LOCUS       NM_001024385            1939 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus cardiolipin synthase 1 (Crls1), transcript variant 1,
            mRNA.
ACCESSION   NM_001024385
VERSION     NM_001024385.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1939)
  AUTHORS   Yoo,Y., Yeon,M., Kim,W.K., Shin,H.B., Lee,S.M., Yoon,M.S., Ro,H.
            and Seo,Y.K.
  TITLE     Age-dependent loss of Crls1 causes myopathy and skeletal muscle
            regeneration failure
  JOURNAL   Exp Mol Med 56 (4), 922-934 (2024)
   PUBMED   38556544
  REMARK    GeneRIF: Age-dependent loss of Crls1 causes myopathy and skeletal
            muscle regeneration failure.
            Erratum:[Exp Mol Med. 2024 Apr;56(4):1031. doi:
            10.1038/s12276-024-01238-7.. PMID: 38658706]
REFERENCE   2  (bases 1 to 1939)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1939)
  AUTHORS   Johnson,J.M., Peterlin,A.D., Balderas,E., Sustarsic,E.G.,
            Maschek,J.A., Lang,M.J., Jara-Ramos,A., Panic,V., Morgan,J.T.,
            Villanueva,C.J., Sanchez,A., Rutter,J., Lodhi,I.J., Cox,J.E.,
            Fisher-Wellman,K.H., Chaudhuri,D., Gerhart-Hines,Z. and Funai,K.
  TITLE     Mitochondrial phosphatidylethanolamine modulates UCP1 to promote
            brown adipose thermogenesis
  JOURNAL   Sci Adv 9 (8), eade7864 (2023)
   PUBMED   36827367
REFERENCE   4  (bases 1 to 1939)
  AUTHORS   Lee,R.G., Balasubramaniam,S., Stentenbach,M., Kralj,T.,
            McCubbin,T., Padman,B., Smith,J., Riley,L.G., Priyadarshi,A.,
            Peng,L., Nuske,M.R., Webster,R., Peacock,K., Roberts,P., Stark,Z.,
            Lemire,G., Ito,Y.A., Boycott,K.M., Geraghty,M.T., van Klinken,J.B.,
            Ferdinandusse,S., Zhou,Y., Walsh,R., Marcellin,E., Thorburn,D.R.,
            Rosciolli,T., Fletcher,J., Rackham,O., Vaz,F.M., Reid,G.E. and
            Filipovska,A.
  CONSRTM   Care4Rare Canada Consortium
  TITLE     Deleterious variants in CRLS1 lead to cardiolipin deficiency and
            cause an autosomal recessive multi-system mitochondrial disease
  JOURNAL   Hum Mol Genet 31 (21), 3597-3612 (2022)
   PUBMED   35147173
  REMARK    Erratum:[Hum Mol Genet. 2023 Mar 20;32(7):1236. doi:
            10.1093/hmg/ddac294.. PMID: 36563328]
REFERENCE   5  (bases 1 to 1939)
  AUTHORS   Xu,M., Yao,J., Shi,Y., Yi,H., Zhao,W., Lin,X. and Yang,Z.
  TITLE     The SRCAP chromatin remodeling complex promotes oxidative
            metabolism during prenatal heart development
  JOURNAL   Development 148 (8) (2021)
   PUBMED   33913477
REFERENCE   6  (bases 1 to 1939)
  AUTHORS   Perez-Garcia,V., Fineberg,E., Wilson,R., Murray,A., Mazzeo,C.I.,
            Tudor,C., Sienerth,A., White,J.K., Tuck,E., Ryder,E.J., Gleeson,D.,
            Siragher,E., Wardle-Jones,H., Staudt,N., Wali,N., Collins,J.,
            Geyer,S., Busch-Nentwich,E.M., Galli,A., Smith,J.C., Robertson,E.,
            Adams,D.J., Weninger,W.J., Mohun,T. and Hemberger,M.
  TITLE     Placentation defects are highly prevalent in embryonic lethal mouse
            mutants
  JOURNAL   Nature 555 (7697), 463-468 (2018)
   PUBMED   29539633
REFERENCE   7  (bases 1 to 1939)
  AUTHORS   Chen,B.B., Coon,T.A., Glasser,J.R., Zou,C., Ellis,B., Das,T.,
            McKelvey,A.C., Rajbhandari,S., Lear,T., Kamga,C., Shiva,S., Li,C.,
            Pilewski,J.M., Callio,J., Chu,C.T., Ray,A., Ray,P., Tyurina,Y.Y.,
            Kagan,V.E. and Mallampalli,R.K.
