LOCUS       NM_172122               6570 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus ciliary rootlet coiled-coil, rootletin (Crocc),
            transcript variant 1, mRNA.
ACCESSION   NM_172122
VERSION     NM_172122.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6570)
  AUTHORS   Van Heurck,R., Bonnefont,J., Wojno,M., Suzuki,I.K.,
            Velez-Bravo,F.D., Erkol,E., Nguyen,D.T., Herpoel,A., Bilheu,A.,
            Beckers,S., Ledent,C. and Vanderhaeghen,P.
  TITLE     CROCCP2 acts as a human-specific modifier of cilia dynamics and
            mTOR signaling to promote expansion of cortical progenitors
  JOURNAL   Neuron 111 (1), 65-80 (2023)
   PUBMED   36334595
REFERENCE   2  (bases 1 to 6570)
  AUTHORS   Turn,R.E., Linnert,J., Gigante,E.D., Wolfrum,U., Caspary,T. and
            Kahn,R.A.
  TITLE     Roles for ELMOD2 and Rootletin in ciliogenesis
  JOURNAL   Mol Biol Cell 32 (8), 800-822 (2021)
   PUBMED   33596093
  REMARK    GeneRIF: Roles for ELMOD2 and Rootletin in ciliogenesis.
REFERENCE   3  (bases 1 to 6570)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6570)
  AUTHORS   Mahuzier,A., Shihavuddin,A., Fournier,C., Lansade,P., Faucourt,M.,
            Menezes,N., Meunier,A., Garfa-Traore,M., Carlier,M.F.,
            Voituriez,R., Genovesio,A., Spassky,N. and Delgehyr,N.
  TITLE     Ependymal cilia beating induces an actin network to protect
            centrioles against shear stress
  JOURNAL   Nat Commun 9 (1), 2279 (2018)
   PUBMED   29891944
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6570)
  AUTHORS   Yadav,S.P., Sharma,N.K., Liu,C., Dong,L., Li,T. and Swaroop,A.
  TITLE     Centrosomal protein CP110 controls maturation of the mother
            centriole during cilia biogenesis
  JOURNAL   Development 143 (9), 1491-1501 (2016)
   PUBMED   26965371
REFERENCE   6  (bases 1 to 6570)
  AUTHORS   Yang,J., Gao,J., Adamian,M., Wen,X.H., Pawlyk,B., Zhang,L.,
            Sanderson,M.J., Zuo,J., Makino,C.L. and Li,T.
  TITLE     The ciliary rootlet maintains long-term stability of sensory cilia
  JOURNAL   Mol Cell Biol 25 (10), 4129-4137 (2005)
   PUBMED   15870283
REFERENCE   7  (bases 1 to 6570)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 6570)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   9  (bases 1 to 6570)
  AUTHORS   Yang,J., Liu,X., Yue,G., Adamian,M., Bulgakov,O. and Li,T.
  TITLE     Rootletin, a novel coiled-coil protein, is a structural component
            of the ciliary rootlet
  JOURNAL   J Cell Biol 159 (3), 431-440 (2002)
   PUBMED   12427867
  REMARK    GeneRIF: Data indicate that ciliary rootlets are composed of
            homopolymeric rootletin protofilaments bundled into variably shaped
            thick filaments.
REFERENCE   10 (bases 1 to 6570)
  AUTHORS   Segade,F., Broekelmann,T.J., Pierce,R.A. and Mecham,R.P.
  TITLE     Revised genomic structure of the human MAGP1 gene and
            identification of alternate transcripts in human and mouse tissues
  JOURNAL   Matrix Biol 19 (7), 671-682 (2000)
   PUBMED   11102756
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645625.15.
