LOCUS       NM_001164735            1371 bp    mRNA    linear   ROD 31-OCT-2023
DEFINITION  Mus musculus cytokine receptor-like factor 2 (Crlf2), transcript
            variant 1, mRNA.
ACCESSION   NM_001164735
VERSION     NM_001164735.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1371)
  AUTHORS   Kim DH, Wang Y, Jung H, Field RL, Zhang X, Liu TC, Ma C, Fraser JS,
            Brestoff JR and Van Dyken SJ.
  TITLE     A type 2 immune circuit in the stomach controls mammalian
            adaptation to dietary chitin
  JOURNAL   Science 381 (6662), 1092-1098 (2023)
   PUBMED   37676935
REFERENCE   2  (bases 1 to 1371)
  AUTHORS   Cui W, Nagano Y, Morita S, Tanoue T, Yamane H, Ishikawa K, Sato T,
            Kubo M, Hori S, Taniguchi T, Hatakeyama M, Atarashi K and Honda K.
  TITLE     Diet-mediated constitutive induction of novel IL-4+ ILC2 cells
            maintains intestinal homeostasis in mice
  JOURNAL   J Exp Med 220 (8) (2023)
   PUBMED   37163450
REFERENCE   3  (bases 1 to 1371)
  AUTHORS   Wang D, Wang F, Huang Y, Wang J, Luo H, Zhang P, Peng J, Tang G,
            Wang Y, Yu L and Ni D.
  TITLE     TSLP/TSLPR promotes renal fibrosis by activating STAT3 in renal
            fibroblasts
  JOURNAL   Int Immunopharmacol 121, 110430 (2023)
   PUBMED   37364323
  REMARK    GeneRIF: TSLP/TSLPR promotes renal fibrosis by activating STAT3 in
            renal fibroblasts.
REFERENCE   4  (bases 1 to 1371)
  AUTHORS   Messerschmidt,J.L., Azin,M., Dempsey,K.E. and Demehri,S.
  TITLE     TSLP/dendritic cell axis promotes CD4+ T cell tolerance to the gut
            microbiome
  JOURNAL   JCI Insight 8 (13), e160690 (2023)
   PUBMED   37427591
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1371)
  AUTHORS   Brandt EB, Ruff BP, Filuta AL, Chang WC, Shik D and Khurana Hershey
            GK.
  TITLE     Thymic stromal lymphopoietin rather than IL-33 drives food allergy
            after epicutaneous sensitization to food allergen
  JOURNAL   J Allergy Clin Immunol 151 (6), 1660-1666 (2023)
   PUBMED   36878383
REFERENCE   6  (bases 1 to 1371)
  AUTHORS   Yamaguchi E, Chiba S, Kumano K, Kunisato A, Takahashi T, Takahashi
            T and Hirai H.
  TITLE     Expression of Notch ligands, Jagged1, 2 and Delta1 in antigen
            presenting cells in mice
  JOURNAL   Immunol Lett 81 (1), 59-64 (2002)
   PUBMED   11841846
  REMARK    GeneRIF: expression pattern in antigen presenting cells
REFERENCE   7  (bases 1 to 1371)
  AUTHORS   Park LS, Martin U, Garka K, Gliniak B, Di Santo JP, Muller W,
            Largaespada DA, Copeland NG, Jenkins NA, Farr AG, Ziegler SF,
            Morrissey PJ, Paxton R and Sims JE.
  TITLE     Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor:
            Formation of a functional heteromeric complex requires interleukin
            7 receptor
  JOURNAL   J Exp Med 192 (5), 659-670 (2000)
   PUBMED   10974032
REFERENCE   8  (bases 1 to 1371)
  AUTHORS   Pandey A, Ozaki K, Baumann H, Levin SD, Puel A, Farr AG, Ziegler
            SF, Leonard WJ and Lodish HF.
  TITLE     Cloning of a receptor subunit required for signaling by thymic
            stromal lymphopoietin
  JOURNAL   Nat Immunol 1 (1), 59-64 (2000)
   PUBMED   10881176
REFERENCE   9  (bases 1 to 1371)
  AUTHORS   Hiroyama T, Iwama A, Morita Y, Nakamura Y, Shibuya A and Nakauchi
            H.
  TITLE     Molecular cloning and characterization of CRLM-2, a novel type I
            cytokine receptor preferentially expressed in hematopoietic cells
  JOURNAL   Biochem Biophys Res Commun 272 (1), 224-229 (2000)
   PUBMED   10872831
REFERENCE   10 (bases 1 to 1371)
  AUTHORS   Fujio K, Nosaka T, Kojima T, Kawashima T, Yahata T, Copeland NG,
            Gilbert DJ, Jenkins NA, Yamamoto K, Nishimura T and Kitamura T.
  TITLE     Molecular cloning of a novel type 1 cytokine receptor similar to
            the common gamma chain
  JOURNAL   Blood 95 (7), 2204-2210 (2000)
   PUBMED   10733486
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK149928.1, AF232936.1 and AC116718.21.
