LOCUS       NM_018776               2396 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus cytokine receptor-like factor 3 (Crlf3), transcript
            variant 1, mRNA.
ACCESSION   NM_018776
VERSION     NM_018776.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2396)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2396)
  AUTHORS   Wilson,A.F., Barakat,R., Mu,R., Karush,L.L., Gao,Y., Hartigan,K.A.,
            Chen,J.K., Shu,H., Turner,T.N., Maloney,S.E., Mennerick,S.J.,
            Gutmann,D.H. and Anastasaki,C.
  TITLE     A common single nucleotide variant in the cytokine receptor-like
            factor-3 (CRLF3) gene causes neuronal deficits in human and mouse
            cells
  JOURNAL   Hum Mol Genet 32 (24), 3342-3352 (2023)
   PUBMED   37712888
  REMARK    GeneRIF: A common single nucleotide variant in the cytokine
            receptor-like factor-3 (CRLF3) gene causes neuronal deficits in
            human and mouse cells.
REFERENCE   3  (bases 1 to 2396)
  AUTHORS   Bennett,C., Lawrence,M., Guerrero,J.A., Stritt,S., Waller,A.K.,
            Yan,Y., Mifsud,R.W., Ballester-Beltran,J., Baig,A., Mueller,A.,
            Mayer,L., Warland,J., Penkett,C.J., Akbari,P., Moreau,T.,
            Evans,A.L., Mookerjee,S., Hoffman,G.J., Saeb-Parsy,K., Adams,D.J.,
            Couzens,A.L., Bender,M., Erber,W.N., Nieswandt,B., Read,R.J. and
            Ghevaert,C.
  TITLE     CRLF3 plays a key role in the final stage of platelet genesis and
            is a potential therapeutic target for thrombocythemia
  JOURNAL   Blood 139 (14), 2227-2239 (2022)
   PUBMED   35051265
REFERENCE   4  (bases 1 to 2396)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2396)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 2396)
  AUTHORS   Ryder,E., Doe,B., Gleeson,D., Houghton,R., Dalvi,P., Grau,E.,
            Habib,B., Miklejewska,E., Newman,S., Sethi,D., Sinclair,C.,
            Vyas,S., Wardle-Jones,H., Bottomley,J., Bussell,J., Galli,A.,
            Salisbury,J. and Ramirez-Solis,R.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Rapid conversion of EUCOMM/KOMP-CSD alleles in mouse embryos using
            a cell-permeable Cre recombinase
  JOURNAL   Transgenic Res 23 (1), 177-185 (2014)
   PUBMED   24197666
REFERENCE   7  (bases 1 to 2396)
  AUTHORS   White,J.K., Gerdin,A.K., Karp,N.A., Ryder,E., Buljan,M.,
            Bussell,J.N., Salisbury,J., Clare,S., Ingham,N.J., Podrini,C.,
            Houghton,R., Estabel,J., Bottomley,J.R., Melvin,D.G., Sunter,D.,
            Adams,N.C., Tannahill,D., Logan,D.W., Macarthur,D.G., Flint,J.,
            Mahajan,V.B., Tsang,S.H., Smyth,I., Watt,F.M., Skarnes,W.C.,
            Dougan,G., Adams,D.J., Ramirez-Solis,R., Bradley,A. and Steel,K.P.
  CONSRTM   Sanger Institute Mouse Genetics Project
  TITLE     Genome-wide generation and systematic phenotyping of knockout mice
            reveals new roles for many genes
  JOURNAL   Cell 154 (2), 452-464 (2013)
   PUBMED   23870131
REFERENCE   8  (bases 1 to 2396)
  AUTHORS   Jenne,D.E., Tinschert,S., Dorschner,M.O., Hameister,H., Stephens,K.
            and Kehrer-Sawatzki,H.
  TITLE     Complete physical map and gene content of the human NF1 tumor
            suppressor region in human and mouse
  JOURNAL   Genes Chromosomes Cancer 37 (2), 111-120 (2003)
   PUBMED   12696059
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL591113.14, AK037880.1,
            AK137528.1 and AW986170.1.
            
            On Mar 8, 2013 this sequence version replaced NM_018776.1.
