LOCUS       NM_001136058            3103 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus collapsin response mediator protein 1 (Crmp1),
            transcript variant 1, mRNA.
ACCESSION   NM_001136058
VERSION     NM_001136058.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3103)
  AUTHORS   Chen,C.W., Su,C., Huang,C.Y., Huang,X.R., Cuili,X., Chao,T.,
            Fan,C.H., Ting,C.W., Tsai,Y.W., Yang,K.C., Yeh,T.Y., Hsieh,S.T.,
            Chen,Y.J., Feng,Y., Hunter,T. and Chang,Z.F.
  TITLE     NME3 is a gatekeeper for DRP1-dependent mitophagy in hypoxia
  JOURNAL   Nat Commun 15 (1), 2264 (2024)
   PUBMED   38480688
  REMARK    GeneRIF: NME3 is a gatekeeper for DRP1-dependent mitophagy in
            hypoxia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3103)
  AUTHORS   Zhang,Y. and Gong,X.
  TITLE     Fat mass and obesity associated protein inhibits neuronal
            ferroptosis via the FYN/Drp1 axis and alleviate cerebral
            ischemia/reperfusion injury
  JOURNAL   CNS Neurosci Ther 30 (3), e14636 (2024)
   PUBMED   38430221
  REMARK    GeneRIF: Fat mass and obesity associated protein inhibits neuronal
            ferroptosis via the FYN/Drp1 axis and alleviate cerebral
            ischemia/reperfusion injury.
REFERENCE   3  (bases 1 to 3103)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3103)
  AUTHORS   Tsai,Y.C., Huang,S.M., Peng,H.H., Lin,S.W., Lin,S.R., Chin,T.Y. and
            Huang,S.M.
  TITLE     Imbalance of synaptic and extrasynaptic NMDA receptors induced by
            the deletion of CRMP1 accelerates age-related cognitive decline in
            mice
  JOURNAL   Neurobiol Aging 135, 48-59 (2024)
   PUBMED   38176125
  REMARK    GeneRIF: Imbalance of synaptic and extrasynaptic NMDA receptors
            induced by the deletion of CRMP1 accelerates age-related cognitive
            decline in mice.
REFERENCE   5  (bases 1 to 3103)
  AUTHORS   Su,K.Y., Chien,W.L., Fu,W.M., Yu,I.S., Huang,H.P., Huang,P.H.,
            Lin,S.R., Shih,J.Y., Lin,Y.L., Hsueh,Y.P., Yang,P.C. and Lin,S.W.
  TITLE     Mice deficient in collapsin response mediator protein-1 exhibit
            impaired long-term potentiation and impaired spatial learning and
            memory
  JOURNAL   J Neurosci 27 (10), 2513-2524 (2007)
   PUBMED   17344389
  REMARK    GeneRIF: CRMP-1 may be involved in proper neurite outgrowth in the
            adult hippocampus. Loss of CRMP-1 may affect LTP maintenance and
            spatial learning and memory.
REFERENCE   6  (bases 1 to 3103)
  AUTHORS   Charrier,E., Mosinger,B., Meissirel,C., Aguera,M., Rogemond,V.,
            Reibel,S., Salin,P., Chounlamountri,N., Perrot,V., Belin,M.F.,
            Goshima,Y., Honnorat,J., Thomasset,N. and Kolattukudy,P.
  TITLE     Transient alterations in granule cell proliferation, apoptosis and
            migration in postnatal developing cerebellum of CRMP1-/- mice
  JOURNAL   Genes Cells 11 (12), 1337-1352 (2006)
   PUBMED   17121542
  REMARK    GeneRIF: Mice lacking Crmp1 showed a decrease in the number of
            granule cells migrating out of explants of developing cerebellum.
REFERENCE   7  (bases 1 to 3103)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   8  (bases 1 to 3103)
  AUTHORS   Wightman,P.J., Hayward,B.E. and Bonthron,D.T.
  TITLE     The genes encoding glucokinase regulatory protein and
            ketohexokinase co-localize to mouse chromosome 5
  JOURNAL   Mamm Genome 8 (9), 700-701 (1997)
   PUBMED   9271679
REFERENCE   9  (bases 1 to 3103)
  AUTHORS   Cohen-Salmon,M., Crozet,F., Rebillard,G. and Petit,C.
  TITLE     Cloning and characterization of the mouse collapsin response
            mediator protein-1, Crmp1
  JOURNAL   Mamm Genome 8 (5), 349-351 (1997)
   PUBMED   9107681
REFERENCE   10 (bases 1 to 3103)
  AUTHORS   Hamajima,N., Matsuda,K., Sakata,S., Tamaki,N., Sasaki,M. and
            Nonaka,M.
  TITLE     A novel gene family defined by human dihydropyrimidinase and three
            related proteins with differential tissue distribution
  JOURNAL   Gene 180 (1-2), 157-163 (1996)
   PUBMED   8973361
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CA321187.1, BC065046.1 and
            BM116580.2.
            
            On Jan 18, 2013 this sequence version replaced NM_001136058.1.