            
            [WARNING] On Nov 22, 2023 this sequence was replaced by
            NM_001164735.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF201963.1, SRR13422597.608501.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-370               AK149928.1         2-371
            371-759             AF232936.1         335-723
            760-792             AC116718.21        170154-170186
            793-1371            AF232936.1         724-1302
FEATURES             Location/Qualifiers
     source          1..1371
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 53.24 cM"
     gene            1..1371
                     /gene="Crlf2"
                     /gene_synonym="CRLM2; Ly114; Tslpr"
                     /note="cytokine receptor-like factor 2"
                     /db_xref="GeneID:57914"
                     /db_xref="MGI:MGI:1889506"
     exon            1..189
                     /gene="Crlf2"
                     /gene_synonym="CRLM2; Ly114; Tslpr"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1223
                     /gene="Crlf2"
                     /gene_synonym="CRLM2; Ly114; Tslpr"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; TSLP receptor; type I cytokine receptor delta
                     1; cytokine receptor-like molecule 2; thymic stromal
                     lymphopoietin protein receptor; lymphocyte antigen 114;
                     thymic stromal-derived lymphopoietin, receptor"
                     /codon_start=1
                     /product="cytokine receptor-like factor 2 isoform 1
                     precursor"
                     /protein_id="NP_001158207.1"
                     /db_xref="GeneID:57914"
                     /db_xref="MGI:MGI:1889506"
                     /translation="MAWALAVILLPRLLAAAAAAAAVTSRGDVTVVCHDLETVEVTWG
                     SGPDHHGANLSLEFRYGTGALQPCPRYFLSGAGVTSGCILPAARAGLLELALRDGGGA
                     MVFKARQRASAWLKPRPPWNVTLLWTPDGDVTVSWPAHSYLGLDYEVQHRESNDDEDA
                     WQTTSGPCCDLTVGGLDPVRCYDFRVRASPRAAHYGLEAQPSEWTAVTRLSGAASAGD
                     PCAAHLPPLASCTASPAPSPALAPPLLPLGCGLAALLTLSLLLAALRLRRVKDALLPC
                     VPDPSGSFPGLFEKHHGNFQAWIADAQATAPPARTEEEDDLIHTKAKRVEPEDGTSLC
                     TVPRPPSFEPRGPGGGAMVSVGGATFMVGDSGYMTL"
     exon            190..286
                     /gene="Crlf2"
                     /gene_synonym="CRLM2; Ly114; Tslpr"
                     /inference="alignment:Splign:2.1.0"
     exon            287..453
                     /gene="Crlf2"
                     /gene_synonym="CRLM2; Ly114; Tslpr"
                     /inference="alignment:Splign:2.1.0"
     exon            454..596
                     /gene="Crlf2"
                     /gene_synonym="CRLM2; Ly114; Tslpr"
                     /inference="alignment:Splign:2.1.0"
     exon            597..759
                     /gene="Crlf2"
                     /gene_synonym="CRLM2; Ly114; Tslpr"
                     /inference="alignment:Splign:2.1.0"
     exon            760..913
                     /gene="Crlf2"
                     /gene_synonym="CRLM2; Ly114; Tslpr"
                     /inference="alignment:Splign:2.1.0"
     exon            914..998
                     /gene="Crlf2"
                     /gene_synonym="CRLM2; Ly114; Tslpr"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1360
                     /gene="Crlf2"
                     /gene_synonym="CRLM2; Ly114; Tslpr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccccggct tcccgttttc ggctctaagc ggcctgggcg ccctcgactc ggaccggctc
       61 ggaccgaacc agctgtcaat cactgcagcg tccgcggccc cgccggcgac atggcatggg
      121 cactcgcggt catcctcctg cctcggctcc ttgcggcggc agcggcggcg gcggcggtga
      181 cgtcacgggg tgatgtcaca gtcgtctgcc atgacctgga gacggtggag gtcacgtggg
      241 gctcgggccc cgaccaccac ggcgccaact tgagcctgga gttccgttat ggcactggcg
      301 ccctgcaacc ctgcccgcga tatttcctgt ccggcgctgg tgtcacttcc gggtgcatcc
      361 tccccgcggc gagggcgggg ctgctggagc tggcactgcg cgacggaggc ggggccatgg
      421 tgtttaaggc taggcagcgc gcgtccgcct ggctgaagcc ccgcccacct tggaatgtga
      481 cgctgctctg gacaccagac ggggacgtga ctgtctcctg gcctgcccac tcctacctgg
      541 gcctggacta cgaggtgcag caccgggaga gcaatgacga tgaggacgcc tggcagacga
      601 cctcagggcc ctgctgtgac ttgacagtgg gcgggctcga ccccgtacgc tgctatgact
      661 tccgggttcg ggcgtcgccc cgggccgcgc actatggcct ggaggcgcag cctagcgagt
      721 ggacagcggt gacaaggctt tccggggcag catccgcggg tgacccctgc gccgcccacc
      781 ttccccccct agcctcctgt accgcaagcc ccgccccatc cccggccctg gccccgcccc
      841 tcctgcccct gggctgcggc ctagcagcgc tgctgacact gtccctgctc ctggccgccc
      901 tgaggcttcg cagggtgaaa gatgcgctgc tgccctgcgt ccctgacccc agcggctcct
      961 tccctggact ctttgagaag catcacggga acttccaggc ctggattgcg gacgcccagg
     1021 ccacagcccc gccagccagg accgaggagg aagatgacct catccacacc aaggctaaga
     1081 gggtggagcc cgaggacggc acctccctct gcaccgtgcc aaggccaccc agcttcgagc
     1141 caagggggcc gggaggcggg gccatggtgt cagtgggcgg ggccacgttc atggtgggcg
     1201 acagcggcta catgaccctg tgaccttgaa gtcactgcca gtctatactt caggctgagg
     1261 tcacttcctg tctttaaata attcaaactc acaaatcctg tgcctgtctg tatgcaaatg
     1321 tggtcacaaa tattcaaata aaatgcaaat gctatgctaa aaaaaaaaaa a
//