            
            On Jan 5, 2023 this sequence version replaced NM_172122.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF527975.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               AL645625.15        136284-136474       c
            192-333             AL645625.15        135714-135855       c
            334-488             AL645625.15        133805-133959       c
            489-674             AL645625.15        129708-129893       c
            675-758             AL645625.15        129536-129619       c
            759-820             AL645625.15        129400-129461       c
            821-986             AL645625.15        129156-129321       c
            987-1093            AL645625.15        128705-128811       c
            1094-1330           AL645625.15        126172-126408       c
            1331-1427           AL645625.15        125685-125781       c
            1428-1511           AL645625.15        124916-124999       c
            1512-1742           AL645625.15        124387-124617       c
            1743-1942           AL645625.15        123724-123923       c
            1943-2125           AL645625.15        120612-120794       c
            2126-2270           AL645625.15        119448-119592       c
            2271-2417           AL645625.15        118451-118597       c
            2418-2648           AL645625.15        117917-118147       c
            2649-2842           AL645625.15        117123-117316       c
            2843-2970           AL645625.15        116738-116865       c
            2971-3140           AL645625.15        115566-115735       c
            3141-3320           AL645625.15        113656-113835       c
            3321-3455           AL645625.15        112913-113047       c
            3456-3599           AL645625.15        112457-112600       c
            3600-3838           AL645625.15        111862-112100       c
            3839-3998           AL645625.15        111105-111264       c
            3999-4166           AL645625.15        108865-109032       c
            4167-4515           AL645625.15        107960-108308       c
            4516-4685           AL645625.15        105032-105201       c
            4686-4806           AL645625.15        104808-104928       c
            4807-4970           AL645625.15        104418-104581       c
            4971-5186           AL645625.15        103038-103253       c
            5187-5411           AL645625.15        102472-102696       c
            5412-5561           AL645625.15        101927-102076       c
            5562-5762           AL645625.15        101432-101632       c
            5763-5894           AL645625.15        101014-101145       c
            5895-6074           AL645625.15        100618-100797       c
            6075-6570           AL645625.15        99401-99896         c
FEATURES             Location/Qualifiers
     source          1..6570
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 73.31 cM"
     gene            1..6570
                     /gene="Crocc"
                     /note="ciliary rootlet coiled-coil, rootletin"
                     /db_xref="GeneID:230872"
                     /db_xref="MGI:MGI:3529431"
     exon            1..191
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..6161
                     /gene="Crocc"
                     /note="isoform 1 is encoded by transcript variant 1;
                     rootletin; ciliary rootlet coiled-coil protein"