            
            Summary: This gene encodes a cytokine receptor-like factor that
            contains a fibronectin type 3 domain. The encoded protein may act
            as a negative regulator of the cell cycle. There is a pseudogene
            for this gene on chromosome 1. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Mar 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF046060.1, AK137528.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AL591113.14        187676-187728       c
            54-1796             AK037880.1         2-1744
            1797-2365           AK137528.1         1749-2317
            2366-2396           AW986170.1         1-31                c
FEATURES             Location/Qualifiers
     source          1..2396
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 47.43 cM"
     gene            1..2396
                     /gene="Crlf3"
                     /gene_synonym="Creme9; Cytor4"
                     /note="cytokine receptor-like factor 3"
                     /db_xref="GeneID:54394"
                     /db_xref="MGI:MGI:1860086"
     exon            1..208
                     /gene="Crlf3"
                     /gene_synonym="Creme9; Cytor4"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1408
                     /gene="Crlf3"
                     /gene_synonym="Creme9; Cytor4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cytokine receptor-like molecule 9; cytokine
                     receptor-related factor 4"
                     /codon_start=1
                     /product="cytokine receptor-like factor 3 isoform 1"
                     /protein_id="NP_061246.1"
                     /db_xref="CCDS:CCDS25126.1"
                     /db_xref="GeneID:54394"
                     /db_xref="MGI:MGI:1860086"
                     /translation="MKGAMEPEPEVLLQEARENVEAAQSYRRELGQRLQGLREAQRQI
                     KESASQTRDVLKQHFSDLKGTLGKLLDERLVTLLQEVDTIEQETIKPLDDCQKLIEHG
                     VNTADDLVREGEIAILGGIEEESDKLWNFTKKASHIQLDSLPEVPLLVDVPCLSAQLD
                     DSILNIVKDHIFKHGTVASRPPVQIEELIEKPGGIIVRWCKVDDDFTAQDYRLQFRKC
                     TANHFEDVYVGSETEFIVLHIDPNVDYQFRVCARGDGRQEWSPWSVPQTGHSTLVPHE
                     WTTGFEGYSLSSRRNIALRNDAESSGVLYSSAPTYFCGQTLTFRVETVGQPDRRDSIG
                     VCAERQNGYESLQRDQAVCISTNGAVFVNGKEMTNQLPAVTSGSTVTFDIEAVTLGTS
                     NSHEGGNAKLRVTISSNNREVVFDWLLEQACGPLYFGCSFFYPGWKVLVF"
     exon            209..416
                     /gene="Crlf3"
                     /gene_synonym="Creme9; Cytor4"
                     /inference="alignment:Splign:2.1.0"
     exon            417..504
                     /gene="Crlf3"
                     /gene_synonym="Creme9; Cytor4"
                     /inference="alignment:Splign:2.1.0"
     exon            505..682
                     /gene="Crlf3"
                     /gene_synonym="Creme9; Cytor4"
                     /inference="alignment:Splign:2.1.0"
     exon            683..905
                     /gene="Crlf3"
                     /gene_synonym="Creme9; Cytor4"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1038
                     /gene="Crlf3"
                     /gene_synonym="Creme9; Cytor4"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1151
                     /gene="Crlf3"
                     /gene_synonym="Creme9; Cytor4"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..2396
                     /gene="Crlf3"
                     /gene_synonym="Creme9; Cytor4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2372..2377
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crlf3"
                     /gene_synonym="Creme9; Cytor4"
