LOCUS       NM_018827               1651 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus cytokine receptor-like factor 1 (Crlf1), transcript
            variant 2, mRNA.
ACCESSION   NM_018827 XM_001005787
VERSION     NM_018827.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1651)
  AUTHORS   Luo,S., Yang,Z., Chen,R., You,D., Teng,F., Yuan,Y., Liu,W., Li,J.
            and Zhang,H.
  TITLE     Cytokine receptor-like factor 1 (CRLF1) promotes cardiac fibrosis
            via ERK1/2 signaling pathway
  JOURNAL   J Zhejiang Univ Sci B 24 (8), 682-697 (2023)
   PUBMED   37551555
  REMARK    GeneRIF: Cytokine receptor-like factor 1 (CRLF1) promotes cardiac
            fibrosis via ERK1/2 signaling pathway.
REFERENCE   2  (bases 1 to 1651)
  AUTHORS   Fidalgo,M.F., Fonseca,C.G., Caldas,P., Raposo,A.A., Balboni,T.,
            Henao-Misikova,L., Grosso,A.R., Vasconcelos,F.F. and Franco,C.A.
  TITLE     Aerocyte specification and lung adaptation to breathing is
            dependent on alternative splicing changes
  JOURNAL   Life Sci Alliance 5 (12), e202201554 (2022)
   PUBMED   36220570
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1651)
  AUTHORS   Xu,H., Ding,C., Guo,C., Xiang,S., Wang,Y., Luo,B. and Xiang,H.
  TITLE     Suppression of CRLF1 promotes the chondrogenic differentiation of
            bone marrow-derived mesenchymal stem and protects cartilage tissue
            from damage in osteoarthritis via activation of miR-320
  JOURNAL   Mol Med 27 (1), 116 (2021)
   PUBMED   34551709
  REMARK    GeneRIF: Suppression of CRLF1 promotes the chondrogenic
            differentiation of bone marrow-derived mesenchymal stem and
            protects cartilage tissue from damage in osteoarthritis via
            activation of miR-320.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1651)
  AUTHORS   Li,H., Kurtzeborn,K., Kupari,J., Gui,Y., Siefker,E., Lu,B.,
            Matlik,K., Olfat,S., Montano-Rodriguez,A.R., Huh,S.H.,
            Costantini,F., Andressoo,J.O. and Kuure,S.
  TITLE     Postnatal prolongation of mammalian nephrogenesis by excess fetal
            GDNF
  JOURNAL   Development 148 (10) (2021)
   PUBMED   34032268
REFERENCE   5  (bases 1 to 1651)
  AUTHORS   Zhang,H., Bagherie-Lachidan,M., Badouel,C., Enderle,L., Peidis,P.,
            Bremner,R., Kuure,S., Jain,S. and McNeill,H.
  TITLE     FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling
  JOURNAL   Dev Cell 48 (6), 780-792 (2019)
   PUBMED   30853441
REFERENCE   6  (bases 1 to 1651)
  AUTHORS   Funatsu,N., Inoue,T. and Nakamura,S.
  TITLE     Gene expression analysis of the late embryonic mouse cerebral
            cortex using DNA microarray: identification of several region- and
            layer-specific genes
  JOURNAL   Cereb Cortex 14 (9), 1031-1044 (2004)
   PUBMED   15142957
REFERENCE   7  (bases 1 to 1651)
  AUTHORS   Forger,N.G., Prevette,D., deLapeyriere,O., de Bovis,B., Wang,S.,
            Bartlett,P. and Oppenheim,R.W.
  TITLE     Cardiotrophin-like cytokine/cytokine-like factor 1 is an essential
            trophic factor for lumbar and facial motoneurons in vivo
  JOURNAL   J Neurosci 23 (26), 8854-8858 (2003)
   PUBMED   14523086
REFERENCE   8  (bases 1 to 1651)
  AUTHORS   Uemura,A., Takizawa,T., Ochiai,W., Yanagisawa,M., Nakashima,K. and
            Taga,T.