  TITLE     E3 ligase subunit Fbxo15 and PINK1 kinase regulate cardiolipin
            synthase 1 stability and mitochondrial function in pneumonia
  JOURNAL   Cell Rep 7 (2), 476-487 (2014)
   PUBMED   24703837
REFERENCE   8  (bases 1 to 1939)
  AUTHORS   Kiebish,M.A., Yang,K., Sims,H.F., Jenkins,C.M., Liu,X.,
            Mancuso,D.J., Zhao,Z., Guan,S., Abendschein,D.R., Han,X. and
            Gross,R.W.
  TITLE     Myocardial regulation of lipidomic flux by cardiolipin synthase:
            setting the beat for bioenergetic efficiency
  JOURNAL   J Biol Chem 287 (30), 25086-25097 (2012)
   PUBMED   22584571
  REMARK    GeneRIF: transgenic expression of cardiolipin synthase attenuated
            maladaptive cardiolipin remodeling and bioenergetic inefficiency in
            myocardium rendered diabetic by streptozotocin treatment.
REFERENCE   9  (bases 1 to 1939)
  AUTHORS   Lu,B., Xu,F.Y., Taylor,W.A., Feingold,K.R. and Hatch,G.M.
  TITLE     Cardiolipin synthase-1 mRNA expression does not correlate with
            endogenous cardiolipin synthase enzyme activity in vitro and in
            vivo in mammalian lipopolysaccharide models of inflammation
  JOURNAL   Inflammation 34 (4), 247-254 (2011)
   PUBMED   20652826
  REMARK    GeneRIF: CLS mRNA levels cannot be correlated with CLS enzyme
            activity nor CL content in the LPS model of inflammation.
REFERENCE   10 (bases 1 to 1939)
  AUTHORS   Cheng,H., Mancuso,D.J., Jiang,X., Guan,S., Yang,J., Yang,K.,
            Sun,G., Gross,R.W. and Han,X.
  TITLE     Shotgun lipidomics reveals the temporally dependent, highly
            diversified cardiolipin profile in the mammalian brain: temporally
            coordinated postnatal diversification of cardiolipin molecular
            species with neuronal remodeling
  JOURNAL   Biochemistry 47 (21), 5869-5880 (2008)
   PUBMED   18454555
  REMARK    GeneRIF: CL has roles in in neuronal signaling, mitochondrial
            bioenergetics, and apoptosis
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK018180.1, BC048702.1 and BC086619.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086619.1, AK002408.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AK018180.1         2-20
            20-1292             BC048702.1         1-1273
            1293-1939           BC086619.1         1250-1896
FEATURES             Location/Qualifiers
     source          1..1939
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 64.77 cM"
     gene            1..1939
                     /gene="Crls1"
                     /gene_synonym="0610009I22Rik; 4930557M15Rik;
                     5730490M08Rik"
                     /note="cardiolipin synthase 1"
                     /db_xref="GeneID:66586"
                     /db_xref="MGI:MGI:1913836"
     exon            1..460
                     /gene="Crls1"
                     /gene_synonym="0610009I22Rik; 4930557M15Rik;
                     5730490M08Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1063
                     /gene="Crls1"
                     /gene_synonym="0610009I22Rik; 4930557M15Rik;
                     5730490M08Rik"
                     /EC_number="2.7.8.41"
                     /note="isoform 1 is encoded by transcript variant 1; CLS;
                     cardiolipin synthase (CMP-forming)"
                     /codon_start=1
                     /product="cardiolipin synthase (CMP-forming) isoform 1"
                     /protein_id="NP_001019556.1"
                     /db_xref="CCDS:CCDS16779.1"
                     /db_xref="GeneID:66586"
                     /db_xref="MGI:MGI:1913836"
                     /translation="MLAWRVARGAWGPLRVALRPPGARLGRGGSRRALLPPAACCLGC
                     LAERWRLRPAAFALRLPGAGPRTHCSGAGKAAPEPAAGGGGAAAQAPSARWVPASAAS
                     SYENPWTIPNLLSMTRIGLAPVLGYLILEEDFNVALGVFALAGLTDLLDGFIARNWAN
                     QKSALGSALDPLADKVLISILYISLTYADLIPVPLTYMIISRDVMLIAAVFYVRYRTL
                     PTPRTLAKYFNPCYATARLKPTFISKVNTAVQLILVAASLAAPVFNYADSIYLQILWC
                     CTAFTTAASAYSYYHYGRKTVQVIKGK"
     exon            461..598
                     /gene="Crls1"
                     /gene_synonym="0610009I22Rik; 4930557M15Rik;
                     5730490M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            599..728