            
            Summary: This gene encodes a protein that is part of the collapsin
            response mediator protein family. The family is comprised of five,
            homologous cytosolic phosphoproteins that are expressed in
            developing and adult nervous tissue and mediate signaling to
            transduce responses to extracellular cues. This protein is a
            Semaphorin 3A signaling molecule that regulates collapse of the
            growth cone. The growth cone mediates axonal pathfinding in
            neurons. This protein is reported to represent a new class of
            microtubule-associated proteins. In humans this protein is reported
            to inhibit cancer cell invasion. In mouse deficiency of this gene
            may be associated with impaired spatial memory performance.
            Alternative splicing results in multiple transcript variants that
            encode different protein isoforms. [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065046.1, AK159049.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                CA321187.1         1-22
            23-3071             BC065046.1         1-3049
            3072-3103           BM116580.2         1-32                c
FEATURES             Location/Qualifiers
     source          1..3103
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 19.96 cM"
     gene            1..3103
                     /gene="Crmp1"
                     /gene_synonym="CRMP-1; Dpysl1; DRP-1; ULIP-3; Ulip3"
                     /note="collapsin response mediator protein 1"
                     /db_xref="GeneID:12933"
                     /db_xref="MGI:MGI:107793"
     exon            1..468
                     /gene="Crmp1"
                     /gene_synonym="CRMP-1; Dpysl1; DRP-1; ULIP-3; Ulip3"
                     /inference="alignment:Splign:2.1.0"
     exon            469..557
                     /gene="Crmp1"
                     /gene_synonym="CRMP-1; Dpysl1; DRP-1; ULIP-3; Ulip3"
                     /inference="alignment:Splign:2.1.0"
     exon            558..742
                     /gene="Crmp1"
                     /gene_synonym="CRMP-1; Dpysl1; DRP-1; ULIP-3; Ulip3"
                     /inference="alignment:Splign:2.1.0"
     exon            743..907
                     /gene="Crmp1"
                     /gene_synonym="CRMP-1; Dpysl1; DRP-1; ULIP-3; Ulip3"
                     /inference="alignment:Splign:2.1.0"
     exon            908..969
                     /gene="Crmp1"
                     /gene_synonym="CRMP-1; Dpysl1; DRP-1; ULIP-3; Ulip3"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1050
                     /gene="Crmp1"
                     /gene_synonym="CRMP-1; Dpysl1; DRP-1; ULIP-3; Ulip3"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1119
                     /gene="Crmp1"
                     /gene_synonym="CRMP-1; Dpysl1; DRP-1; ULIP-3; Ulip3"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1240
                     /gene="Crmp1"
                     /gene_synonym="CRMP-1; Dpysl1; DRP-1; ULIP-3; Ulip3"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1397
                     /gene="Crmp1"
                     /gene_synonym="CRMP-1; Dpysl1; DRP-1; ULIP-3; Ulip3"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1539
                     /gene="Crmp1"
                     /gene_synonym="CRMP-1; Dpysl1; DRP-1; ULIP-3; Ulip3"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1710
                     /gene="Crmp1"
                     /gene_synonym="CRMP-1; Dpysl1; DRP-1; ULIP-3; Ulip3"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1890
                     /gene="Crmp1"
                     /gene_synonym="CRMP-1; Dpysl1; DRP-1; ULIP-3; Ulip3"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2056
                     /gene="Crmp1"
                     /gene_synonym="CRMP-1; Dpysl1; DRP-1; ULIP-3; Ulip3"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..3103
                     /gene="Crmp1"
                     /gene_synonym="CRMP-1; Dpysl1; DRP-1; ULIP-3; Ulip3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3048..3053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crmp1"