  TITLE     Cardiotrophin-like cytokine induces astrocyte differentiation of
            fetal neuroepithelial cells via activation of STAT3
  JOURNAL   Cytokine 18 (1), 1-7 (2002)
   PUBMED   12090754
REFERENCE   9  (bases 1 to 1651)
  AUTHORS   Alexander,W.S., Rakar,S., Robb,L., Farley,A., Willson,T.A.,
            Zhang,J.G., Hartley,L., Kikuchi,Y., Kojima,T., Nomura,H.,
            Hasegawa,M., Maeda,M., Fabri,L., Jachno,K., Nash,A., Metcalf,D.,
            Nicola,N.A. and Hilton,D.J.
  TITLE     Suckling defect in mice lacking the soluble haemopoietin receptor
            NR6
  JOURNAL   Curr Biol 9 (11), 605-608 (1999)
   PUBMED   10359701
REFERENCE   10 (bases 1 to 1651)
  AUTHORS   Elson,G.C., Graber,P., Losberger,C., Herren,S., Gretener,D.,
            Menoud,L.N., Wells,T.N., Kosco-Vilbois,M.H. and Gauchat,J.F.
  TITLE     Cytokine-like factor-1, a novel soluble protein, shares homology
            with members of the cytokine type I receptor family
  JOURNAL   J Immunol 161 (3), 1371-1379 (1998)
   PUBMED   9686600
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC157774.5.
            
            On Mar 11, 2020 this sequence version replaced NM_018827.3.
            
            Summary: This gene encodes a member of the cytokine type I receptor
            family. The encoded protein functions as a cytokine receptor
            subunit and may be involved in immune system regulation and fetal
            development. [provided by RefSeq, Dec 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.4711322.1, AB040038.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               AC157774.5         154500-154752       c
            254-535             AC157774.5         149022-149303       c
            536-665             AC157774.5         148678-148807       c
            666-835             AC157774.5         148401-148570       c
            836-993             AC157774.5         146859-147016       c
            994-1162            AC157774.5         146622-146790       c
            1163-1350           AC157774.5         144408-144595       c
            1351-1393           AC157774.5         144261-144303       c
            1394-1651           AC157774.5         143822-144079       c
FEATURES             Location/Qualifiers
     source          1..1651
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.15 cM"
     gene            1..1651
                     /gene="Crlf1"
                     /gene_synonym="CLF-1; CRLM-3; CRLM3; NR6; NR6.1"
                     /note="cytokine receptor-like factor 1"
                     /db_xref="GeneID:12931"
                     /db_xref="MGI:MGI:1340030"
     exon            1..253
                     /gene="Crlf1"
                     /gene_synonym="CLF-1; CRLM-3; CRLM3; NR6; NR6.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1407
                     /gene="Crlf1"
                     /gene_synonym="CLF-1; CRLM-3; CRLM3; NR6; NR6.1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; cytokine-like factor 1; novel cytokine receptor
                     6; cytokine receptor-like molecule 3"
                     /codon_start=1
                     /product="cytokine receptor-like factor 1 isoform 2
                     precursor"
                     /protein_id="NP_061297.1"
                     /db_xref="CCDS:CCDS22369.1"
                     /db_xref="GeneID:12931"
                     /db_xref="MGI:MGI:1340030"
                     /translation="MPAGRPGPVAQSARRPPRPLSSLWSPLLLCVLGVPRGGSGAHTA
                     VISPQDPTLLIGSSLQATCSIHGDTPGATAEGLYWTLNGRRLPSELSRLLNTSTLALA
                     LANLNGSRQQSGDNLVCHARDGSILAGSCLYVGLPPEKPFNISCWSRNMKDLTCRWTP
                     GAHGETFLHTNYSLKYKLRWYGQDNTCEEYHTVGPHSCHIPKDLALFTPYEIWVEATN
                     RLGSARSDVLTLDVLDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQ
                     IRYRVEDSVDWKVVDDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSEWS
                     HPTAASTPRSERPGPGGGVCEPRGGEPSSGPVRRELKQFLGWLKKHAYCSNLSFRLYD
                     QWRAWMQKSHKTRNQDEGILPSGRRGAARGPAG"
     exon            254..535
                     /gene="Crlf1"
                     /gene_synonym="CLF-1; CRLM-3; CRLM3; NR6; NR6.1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..665
                     /gene="Crlf1"
                     /gene_synonym="CLF-1; CRLM-3; CRLM3; NR6; NR6.1"
                     /inference="alignment:Splign:2.1.0"
     exon            666..835
                     /gene="Crlf1"
                     /gene_synonym="CLF-1; CRLM-3; CRLM3; NR6; NR6.1"
                     /inference="alignment:Splign:2.1.0"
     exon            836..993
                     /gene="Crlf1"
                     /gene_synonym="CLF-1; CRLM-3; CRLM3; NR6; NR6.1"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1162
                     /gene="Crlf1"
                     /gene_synonym="CLF-1; CRLM-3; CRLM3; NR6; NR6.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1350
                     /gene="Crlf1"
                     /gene_synonym="CLF-1; CRLM-3; CRLM3; NR6; NR6.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1393
                     /gene="Crlf1"
                     /gene_synonym="CLF-1; CRLM-3; CRLM3; NR6; NR6.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1651
                     /gene="Crlf1"
                     /gene_synonym="CLF-1; CRLM-3; CRLM3; NR6; NR6.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1627..1632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Crlf1"
                     /gene_synonym="CLF-1; CRLM-3; CRLM3; NR6; NR6.1"
                     /note="hexamer: AATAAA"
     polyA_site      1651
                     /gene="Crlf1"
                     /gene_synonym="CLF-1; CRLM-3; CRLM3; NR6; NR6.1"
                     /note="major polyA site"
ORIGIN      
        1 agacttgctc cggccttcgc tgtccgcgcc cagtgacgcg cgtgaggacc cgagccccaa
       61 tctgcacccc gcagactcgc ccccgcccca taccggcgtt gcagtcaccg cccgttgcgc
      121 gccaccccca tgcccgcggg tcgcccgggc cccgtcgccc aatccgcgcg gcggccgccg
      181 cggccgctgt cctcgctgtg gtcgcctctg ttgctctgtg tcctcggggt gcctcggggc
      241 ggatcgggag cccacacagc tgtaatcagc ccccaggacc ccacccttct catcggctcc
      301 tccctgcaag ctacctgctc tatacatgga gacacacctg gggccaccgc tgaggggctc
      361 tactggaccc tcaatggtcg ccgcctgccc tctgagctgt cccgcctcct taacacctcc
      421 accctggccc tggccctggc taaccttaat gggtccaggc agcagtcagg agacaatctg
      481 gtgtgtcacg cccgagatgg cagcattctg gctggctcct gcctctatgt tggcttgccc
      541 cctgagaagc cttttaacat cagctgctgg tcccggaaca tgaaggatct cacgtgccgc
      601 tggacaccgg gtgcacacgg ggagacattc ttacatacca actactccct caagtacaag
      661 ctgaggtggt acggtcagga taacacatgt gaggagtacc acactgtggg ccctcactca
      721 tgccatatcc ccaaggacct ggccctcttc actccctatg agatctgggt ggaagccacc
      781 aatcgcctag gctcagcaag atctgatgtc ctcacactgg atgtcctgga cgtggtgacc
      841 acggaccccc cacccgacgt gcacgtgagc cgcgttgggg gcctggagga ccagctgagt
      901 gtgcgctggg tctcaccacc agctctcaag gatttcctct tccaagccaa gtaccagatc
      961 cgctaccgcg tggaggacag cgtggactgg aaggtggtgg atgacgtcag caaccagacc
     1021 tcctgccgtc tcgcgggcct gaagcccggc accgtttact tcgtccaagt gcgttgtaac
     1081 ccattcggga tctatgggtc gaaaaaggcg ggaatctgga gcgagtggag ccaccccacc
     1141 gctgcctcca cccctcgaag tgagcgcccg ggcccgggcg gcggggtgtg cgagccgcgg
     1201 ggcggcgagc ccagctcggg cccggtgcgg cgcgagctca agcagttcct cggctggctc
     1261 aagaagcacg catactgctc gaaccttagt ttccgcctgt acgaccagtg gcgtgcttgg
     1321 atgcagaagt cacacaagac ccgaaaccag gacgagggga tcctgccctc gggcagacgg
     1381 ggtgcggcga gaggtcctgc cggctaaact ctaaggatag gccatcctcc tgctgggtca
     1441 gacctggagg ctcacctgaa ttggagcccc tctgtaccat ctgggcaaca aagaaaccta
     1501 ccagaggctg gggcacaatg agctcccaca accacagctt tggtccacat gatggtcaca
     1561 cttggatata ccccagtgtg ggtagggttg gggtattgca gggcctccca agagtctctt
     1621 taaataaata aaggagttgt tcaggtcccg a
//