                     /codon_start=1
                     /product="rootletin isoform 1"
                     /protein_id="NP_742120.2"
                     /db_xref="CCDS:CCDS18861.1"
                     /db_xref="GeneID:230872"
                     /db_xref="MGI:MGI:3529431"
                     /translation="MSLGLAGSLQAQLALEIVIQSLENCVLGPNQEKSLSVQNRVQDF
                     QGASLLVCAREVIASNLSRPETPAPLQVPEMASLLSLQEENQLLQQELSRVEDLLAQS
                     RAERDELAIKYNAVNERLEQAVRLETGELEAQEPRGLVRQSVELRRQLQEEQSSYRRK
                     LQAYQEGQQRQAQLVQRLQAKILQYKKQCSELEKQLMDRSTELEQQRLRDTEHSQDLD
                     SALLRLEEEQQRSASLAQVNAMLREQLDQANLANQALSEDIRKVTSDWTRSCKELEQR
                     EAVWRREEESFNTYFSSEHSRLLRLWRQVMGLRRQASEVKMGTERDLLQLGGELVRTS
                     RAVQELGLGLSASLHRAESKAEAALEKQKLLQAQLEEQLQAKLLREKDLAQLQVQSDL
                     DKADLSARVTELALSVEHLQNQNSEKDQVNRTLSDKLEALESLRLQEQTTLDTEDGEG
                     LQQTLRDLAQAALSDTESGVQLSSSERTADTSDGSLRGFSGQRTPTPPRHSPGRGRSP
                     RRGLSPACSDSSTLTLIHSALHKRQLQVQDMRGRYEASQELLGSVRKQLSDSEGERRG
                     LEEQLQRLRDQTAASAQAQEDAQREAQRLRSANELLSREKGNLTHSLQVTQQQAKELR
                     QELEKLQAAQEELKRQHNQLEDAQEDSVQEGARARRELERSHRQLEQLEVKRSGLTKE
                     LVEVREALSCAILQRDVLQTEKAEVAEALTKAEAGRAQLELSLTKLRAEEASLRDSLS
                     KMSALNESLAQDKLELNRLIAQLEEEKVALLGRQQQAEHATTMAVEKQELLEQLRLEQ
                     EVERQGLQGSLCVAEQAREALEQQILVLRSERSHLQEQLAQLSRQLSGRDQELEQALR
                     ESQRQVEALERAAREKEAMAKERAGLAVKLAAAEREGRTLSEEAIRLRLEKEALESSL
                     FDVQRQLAQLEARREQLEADSQALLLAKETLTGELAGLRQQVTSTEEKAALDKELMTQ
                     KLVQAEREAQASLREQRAAHEEDLQRLQHEKEAAWRELQAERAQLQGQLQQEREELLA
                     RMEAEKEELSKEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLAA
                     ISLEMERQKRDAQSRQEQDRNTLNALTSELRDLRAQLEEATAAHAQTVKELEERTGNL
                     GRQREACMREAEELRTQLRVLEDTRDGLRRELLEAQRKGRDSQDSSEAHRQEASELRR
                     SLSEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARVSVAKEA
                     GELRASLQEVERSRLEARRELQELRRQMKTLDSDNGRLGRELADLQGRLALGERTEKE
                     SRREALGLRQRLLKGESSLEALKQELQGSQRKLQEQEAEFRARERGLLGSLEEARGAE
                     KRLLDSARSLELRLEAVRAETSELGLRLSAAEGRAQGLEVELARVEAQRRVAEAQLGG
                     LRSALRRGLGLGRVSSSPAREAPAGGSGDGLSSPSPLEYSPRSQPPSPGLIASPAPPD
                     LDPEAVRDALRDFLQELRSAQRERDELKVQTSTLSQQLVEMEAERDHAASRAKQLQKA
                     VAESEEAWRSADRRLSGAQAELALQEESVRRSKRECRATLDQMAVLERSLQATESELR
                     ASQEKVSKMKATEAKLESDKRRLKEVLDASESRSIKLELQRRALEGELQRSRLGLGDR
                     EAHAQALQDRVDSLQRQVADSEVKAGTLQLTVERLSGALAKVEESEGNLRSKVQSLTD
                     ALTQSSASLSSTQDKNLHLQKALSTCEHDRQVLQERLDAARQALSEARRQSSSLGEQV
                     QTLRGELASLELQRGDAEGQLQQLQQALRQRQEGEAMALRSVQKLQEERRLLQERLGS
                     LQRALAQLEAEKRDLERSALQFDKDRVALRKTLDKVEREKLRSHEDTLRLNAERGRLD
                     RTLTGAELDLAEAQQQIQHLEAQVDVALEGNHNPVQPEAGEQQLELQQEVERLRSAQV
                     QTERTLEARERAHRQRVSGLEEQVSTLKAQLHQELRRSSASVSLPPGTPEK"
     exon            192..333
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            334..488
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            489..674
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            675..758
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            759..820
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            821..986
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1093