                     /gene_synonym="CRMP-1; Dpysl1; DRP-1; ULIP-3; Ulip3"
                     /note="hexamer: AATAAA"
     polyA_site      3071
                     /gene="Crmp1"
                     /gene_synonym="CRMP-1; Dpysl1; DRP-1; ULIP-3; Ulip3"
                     /note="major polyA site"
ORIGIN      
        1 cgcagtcgcg cttgggccgc cgcgggcccg caccgaggcg ctcagcgcgg agccagcggt
       61 ggcgagagct gaccgccgga gacggggatg gcggagcggc ggcgcgcgtg gaacacggag
      121 gacgacctgc cggtgtacct ggcgcggcca ggcagcgcgg cgcagacccc gcgccagaag
      181 tacggcggca tgttcgccgc cgtggagggc gcctacgaga acaagaccat cgacttcgac
      241 gcctacagcg tgggccgccg cggctccgcg cgcacaccac gcagcgctgg ccggcccgac
      301 gccgtgggcc tgccgtgccc cggcggcagc gaagacacgg ccagtgatgt gagcgagccc
      361 tcgggctctg ctgtcagttc gccaggcgat cgcgatgaca gaccgccagc gttgcgcatc
      421 cgatgtcctg cgccccgcga cctgccactc ggccgggaca atggccagag tgaccggctc
      481 ctcatcagag gtggacgcat catcaatgat gaccagtcct tctacgccga tgtctaccta
      541 gaagatggac tcataaaaca aataggagag aacctgattg ttcctggtgg agtgaagacc
      601 atcgaggcga atggccgaat ggtcattccc ggtggcattg atgtcaacac ttacctgcag
      661 aagccctccc agggcatgac ctcggctgat gacttcttcc agggcactaa agcagcgctg
      721 gcaggtggaa ccacgatgat cattgaccac gttgttcctg aacctgggtc cagcttgttg
      781 acttcctttg agaaatggca cgaagcagca gacaccaaat cctgctgtga ctattccctc
      841 cacgtggaca tcacaagctg gtatgatggt gttcgggaag agctggaggt gctggtgcag
      901 gacaaaggtg tcaactcctt ccaagtctac atggcgtata aggacctgta ccagatgtct
      961 gacagccagc tgtatgaagc cttcaccttc cttaagggtt tgggagctgt gatcttagtc
     1021 catgcagaaa atggagattt gatagctcag gaacaaaaac ggatcctgga gatgggcatc
     1081 acgggtcccg agggtcatgc tctgagcaga cccgaggagc tggaggccga ggctgtgttc
     1141 cgggctattg ccattgcagg ccggatcaat tgccctgtgt acatcaccaa ggtcatgagc
     1201 aagagtgcag cggacatcat cgcactggcc aggaagaaag gccctcttgt cttcggtgag
     1261 cccatagccg ccagcctggg aaccgatggc acccactact ggagcaagaa ctgggccaag
     1321 gcagctgcat ttgtgacttc ccctcccctg agcccagacc ccaccactcc tgactacttg
     1381 acctccttgc tggcctgtgg agacttgcag gtcacaggta gtggccactg tccctacagt
     1441 actgctcaga aggctgtggg caaggacaac ttcactctga tccctgaggg tgtcaatggt
     1501 atagaagagc ggatgaccgt tgtctgggac aaggcagtgg ctactggcaa gatggatgag
     1561 aaccagtttg tagccgtcac cagcaccaac gcagccaaga tcttcaacct gtacccgagg
     1621 aaaggtcgga tcgctgtggg ctccgatgct gacgtagtca tctgggaccc agataagatg
     1681 aagaccataa cagccaaaag ccataaatca actgtggagt acaacatctt tgagggcatg
     1741 gagtgccacg gctcccccct ggtggtcatc agtcagggca agattgtctt tgaggatgga
     1801 aacatcagtg tcagcaaggg catgggccgc ttcatccctc ggaagccatt cccagagcat
     1861 ctctaccagc gtgtcaggat cagaagcaag gttttcgggt tgcatagtgt ttccaggggc
     1921 atgtacgatg ggcctgtgta cgaggtgcca gctacaccca aacatgctgc tcctgctcct
     1981 tctgccaaat cctcgccttc taaacaccaa cccccaccca tccggaacct ccaccagtcc
     2041 aacttcagct tatcaggtgc ccagatagat gacaacaatc caaggcgtac aggccaccgc
     2101 attgtggcgc cccctggtgg ccgctccaac atcaccagcc tcggttgacc tcagatgagc
     2161 cagatatgca agagtgaagg attatgggaa aacgtccatt ccttttccgt gtttttgaag
     2221 cccacagttt tagttggtac tgacggaggg gagattgagc gatgctcttt ccttctctgt
     2281 ttaggaagaa gtggtactag tgtggtgtgt ttgcctggaa gtccctcgcc cacagtgtgt
     2341 gttcacaccg actccacctc agagcatggt gcctccgttt tcccttccta gtgaccccag
     2401 gtttagcatc gtcctatact gttccctcca ctcctccatg accctctgag tgatggttct
     2461 tttgcgccct gtagctgttc taggatagga tgcatgttag taagttacgt atgcaagtct
     2521 gagcgcgcgc ggctgatgga catcgtcgag gaccgacata gacccgatgc caagacctta
     2581 gccccaaggg gagatttcca aactcttaaa aatgaaggct cccatgagtc ttcactagaa
     2641 agatgtggtc cccatcccca ccctgactga gacctgtgaa gatgcagagt ggcagggaag
     2701 gtcacagagc tccaccaccc atgtcctgtg tcaacaaccc ggtccctgtg gcacctgtaa
     2761 ctggccatag tgtctttctg gtctgtgtgt tcttccagcc agccttgggc tttgggccca
     2821 gccaggctca cacccagaaa ggggtgtcct gacaccccac ccaggccttg aggacggtgc
     2881 ggtaatgact gcccaggctg cctgagtctc tgaccctctg aggagttcga gcagggcagt
     2941 cagattttta aagttttgta cagttttcct ttgtattcac ttccattttt acttaataac
     3001 tgacttgttg gtggctctta tttctgaatt caaagcttgt gaaaaaaaat aaagaaatta
     3061 aattgcccgt tgatctgagt gggtgttttc acttgggttt atc
//