                     /note="hexamer: AATAAA"
     regulatory      2379..2384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crlf3"
                     /gene_synonym="Creme9; Cytor4"
                     /note="hexamer: AATGAA"
     polyA_site      2380
                     /gene="Crlf3"
                     /gene_synonym="Creme9; Cytor4"
     polyA_site      2391
                     /gene="Crlf3"
                     /gene_synonym="Creme9; Cytor4"
                     /note="major polyA site"
     polyA_site      2396
                     /gene="Crlf3"
                     /gene_synonym="Creme9; Cytor4"
ORIGIN      
        1 cgcttccgct gcgcgaggcc gctcggggtc gctcgcggga gctaggcgca gtcgggaatc
       61 cggcgggccg cgcgaccaga tgaagggcgc gatggagccg gagcccgagg tgctgcttca
      121 ggaagcccgc gagaacgtgg aggcggcgca gagctaccgg cgggagctgg gccagcggct
      181 gcaggggctg cgggaggcgc agaggcagat aaaggagagt gcttcacaga caagagatgt
      241 cctcaaacag cattttagtg atttaaaagg aacccttggg aagctattgg atgagcgatt
      301 ggtgaccctt ttgcaagagg tggacaccat tgaacaggag accatcaaac cactagatga
      361 ctgccagaaa ctcatagagc atggggtcaa cactgcagat gacctggtcc gagaaggtga
      421 gattgccatt cttggtggta tcgaagaaga gagtgataaa ctgtggaact ttaccaaaaa
      481 ggcctcacac attcagctgg acagcttacc agaagtgccc ttgctagttg atgtaccctg
      541 tttgtcggct cagttggacg attccattct taacatagtg aaagaccaca tttttaagca
      601 tggaacagta gcttcccgcc caccagtaca gattgaagaa ttaatagaga aacctggagg
      661 catcatagtg cgatggtgta aggtggatga tgacttcaca gcccaagatt acaggcttca
      721 gttccgcaaa tgtactgcaa atcattttga agacgtgtat gtaggttctg aaacggagtt
      781 catagtgttg cacatagacc ccaatgtaga ttatcaattc agagtctgcg cccgaggaga
      841 cggcaggcag gaatggagtc cttggagtgt tccccagaca ggccactcca cactggtgcc
      901 tcatgagtgg acaactggct ttgagggata cagtctgagc agtcgaagaa atatagccct
      961 ccggaatgat gccgagtcct cgggtgttct ctactccagc gctccaacct acttctgtgg
     1021 gcagacgctg acattcagag ttgaaactgt gggacagcca gaccgaagag acagtatagg
     1081 agtatgtgca gaaaggcaga atggctacga atctctgcag cgggaccaag ccgtgtgcat
     1141 cagcacgaat ggtgcagtct ttgtcaatgg aaaagaaatg accaatcagt tgcctgcagt
     1201 tacctctggc tccactgtca catttgatat cgaagctgtg actctaggaa cttctaacag
     1261 ccatgaaggt gggaacgcca agctccgagt gaccatcagc tccaataacc gggaggtggt
     1321 gtttgactgg ctgctcgagc aggcctgtgg ccctctttac ttcggatgct cgtttttcta
     1381 ccctggatgg aaagtgctgg tattttagca tttgaagggc ttggctttga tgtgagggtt
     1441 tgctgtttct gtcctcagtt tagttgtctc tgactttgaa aaggtgagct tacctctctg
     1501 tccaccggaa attaaaaatg tttctgggtt caccttgtaa ggtttcagta agaagtgagc
     1561 tgagtgatgt ggacaaaacc atagctcagt tttgttttga agtacaaata tcaaactagc
     1621 tttaaaagtc tgcatacttt ttccactgtt cttcctgaag ttggttgtta gaacagaaaa
     1681 tgtcacatta gtaagtcttc atcaagattg aaggccagaa gtaaacacag aagacagcga
     1741 gaggccaggc tcctcggtgc ttgtccagtc ctgagtgttc accctctcca cgtccccctc
     1801 cgggagtgtc tgggtctgag ccagcatctg tgacagccag tgttagcatc tttttactgg
     1861 agtgtgacac agagagggca gaggtctgca ttcctcaagg tgaagctact tttggaagaa
     1921 cacagcagtg ttagcaggtc acgtgtgcac agcaggcccc atgcatcttt cctcagccgt
     1981 gcacacgggc tgtgtgcagt gttatagtca gtgtgatgtc aggttgagaa ctggtctttt
     2041 agtggaccaa ggaaataaag gataaatact tgacctattt tttttaaact taaatttctg
     2101 taaaatattt atttgactta cttaatatgt aaaaaaatcg tggtcttgtt ataccagcat
     2161 acatataatt tttaatgtga atttttgttt gttttttatc aatagtaaaa aaaaaaagtg
     2221 gaaaagcaag tgtggtattt ttgtaagata atttatttgg ggattcatgt tccctttcga
     2281 caatcatgac ttttcctccc gttttatgta taagtaagtg cccttctcat gttagaggtt
     2341 ctagagtgcc gtatccagcc ttatgaaaca aaataaaaaa tgaaaaatta acagaa
//