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1330
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1427
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1511
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1742
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1942
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2125
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2270
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2417
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2648
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..2842
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..2970
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            2971..3140
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            3141..3320
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            3321..3455
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            3456..3599
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            3600..3838
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            3839..3998
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            3999..4166
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            4167..4515
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            4516..4685
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            4686..4806
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            4807..4970
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            4971..5186
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            5187..5411
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            5412..5561
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            5562..5762
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            5763..5894
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            5895..6074
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     exon            6075..6570
                     /gene="Crocc"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      6570
                     /gene="Crocc"
                     /note="major polyA site"
ORIGIN      
        1 aatctgccgg gctgctcagc ccagcagcct ggcattggtg tgttagtgcg ttggtgcatg
       61 tagctgagac gctcttcgac ctctgtactt tgaggagggg ggctgtggag tgcccacaga
      121 cccccctctc catgagcctg gggctggcag gatctctgca ggctcagctg gcactggaga
      181 ttgtgatcca gtctctggag aactgtgttc tgggaccaaa ccaagagaag agcctgagtg
      241 tgcagaaccg ggtccaggac ttccagggag ccagcctgct tgtctgcgcc agggaggtca
      301 tcgccagcaa cctctcccgg cctgagaccc cagccccact ccaggtccca gagatggcct
      361 cactgctgtc gctgcaggag gaaaaccagc tgctgcagca ggagctgtcc cgcgtggagg
      421 acctgctggc ccagagccgc gcagagcggg atgagctggc catcaagtac aatgctgtca
      481 atgagaggct ggagcaggct gtgcggctgg aaactgggga gctggaggca caggagccca
      541 gagggctggt gcggcagagc gtggagctgc ggaggcagct gcaggaggag cagtcctcct
      601 accggcgcaa gctgcaggcc taccaggagg gccagcagcg gcaggcccag ctagtgcagc
      661 ggctgcaggc caagattctg cagtacaaga agcagtgctc agagctggag aagcagctga
      721 tggacaggtc tactgaactg gagcagcagc gactgaggga cacagaacac agccaggacc
      781 tggacagcgc tcttctgcgc ctagaggagg aacagcagag aagtgccagc ctggcccagg
      841 tgaatgccat gctgagagag cagctggacc aggccaactt ggccaaccag gctctgagcg
      901 aggacatacg caaggtgacc agtgactgga cccgcagctg taaggagctg gagcagcggg
      961 aggcagtgtg gaggcgcgag gaagagtcct tcaacaccta cttcagcagc gagcacagcc