                     /gene="Crls1"
                     /gene_synonym="0610009I22Rik; 4930557M15Rik;
                     5730490M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            729..814
                     /gene="Crls1"
                     /gene_synonym="0610009I22Rik; 4930557M15Rik;
                     5730490M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            815..883
                     /gene="Crls1"
                     /gene_synonym="0610009I22Rik; 4930557M15Rik;
                     5730490M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            884..975
                     /gene="Crls1"
                     /gene_synonym="0610009I22Rik; 4930557M15Rik;
                     5730490M08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1912
                     /gene="Crls1"
                     /gene_synonym="0610009I22Rik; 4930557M15Rik;
                     5730490M08Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1266..1271
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crls1"
                     /gene_synonym="0610009I22Rik; 4930557M15Rik;
                     5730490M08Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1292
                     /gene="Crls1"
                     /gene_synonym="0610009I22Rik; 4930557M15Rik;
                     5730490M08Rik"
                     /note="major polyA site"
     regulatory      1881..1886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crls1"
                     /gene_synonym="0610009I22Rik; 4930557M15Rik;
                     5730490M08Rik"
                     /note="hexamer: GATAAA"
     polyA_site      1904
                     /gene="Crls1"
                     /gene_synonym="0610009I22Rik; 4930557M15Rik;
                     5730490M08Rik"
ORIGIN      
        1 acctgtataa gcggaaagtg ccagagtgta gaaattagta tggagctgtc catacggcct
       61 cggcaccgct cgacttctct agagaagctg gcagccggtg ccaggggcgt ctgagttctc
      121 gactcttgga ctccgtggag gccacacggc catgttggct tggcgcgtgg cgcgcggcgc
      181 gtggggccct cttcgcgtgg ccctccggcc tccgggggcg cggctcggca ggggcggctc
      241 ccgcagggcc ctgctgccgc ccgcggcctg ctgcctcggc tgcctggctg agcgctggcg
      301 gctgcggccg gccgcgttcg ccttgcggct gcccggcgcc ggcccgcgga cccactgctc
      361 gggcgcgggg aaggcagccc cggagcccgc cgccggagga ggaggtgccg ccgcgcaggc
      421 ccccagcgcc cgatgggtcc cggcgagcgc cgccagctcg tatgaaaatc catggacaat
      481 cccaaatttg ttgtcaatga caagaattgg cctggccccc gtgttgggct acctgattct
      541 tgaagaagac tttaatgttg cactaggtgt ttttgcttta gccgggctaa cggatttgtt
      601 ggatggattt attgctcgaa actgggccaa ccaaaaatca gctttgggaa gtgctcttga
      661 tccacttgct gataaagttc ttatcagcat cttatatatt agcttgacct atgcagatct
      721 tattccagtc ccactcactt acatgataat ttcaagagat gtaatgttga tcgctgctgt
      781 gttttatgtc agataccgaa ctctgccaac accgcgaaca ctagctaagt acttcaatcc
      841 ttgctatgcc acggctaggt taaaaccaac attcatcagc aaggtaaata cagcagtcca
      901 gttaattttg gtggcagctt ctttggcagc tccagttttc aattatgctg acagcattta
      961 tcttcagata ctatggtgtt gcacagcatt cactacagct gcatcagcat acagttatta
     1021 tcactatggt cggaaaactg ttcaggtgat aaagggcaaa tgagaagcac ccagatccag
     1081 cagcaaggaa gcaacttcgt catcggcagc agcgccagcg aaagctacag gactttcctg
     1141 atcttggtgt tcagcttgcg aaaggtcttg tcagacaaac catgtcttca aaactgaaga
     1201 aatgtacggc gaaaataagc tcgatcatgg gcctatacag aatttccagt gtatttttaa
     1261 atacaaataa aactataatg tagaattttt aatcttaggt ttttgattaa tttgtgagat
     1321 gaattattct tgtttttttt tttttttatg ttttttaaaa acatagttgg taacatggaa
     1381 acaaaggaaa gcaggaggga atttcctaag attggataca caccatacac agcatgtcta
     1441 tacattttta tgcttgaatt ttaaatctat aaatacatta acagttcatg tgattaatac
     1501 ttgatcattt gaaaactgag aataaactta gctgtgggta ctgtaaaggt gtacagagct
     1561 ttaaaatgca gtacattttg aaaacaaaaa agaacaaata aaacagaagg cattgaagtt
     1621 cacgagtagt cttccagcct ctcaggtacc aaatagttta tgtatcagga taacagataa
     1681 cgcaggagtc agagggagaa cacatgtatt acgctttgca tcttacaggc aaagcatgac
     1741 atcatgcctt ctccctgttt gtaatgggat gtttgatact ggaaccagtg ctcatatgtc
     1801 atgtaaatag gatgaaactt tctatttttc aaagtttttt tttttttttt taactttggg
     1861 gaatcttcta ttgttaacat gataaaaaag aaataaaaga gctggaaaaa aaaaaaaaaa
     1921 aaaaaaaaaa aaaaaaaaa
//
