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data because no single transcript was available for the full length
            of the gene. The extent of this transcript is supported by
            transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X17496.1, BC011124.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AC131177.9         165984-166128
            146-1698            AC131177.9         166342-167894
FEATURES             Location/Qualifiers
     source          1..1698
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 80.13 cM"
     gene            1..1698
                     /gene="Crp"
                     /note="C-reactive protein, pentraxin-related"
                     /db_xref="GeneID:12944"
                     /db_xref="MGI:MGI:88512"
     exon            1..145
                     /gene="Crp"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..759
                     /gene="Crp"
                     /note="C-reactive protein, petaxin related"
                     /codon_start=1
                     /product="C-reactive protein precursor"
                     /protein_id="NP_031794.3"
                     /db_xref="CCDS:CCDS35787.1"
                     /db_xref="GeneID:12944"
                     /db_xref="MGI:MGI:88512"
                     /translation="MEKLLWCLLIMISFSRTFGHEDMFKKAFVFPKESDTSYVSLEAE
                     SKKPLNTFTVCLHFYTALSTVRSFSVFSYATKKNSNDILIFWNKDKQYTFGVGGAEVR
                     FMVSEIPEAPTHICASWESATGIVEFWIDGKPKVRKSLHKGYTVGPDASIILGQEQDS
                     YGGDFDAKQSLVGDIGDVNMWDFVLSPEQISTVYVGGTLSPNVLNWRALNYKAQGDVF
                     IKPQLWS"
     exon            146..1698
                     /gene="Crp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1672..1677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crp"
                     /note="hexamer: AATAAA"
     polyA_site      1698
                     /gene="Crp"
                     /note="major polyA site"
ORIGIN      
        1 aagcgttcca ggactccttg tccttgatct ttcagacaaa acactgtcct cttagtccag
       61 atcccagcag catccatagc catggagaag ctactctggt gccttctgat catgatcagc
      121 ttctctcgga cttttggtca tgaagacatg tttaaaaagg cctttgtatt tcccaaggag
      181 tcagatactt cctatgtgtc tctggaagca gagtcaaaga agccactgaa cacctttact
      241 gtgtgtctcc atttctacac tgctctgagc acagtgcgca gcttcagtgt cttctcttat
      301 gctaccaaga agaactctaa cgacattctc atattttgga ataaggataa acagtatact
      361 tttggagtgg gtggtgctga agtacgattc atggtttcag agattcctga ggctccaaca
      421 cacatctgtg ccagctggga gtctgctacg gggattgtag agttctggat tgatgggaaa
      481 cccaaggtgc ggaaaagtct gcacaagggc tacactgtgg ggccagatgc aagcatcatc
      541 ttggggcagg agcaggactc gtatggcggt gactttgatg caaagcagtc tttggtggga
      601 gacatcggag atgtgaacat gtgggacttt gtgctatctc cagaacagat cagcacagtc
      661 tatgttggtg ggacactcag ccccaatgtt ttgaactggc gggcactgaa ctataaagca
      721 cagggtgatg tgtttattaa gccgcagctg tggtcctgac ctactgttgt gagccctgaa
      781 gcacctcctg ggattacatt ctctcccttg tctcgggtta tgaacctttt agccccagca
      841 gatgttgtag gtctgttctg tgaatatggc ctttcacttc tctgctttgt ggtcctcagc
      901 actagagcac ggaatttaaa tggaaggctt ccagcataag catcccacta ggactctacc
      961 aaagagaatc tgacttaccc atggttttat atatatatat gtaaatatcc atatatatat
     1021 atataattga aaaaatttca gacataattc ttctccctca catagatgaa aaaatagatg
     1081 cacagaaagg agaataattt tttattgttt ttgttttata atgtcatctt gagtgctgta
     1141 tttacatact ttctatccct ccctcttcag atcctttcct atccttccaa attctctctc
     1201 aaattcatga tgtcttatta ttagccttat gcatatatac atatgcataa tacctatcat
     1261 ctatcaatca atcaatcaat caatcaatct atctatctat ctatctatct atctatctat
     1321 ctatctatct atctatctac ctatctatca tctattcatc agtcatccat cttactgatt
     1381 acatttagtg cttcttgtat tttgttgaag actggacact ggataatcta tcaggagggc
     1441 ccctccctga agactgattg tccttttctc agcagccact gattacctct agctcttcat
     1501 atagggttct gtctttgtga aatttcttct gtccatgttg catgtcaatt ggtgtcatta
     1561 tgcaggtctt gtttgggcaa cctagagtga tggagcactg actacactgt gctcagaatc
     1621 agttcttttc tggaataaaa tctgtacctg aacttcccca gtccatgagt caataaagtc
     1681 acctttggct tgaatgaa
//