     1021 gcctgctccg cctctggagg caggtcatgg ggctccgacg gcaggccagc gaggtgaaga
     1081 tgggcacgga gagggacttg ttgcagctgg gcggggagct cgtccgcaca tcccgggctg
     1141 tccaggagct gggcctcgga ctgagtgcca gcctgcatcg ggctgagagc aaggcagagg
     1201 cagctctgga gaagcaaaag ctgctgcagg cccaactaga ggagcagcta caggccaagc
     1261 tgctccggga gaaggacctg gcccaactgc aggtgcagag tgacctggac aaggctgatc
     1321 tcagtgccag agtgacagag ctggccctgt ccgtggagca ccttcagaat cagaactcag
     1381 agaaggacca ggtcaacagg accctctctg acaagctgga ggccctggag tcactgcggc
     1441 ttcaggaaca gacaaccctg gacactgagg atggagaggg gctgcagcag accctgaggg
     1501 acctggcaca ggctgcccta tctgacactg agagtggtgt gcagctcagc agctcagagc
     1561 gcactgcgga cacctctgac ggcagcctgc gcgggttctc tggccagcgg actccaactc
     1621 caccgcggca ttctccgggt cgaggtcgtt ctccgcgccg aggcctgtcc ccagcctgct
     1681 ccgactcctc cacactcacg ctgatccact cagccctgca caagcgccag ctacaggttc
     1741 aggacatgcg tggacgctat gaagccagcc aagaactgct gggttccgta cgcaagcagc
     1801 tcagtgacag tgagggcgag cggcgtggcc tggaggagca gctacagcgc ctgcgggacc
     1861 agacagcagc ctcagcccag gcccaagagg atgcgcagcg cgaggcccag cgcctacgca
     1921 gtgccaacga gctcctgagc agggagaagg ggaacctgac ccacagcctg caggtgaccc
     1981 agcagcaagc taaggagctg cgccaggagc tggagaagct gcaggctgcc caggaggagc
     2041 tgaaacgtca gcataaccaa ctggaggacg cgcaggagga ctcggtgcag gagggcgccc
     2101 gggcccgccg ggagctggag cgcagccata ggcagctgga acagctggag gtgaagcgct
     2161 cagggctgac taaggagctg gtggaggtgc gggaggcact gagctgcgcc atactgcaga
     2221 gggatgtact gcagacggag aaggcagagg tggccgaggc gctaaccaag gctgaagcag
     2281 gccgagcgca gctggagctc tccctgacca agctgagggc agaggaggcc tccctgcgag
     2341 actccttatc caagatgagt gccctgaatg agagcctcgc ccaggacaag ctggaattaa
     2401 accgccttat cgcccagcta gaggaagaaa aggtggcact cctgggccgc cagcagcagg
     2461 cagaacatgc cactacgatg gccgtggaga agcaggaact tttggagcag ctgaggctgg
     2521 agcaggaggt ggagaggcag ggcctacagg gctccctgtg tgtggctgag caggcccggg
     2581 aggcgctgga acaacagatc cttgtactgc gcagcgaacg cagccatctg caggagcagt
     2641 tggcccagct ctcccggcag ctgagtggac gggaccagga gctggagcaa gccctgcggg
     2701 agtcccagcg gcaggtggaa gcactggagc gcgctgcccg ggagaaggag gctatggcca
     2761 aggagcgggc tggcctggca gtgaagctgg cagcagcaga gcgggagggc cggaccctgt
     2821 cagaggaggc cattcgcctg cgcctggaga aggaggccct ggagagcagc ctatttgacg
     2881 tgcagaggca gctggctcag ctcgaggccc gccgagagca gctagaagcc gacagtcaag
     2941 ccctgctgct ggccaaggaa actctgactg gggagctggc aggcctacgg cagcaggtaa
     3001 catccacaga agagaaggca gccttggaca aggagctgat gacccagaag ctagtgcaag
     3061 ccgagcggga ggcacaggcc tctctgcggg agcagcgggc agcccatgag gaggatctcc
     3121 agagactgca gcatgagaag gaggctgcat ggcgggagct tcaggcagag cgggcccagc
     3181 tgcagggcca gctgcagcag gagcgagagg agctgctggc acggatggag gccgagaagg
     3241 aggagctgag caaggagatt gccgcgctgc agcaggagcg ggacgagggc ctgctgctgg
     3301 cagagagcga aaagcagcag gccttgtccc tgaaggagtc cgagaagacg gcgctgtcgg
     3361 agaagttgat gggaactcgg cacagtctgg ctgccatctc tctggagatg gaacggcaga
     3421 agcgagatgc ccagagccgg caggaacagg accggaacac actgaacgcc ctgacatctg
     3481 aacttcgaga cctccgggcc cagctggagg aagccactgc cgcccatgcc cagacggtga
     3541 aagagctgga ggaacggacg gggaacctgg gccggcagcg ggaggcctgc atgcgggagg
     3601 cagaagagct gaggactcag ctgcgtgtgt tggaggacac ccgcgatggg ctgcggcggg
     3661 agctgctgga ggctcagcgt aagggtcggg acagtcagga cagctccgaa gcccatcgcc
     3721 aagaggctag tgagctgcgg cgcagcctga gtgagggcgc caaggagcgg gaggccctgc
     3781 ggcggtccaa cgaggagctg aggtctgcag tgaagaaggc ggagagtgag cgcatcagcc
     3841 tgaagcttgc caatgaggac aaggagcaga agttggccct cctggaagag gctcgagtgt
     3901 ctgtagccaa ggaggctgga gagctgcggg cctcgctgca ggaggtggag cgatcccggc
     3961 tggaggctcg acgtgagctg caggagctta ggcgacagat gaagacactg gacagtgaca
     4021 atggcaggct gggccgggag ctggcagacc tgcagggccg cttggccctg ggtgagcgga
     4081 cggagaagga gagcaggcga gaggccctgg gcctacggca gaggttgctg aaaggcgaga
     4141 gcagcctgga agccctgaaa caggagctcc agggttccca gaggaagctg caggagcaag
     4201 aggccgagtt ccgggcgcgg gagcgaggcc tgttgggctc cctggaggag gcgcgtggtg
     4261 ccgagaagag gcttctggac tctgcccgca gcctggagct gaggctggag gcggtgcggg
     4321 cagagacctc agagctgggg ctgcggctga gcgcggccga gggccgggcg cagggtctgg
     4381 aggtcgagct tgcccgcgtg gaggcgcagc ggcgggtggc cgaggcccag ctaggcggcc
     4441 tgcgctccgc cctgcgccgg ggcctaggcc tgggccgagt gtccagctcc ccagcccggg
     4501 aggcgcctgc tggaggaagt ggggatggtc ttagcagccc cagtcctttg gaatatagcc
     4561 ctcggtccca gcccccctct ccagggctca ttgcctcccc ggcacctcca gacttggacc
     4621 cagaagctgt gcgtgatgcc ctccgagact tcctgcaaga gctgcggagc gcccagcggg
     4681 agcgggatga acttaaggtc cagaccagca ccctgagcca acagctggtg gagatggagg
     4741 cagagagaga ccatgcagcc tcaagggcca agcagctgca gaaggcagtc gctgagagcg
     4801 aggaagcctg gcgcagtgca gacaggcggc tgagcggggc ccaggcagag ctggcactgc
     4861 aggaagagag tgtgcgacgt agcaagcggg agtgcagggc cacgctggac cagatggcag
     4921 tgctggagag gagcctgcag gccaccgaga gcgagctccg agccagccag gagaaagtca
     4981 gcaagatgaa ggccaccgag gcgaagctgg agagcgacaa gcggcggctg aaggaggtgc
     5041 tggatgcctc tgagagccgc tccatcaaac tggagctgca gcggcgcgct cttgagggcg
     5101 agctgcagcg cagccgcctc ggcctggggg accgggaggc ccatgcgcag gccctccagg
     5161 atcgggtgga ctccctgcag agacaggtgg cagacagtga ggtgaaggca gggaccttac
     5221 agctgacagt ggagcggctc agtggggcac tggccaaggt ggaggagagc gaggggaacc
     5281 tgcggagcaa ggtgcagagc ttgacagatg ccctgaccca gagcagcgcc agcctcagca
     5341 gcactcagga caagaatctg cacctacaga aggccttgag tacctgtgaa catgaccgcc
     5401 aagtgctaca ggaacggctg gatgcagcca gacaggcatt gtctgaagcg cgaagacaaa
     5461 gcagctccct gggtgaacag gtgcagactt tgaggggcga gctggccagc ctggagctgc
     5521 agcggggcga tgctgagggc cagctgcagc agctgcagca ggcgctgcga cagcggcagg
     5581 aaggggaggc catggctctg cgctccgtcc agaagctgca ggaggagcgg cgcctgttgc
     5641 aggagcgcct gggcagtctg cagcgagccc tggcccagct ggaagctgag aaacgtgatc
     5701 tggagcgctc agccctgcag ttcgacaagg accgtgtggc cctcaggaag acgctggata
     5761 aggtggagcg ggagaagctt cgaagccatg aggacaccct gcgcttgaat gcagagaggg
     5821 gccgcctgga ccgcacactc acaggagctg agctggacct ggccgaggcc caacagcaga
     5881 tccaacattt ggaggcacag gtggatgtag ccctggaggg gaaccacaat ccggtccagc
     5941 cagaggcggg tgagcagcaa ctggaactgc aacaggaggt tgaacgcctg cgcagtgccc
     6001 aggtacagac ggagcgcaca ctggaggcac gggagcgggc ccaccgccag agggtgtcag
     6061 ggctcgagga gcaggtatcc acactgaagg cacagctaca ccaggagctt cgcaggagct
     6121 cggcatccgt ctccctaccc cctggcaccc ctgagaaatg agacccttct agtcctgagc
     6181 aggtcccctg ggcaggagag acaccctttg tagcatagcc tgcccagggc ctggtcatca
     6241 gagtgctgtg tgagggagct ggggtggcag agatgatggc ttctcagagt tgctacaacc
     6301 tgtactaccc cgggcctctc ctggaagagc ctcttgatgg cccaaggctg catgagccag
     6361 ccaggggcca gggagagcac ttgtttctgg cagcagcaga acaaggcttc cccagaaagg
     6421 ctacctgagc cagagcagcc cccagcgtct gtccttgaca tcctgtcaga agctccctcg
     6481 tgaccttaga gcccttgtat ttttatactt ttttataatg ttgactgtgg agagcgtttg
     6541 tgctttttgt aacgtgacct gttttctaga
//
